ATE334969T1 - Triptolid-prodrugs mit hoher wasserlöslichkeit - Google Patents

Triptolid-prodrugs mit hoher wasserlöslichkeit

Info

Publication number: ATE334969T1
Authority: AT; Austria
Prior art keywords: water solubility; high water; triptolide; triptolide prodrugs; prodrugs
Prior art date: 1998-09-02

Application number

AT03016090T

Other languages

English (en)

Inventor

John H Musser

Original Assignee

Pharmagenesis Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-09-02

Filing date

1999-09-02

Publication date

2006-08-15

1999-09-02 Application filed by Pharmagenesis Inc filed Critical Pharmagenesis Inc

2006-08-15 Application granted granted Critical

2006-08-15 Publication of ATE334969T1 publication Critical patent/ATE334969T1/de

Links

DFBIRQPKNDILPW-CIVMWXNOSA-N Triptolide Chemical compound O=C1OCC([C@@H]2C3)=C1CC[C@]2(C)[C@]12O[C@H]1[C@@H]1O[C@]1(C(C)C)[C@@H](O)[C@]21[C@H]3O1 DFBIRQPKNDILPW-CIVMWXNOSA-N 0.000 title abstract 2
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title abstract 2
229940002612 prodrug Drugs 0.000 title 1
239000000651 prodrug Substances 0.000 title 1
YKUJZZHGTWVWHA-UHFFFAOYSA-N triptolide Natural products COC12CC3OC3(C(C)C)C(O)C14OC4CC5C6=C(CCC25C)C(=O)OC6 YKUJZZHGTWVWHA-UHFFFAOYSA-N 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 3
230000003110 anti-inflammatory effect Effects 0.000 abstract 1
230000001506 immunosuppresive effect Effects 0.000 abstract 1
230000001988 toxicity Effects 0.000 abstract 1
231100000419 toxicity Toxicity 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
- C07D493/14—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Immunology (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Rheumatology (AREA)
Pain & Pain Management (AREA)
Transplantation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Saccharide Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

AT03016090T 1998-09-02 1999-09-02 Triptolid-prodrugs mit hoher wasserlöslichkeit ATE334969T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US9880998P	1998-09-02	1998-09-02

Publications (1)

Publication Number	Publication Date
ATE334969T1 true ATE334969T1 (de)	2006-08-15

Family

ID=22270998

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT99949582T ATE245145T1 (de)	1998-09-02	1999-09-02	Gut wasserlösliche triptolid-prodrugs
AT03016090T ATE334969T1 (de)	1998-09-02	1999-09-02	Triptolid-prodrugs mit hoher wasserlöslichkeit

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
AT99949582T ATE245145T1 (de)	1998-09-02	1999-09-02	Gut wasserlösliche triptolid-prodrugs

Country Status (9)

