ATE245145T1 - Gut wasserlösliche triptolid-prodrugs - Google Patents

Gut wasserlösliche triptolid-prodrugs

Info

Publication number: ATE245145T1
Authority: AT; Austria
Prior art keywords: water soluble; highly water; triptolide prodrugs; prodrugs; soluble triptolide
Prior art date: 1998-09-02

Application number

AT99949582T

Other languages

English (en)

Inventor

John H Musser

Original Assignee

Pharmagenesis Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-09-02

Filing date

1999-09-02

Publication date

2003-08-15

1999-09-02 Application filed by Pharmagenesis Inc filed Critical Pharmagenesis Inc

2003-08-15 Application granted granted Critical

2003-08-15 Publication of ATE245145T1 publication Critical patent/ATE245145T1/de

Links

DFBIRQPKNDILPW-CIVMWXNOSA-N Triptolide Chemical compound O=C1OCC([C@@H]2C3)=C1CC[C@]2(C)[C@]12O[C@H]1[C@@H]1O[C@]1(C(C)C)[C@@H](O)[C@]21[C@H]3O1 DFBIRQPKNDILPW-CIVMWXNOSA-N 0.000 title abstract 2
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title abstract 2
229940002612 prodrug Drugs 0.000 title 1
239000000651 prodrug Substances 0.000 title 1
YKUJZZHGTWVWHA-UHFFFAOYSA-N triptolide Natural products COC12CC3OC3(C(C)C)C(O)C14OC4CC5C6=C(CCC25C)C(=O)OC6 YKUJZZHGTWVWHA-UHFFFAOYSA-N 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 3
230000003110 anti-inflammatory effect Effects 0.000 abstract 1
230000001506 immunosuppresive effect Effects 0.000 abstract 1
230000001988 toxicity Effects 0.000 abstract 1
231100000419 toxicity Toxicity 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
- C07D493/14—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Immunology (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Transplantation (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)

AT99949582T 1998-09-02 1999-09-02 Gut wasserlösliche triptolid-prodrugs ATE245145T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US9880998P	1998-09-02	1998-09-02
PCT/US1999/020150 WO2000012483A1 (en)	1998-09-02	1999-09-02	Triptolide prodrugs having high aqueous solubility

Publications (1)

Publication Number	Publication Date
ATE245145T1 true ATE245145T1 (de)	2003-08-15

Family

ID=22270998

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT03016090T ATE334969T1 (de)	1998-09-02	1999-09-02	Triptolid-prodrugs mit hoher wasserlöslichkeit
AT99949582T ATE245145T1 (de)	1998-09-02	1999-09-02	Gut wasserlösliche triptolid-prodrugs

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
AT03016090T ATE334969T1 (de)	1998-09-02	1999-09-02	Triptolid-prodrugs mit hoher wasserlöslichkeit

Country Status (9)

