ATE246506T1 - Darmlösliche sprudelnde zusammensetzungen - Google Patents

Darmlösliche sprudelnde zusammensetzungen

Info

Publication number: ATE246506T1
Authority: AT; Austria
Prior art keywords: glycyrrhizin; preparation; present; effective compositions; soluble effective
Prior art date: 1998-03-11

Application number

AT99939145T

Other languages

English (en)

Inventor

Hashime Kanazawa

Kenji Shimizu

Kazuhiro Sasaki

Tetsuya Sugimoto

Original Assignee

Grelan Pharmaceutical Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-03-11

Filing date

1999-03-10

Publication date

2003-08-15

1999-03-10 Application filed by Grelan Pharmaceutical Co filed Critical Grelan Pharmaceutical Co

2003-08-15 Application granted granted Critical

2003-08-15 Publication of ATE246506T1 publication Critical patent/ATE246506T1/de

Links

230000000968 intestinal effect Effects 0.000 title 1
239000000203 mixture Substances 0.000 title 1
238000002360 preparation method Methods 0.000 abstract 4
239000004378 Glycyrrhizin Substances 0.000 abstract 3
LPLVUJXQOOQHMX-UHFFFAOYSA-N glycyrrhetinic acid glycoside Natural products C1CC(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2=O)C(O)=O)C)(C)CC2)(C)C2C(C)(C)C1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O LPLVUJXQOOQHMX-UHFFFAOYSA-N 0.000 abstract 3
229960004949 glycyrrhizic acid Drugs 0.000 abstract 3
UYRUBYNTXSDKQT-UHFFFAOYSA-N glycyrrhizic acid Natural products CC1(C)C(CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(=O)O)OC6OC(C(O)C(O)C6OC7OC(O)C(O)C(O)C7C(=O)O)C(=O)O UYRUBYNTXSDKQT-UHFFFAOYSA-N 0.000 abstract 3
235000019410 glycyrrhizin Nutrition 0.000 abstract 3
LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 abstract 3
238000010521 absorption reaction Methods 0.000 abstract 2
239000003795 chemical substances by application Substances 0.000 abstract 2
210000001035 gastrointestinal tract Anatomy 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
239000003623 enhancer Substances 0.000 abstract 1
150000004667 medium chain fatty acids Chemical class 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0007—Effervescent
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4891—Coated capsules; Multilayered drug free capsule shells
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Molecular Biology (AREA)
Oil, Petroleum & Natural Gas (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Gastroenterology & Hepatology (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Curing Cements, Concrete, And Artificial Stone (AREA)
Compounds Of Unknown Constitution (AREA)

AT99939145T 1998-03-11 1999-03-10 Darmlösliche sprudelnde zusammensetzungen ATE246506T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP7648798		1998-03-11
PCT/JP1999/001157 WO1999045934A1 (fr)	1998-03-11	1999-03-10	Preparations entero-solubles effervescentes

Publications (1)

Publication Number	Publication Date
ATE246506T1 true ATE246506T1 (de)	2003-08-15

Family

ID=13606583

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99939145T ATE246506T1 (de)	1998-03-11	1999-03-10	Darmlösliche sprudelnde zusammensetzungen

Country Status (9)

Country	Link
US (1)	US6326360B1 (de)
EP (1)	EP1062952B1 (de)
JP (1)	JP4372347B2 (de)
KR (1)	KR20010041696A (de)
CN (1)	CN1160079C (de)
AT (1)	ATE246506T1 (de)
DE (1)	DE69910183T2 (de)
DK (1)	DK1062952T3 (de)
WO (1)	WO1999045934A1 (de)

