ATE244715T1 - Azol-verbindungen, ihre herstellung und ihre verwendung - Google Patents
Azol-verbindungen, ihre herstellung und ihre verwendungInfo
- Publication number
- ATE244715T1 ATE244715T1 AT98911100T AT98911100T ATE244715T1 AT E244715 T1 ATE244715 T1 AT E244715T1 AT 98911100 T AT98911100 T AT 98911100T AT 98911100 T AT98911100 T AT 98911100T AT E244715 T1 ATE244715 T1 AT E244715T1
- Authority
- AT
- Austria
- Prior art keywords
- production
- vivo
- eliminated
- azole compounds
- quaternized
- Prior art date
Links
- 150000003851 azoles Chemical class 0.000 title 1
- -1 1,2,4-triazol-1-yl compound Chemical class 0.000 abstract 2
- KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical group C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 abstract 2
- 238000001727 in vivo Methods 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 238000010521 absorption reaction Methods 0.000 abstract 1
- 230000000843 anti-fungal effect Effects 0.000 abstract 1
- 229940121375 antifungal agent Drugs 0.000 abstract 1
- 230000006806 disease prevention Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 238000002347 injection Methods 0.000 abstract 1
- 239000007924 injection Substances 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Coloring (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP8086397 | 1997-03-31 | ||
| JP18239597 | 1997-07-08 | ||
| JP33729997 | 1997-12-08 | ||
| PCT/JP1998/001441 WO1998043970A1 (en) | 1997-03-31 | 1998-03-30 | Azole compounds, their production and their use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE244715T1 true ATE244715T1 (de) | 2003-07-15 |
Family
ID=27303408
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98911100T ATE244715T1 (de) | 1997-03-31 | 1998-03-30 | Azol-verbindungen, ihre herstellung und ihre verwendung |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6407129B1 (de) |
| EP (1) | EP0973768B1 (de) |
| JP (1) | JP2000198773A (de) |
| KR (1) | KR20010005792A (de) |
| CN (1) | CN1251098A (de) |
| AT (1) | ATE244715T1 (de) |
| AU (1) | AU6520098A (de) |
| CA (1) | CA2281875A1 (de) |
| DE (1) | DE69816284T2 (de) |
| RU (1) | RU2189982C2 (de) |
| WO (1) | WO1998043970A1 (de) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19751525C2 (de) | 1997-11-20 | 2003-02-13 | Bat Cigarettenfab Gmbh | Verfahren und Vorrichtung zur Regelung der Ausgangsfeuchte von Tabak |
| EP1120116A1 (de) * | 1998-09-29 | 2001-08-01 | Takeda Chemical Industries, Ltd. | Antimykotische arzneimittelzusammensetzung |
| AU1915500A (en) | 1998-11-20 | 2000-06-13 | Bristol-Myers Squibb Company | Water soluble prodrugs of azole compounds |
| US6235728B1 (en) | 1999-02-19 | 2001-05-22 | Bristol-Myers Squibb Company | Water-soluble prodrugs of azole compounds |
| CN1185230C (zh) * | 1999-11-02 | 2005-01-19 | 巴斯利尔药物股份公司 | N－取代的氨基甲酰氧基烷基－吡咯鎓衍生物 |
| US6812238B1 (en) | 1999-11-02 | 2004-11-02 | Basilea Pharmaceutica Ag | N-substituted carbamoyloxyalkyl-azolium derivatives |
| US6376548B1 (en) | 2000-01-28 | 2002-04-23 | Rohm And Haas Company | Enhanced propertied pesticides |
| RU2238092C2 (ru) * | 2002-10-08 | 2004-10-20 | Нестерук Владимир Викторович | Водная лекарственная композиция для лечения заболеваний кожи |
| US20070078116A1 (en) * | 2003-08-20 | 2007-04-05 | Fairfield Clinical Trials, Llc | Method of treatment of otitis externa |
| US20050159369A1 (en) * | 2003-08-20 | 2005-07-21 | Qtm Llc | Method of treatment of otitis externa |
| GB0402491D0 (en) * | 2004-02-04 | 2004-03-10 | Pfizer Ltd | Medicaments |
| RU2361872C2 (ru) | 2004-05-26 | 2009-07-20 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | Циннамидное соединение |
| DE602005019602D1 (de) | 2004-10-26 | 2010-04-08 | Eisai R&D Man Co Ltd | Amorphe form einer zimtsäureamidverbindung |
| RU2276609C1 (ru) * | 2005-04-29 | 2006-05-20 | Государственное образовательное учреждение высшего профессионального образования "БАШКИРСКИЙ ГОСУДАРСТВЕННЫЙ МЕДИЦИНСКИЙ УНИВЕРСИТЕТ Федерального Агентства по здравоохранению и социальному развитию" (ГОУ ВПО БГМУ РОСЗДРАВА) | Средство для наружного лечения инфильтративно-нагноительных форм трихофитии волосистой части головы |
| TWI370130B (en) | 2005-11-24 | 2012-08-11 | Eisai R&D Man Co Ltd | Two cyclic cinnamide compound |
| KR20080069221A (ko) | 2005-11-24 | 2008-07-25 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 모르폴린 타입의 신나미드 화합물 |