Country	Link
US (1)	US6150539A (de)
EP (1)	EP1109789B1 (de)
JP (1)	JP2002523495A (de)
CN (1)	CN1316997A (de)
AT (2)	ATE245145T1 (de)
AU (1)	AU764123B2 (de)
CA (1)	CA2342901A1 (de)
DE (2)	DE69932649T2 (de)
WO (1)	WO2000012483A1 (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6548537B1 (en)	1998-09-02	2003-04-15	Pharmagenesis, Inc.	Triptolide prodrugs having high aqueous solubility
CA2376008A1 (en) *	1999-06-02	2000-12-14	Oxford Natural Products Plc	Combination of glucosamine with herbal extracts of tripterygium, ligustrum and erycibe
US6620843B2 (en)	2001-01-19	2003-09-16	Pharmagenesis	Anticancer treatment using triptolide prodrugs
US6569893B2 (en)	2001-03-15	2003-05-27	Pharmagenesis, Inc.	Amino acid derivatives of triptolide compounds as immune modulators and anticancer agents
JP4680589B2 (ja) *	2002-05-31	2011-05-11	ファーマジェネシス，インコーポレイテッド	アポトーシスおよび免疫抑制の調節のためのトリプトリド誘導体
CN100398544C (zh) *	2002-09-18	2008-07-02	成都达远药物有限公司	高免疫抑制活性的水溶性雷公藤内酯醇衍生物及其应用
WO2004058246A1 (en) *	2002-12-17	2004-07-15	Pharmagenesis, Inc.	Triptolide derivatives as immunomodulator and anticancer agents
US6943259B2 (en) *	2003-02-25	2005-09-13	Pharmagenesis, Inc.	Halogenated triptolide derivatives as immunomodulators and anticancer agents
CN100408583C (zh) *	2003-02-25	2008-08-06	美国泛华医药公司	用作免疫调节剂和抗癌药的卤代雷公藤内酯醇衍生物
WO2005020887A2 (en) *	2003-06-27	2005-03-10	Pharmagenesis, Inc.	Method for treatment of severe acute respiratory syndrome
US7820834B2 (en) *	2003-12-24	2010-10-26	Pharmagenesis, Inc.	Triptolide 5,6-derivatives as immunomodulators and anticancer agents
CN1917893A (zh)	2004-02-09	2007-02-21	美国泛华医药公司	从雷公藤多苷中分离雷公藤内酯醇化合物的方法
DK1732536T3 (da)	2004-03-02	2012-06-25	Pharmagenesis Inc	Tripolidlactonringderivater som immunomodulatorer og anticancermidler
WO2006012204A2 (en) *	2004-06-25	2006-02-02	Pharmagenesis, Inc.	Method for treatment of inflammatory disorders using triptolide compounds
US8617906B2 (en)	2004-10-13	2013-12-31	Pharmagenesis, Inc.	Identification and screening of triptolide target molecules
CN104387406A (zh)	2009-02-05	2015-03-04	药物起源公司	作为抗癌药和免疫调制剂的雷公藤内酯 c-环衍生物
US9150600B2 (en)	2009-05-07	2015-10-06	Regents Of The University Of Minnesota	Triptolide prodrugs
EP2427467B1 (de)	2009-05-07	2015-08-05	Regents of the University of Minnesota	Triptolid-prodrugs
RS58781B1 (sr)	2012-08-23	2019-06-28	Senestech Inc	Kompozicije i postupci za redukciju reproduktivnog kapaciteta ženki pacova
WO2014167581A2 (en) *	2013-04-01	2014-10-16	Laurus Labs Private Limited	An improved process for the preparation of triptolide prodrugs
WO2015127011A1 (en)	2014-02-21	2015-08-27	Institute Of Cancer Research D/B/A The Research Institute Of Fox Chase Cancer Center	C-myc as a biomarker for tumor sensitivity to treatment with rna polymerase ii inhibition
ES2873962T3 (es) *	2014-06-06	2021-11-04	Scripps Research Inst	Compuestos de fluoruro de azufre (VI) y métodos para la preparación de los mismos
CN106883284B (zh) *	2017-03-03	2018-10-16	广东省中医院	雷公藤内酯三醇的快速安全制备方法
CN106995450B (zh) *	2017-05-19	2019-04-02	湖北大学	一种雷公藤甲素衍生物及其制备方法和用途
CN110759929B (zh) *	2018-07-27	2022-05-03	上海医药集团股份有限公司	(5r)-5-羟基雷公藤内酯醇的制备方法
JP7353500B2 (ja) *	2019-12-30	2023-09-29	グゥアンドンプロビンシャルホスピタルオブティーシーエム	アクリル酸トリプトリド、その調製方法および用途
US20230303618A1 (en)	2020-08-21	2023-09-28	Reyoung Corporation	Triptolide conjugates and uses thereof
WO2023143330A1 (zh) *	2022-01-25	2023-08-03	杭州卫本医药科技有限公司	具有杀伤myc阳性细胞功能雷公藤二萜类环氧化合物、及其制备方法和应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN1027371C (zh) *	1989-09-08	1995-01-11	中国医学科学院皮肤病研究所	二萜内酯化合物的合成方法
US5663335A (en) *	1996-03-01	1997-09-02	Pharmagenesis, Inc.	Immunosuppressive compounds and methods
UA57757C2 (uk) *	1996-12-20	2003-07-15	Сос'Єте Де Консей Де Решерш Е Даплікасьон С'Єнтіфік (С.К.Р.А.С.)	Аналоги камптотецину, спосіб їх отримання (варіанти) і фармацевтична композиція
US5972998A (en) *	1997-05-23	1999-10-26	Hoechst Marion Roussel, Inc.	Triptolide derivatives useful in the treatment of autoimmune diseases

1999
- 1999-09-02 DE DE69932649T patent/DE69932649T2/de not_active Expired - Fee Related
- 1999-09-02 CA CA002342901A patent/CA2342901A1/en not_active Abandoned
- 1999-09-02 AU AU62425/99A patent/AU764123B2/en not_active Ceased
- 1999-09-02 AT AT99949582T patent/ATE245145T1/de not_active IP Right Cessation
- 1999-09-02 JP JP2000567513A patent/JP2002523495A/ja active Pending
- 1999-09-02 DE DE69909633T patent/DE69909633T2/de not_active Expired - Fee Related
- 1999-09-02 WO PCT/US1999/020150 patent/WO2000012483A1/en not_active Ceased
- 1999-09-02 EP EP99949582A patent/EP1109789B1/de not_active Expired - Lifetime
- 1999-09-02 CN CN99810578A patent/CN1316997A/zh active Pending
- 1999-09-02 US US09/389,769 patent/US6150539A/en not_active Expired - Fee Related
- 1999-09-02 AT AT03016090T patent/ATE334969T1/de not_active IP Right Cessation

Also Published As

Publication number	Publication date
US6150539A (en)	2000-11-21
AU6242599A (en)	2000-03-21
DE69909633D1 (de)	2003-08-21
DE69909633T2 (de)	2004-05-13
EP1109789A1 (de)	2001-06-27
CN1316997A (zh)	2001-10-10
JP2002523495A (ja)	2002-07-30
DE69932649T2 (de)	2007-08-09
DE69932649D1 (de)	2006-09-14
AU764123B2 (en)	2003-08-07
WO2000012483A1 (en)	2000-03-09
CA2342901A1 (en)	2000-03-09
EP1109789B1 (de)	2003-07-16
EP1109789A4 (de)	2002-01-02
ATE245145T1 (de)	2003-08-15

Legal Events

Date	Code	Title	Description
2007-02-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE69932649D1 (de)	2006-09-14	Triptolid-Prodrugs mit hoher Wasserlöslichkeit
PT907652E (pt)	2005-08-31	Compostos e processos imunossupressores
TR199801629A2 (xx)	1999-10-21	Fungisidal 2 -metoksibenzofenonlar.
DE69907977D1 (de)	2003-06-18	Pyrrolobenzodiazepine
IS1806B (is)	2002-03-08	Arylthíósambönd sem varnarefni gegn bakteríum og veirum
TR200100805T2 (tr)	2001-08-21	Tetrahidropiridoeterler
BG103310A (en)	2000-05-31	Benzonaphthyridins as bronchial therapeutical means
DE69919255D1 (de)	2004-09-16	Graviervorrichtung
ID16851A (id)	1997-11-13	Perintang yang ditingkatkan modulnya.
DE69930135D1 (de)	2006-04-27	Pseudomorphe transistoren mit hoher elektronenbeweglichkeit
EA200100854A1 (ru)	2002-02-28	Кальций-литические соединения
DE60008400D1 (de)	2004-03-25	Triazolopyrimidinderivate
MX9205938A (es)	1993-05-01	Compuestos de di-ter-butilfenol utiles como agentes antiinflamatorios
BR0109512A (pt)	2002-12-17	Imidazopiridinas tricìclicas
GT199500039AA (es)	1997-01-21	Compuestos ariltios
ITMI930819A1 (it)	1994-10-27	Derivati eterobiciclici ad attivita' fungicida
FI914156A0 (fi)	1991-09-03	Kompositioner.
ES2138362T4 (es)	2000-05-16	Derivados de citisina con contenido de fosforo.
ES2101531T3 (es)	1997-07-01	Derivados de benzo(f)quinoxalinadiona, su preparacion y su utilizacion en medicamentos.
TR199901284A2 (xx)	2000-01-21	Ester bile�imleri.
MY116769A (en)	2004-03-31	Immunosuppressive compounds and methods
SE9800932D0 (sv)	1998-03-20	New compunds
GB9911556D0 (en)	1999-07-21	Immunosuppressant tricyclic compounds
ECSP993064A (es)	1999-10-06	Compuestos organicos
TH15423A (th)	1995-01-27	อนุพันธ์ไธอะโซโลพิริมิดีน