Country	Link
US (1)	US6150539A (de)
EP (1)	EP1109789B1 (de)
JP (1)	JP2002523495A (de)
CN (1)	CN1316997A (de)
AT (2)	ATE334969T1 (de)
AU (1)	AU764123B2 (de)
CA (1)	CA2342901A1 (de)
DE (2)	DE69932649T2 (de)
WO (1)	WO2000012483A1 (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6548537B1 (en) *	1998-09-02	2003-04-15	Pharmagenesis, Inc.	Triptolide prodrugs having high aqueous solubility
GB2367492A (en) *	1999-06-02	2002-04-10	Oxford Natural Products Plc	Combination of glucosamine with herbal extracts of triptergium, ligustrum and erycibe
US6620843B2 (en) *	2001-01-19	2003-09-16	Pharmagenesis	Anticancer treatment using triptolide prodrugs
US6569893B2 (en)	2001-03-15	2003-05-27	Pharmagenesis, Inc.	Amino acid derivatives of triptolide compounds as immune modulators and anticancer agents
JP4680589B2 (ja) *	2002-05-31	2011-05-11	ファーマジェネシス，インコーポレイテッド	アポトーシスおよび免疫抑制の調節のためのトリプトリド誘導体
CN100398544C (zh) *	2002-09-18	2008-07-02	成都达远药物有限公司	高免疫抑制活性的水溶性雷公藤内酯醇衍生物及其应用
JP2006513209A (ja) *	2002-12-17	2006-04-20	ファーマジェネシス，インコーポレイテッド	免疫調節因子および抗癌剤としてのトリプトライド誘導体
US6943259B2 (en) *	2003-02-25	2005-09-13	Pharmagenesis, Inc.	Halogenated triptolide derivatives as immunomodulators and anticancer agents
CN100408583C (zh) *	2003-02-25	2008-08-06	美国泛华医药公司	用作免疫调节剂和抗癌药的卤代雷公藤内酯醇衍生物
WO2005020887A2 (en) *	2003-06-27	2005-03-10	Pharmagenesis, Inc.	Method for treatment of severe acute respiratory syndrome
US7820834B2 (en) *	2003-12-24	2010-10-26	Pharmagenesis, Inc.	Triptolide 5,6-derivatives as immunomodulators and anticancer agents
EP1722806A4 (de)	2004-02-09	2009-09-16	Pharmagenesis Inc	Verfahren zur isolierung von triptolid-verbindungen aus tripterygium wilfordii
ES2385716T3 (es) *	2004-03-02	2012-07-30	Pharmagenesis, Inc.	Derivados en el anillo de lactona de triptolida como inmunomoduladores y agentes anticáncer
WO2006012204A2 (en) *	2004-06-25	2006-02-02	Pharmagenesis, Inc.	Method for treatment of inflammatory disorders using triptolide compounds
US8617906B2 (en)	2004-10-13	2013-12-31	Pharmagenesis, Inc.	Identification and screening of triptolide target molecules
AU2010210594B2 (en) *	2009-02-05	2015-02-12	Pharmagenesis, Inc.	Triptolide C-ring derivatives as anticancer agents and immune modulators
MY160392A (en) *	2009-05-07	2017-03-15	Univ Minnesota	Triptolide prodrugs
US9150600B2 (en)	2009-05-07	2015-10-06	Regents Of The University Of Minnesota	Triptolide prodrugs
MX368417B (es)	2012-08-23	2019-10-02	Senestech Inc	Reduccion de la capacidad reproductiva de mamiferos.
WO2014167581A2 (en) *	2013-04-01	2014-10-16	Laurus Labs Private Limited	An improved process for the preparation of triptolide prodrugs
WO2015127011A1 (en)	2014-02-21	2015-08-27	Institute Of Cancer Research D/B/A The Research Institute Of Fox Chase Cancer Center	C-myc as a biomarker for tumor sensitivity to treatment with rna polymerase ii inhibition
CN106659700B (zh) *	2014-06-06	2020-07-10	斯克里普斯研究所	氟化硫(vi)化合物及其制备方法
CN106883284B (zh) *	2017-03-03	2018-10-16	广东省中医院	雷公藤内酯三醇的快速安全制备方法
CN106995450B (zh) *	2017-05-19	2019-04-02	湖北大学	一种雷公藤甲素衍生物及其制备方法和用途
CN110759929B (zh) *	2018-07-27	2022-05-03	上海医药集团股份有限公司	(5r)-5-羟基雷公藤内酯醇的制备方法
US11660285B2 (en) *	2019-12-30	2023-05-30	Guangdong Provincial Hospital of TCM	Triptolide acrylate, preparation method therefor and use thereof
EP4200022A1 (de)	2020-08-21	2023-06-28	Reyoung Corporation	Triptolidkonjugate und verwendungen davon
WO2023143330A1 (zh) *	2022-01-25	2023-08-03	杭州卫本医药科技有限公司	具有杀伤myc阳性细胞功能雷公藤二萜类环氧化合物、及其制备方法和应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN1027371C (zh) *	1989-09-08	1995-01-11	中国医学科学院皮肤病研究所	二萜内酯化合物的合成方法
US5663335A (en) *	1996-03-01	1997-09-02	Pharmagenesis, Inc.	Immunosuppressive compounds and methods
UA57757C2 (uk) *	1996-12-20	2003-07-15	Сос'Єте Де Консей Де Решерш Е Даплікасьон С'Єнтіфік (С.К.Р.А.С.)	Аналоги камптотецину, спосіб їх отримання (варіанти) і фармацевтична композиція
US5972998A (en) *	1997-05-23	1999-10-26	Hoechst Marion Roussel, Inc.	Triptolide derivatives useful in the treatment of autoimmune diseases

