ATE248855T1 - Methoden zur herstellung von rekombinanten peptiden mit einer geringen menge von trisulfiden - Google Patents

Methoden zur herstellung von rekombinanten peptiden mit einer geringen menge von trisulfiden

Info

Publication number
ATE248855T1
ATE248855T1 AT99933442T AT99933442T ATE248855T1 AT E248855 T1 ATE248855 T1 AT E248855T1 AT 99933442 T AT99933442 T AT 99933442T AT 99933442 T AT99933442 T AT 99933442T AT E248855 T1 ATE248855 T1 AT E248855T1
Authority
AT
Austria
Prior art keywords
methods
trisulfides
recombinant peptides
recombinant
small amount
Prior art date
Application number
AT99933442T
Other languages
English (en)
Inventor
Barbro Hemmendorff
Andreas Castan
Anders Persson
Original Assignee
Pharmacia Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=20412012&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE248855(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pharmacia Ab filed Critical Pharmacia Ab
Application granted granted Critical
Publication of ATE248855T1 publication Critical patent/ATE248855T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormone [GH], i.e. somatotropin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT99933442T 1998-07-08 1999-07-05 Methoden zur herstellung von rekombinanten peptiden mit einer geringen menge von trisulfiden ATE248855T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9802454A SE9802454D0 (sv) 1998-07-08 1998-07-08 Production of peptides
PCT/SE1999/001222 WO2000002900A1 (en) 1998-07-08 1999-07-05 Method for the production of recombinant peptides with a low amount of trisulfides

Publications (1)

Publication Number Publication Date
ATE248855T1 true ATE248855T1 (de) 2003-09-15

Family

ID=20412012

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99933442T ATE248855T1 (de) 1998-07-08 1999-07-05 Methoden zur herstellung von rekombinanten peptiden mit einer geringen menge von trisulfiden

Country Status (14)

Country Link
US (2) US7232894B1 (de)
EP (1) EP1095055B1 (de)
JP (1) JP2002520332A (de)
AT (1) ATE248855T1 (de)
AU (1) AU755083B2 (de)
CA (1) CA2344506C (de)
DE (1) DE69911024T2 (de)
DK (1) DK1095055T3 (de)
ES (1) ES2207255T3 (de)
IL (1) IL140668A0 (de)
NZ (1) NZ509179A (de)
PT (1) PT1095055E (de)
SE (1) SE9802454D0 (de)
WO (1) WO2000002900A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60042969D1 (de) 1999-03-02 2009-10-29 Life Technologies Corp Zubereitungen und methoden zur verwendung in rekombinatorischem klonen von nukleinsäuren
JP5118796B2 (ja) 1999-06-28 2013-01-16 ジェネンテック， インコーポレイテッド 二価の金属イオンを利用したＡｐｏ−２リガンドの製造方法
CN1697839B (zh) * 2002-08-28 2010-10-27 法玛西亚公司 同工型杂质水平较低的生长激素及其拮抗剂的制备方法
US20040048315A1 (en) * 2002-08-28 2004-03-11 Pharmacia Corporation Method for the preparation of growth hormone and antagonist thereof having lower levels of isoform impurities thereof
EP1545428B1 (de) * 2002-09-20 2009-12-30 Pharmacia Corporation Verfahren zur verringerung der aggregatmengen des pegylierten proteins
JP2007512838A (ja) 2003-12-01 2007-05-24 インヴィトロジェン コーポレーション 組換え部位を含む核酸分子およびその使用方法
DE602005020505D1 (de) * 2004-12-29 2010-05-20 Novo Nordisk Healthcare Ag Verfahren zur verhinderung der bildung von trisulfidderivaten von polypeptiden
EP2483289B2 (de) * 2009-10-02 2025-03-26 Biogen MA Inc. Verfahren zur vorbeugung und entfernung von trisulphid-bindungen
US9562252B2 (en) 2011-05-13 2017-02-07 Biogen Ma Inc. Methods of preventing and removing trisulfide bonds
SG10202102467RA (en) 2014-07-24 2021-04-29 Genentech Inc Methods of conjugating an agent to a thiol moiety in a protein that contains at least one trisulfide bond

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5256546A (en) * 1983-07-15 1993-10-26 Bio-Technology General Corp. Bacterial expression of porcine growth hormone
US4985544A (en) * 1987-08-04 1991-01-15 Kyowa Hakko Kogyo Co., Ltd. Process for renaturing fish growth hormone
DK44593D0 (da) 1993-04-20 1993-04-20 Novo Nordisk As Fremgangsmaade til fremstilling af et polypeptid
US5663304A (en) * 1993-08-20 1997-09-02 Genentech, Inc. Refolding of misfolded insulin-like growth factor-I
ZA955789B (en) * 1994-07-15 1996-03-11 Novo Nordisk As A method of converting a hydrophobic derivative of a polypeptide into the native form

Also Published As

Publication number Publication date
SE9802454D0 (sv) 1998-07-08
AU4949699A (en) 2000-02-01
ES2207255T3 (es) 2004-05-16
PT1095055E (pt) 2003-12-31
DE69911024D1 (de) 2003-10-09
JP2002520332A (ja) 2002-07-09
DK1095055T3 (da) 2003-12-22
WO2000002900A1 (en) 2000-01-20
IL140668A0 (en) 2002-02-10
EP1095055B1 (de) 2003-09-03
DE69911024T2 (de) 2004-04-01
NZ509179A (en) 2003-01-31
CA2344506C (en) 2010-05-11
US20070232792A1 (en) 2007-10-04
AU755083B2 (en) 2002-12-05
US7232894B1 (en) 2007-06-19
EP1095055A1 (de) 2001-05-02
CA2344506A1 (en) 2000-01-20

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