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US6414016B1 (en)	2000-09-05	2002-07-02	Sucampo, A.G.	Anti-constipation composition
PT1385498E (pt) *	2001-04-18	2007-12-14	Prometic Biosciences Inc	Ácidos gordos como factores de sobrevivência e activação de neutrófilos
EP1390024A4 (de) *	2001-05-11	2010-02-17	Merrion Res Iii Ltd	Isostearinsäuresalze als permeationsverbesserer
WO2002092069A1 (en) *	2001-05-11	2002-11-21	Elan Corporation, Plc	Permeation enhancers
US20030068356A1 (en)	2001-07-10	2003-04-10	Pather S. Indiran	Sequential drug delivery systems
JP3980851B2 (ja) *	2001-08-30	2007-09-26	有限会社ゴトーコーポレーション	固型製剤、その製造方法、及び食品
GB0217056D0 (en) *	2002-07-23	2002-08-28	Ass Octel	Use
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UA76639C2 (uk) *	2002-08-02	2006-08-15	Олєг Ільіч Епштєйн	Гомеопатичний лікарський засіб та спосіб лікування еректильних дисфункцій
UA76638C2 (en)	2002-08-02	2006-08-15	Oleh Illich Epshtein	Homeopathic medication based on anti-interferon antibodies and method for treating a pathological syndrome associated with interferon
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WO2005065319A2 (en) *	2003-12-31	2005-07-21	Cima Labs Inc.	Generally linear effervescent oral fentanyl dosage form and methods of administering
WO2005065317A2 (en)	2003-12-31	2005-07-21	Cima Labs Inc.	Effervescent oral fentanyl dosage form
WO2005065318A2 (en)	2003-12-31	2005-07-21	Cima Labs Inc.	Effervescent oral opiate dosage form
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US20070219131A1 (en) *	2004-04-15	2007-09-20	Ben-Sasson Shmuel A	Compositions capable of facilitating penetration across a biological barrier
US20060067977A1 (en)	2004-09-28	2006-03-30	Atrium Medical Corporation	Pre-dried drug delivery coating for use with a stent
US9012506B2 (en)	2004-09-28	2015-04-21	Atrium Medical Corporation	Cross-linked fatty acid-based biomaterials
EP1811933B1 (de)	2004-09-28	2016-03-23	Atrium Medical Corporation	Barriereschicht
US9000040B2 (en)	2004-09-28	2015-04-07	Atrium Medical Corporation	Cross-linked fatty acid-based biomaterials
US9801982B2 (en)	2004-09-28	2017-10-31	Atrium Medical Corporation	Implantable barrier device
US8367099B2 (en)	2004-09-28	2013-02-05	Atrium Medical Corporation	Perforated fatty acid films
US8312836B2 (en)	2004-09-28	2012-11-20	Atrium Medical Corporation	Method and apparatus for application of a fresh coating on a medical device
US9427423B2 (en)	2009-03-10	2016-08-30	Atrium Medical Corporation	Fatty-acid based particles
US9278161B2 (en)	2005-09-28	2016-03-08	Atrium Medical Corporation	Tissue-separating fatty acid adhesion barrier
CA2626030A1 (en)	2005-10-15	2007-04-26	Atrium Medical Corporation	Hydrophobic cross-linked gels for bioabsorbable drug carrier coatings
CN100391466C (zh) *	2006-02-17	2008-06-04	武汉大学	甘草酸铵盐在制备治疗炎症性肠病药物中的应用
RU2309732C1 (ru) *	2006-03-13	2007-11-10	Олег Ильич Эпштейн	Спрессованная твердая оральная форма лекарственного препарата и способ получения твердой оральной формы лекарственного препарата
CN105232482A (zh) *	2006-04-07	2016-01-13	默里昂研究Iii有限公司	包含增强剂的固体口服剂型
WO2007149010A1 (en) *	2006-06-06	2007-12-27	Oleg Iliich Epshtein	Medicinal agent for treating fatness, diabetes, and diseases associated with impaired glucose tolerance
US20070292512A1 (en) *	2006-06-09	2007-12-20	Merrion Research Ii Limited	Solid Oral Dosage Form Containing an Enhancer
EP2083875B1 (de)	2006-11-06	2013-03-27	Atrium Medical Corporation	Beschichtetes chirurgisches netz
US9492596B2 (en)	2006-11-06	2016-11-15	Atrium Medical Corporation	Barrier layer with underlying medical device and one or more reinforcing support structures
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CN106974888B (zh) *	2008-09-17	2019-08-02	克艾思马有限公司	药物组合物和相关的给药方法
US20110038910A1 (en)	2009-08-11	2011-02-17	Atrium Medical Corporation	Anti-infective antimicrobial-containing biomaterials
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WO2012009707A2 (en)	2010-07-16	2012-01-19	Atrium Medical Corporation	Composition and methods for altering the rate of hydrolysis of cured oil-based materials
UA112755C2 (uk)	2010-07-21	2016-10-25	Олєг Ільіч Епштейн	Метод лікування синдрому дефіциту уваги і гіперактивності
SMT201800226T1 (it)	2010-10-07	2018-07-17	California Inst Of Techn	Trattamento probiotico contro l'autismo
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CN102499925B (zh) *	2011-10-21	2015-11-11	上海中医药大学	一种中性粒细胞弹性蛋白酶抑制剂
US9867880B2 (en)	2012-06-13	2018-01-16	Atrium Medical Corporation	Cured oil-hydrogel biomaterial compositions for controlled drug delivery
WO2014118997A1 (ja) *	2013-01-30	2014-08-07	宏輝システムズ株式会社	新規多価アルコール基剤ソフトカプセル製剤
CN103330684A (zh) *	2013-07-01	2013-10-02	杭州市西溪医院	甘草酸二铵脂质复合物泡腾颗粒的制备方法
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1999
- 1999-03-10 AT AT99939145T patent/ATE246506T1/de not_active IP Right Cessation
- 1999-03-10 EP EP99939145A patent/EP1062952B1/de not_active Expired - Lifetime
- 1999-03-10 WO PCT/JP1999/001157 patent/WO1999045934A1/ja not_active Ceased
- 1999-03-10 US US09/623,706 patent/US6326360B1/en not_active Expired - Fee Related
- 1999-03-10 CN CNB998038903A patent/CN1160079C/zh not_active Expired - Fee Related
- 1999-03-10 KR KR1020007009915A patent/KR20010041696A/ko not_active Abandoned
- 1999-03-10 JP JP2000535349A patent/JP4372347B2/ja not_active Expired - Fee Related
- 1999-03-10 DE DE69910183T patent/DE69910183T2/de not_active Expired - Fee Related
- 1999-03-10 DK DK99939145T patent/DK1062952T3/da active

