ATE246489T1 - Implantierbares diffusionabgabesystem - Google Patents

Implantierbares diffusionabgabesystem

Info

Publication number
ATE246489T1
ATE246489T1 AT98911690T AT98911690T ATE246489T1 AT E246489 T1 ATE246489 T1 AT E246489T1 AT 98911690 T AT98911690 T AT 98911690T AT 98911690 T AT98911690 T AT 98911690T AT E246489 T1 ATE246489 T1 AT E246489T1
Authority
AT
Austria
Prior art keywords
beneficial agent
delivery system
delivering
reservoir
capillary channel
Prior art date
Application number
AT98911690T
Other languages
English (en)
Inventor
Wouter E Roorda
Keith E Dionne
James E Brown
Jeremy C Wright
Craig R Davis
Steven J Prestrelski
Stelios T Tzannis
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corp filed Critical Alza Corp
Application granted granted Critical
Publication of ATE246489T1 publication Critical patent/ATE246489T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/0067—Means for introducing or releasing pharmaceutical products into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biochemistry (AREA)
  • Dermatology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • AIDS & HIV (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Preparation (AREA)
  • Prostheses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Electrotherapy Devices (AREA)
AT98911690T 1997-03-31 1998-03-17 Implantierbares diffusionabgabesystem ATE246489T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4219697P 1997-03-31 1997-03-31
PCT/US1998/005138 WO1998043611A1 (en) 1997-03-31 1998-03-17 Diffusional implantable delivery system

Publications (1)

Publication Number Publication Date
ATE246489T1 true ATE246489T1 (de) 2003-08-15

Family

ID=21920574

Family Applications (2)

Application Number Title Priority Date Filing Date
AT98911690T ATE246489T1 (de) 1997-03-31 1998-03-17 Implantierbares diffusionabgabesystem
AT03075231T ATE333266T1 (de) 1997-03-31 1998-03-17 Diffusionsgesteuertes implantierbares verabreichungssystem

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT03075231T ATE333266T1 (de) 1997-03-31 1998-03-17 Diffusionsgesteuertes implantierbares verabreichungssystem

Country Status (15)

Country Link
US (1) US5972369A (de)
EP (1) EP0973499B1 (de)
JP (1) JP2001518880A (de)
KR (1) KR100523199B1 (de)
CN (2) CN1138579C (de)
AT (2) ATE246489T1 (de)
AU (1) AU729870B2 (de)
CA (1) CA2284058C (de)
DE (2) DE69835305T2 (de)
DK (1) DK0973499T3 (de)
ES (1) ES2205462T3 (de)
IL (2) IL159636A0 (de)
NZ (1) NZ500018A (de)
PT (1) PT973499E (de)
WO (1) WO1998043611A1 (de)

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DK0973499T3 (da) 2003-11-17
KR20010005834A (ko) 2001-01-15
PT973499E (pt) 2003-12-31
AU6558898A (en) 1998-10-22
CA2284058C (en) 2007-02-20
CN1305462C (zh) 2007-03-21
WO1998043611A1 (en) 1998-10-08
KR100523199B1 (ko) 2005-10-21
US5972369A (en) 1999-10-26
IL132040A0 (en) 2001-03-19
EP0973499A1 (de) 2000-01-26
CN1251986A (zh) 2000-05-03
DE69816980D1 (de) 2003-09-11
HK1027756A1 (en) 2001-01-23
AU729870B2 (en) 2001-02-15
EP0973499B1 (de) 2003-08-06
DE69816980T2 (de) 2004-07-22
CN1138579C (zh) 2004-02-18
ATE333266T1 (de) 2006-08-15
CA2284058A1 (en) 1998-10-08
CN1500475A (zh) 2004-06-02
IL159636A0 (en) 2004-06-01
IL132040A (en) 2004-07-25
NZ500018A (en) 2001-07-27
ES2205462T3 (es) 2004-05-01
DE69835305T2 (de) 2007-07-19
DE69835305D1 (de) 2006-08-31
JP2001518880A (ja) 2001-10-16

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