ATE244249T1 - Kristallinisches aminsalz von cefdinir - Google Patents

Kristallinisches aminsalz von cefdinir

Info

Publication number
ATE244249T1
ATE244249T1 AT98921425T AT98921425T ATE244249T1 AT E244249 T1 ATE244249 T1 AT E244249T1 AT 98921425 T AT98921425 T AT 98921425T AT 98921425 T AT98921425 T AT 98921425T AT E244249 T1 ATE244249 T1 AT E244249T1
Authority
AT
Austria
Prior art keywords
cefdinir
amine salt
crystalline amine
crystalline
salt
Prior art date
Application number
AT98921425T
Other languages
English (en)
Inventor
Hubert Sturm
Siegfried Wolf
Johannes Ludescher
Original Assignee
Biochemie Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biochemie Gmbh filed Critical Biochemie Gmbh
Application granted granted Critical
Publication of ATE244249T1 publication Critical patent/ATE244249T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/22—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with radicals containing only hydrogen and carbon atoms, attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT98921425T 1997-04-04 1998-04-02 Kristallinisches aminsalz von cefdinir ATE244249T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AT0057097A AT405283B (de) 1997-04-04 1997-04-04 Neues kristallines 7-(z)-(2-(2-aminothiazol-4-yl) -2-hydroxyiminoacetamido)-3-vinyl-3-cephem-4- carbonsäure dicyclohexylammoniumsalz und verfahren zu dessen herstellung
PCT/EP1998/001953 WO1998045299A1 (en) 1997-04-04 1998-04-02 Crystalline amine salt of cefdinir
EP98921425A EP0973779B1 (de) 1997-04-04 1998-04-02 Kristallinisches aminsalz von cefdinir

Publications (1)

Publication Number Publication Date
ATE244249T1 true ATE244249T1 (de) 2003-07-15

Family

ID=3494111

Family Applications (2)

Application Number Title Priority Date Filing Date
AT0057097A AT405283B (de) 1997-04-04 1997-04-04 Neues kristallines 7-(z)-(2-(2-aminothiazol-4-yl) -2-hydroxyiminoacetamido)-3-vinyl-3-cephem-4- carbonsäure dicyclohexylammoniumsalz und verfahren zu dessen herstellung
AT98921425T ATE244249T1 (de) 1997-04-04 1998-04-02 Kristallinisches aminsalz von cefdinir

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT0057097A AT405283B (de) 1997-04-04 1997-04-04 Neues kristallines 7-(z)-(2-(2-aminothiazol-4-yl) -2-hydroxyiminoacetamido)-3-vinyl-3-cephem-4- carbonsäure dicyclohexylammoniumsalz und verfahren zu dessen herstellung

Country Status (18)