1999
- 1999-09-02 DE DE69932649T patent/DE69932649T2/de not_active Expired - Fee Related
- 1999-09-02 AU AU62425/99A patent/AU764123B2/en not_active Ceased
- 1999-09-02 EP EP99949582A patent/EP1109789B1/de not_active Expired - Lifetime
- 1999-09-02 WO PCT/US1999/020150 patent/WO2000012483A1/en not_active Ceased
- 1999-09-02 AT AT03016090T patent/ATE334969T1/de not_active IP Right Cessation
- 1999-09-02 JP JP2000567513A patent/JP2002523495A/ja active Pending
- 1999-09-02 AT AT99949582T patent/ATE245145T1/de not_active IP Right Cessation
- 1999-09-02 DE DE69909633T patent/DE69909633T2/de not_active Expired - Fee Related
- 1999-09-02 CA CA002342901A patent/CA2342901A1/en not_active Abandoned
- 1999-09-02 US US09/389,769 patent/US6150539A/en not_active Expired - Fee Related
- 1999-09-02 CN CN99810578A patent/CN1316997A/zh active Pending

Also Published As

Publication number	Publication date
AU764123B2 (en)	2003-08-07
DE69909633D1 (de)	2003-08-21
EP1109789A4 (de)	2002-01-02
DE69932649T2 (de)	2007-08-09
CA2342901A1 (en)	2000-03-09
ATE334969T1 (de)	2006-08-15
EP1109789B1 (de)	2003-07-16
CN1316997A (zh)	2001-10-10
US6150539A (en)	2000-11-21
EP1109789A1 (de)	2001-06-27
AU6242599A (en)	2000-03-21
JP2002523495A (ja)	2002-07-30
DE69932649D1 (de)	2006-09-14
DE69909633T2 (de)	2004-05-13
WO2000012483A1 (en)	2000-03-09

Legal Events

Date	Code	Title	Description
2004-01-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE245145T1 (de)	2003-08-15	Gut wasserlösliche triptolid-prodrugs
PT907652E (pt)	2005-08-31	Compostos e processos imunossupressores
DE69925133D1 (de)	2005-06-09	Pyrrolobenzodiazepine
BG105967A (en)	2002-08-30	C(7) ester substituted taxanes and their use as antitumor agents
DE69919187D1 (de)	2004-09-09	Federbelasteter diffusor mit schaufeln
TR200100805T2 (tr)	2001-08-21	Tetrahidropiridoeterler
ID26626A (id)	2001-01-25	Derivat-derivat 2-piridilmetilamin yang berguna sebagai fungisida-fungisida
ID23216A (id)	2000-03-30	Peralatan penurun air-dalam
WO2002070472A3 (en)	2002-10-24	Triptolide prodrugs having high aqueous solubility
ATE297904T1 (de)	2005-07-15	Halo-alkoxycarbonylverbindungen
ATE265455T1 (de)	2004-05-15	Tetrahydropyridoverbindungen
NO20023172D0 (no)	2002-06-28	10, 11-difluormetylendioksycamptothecin-forbindelser med topoisomerase I inhibering
EA199900534A1 (ru)	2000-02-28	Имидазопиридазины
BG105964A (en)	2002-08-30	C(10) carbonate substituted taxanes and their use as antitumor agents
ITTO970975A0 (it)	1997-11-07	Composizioni organiche.
PT1139758E (pt)	2003-09-30	Mistura fungicida
NO993319L (no)	2000-01-07	Detergensblanding
MY116769A (en)	2004-03-31	Immunosuppressive compounds and methods
ATE231838T1 (de)	2003-02-15	N,n'-diacylthiocystine
FI980196A0 (fi)	1998-01-29	Anordning foer att avlaegsna bark fraon traestroemmen innehaollande trae och bark
SK2193U (sk)	1999-06-11	Prihnojovacie zariadenie
FIU980078U0 (fi)	1998-02-12	Maanviljelylaite
FR2781111B1 (fr)	2002-10-31	Agencement d'un haut-parleur audiophonique avec des moyens d'eclairage
FI982144A0 (fi)	1998-10-02	Liikuntarajoitteisten asusteet