ATE248598T1 - Inhibitoren der kainsäure-neurotoxizität sowie pyridothiazinderivate - Google Patents

Inhibitoren der kainsäure-neurotoxizität sowie pyridothiazinderivate

Info

Publication number: ATE248598T1
Authority: AT; Austria
Prior art keywords: formula; inhibitors; neuronotoxicity; kaine; pharmaceutically acceptable
Prior art date: 1995-11-15

Application number

AT96938464T

Other languages

English (en)

Inventor

Jun-Ichi Shishikura

Hiroshi Inami

Tomoyuki Yasunaga

Masaaki Hirano

Shuichi Sakamoto

Kazushige Ohno

Masamichi Okada

Shin-Ichi Tsukamoto

Original Assignee

Yamanouchi Pharma Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-11-15

Filing date

1996-11-14

Publication date

2003-09-15

1996-11-14 Application filed by Yamanouchi Pharma Co Ltd filed Critical Yamanouchi Pharma Co Ltd

2003-09-15 Application granted granted Critical

2003-09-15 Publication of ATE248598T1 publication Critical patent/ATE248598T1/de

Links

WQEBRZKYXXZALY-UHFFFAOYSA-N 2h-pyrido[2,3-e]thiazine Chemical class C1=CN=C2C=CNSC2=C1 WQEBRZKYXXZALY-UHFFFAOYSA-N 0.000 title abstract 2
239000003112 inhibitor Substances 0.000 title abstract 2
206010029350 Neurotoxicity Diseases 0.000 title 1
206010044221 Toxic encephalopathy Diseases 0.000 title 1
239000002253 acid Substances 0.000 title 1
230000007135 neurotoxicity Effects 0.000 title 1
231100000228 neurotoxicity Toxicity 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 1
239000004480 active ingredient Substances 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
VLSMHEGGTFMBBZ-UHFFFAOYSA-N alpha-Kainic acid Natural products CC(=C)C1CNC(C(O)=O)C1CC(O)=O VLSMHEGGTFMBBZ-UHFFFAOYSA-N 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
125000005842 heteroatom Chemical group 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
230000005764 inhibitory process Effects 0.000 abstract 1
VLSMHEGGTFMBBZ-OOZYFLPDSA-N kainic acid Chemical compound CC(=C)[C@H]1CN[C@H](C(O)=O)[C@H]1CC(O)=O VLSMHEGGTFMBBZ-OOZYFLPDSA-N 0.000 abstract 1
229950006874 kainic acid Drugs 0.000 abstract 1
210000002569 neuron Anatomy 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
239000003223 protective agent Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
Psychology (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

AT96938464T 1995-11-15 1996-11-14 Inhibitoren der kainsäure-neurotoxizität sowie pyridothiazinderivate ATE248598T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP29685795		1995-11-15
PCT/JP1996/003339 WO1997017970A1 (fr)	1995-11-15	1996-11-14	Inhibiteurs de la neurotoxicite de l'acide kainique et derives de la pyridothiazine

Publications (1)

Publication Number	Publication Date
ATE248598T1 true ATE248598T1 (de)	2003-09-15

Family

ID=17839067

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT96938464T ATE248598T1 (de)	1995-11-15	1996-11-14	Inhibitoren der kainsäure-neurotoxizität sowie pyridothiazinderivate

Country Status (12)

Country	Link
US (1)	US6133258A (de)
EP (1)	EP0878196B1 (de)
JP (1)	JP3117725B2 (de)
KR (1)	KR100444697B1 (de)
CN (1)	CN1202109A (de)
AT (1)	ATE248598T1 (de)
AU (1)	AU713847B2 (de)
CA (1)	CA2237911A1 (de)
DE (1)	DE69629838T2 (de)
ES (1)	ES2206604T3 (de)
TW (1)	TW446708B (de)
WO (1)	WO1997017970A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6362009B1 (en)	1997-11-21	2002-03-26	Merck & Co., Inc.	Solid phase synthesis of heterocycles
JP2002519373A (ja) *	1998-07-02	2002-07-02	エーザイ株式会社	製薬組成物及びそれらの使用
WO2000051992A1 (en) *	1999-03-04	2000-09-08	E.I. Du Pont De Nemours And Company	Fused bicyclic oxazinone and thiazinone fungicides
DE60041365D1 (de) *	1999-06-04	2009-02-26	Vereniging Voor Christelijk Wetenschappelijk Onderwijs	Verwendung von Riluzol zur Behandlung Multipler Sklerose
AU777537B2 (en) *	1999-06-04	2004-10-21	Vereniging Voor Christelijk Wetenschappelijk Onderwijs	Use of riluzole for the treatment of multiple sclerosis
JP4200902B2 (ja) *	2002-03-29	2008-12-24	アステラス製薬株式会社	神経膠芽腫治療剤
AP2005003319A0 (en) *	2002-11-19	2005-06-30	Achillion Pharmaceitucals Inc	Substituted aryl thioureas and related compounds; inhibitors of viral replication
TW200600492A (en) *	2004-05-18	2006-01-01	Achillion Pharmaceuticals Inc	Substituted aryl acylthioureas and related compounds; inhibitors of viral replication
JP2006009963A (ja)	2004-06-25	2006-01-12	Ntn Corp	転がり軸受
CN104672256B (zh) *	2013-11-29	2017-10-31	沈阳药科大学	4H‑吡啶并[3,2‑e][1,3]噻嗪‑4‑酮类衍生物及其应用
WO2016039936A2 (en) *	2014-09-09	2016-03-17	Ptc Therapeutics, Inc.	Monocyclic substituted 2-pyridinone antibacterial compounds

