ATE246009T1 - Thiolierung von peptiden zur strahlendiagnostik und strahlentherapie auf radionuklidbasis - Google Patents

Thiolierung von peptiden zur strahlendiagnostik und strahlentherapie auf radionuklidbasis

Info

Publication number: ATE246009T1
Authority: AT; Austria
Prior art keywords: peptide; thiol; radiation; thiolation; radionuclide
Prior art date: 1995-06-07

Application number

AT96919062T

Other languages

English (en)

Inventor

Serengulam V Govindan

Gary L Griffiths

Hans L Hansen

Original Assignee

Immunomedics Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-06-07

Filing date

1996-06-07

Publication date

2003-08-15

1995-06-07 Priority claimed from US08/483,095 external-priority patent/US5746996A/en

1996-06-07 Application filed by Immunomedics Inc filed Critical Immunomedics Inc

2003-08-15 Application granted granted Critical

2003-08-15 Publication of ATE246009T1 publication Critical patent/ATE246009T1/de

Links

108090000765 processed proteins & peptides Proteins 0.000 title abstract 4
102000004196 processed proteins & peptides Human genes 0.000 title 1
230000005855 radiation Effects 0.000 title 1
238000001959 radiotherapy Methods 0.000 title 1
238000006177 thiolation reaction Methods 0.000 title 1
238000000034 method Methods 0.000 abstract 3
-1 e.g. Proteins 0.000 abstract 2
238000000163 radioactive labelling Methods 0.000 abstract 2
206010028980 Neoplasm Diseases 0.000 abstract 1
102000005157 Somatostatin Human genes 0.000 abstract 1
108010056088 Somatostatin Proteins 0.000 abstract 1
102000055135 Vasoactive Intestinal Peptide Human genes 0.000 abstract 1
108010003205 Vasoactive Intestinal Peptide Proteins 0.000 abstract 1
230000001588 bifunctional effect Effects 0.000 abstract 1
239000002738 chelating agent Substances 0.000 abstract 1
238000001514 detection method Methods 0.000 abstract 1
238000003384 imaging method Methods 0.000 abstract 1
VBUWHHLIZKOSMS-RIWXPGAOSA-N invicorp Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)C(C)C)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=C(O)C=C1 VBUWHHLIZKOSMS-RIWXPGAOSA-N 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
229910052702 rhenium Inorganic materials 0.000 abstract 1
WUAPFZMCVAUBPE-UHFFFAOYSA-N rhenium atom Chemical compound [Re] WUAPFZMCVAUBPE-UHFFFAOYSA-N 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
NHXLMOGPVYXJNR-ATOGVRKGSA-N somatostatin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)CNC(=O)[C@H](C)N)C(O)=O)=O)[C@H](O)C)C1=CC=CC=C1 NHXLMOGPVYXJNR-ATOGVRKGSA-N 0.000 abstract 1
229960000553 somatostatin Drugs 0.000 abstract 1
229910052713 technetium Inorganic materials 0.000 abstract 1
GKLVYJBZJHMRIY-UHFFFAOYSA-N technetium atom Chemical compound [Tc] GKLVYJBZJHMRIY-UHFFFAOYSA-N 0.000 abstract 1
238000002560 therapeutic procedure Methods 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/083—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the peptide being octreotide or a somatostatin-receptor-binding peptide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Optics & Photonics (AREA)
Physics & Mathematics (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AT96919062T 1995-06-07 1996-06-07 Thiolierung von peptiden zur strahlendiagnostik und strahlentherapie auf radionuklidbasis ATE246009T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US48309895A	1995-06-07	1995-06-07
US08/483,095 US5746996A (en)	1994-06-03	1995-06-07	Thiolation of peptides for radionuclide-based radiodetection and radiotherapy
PCT/US1996/008693 WO1996040289A1 (en)	1995-06-07	1996-06-07	Thiolation of peptides for radionuclide-based radiodetection and radiotherapy

Publications (1)

Publication Number	Publication Date
ATE246009T1 true ATE246009T1 (de)	2003-08-15

Family

ID=27047528

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT96919062T ATE246009T1 (de)	1995-06-07	1996-06-07	Thiolierung von peptiden zur strahlendiagnostik und strahlentherapie auf radionuklidbasis

Country Status (8)