Also Published As

Publication number	Publication date
EP1062952A4 (de)	2002-06-12
EP1062952B1 (de)	2003-08-06
EP1062952A1 (de)	2000-12-27
US6326360B1 (en)	2001-12-04
DE69910183T2 (de)	2004-06-03
CN1292703A (zh)	2001-04-25
KR20010041696A (ko)	2001-05-25
DK1062952T3 (da)	2003-11-24
WO1999045934A1 (fr)	1999-09-16
JP4372347B2 (ja)	2009-11-25
DE69910183D1 (de)	2003-09-11
CN1160079C (zh)	2004-08-04

Legal Events

Date	Code	Title	Description
2004-02-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE246506T1 (de)	2003-08-15	Darmlösliche sprudelnde zusammensetzungen
EE05450B1 (et)	2011-08-15	4-jodofenlaminobenshdroksaamhapete oksgeenitud estrid, nende kristallvormid ja farmatseutilised kompositsioonid ning kasutamine
DE69534676D1 (de)	2006-01-12	Orale Verabreichung von chemisch modifizierten Proteinen
HUP0000450A3 (en)	2001-02-28	The use of 7-(2-oxa-5,8-diazabicyclo[4.3.0]non-8-yl)-quinolone carboxylic acid and naphthyridon carboxylic acid derivatives for the preparation of pharmaceutical compositions treating helicobacter pylori infections and associated gastroduodenal diseases
IS4067A (is)	1994-02-27	PEG-Interferonafleiður, aðferð til framleiðslu þeirra, og notkunar sem lyfja
BR9710509A (pt)	1999-08-17	FÄrmula de vacina polinucleot¡dica contra as patologias caninas especialmente as patologias respiratÄrias e digestivas
FI940629A7 (fi)	1994-08-14	Valmiste ruoansulatuskanavan sisäiseen ravitsemukseen
EP1247456A3 (de)	2003-12-10	Wohlschmeckende pharmazeutische Zusammensetzung für Haustiere
MY117606A (en)	2004-07-31	Orally administrable formulations of quinolone- or naphthyridonecarboxylic acids
DE69225979D1 (de)	1998-07-23	Orale zubereitung zur freisetzung im unteren verdauungstract
EP1219630A4 (de)	2004-05-26	Immunverstärkende verbindungen
DE69101152D1 (de)	1994-03-24	Poly-(alpha-Hydroxyakrylsäure) und Derivate als zahnsteinverhindernde Wirkstoffe in oralen Zusammensetzungen.
DE60213283D1 (de)	2006-08-31	Pharmazeutische zusammensetzung enthaltend magermilchpulver
DE69837142D1 (de)	2007-04-05	Herstellung einer fumarsäureenthaltenden lebensmittelsäurezusammensetzung
CA2252399A1 (en)	1997-11-06	Composition for demonstrating the presence of ammonia in exhaled air
PT912167E (pt)	2003-03-31	Granulos de derivados de hexa-hidropirazina administraveis por via oral
ATE145788T1 (de)	1996-12-15	Herbizide zusammensetzungen
PT1312355E (pt)	2003-10-31	Composicoes farmaceuticas nao-efervescentes soluveis em agua compreendendo drogas anti-inflamatorias nao-esteroides
CA2374471A1 (en)	2000-12-07	Therapeutically and/or nutritionally enhanced derivatives of active ingredients and orally administrable compositions containing same
GB9827095D0 (en)	1999-02-03	Administration of benefical substances to ruminant animals
CA2383755A1 (en)	2001-03-15	Non-hygroscopic salts of active ingredients having therapeutical and/or nutritional activities and orally administrable compositions containing same
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