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3157647A (en) *	1960-10-31	1964-11-17	Olin Mathieson	Process for producing nu-alkyl and nu-aralkyl thiadiazine compounds
US3288678A (en) *	1963-09-12	1966-11-29	Ciba Geigy Corp	Diuretic compositions
GB1368948A (en) *	1970-11-11	1974-10-02	Manuf Prod Pharma	Pyridine derivatives
FR2703051B1 (fr) *	1993-03-26	1995-04-28	Adir	Nouvelles pyridothiadiazines, leurs procédés de préparation, et les compositions pharmaceutiques qui les contiennent.
FR2722502B1 (fr) *	1994-07-12	1996-08-23	Adir	Nouveau derive de benzothiadiazine, son procede depreparation et les compositions pharmaceutiques qui le contiennent

1996
- 1996-11-14 JP JP09518741A patent/JP3117725B2/ja not_active Expired - Fee Related
- 1996-11-14 CA CA002237911A patent/CA2237911A1/en not_active Abandoned
- 1996-11-14 CN CN96198248A patent/CN1202109A/zh active Pending
- 1996-11-14 DE DE69629838T patent/DE69629838T2/de not_active Expired - Fee Related
- 1996-11-14 AU AU75870/96A patent/AU713847B2/en not_active Ceased
- 1996-11-14 AT AT96938464T patent/ATE248598T1/de not_active IP Right Cessation
- 1996-11-14 WO PCT/JP1996/003339 patent/WO1997017970A1/ja not_active Ceased
- 1996-11-14 KR KR10-1998-0703550A patent/KR100444697B1/ko not_active Expired - Fee Related
- 1996-11-14 EP EP96938464A patent/EP0878196B1/de not_active Expired - Lifetime
- 1996-11-14 US US09/068,534 patent/US6133258A/en not_active Expired - Fee Related
- 1996-11-14 ES ES96938464T patent/ES2206604T3/es not_active Expired - Lifetime
- 1996-11-15 TW TW085114007A patent/TW446708B/zh not_active IP Right Cessation

Also Published As

Publication number	Publication date
KR19990067528A (ko)	1999-08-25
EP0878196A4 (de)	2001-04-11
WO1997017970A1 (fr)	1997-05-22
DE69629838D1 (de)	2003-10-09
CN1202109A (zh)	1998-12-16
EP0878196A1 (de)	1998-11-18
TW446708B (en)	2001-07-21
EP0878196B1 (de)	2003-09-03
US6133258A (en)	2000-10-17
JP3117725B2 (ja)	2000-12-18
AU7587096A (en)	1997-06-05
AU713847B2 (en)	1999-12-09
KR100444697B1 (ko)	2005-01-13
CA2237911A1 (en)	1997-05-22
ES2206604T3 (es)	2004-05-16
DE69629838T2 (de)	2004-07-08

Legal Events

Date	Code	Title	Description
2004-03-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
EP0607439A4 (de)	1994-12-07	Stickstoff enthaltende hydrocyclische verbindungen.
LU91210I2 (fr)	2006-11-06	Emodepside & Praziquantel ainsi que leurs dérivés pharmaceutiqement acceptables (PROFENDER)
CA2311742A1 (en)	1999-06-10	6-amino-9-benzyl-8-hydroxypurine derivatives
ATE170840T1 (de)	1998-09-15	Hydroxamsäure derivate als collagenase inhibitore
ATE223378T1 (de)	2002-09-15	Prolineamid-derivate
ATE156116T1 (de)	1997-08-15	Auf aromatischen sulfonamiden basierende hydroxamsäurederivate
DE69328856D1 (de)	2000-07-20	Hypoglykämische Dihydrochalconderivate
DE69820248D1 (de)	2004-01-15	Pyrrolidin-derivate die eine phospholipase-a2-hemmende wirkung haben
AU689304B2 (en)	1998-03-26	Quinazoline derivative
AU6601294A (en)	1995-01-12	Amide and urea derivatives having anti-hypercholesteremic activity, their preparation and their therapeutic uses
DE69309435D1 (de)	1997-05-07	Restenosehemmer nach perkutaner koronarer arterioplastie
DE69629838D1 (de)	2003-10-09	Inhibitoren der kainsäure-neurotoxizität sowie pyridothiazinderivate
DK0916651T3 (da)	2003-12-01	Phenylalkylcarboxylsyrederivater
DE69229637D1 (de)	1999-08-26	Oxazolidone Derivative als Monoamine-Oxidaseinhibitoren
ATE194982T1 (de)	2000-08-15	Benzoxazepin-derivate als cholinesterase- inhibitoren
DE69600231D1 (de)	1998-05-20	N-Arylalkylphenylacetamidderivate
EP0982029A4 (de)	2002-07-03	Vorbeugende /heilmittel fuer arteriosklerose