Country	Link
EP (1)	EP0831936B1 (de)
JP (1)	JPH11507623A (de)
AT (1)	ATE246009T1 (de)
AU (1)	AU709219B2 (de)
CA (1)	CA2222966C (de)
DE (1)	DE69629295T2 (de)
ES (1)	ES2206579T3 (de)
WO (1)	WO1996040289A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6576746B2 (en)	1998-10-13	2003-06-10	Immunomedics, Inc.	Site-specific labeling of disulfide-containing targeting vectors
ES2242426T3 (es) *	1998-10-13	2005-11-01	Immunomedics, Inc.	Marcado especifico del sitio de vectores que contienen disulfuro dirigidos contra dianas.
CA2567478C (en)	2004-05-24	2014-04-01	Institut De Cardiologie De Montreal	Labelled adrenomedullin derivatives and their use for imaging and therapy
DK2155781T3 (da) *	2007-05-11	2013-06-17	Inst Cardiologie Montreal	Mærkede adrenomedullinderivater og deres anvendelse til visualisering og terapi
JP2009051784A (ja) *	2007-08-28	2009-03-12	Inst Nuclear Energy Research Rocaec	癌を抑制する放射性物質及びその調整方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5180816A (en) *	1988-08-24	1993-01-19	Centocor	One vial method for labeling protein/linker conjugates with technetium-99M
WO1992021383A1 (en) *	1991-06-03	1992-12-10	Mallinckrodt Medical, Inc.	Radiolabelled somatostatin derivatives, their preparation and use
US5225180A (en) *	1991-09-10	1993-07-06	Diatech, Inc.	Technetium-99m labeled somatostatin-derived peptides for imaging
DK0629133T3 (da) *	1992-01-03	2001-04-02	Rhomed Inc	Farmaceutisk anvendelse af peptidmetalioner
IL113610A0 (en) *	1994-06-03	1995-08-31	Immunomedics Inc	A method of radiolabeling a protein, radiolabeled proteins prepared thereby and diagnostic kits containing the same

1996
- 1996-06-07 JP JP9501201A patent/JPH11507623A/ja active Pending
- 1996-06-07 CA CA002222966A patent/CA2222966C/en not_active Expired - Fee Related
- 1996-06-07 WO PCT/US1996/008693 patent/WO1996040289A1/en not_active Ceased
- 1996-06-07 ES ES96919062T patent/ES2206579T3/es not_active Expired - Lifetime
- 1996-06-07 EP EP96919062A patent/EP0831936B1/de not_active Expired - Lifetime
- 1996-06-07 DE DE69629295T patent/DE69629295T2/de not_active Expired - Lifetime
- 1996-06-07 AT AT96919062T patent/ATE246009T1/de not_active IP Right Cessation
- 1996-06-07 AU AU61500/96A patent/AU709219B2/en not_active Ceased

Also Published As

Publication number	Publication date
JPH11507623A (ja)	1999-07-06
EP0831936A1 (de)	1998-04-01
WO1996040289A1 (en)	1996-12-19
ES2206579T3 (es)	2004-05-16
CA2222966C (en)	2007-03-13
DE69629295T2 (de)	2004-05-13
AU6150096A (en)	1996-12-30
DE69629295D1 (de)	2003-09-04
CA2222966A1 (en)	1996-12-19
AU709219B2 (en)	1999-08-26
EP0831936A4 (de)	2001-05-16
EP0831936B1 (de)	2003-07-30

Legal Events

Date

Code

Title

Description

2004-03-15

UEP

Publication of translation of european patent specification

Ref document number: 0831936

Country of ref document: EP

2007-03-15

REN

Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
MX9707426A (es)	1998-07-31	Peptidos marcados radioactivamente para diagnostico y terapia.
DK0644778T3 (da)	1997-11-03	Technetium-99-mærkede peptider til imagografi
DK0762901T3 (da)	2006-08-21	Technetium-99m-mærkede peptider til imagografi
DK0804481T3 (da)	2003-07-28	Somatostatin-derivater og deres radioaktivt mærkede produkter
ATE213168T1 (de)	2002-02-15	Technetium - 99m markierte peptide zur bildformung
DK0649434T3 (da)	2001-11-12	Radioaktivt mærkede somatostatin-afledte peptider til billeddannende og terapeutiske anvendelser
ES2158897T3 (es)	2001-09-16	Peptidos radiomarcados derivados de somatostatina y utilizados en procedimientos de formacion de imagenes y terapeuticos.
DK0630265T3 (da)	2003-06-30	Technetium-99m mærkede peptider til afbildning af inflammation
DK0641222T3 (da)	2000-12-11	Peptider mærket med technetium-99m til trombeafbildning
ATE340594T1 (de)	2006-10-15	Somatostatin bindende peptide-metallchelat konjugate
ZA956254B (en)	1996-03-13	Peptides
Arano et al.	1997	Conventional and high-yield synthesis of DTPA-conjugated peptides: application of a monoreactive DTPA to DTPA-D-Phe1-octreotide synthesis
AU703230B2 (en)	1999-03-18	Metal chelate forming peptides and use thereof
ATE246009T1 (de)	2003-08-15	Thiolierung von peptiden zur strahlendiagnostik und strahlentherapie auf radionuklidbasis
CA2347670A1 (en)	1995-01-05	Radiolabeled somatostatin-derived peptides for imaging