Country Link
US (1) US6350869B1 (de)
EP (1) EP0973779B1 (de)
JP (1) JP3421354B2 (de)
KR (1) KR100442717B1 (de)
CN (1) CN1139596C (de)
AT (2) AT405283B (de)
AU (1) AU731413B2 (de)
BR (1) BR9809745A (de)
CA (1) CA2283718A1 (de)
DE (1) DE69816056T2 (de)
HU (1) HUP0002987A3 (de)
ID (1) ID22536A (de)
IL (1) IL131755A0 (de)
NO (1) NO994466L (de)
PL (1) PL335620A1 (de)
SK (1) SK134399A3 (de)
TR (1) TR199902406T2 (de)
WO (1) WO1998045299A1 (de)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080113025A1 (en) * 1998-11-02 2008-05-15 Elan Pharma International Limited Compositions comprising nanoparticulate naproxen and controlled release hydrocodone
KR100451672B1 (ko) * 2001-06-05 2004-10-08 한미약품 주식회사 결정성 세프디니르 산부가염, 이의 제조방법 및 이를이용한 세프디니르의 제조방법
ITMI20020913A0 (it) * 2002-04-29 2002-04-29 Acs Dobfar Spa Nuova forma cristallina del cefdinir
KR20110005727A (ko) 2002-08-13 2011-01-18 산도즈 아게 세프디니르 중간체
ITMI20022076A1 (it) 2002-10-01 2004-04-02 Antibioticos Spa Sali di intermedi del cefdinir.
US7244842B2 (en) * 2002-11-15 2007-07-17 Orchid Chemicals & Pharmaceuticals Ltd. Amorphous hydrate of a cephalosporin antibiotic
ITMI20022724A1 (it) * 2002-12-20 2004-06-21 Antibioticos Spa Sali cristallini del cefdinir.
CN100357294C (zh) * 2003-03-24 2007-12-26 桑多斯股份公司 7－[2－(2－氨基噻唑－4－基)－2－羟基亚氨基乙酰胺－3－乙烯基－3－头孢烯－4－羧酸(顺式异构体)的新型晶体和其制备方法
WO2004104010A1 (en) * 2003-05-20 2004-12-02 Ranbaxy Laboratories Limited Crystalline form of cefdinir
US20050137182A1 (en) * 2003-06-02 2005-06-23 Ramesh Dandala Novel crystalline form of cefdinir
US20040242556A1 (en) * 2003-06-02 2004-12-02 Ramesh Dandala Novel crystalline form of cefdinir
US20050059819A1 (en) * 2003-09-12 2005-03-17 Duerst Richard W. Cefdinir pyridine salt
US20050059818A1 (en) * 2003-09-12 2005-03-17 Duerst Richard W. Polymorph of a pharmaceutical
US20050113355A1 (en) * 2003-09-12 2005-05-26 Duerst Richard W. Cefdinir pyridine salt
US20060142563A1 (en) * 2004-03-16 2006-06-29 Devalina Law Crystalline anhydrous cefdinir and crystalline cefdinir hydrates
US20060142261A1 (en) * 2004-03-16 2006-06-29 Devalina Law Crystalline anhydrous cefdinir and crystalline cefdinir hydrates
US20050209211A1 (en) * 2004-03-16 2005-09-22 Devalina Law Trihemihydrate, anhydrate and novel hydrate forms of Cefdinir
US20060211676A1 (en) * 2004-03-16 2006-09-21 Devalina Law Crystalline anhydrous cefdinir and crystalline cefdinir hydrates
WO2005090360A1 (en) * 2004-03-19 2005-09-29 Orchid Chemicals & Pharmaceuticals Limited Novel polymorph of cefdinir
US20060069079A1 (en) * 2004-09-27 2006-03-30 Sever Nancy E Stable amorphous cefdinir
US20050245738A1 (en) * 2004-05-03 2005-11-03 Lupin Ltd Stable bioavailable crystalline form or cefdinir and a process for the preparation thereof
WO2006010978A1 (en) * 2004-06-30 2006-02-02 Wockhardt Limited Cefdinir polymorphic forms, and imidazole salt
US7741478B2 (en) 2004-07-05 2010-06-22 Orchid Chemicals & Pharmaceuticals Limited Salts in the preparation of cephalosporin antibiotics
WO2006018807A1 (en) * 2004-08-16 2006-02-23 Ranbaxy Laboratories Limited Crystalline forms of cefdinir
ITMI20042231A1 (it) * 2004-11-19 2005-02-19 Antibioticos Spa Cefdinir sale d'ammonio in forma cristallina
WO2006059753A1 (en) * 2004-11-30 2006-06-08 Astellas Pharma Inc. Novel oral pharmaceutical suspension of cefdinir crystal
GB2421024A (en) * 2004-12-07 2006-06-14 Sandoz Ag Cefdinir crystalline form C
WO2006117794A1 (en) * 2005-05-02 2006-11-09 Hetero Drugs Limited A novel crystalline form of cefdinir
US20080287673A1 (en) * 2005-06-15 2008-11-20 Parthasaradhi Reddy Bandk Cefdinir process
CN1903860B (zh) * 2005-07-25 2012-01-18 四川抗菌素工业研究所有限公司 溶媒法制备高纯度头孢他美钠工艺及医药用途
EP1828208A2 (de) * 2005-10-31 2007-09-05 Teva Pharmaceutical Industries Ltd Kristalline form eines cefdinir-cäsiumsalzes
US20070128268A1 (en) * 2005-12-07 2007-06-07 Herwig Jennewein Pharmaceutical compositions comprising an antibiotic
CN101481383B (zh) 2008-12-31 2012-01-11 杭州奥默医药技术有限公司 头孢地尼酸式复盐化合物及制备方法
TR200909784A1 (tr) * 2009-12-25 2011-07-21 Bi̇lgi̇ç Mahmut Yeni sefdinir tuzları
US8614315B2 (en) 2009-12-25 2013-12-24 Mahmut Bilgic Cefdinir and cefixime formulations and uses thereof
CN102010427B (zh) * 2010-11-19 2012-09-12 苏州中联化学制药有限公司 一种头孢地尼的制备方法
CN101974020B (zh) * 2010-11-19 2012-09-12 苏州中联化学制药有限公司 一种头孢地尼的合成方法
CN103012433B (zh) * 2012-12-13 2015-06-24 珠海保税区丽珠合成制药有限公司 头孢地尼晶型b的制备方法
CN111039958B (zh) * 2017-05-31 2022-05-20 郑州大学第一附属医院 头孢地尼的制备方法
CN107286148B (zh) * 2017-06-20 2019-10-15 广州市桐晖通医药科技有限公司 一种头孢地尼的制备方法及其新的中间体化合物
CN111635419B (zh) * 2020-07-13 2022-05-24 广药白云山化学制药(珠海)有限公司 一种头孢地尼精制母液的处理方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR5564M (de) * 1964-03-14 1968-01-02
GB8323034D0 (en) * 1983-08-26 1983-09-28 Fujisawo Pharmaceutical Co Ltd 7-substituted-3-vinyl-3-cephem compounds
ZA885709B (en) 1987-08-19 1989-04-26 Fujisawa Pharmaceutical Co Novel crystalline 7-(2-(2-aminothiazol-4-yl)-2-hydroxyiminoacetamido)-3-vinyl-3-cephem-4-carboxylic acid(syn isomer)
DK0630380T3 (da) * 1992-02-05 2001-12-10 Biochemie Gmbh Fremgangsmåde til rensning af et 3-cephem-4-carboxylsyrederivat
JPH09504306A (ja) * 1994-07-22 1997-04-28 アンテイビオテイコス・エツセ・ピー・アー グリタリル７−ａｃａ誘導体とその調整のためのプロセス
AT403049B (de) * 1995-08-14 1997-10-27 Biochemie Gmbh Abreicherung von 7-adca in 3-vinyl-aca
ES2175167T3 (es) * 1995-12-27 2002-11-16 Hanmi Pharmaceutical Co Ltd Procedimiento para la preparacion de cefdinir.
AT404251B (de) * 1996-08-14 1998-10-27 Biochemie Gmbh Neues kristallines salz von cefixim

Also Published As

Publication number Publication date
CN1251590A (zh) 2000-04-26
SK134399A3 (en) 2000-05-16
TR199902406T2 (xx) 2000-02-21
DE69816056D1 (de) 2003-08-07
US6350869B1 (en) 2002-02-26
NO994466D0 (no) 1999-09-15
IL131755A0 (en) 2001-03-19
PL335620A1 (en) 2000-05-08
CN1139596C (zh) 2004-02-25
BR9809745A (pt) 2000-06-20
EP0973779B1 (de) 2003-07-02
AU731413B2 (en) 2001-03-29
DE69816056T2 (de) 2004-04-15
HUP0002987A3 (en) 2001-04-28
AT405283B (de) 1999-06-25
AU7428898A (en) 1998-10-30
KR100442717B1 (ko) 2004-08-02
NO994466L (no) 1999-09-15
HUP0002987A2 (hu) 2001-02-28
CA2283718A1 (en) 1998-10-15
EP0973779A1 (de) 2000-01-26
JP3421354B2 (ja) 2003-06-30
ATA57097A (de) 1998-11-15
ID22536A (id) 1999-11-04
KR20010005907A (ko) 2001-01-15
WO1998045299A1 (en) 1998-10-15
JP2000514833A (ja) 2000-11-07

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Legal Events

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