| TWI378091B (en) | 2006-03-09 | 2012-12-01 | Eisai R&D Man Co Ltd | Multi-cyclic cinnamide derivatives |
| US7737141B2 (en) | 2006-07-28 | 2010-06-15 | Eisai R&D Management Co., Ltd. | Prodrug of cinnamide compound |
| CL2008000582A1 (es) | 2007-02-28 | 2008-06-27 | Eisai R&D Man Co Ltd | Compuestos ciclicos derivados de oximorfolina condensados; farmacos que comprenden a dichos compuestos; y su uso para tratar enfermedad de alzheimer, demencia senil, sindrome de down o amiloidosis. |
| EP1990617A1 (de) * | 2007-05-09 | 2008-11-12 | FOSS Analytical A/S | Bestimmung von Tanninen in der Weinherstellung |
| US7935815B2 (en) | 2007-08-31 | 2011-05-03 | Eisai R&D Management Co., Ltd. | Imidazoyl pyridine compounds and salts thereof |
| BRPI0815773A2 (pt) | 2007-08-31 | 2019-09-24 | Eisai R&D Man Co Ltd | composto, e, medicamento. |
| CN101808639B (zh) * | 2007-09-05 | 2012-12-05 | 宝丽制药股份有限公司 | 抗真菌医药组合物 |
| RU2377006C1 (ru) * | 2008-05-15 | 2009-12-27 | Государственное образовательное учреждение высшего профессионального образования "Московская медицинская академия имени Н.М. Сеченова Федерального агентства по здравоохранению и социальному развитию" (ГОУ ВПО ММА им. И.М. Сеченова Росздрава) | Препарат, содержащий стафилококковый бактериофаг в качестве препарата для лечения кандидоза |
| KR102567090B1 (ko) * | 2016-11-28 | 2023-08-17 | 셀릭스 바이오 프라이빗 리미티드 | 곰팡이 감염의 치료를 위한 조성물 및 방법 |
| RU2770033C2 (ru) | 2016-11-28 | 2022-04-14 | Целликс Био Прайвет Лимитед | Композиции и способы лечения инфекционных заболеваний ротовой полости |
| WO2018149359A1 (zh) * | 2017-02-17 | 2018-08-23 | 武汉朗来科技发展有限公司 | 三氮唑抗菌衍生物、其药物组合物和用途 |
| US20200138964A1 (en) * | 2017-04-25 | 2020-05-07 | Seikagaku Corporation | Tertiary amine compound or imine compound-polymer conjugate and production method therefor |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3998815A (en) | 1974-06-24 | 1976-12-21 | Interx Research Corporation | 1-hydrocarbonoyloxymethyl-3-carbamoyl or 3-carboethoxy-pyridinium salts |
| US4061722A (en) | 1976-04-26 | 1977-12-06 | Interx Research Corporation | Selected quaternary ammonium salts of pilocarpine useful in reducing intraocular pressure in warm-blooded animals |
| EP0548553A1 (de) | 1991-11-25 | 1993-06-30 | Takeda Chemical Industries, Ltd. | Optisch aktive Azolverbindungen, ihre Herstellung und Anwendung |
| TW218017B (de) | 1992-04-28 | 1993-12-21 | Takeda Pharm Industry Co Ltd | |
| JPH08104676A (ja) * | 1993-09-24 | 1996-04-23 | Takeda Chem Ind Ltd | アゾール化合物、その製造方法及び用途 |
| TW297813B (de) * | 1993-09-24 | 1997-02-11 | Takeda Pharm Industry Co Ltd | |
| WO1996025410A1 (en) * | 1995-02-17 | 1996-08-22 | Takeda Chemical Industries, Ltd. | Azole compounds, their production and use |
| TW318841B (de) * | 1995-02-17 | 1997-11-01 | Takeda Pharm Industry Co Ltd | |
| EP0829478A3 (de) | 1996-09-09 | 1998-03-25 | F. Hoffmann-La Roche Ag | N-Benzylimidazolium und N-Benzyltriazolium Derivate, deren Herstellung und deren Verwendung als fungizides und anti-mykotisches Mittel |
-
1998
- 1998-03-30 CN CN98803552A patent/CN1251098A/zh active Pending
- 1998-03-30 DE DE69816284T patent/DE69816284T2/de not_active Expired - Fee Related
- 1998-03-30 US US09/381,479 patent/US6407129B1/en not_active Expired - Fee Related
- 1998-03-30 WO PCT/JP1998/001441 patent/WO1998043970A1/en not_active Ceased
- 1998-03-30 KR KR1019997008864A patent/KR20010005792A/ko not_active Withdrawn
- 1998-03-30 RU RU99123064/04A patent/RU2189982C2/ru not_active IP Right Cessation
- 1998-03-30 AT AT98911100T patent/ATE244715T1/de not_active IP Right Cessation
- 1998-03-30 EP EP98911100A patent/EP0973768B1/de not_active Expired - Lifetime
- 1998-03-30 CA CA002281875A patent/CA2281875A1/en not_active Abandoned
- 1998-03-30 AU AU65200/98A patent/AU6520098A/en not_active Abandoned
-
2000
- 2000-02-28 JP JP2000056015A patent/JP2000198773A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| KR20010005792A (ko) | 2001-01-15 |
| RU2189982C2 (ru) | 2002-09-27 |
| DE69816284D1 (de) | 2003-08-14 |
| AU6520098A (en) | 1998-10-22 |
| WO1998043970A1 (en) | 1998-10-08 |
| CN1251098A (zh) | 2000-04-19 |
| JP2000198773A (ja) | 2000-07-18 |
| DE69816284T2 (de) | 2004-05-27 |
| US6407129B1 (en) | 2002-06-18 |
| EP0973768B1 (de) | 2003-07-09 |
| EP0973768A1 (de) | 2000-01-26 |
| CA2281875A1 (en) | 1998-10-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |