ATE247467T1 - Neue therapeutische verwendung von 1,6-dimethyl- 8beta-hydroxymethyl-10alpha-methoxyergolin - Google Patents
Neue therapeutische verwendung von 1,6-dimethyl- 8beta-hydroxymethyl-10alpha-methoxyergolinInfo
- Publication number
- ATE247467T1 ATE247467T1 AT99956110T AT99956110T ATE247467T1 AT E247467 T1 ATE247467 T1 AT E247467T1 AT 99956110 T AT99956110 T AT 99956110T AT 99956110 T AT99956110 T AT 99956110T AT E247467 T1 ATE247467 T1 AT E247467T1
- Authority
- AT
- Austria
- Prior art keywords
- methoxyergoline
- 10alpha
- 8beta
- hydroxymethyl
- dimethyl
- Prior art date
Links
- LVXVIPZBNJSUKL-NJAPINKUSA-N [(6ar,9r,10as)-10a-methoxy-4,7-dimethyl-6a,8,9,10-tetrahydro-6h-indolo[4,3-fg]quinoline-9-yl]methanol Chemical compound C1=CC([C@]2(OC)[C@H](N(C)C[C@H](CO)C2)C2)=C3C2=CN(C)C3=C1 LVXVIPZBNJSUKL-NJAPINKUSA-N 0.000 title abstract 2
- 230000001225 therapeutic effect Effects 0.000 title 1
- 208000005264 motor neuron disease Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/48—Ergoline derivatives, e.g. lysergic acid, ergotamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9814792A FR2786099B1 (fr) | 1998-11-24 | 1998-11-24 | Nouvelle application therapeutique de la 1,6-dimethyl-8beta- hydroxymethyl-10alpha-methoxyergoline |
| PCT/FR1999/002868 WO2000030644A1 (fr) | 1998-11-24 | 1999-11-22 | NOUVELLE APPLICATION THERAPEUTIQUE DE LA 1, 6- DIMETHYL-8β -HYDROXYMETHYL -10α- METHOXYERGOLINE |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE247467T1 true ATE247467T1 (de) | 2003-09-15 |
Family
ID=9533129
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99956110T ATE247467T1 (de) | 1998-11-24 | 1999-11-22 | Neue therapeutische verwendung von 1,6-dimethyl- 8beta-hydroxymethyl-10alpha-methoxyergolin |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US6339095B2 (de) |
| EP (1) | EP1133297B1 (de) |
| JP (1) | JP4637360B2 (de) |
| AT (1) | ATE247467T1 (de) |
| AU (1) | AU1278700A (de) |
| DE (1) | DE69910608T2 (de) |
| DK (1) | DK1133297T3 (de) |
| ES (1) | ES2201802T3 (de) |
| FR (1) | FR2786099B1 (de) |
| PT (1) | PT1133297E (de) |
| WO (1) | WO2000030644A1 (de) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2786101B1 (fr) * | 1998-11-24 | 2002-07-05 | Aventis Laboratoire | Utilisation de la nicergoline dans le traitement de la spasticite |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| YU39278B (en) * | 1976-12-22 | 1984-10-31 | Lek Tovarna Farmacevtskih | Process for preparing 5-bromo nicotinic acid esters |
| IT1094965B (it) * | 1978-04-05 | 1985-08-10 | Corvi Mora E | Procedimento di preparazione di derivati del lisergolo |
| IT1173489B (it) * | 1984-03-27 | 1987-06-24 | Inverni Della Beffa Spa | Procedimento di preparazione di 1-metil-10alfa-metossilumilisergolo e di suci esteri,e intermedi per la loro preparazione |
| FR2584719B1 (fr) * | 1985-07-11 | 1987-10-02 | Rhone Poulenc Sante | Procede de preparation des derives n-methyles du lysergol et du methoxy-10a lumilysergol |
| HU196394B (en) * | 1986-06-27 | 1988-11-28 | Richter Gedeon Vegyeszet | Process for preparing 2-halogenated ergoline derivatives |
| CH674367A5 (de) * | 1987-06-16 | 1990-05-31 | Arysearch Arylan Ag | |
| AT397437B (de) * | 1989-10-25 | 1994-04-25 | Kwizda Fa F Johann | Hybridzellinien zur herstellung monoklonaler antikörper gegen bromnicotinsäure und 1-methyl- 10alpha-methoxydihydrolysergol; antikörper und verfahren zu ihrer herstellung; ihre diagnostischeverwendung und diese antikörper enthaltende diagnostische zusammensetzung |
| IT1252163B (it) * | 1991-12-03 | 1995-06-05 | Poli Ind Chimica Spa | Composizioni farmaceutiche per la neuroprotezione nelle malattie neurologiche di carattere degenerativo o su base ischemica |
| US6297254B1 (en) * | 1999-12-01 | 2001-10-02 | Aventis Pharma S. A. | Method for the prevention or treatment of a motoneuron disease |
-
1998
- 1998-11-24 FR FR9814792A patent/FR2786099B1/fr not_active Expired - Fee Related
-
1999
- 1999-11-22 WO PCT/FR1999/002868 patent/WO2000030644A1/fr not_active Ceased
- 1999-11-22 AU AU12787/00A patent/AU1278700A/en not_active Abandoned
- 1999-11-22 JP JP2000583527A patent/JP4637360B2/ja not_active Expired - Fee Related
- 1999-11-22 DK DK99956110T patent/DK1133297T3/da active
- 1999-11-22 AT AT99956110T patent/ATE247467T1/de active
- 1999-11-22 PT PT99956110T patent/PT1133297E/pt unknown
- 1999-11-22 ES ES99956110T patent/ES2201802T3/es not_active Expired - Lifetime
- 1999-11-22 DE DE69910608T patent/DE69910608T2/de not_active Expired - Lifetime
- 1999-11-22 EP EP99956110A patent/EP1133297B1/de not_active Expired - Lifetime
-
2001
- 2001-05-23 US US09/863,610 patent/US6339095B2/en not_active Expired - Lifetime
- 2001-11-29 US US09/998,765 patent/US6451818B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| ES2201802T3 (es) | 2004-03-16 |
| DE69910608D1 (de) | 2003-09-25 |
| PT1133297E (pt) | 2003-11-28 |
| US20020065294A1 (en) | 2002-05-30 |
| DK1133297T3 (da) | 2003-11-24 |
| DE69910608T2 (de) | 2004-08-05 |
| FR2786099A1 (fr) | 2000-05-26 |
| WO2000030644A1 (fr) | 2000-06-02 |
| EP1133297B1 (de) | 2003-08-20 |
| US6339095B2 (en) | 2002-01-15 |
| US6451818B1 (en) | 2002-09-17 |
| JP4637360B2 (ja) | 2011-02-23 |
| FR2786099B1 (fr) | 2000-12-29 |
| EP1133297A1 (de) | 2001-09-19 |
| JP2002530337A (ja) | 2002-09-17 |
| US20010047011A1 (en) | 2001-11-29 |
| AU1278700A (en) | 2000-06-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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