ATE408020T1 - Verfahren zur herstellung von faktor vii - Google Patents

Verfahren zur herstellung von faktor vii

Info

Publication number
ATE408020T1
ATE408020T1 AT99955836T AT99955836T ATE408020T1 AT E408020 T1 ATE408020 T1 AT E408020T1 AT 99955836 T AT99955836 T AT 99955836T AT 99955836 T AT99955836 T AT 99955836T AT E408020 T1 ATE408020 T1 AT E408020T1
Authority
AT
Austria
Prior art keywords
factor vii
producing factor
cells
producing
fvii
Prior art date
Application number
AT99955836T
Other languages
English (en)
Inventor
Helle Woeldike
Finn Wiberg
Lars Nielsen
Original Assignee
Novo Nordisk Healthcare Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk Healthcare Ag filed Critical Novo Nordisk Healthcare Ag
Application granted granted Critical
Publication of ATE408020T1 publication Critical patent/ATE408020T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6437—Coagulation factor VIIa (3.4.21.21)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21021—Coagulation factor VIIa (3.4.21.21)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT99955836T 1998-11-06 1999-11-05 Verfahren zur herstellung von faktor vii ATE408020T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DKPA199801436 1998-11-06
DKPA199801439 1998-11-09
US10806598P 1998-11-12 1998-11-12
PCT/DK1999/000607 WO2000028065A1 (en) 1998-11-06 1999-11-05 Method for the production of fvii

Publications (1)

Publication Number Publication Date
ATE408020T1 true ATE408020T1 (de) 2008-09-15

Family

ID=27221287

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99955836T ATE408020T1 (de) 1998-11-06 1999-11-05 Verfahren zur herstellung von faktor vii

Country Status (8)

Country Link
US (2) US6329176B1 (de)
EP (1) EP1127154B1 (de)
JP (1) JP4463988B2 (de)
AT (1) ATE408020T1 (de)
AU (1) AU1262900A (de)
DE (1) DE69939548D1 (de)
ES (1) ES2315022T3 (de)
WO (1) WO2000028065A1 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6747003B1 (en) 1997-10-23 2004-06-08 Regents Of The University Of Minnesota Modified vitamin K-dependent polypeptides
US7247708B2 (en) 1997-10-23 2007-07-24 Regents Of The University Of Minnesota Modified vitamin K-dependent polypeptides
SK782002A3 (en) 1999-07-21 2003-08-05 Lexigen Pharm Corp FC fusion proteins for enhancing the immunogenicity of protein and peptide antigens
CN100488562C (zh) 2000-02-11 2009-05-20 拜耳医药保健有限公司 凝血因子VⅡ或VⅡa样分子
US7220837B1 (en) 2000-04-28 2007-05-22 Regents Of The University Of Minnesota Modified vitamin K-dependent polypeptides
US7812132B2 (en) 2000-04-28 2010-10-12 Regents Of The University Of Minnesota Modified vitamin K-dependent polypeptides
US20030211094A1 (en) 2001-06-26 2003-11-13 Nelsestuen Gary L. High molecular weight derivatives of vitamin k-dependent polypeptides
BR0114374A (pt) * 2000-10-02 2003-12-30 Novo Nordisk As Preparação compreendendo uma pluralidade de polipeptìdeos de fator vii, métodos para a determinação do padrão de glicoforma de fator vii e de polipeptìdeos relacionados com fator vii, e para a produção da dita preparação, formulação farmacêutica, métodos para o tratamento de uma sìndrome responsiva a fator vii, para a prevenção de sangramento indesejado, para a prevenção de coagulação sanguìnea indesejada, e para prevenção de reações mediadas por fator de tecido, e, uso da preparação
EP1434857B1 (de) 2001-10-02 2007-08-01 Novo Nordisk Health Care AG Verfahren zur herstelllung rekombinanter proteine in eukaryontischen zellen
MXPA04010781A (es) 2002-04-30 2005-03-07 Maxygen Holdings Ltd Variantes de polipeptido del factor vii o viia.
ES2327044T3 (es) 2003-03-20 2009-10-23 Bayer Healthcare Llc Variantes de fvii o fviia.
EP3002012A1 (de) 2003-05-06 2016-04-06 Biogen Hemophilia Inc. Chimäre proteine mit gerinnungsfaktor fc zur behandlung von hämophilie
EP1624846A2 (de) * 2003-05-06 2006-02-15 Syntonix Pharmaceuticals, Inc. Hemmung der arzneimittelbindung an serumalbumin
US7348004B2 (en) 2003-05-06 2008-03-25 Syntonix Pharmaceuticals, Inc. Immunoglobulin chimeric monomer-dimer hybrids
TWI353991B (en) * 2003-05-06 2011-12-11 Syntonix Pharmaceuticals Inc Immunoglobulin chimeric monomer-dimer hybrids
MXPA05013769A (es) 2003-06-19 2006-03-08 Maxygen Holdings Ltd Variantes del dominio gla del factor vii o viia.
CN101870729A (zh) 2003-09-09 2010-10-27 诺和诺德医疗保健公司 凝固因子ⅶ多肽
ES2399138T3 (es) 2006-03-16 2013-03-26 Stellaris Pharmaceuticals Aps Tratamiento local con factor VII
DK2440239T3 (en) 2009-06-09 2017-10-16 Prolong Pharmaceuticals Llc HEMOGLOBIN FORMATIONS
US10172950B2 (en) 2009-06-09 2019-01-08 Prolong Pharmaceuticals, LLC Hemoglobin compositions
US10172949B2 (en) 2009-06-09 2019-01-08 Prolong Pharmaceuticals, LLC Hemoglobin compositions
RU2448160C1 (ru) * 2010-11-11 2012-04-20 Закрытое акционерное общество "ГЕНЕРИУМ" РЕКОМБИНАНТНАЯ ПЛАЗМИДНАЯ ДНК pAP271, КОДИРУЮЩАЯ ПОЛИПЕПТИД ФАКТОРА VII СВЕРТЫВАЕМОСТИ КРОВИ ЧЕЛОВЕКА, И ЛИНИЯ КЛЕТОК Mesocricetus auratus ВНК 21 k.13 (2H7) - ПРОДУЦЕНТ РЕКОМБИНАНТНОГО ФАКТОРА VII СВЕРТЫВАЕМОСТИ КРОВИ ЧЕЛОВЕКА
AR095527A1 (es) 2013-03-15 2015-10-21 Biogen Idec Inc Formulaciones de polipéptido fc-factor ix
BR102015012334A2 (pt) 2015-05-27 2016-11-29 Fundação Hemoct De Ribeirão Preto Fundherp processo de produção do fator vii de coagulação sanguínea e fator vii de coagulação sanguínea

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5516650A (en) * 1985-06-27 1996-05-14 Zymogenetics, Inc. Production of activated protein C
CA1340740C (en) * 1987-12-08 1999-09-14 Eileen R. Mulvihill Co-expression in eukaryotic cells
IE914102A1 (en) * 1990-11-26 1992-06-03 Genetics Inst Expression of pace in host cells and methods of use thereof
DK0548012T3 (da) * 1991-12-16 1998-04-14 Ciba Geigy Ag Endoplasmatisk reticulum-placeret rekombinant dibasisk endoprotease samt dens anvendelse

Also Published As

Publication number Publication date
ES2315022T3 (es) 2009-03-16
AU1262900A (en) 2000-05-29
JP2003523168A (ja) 2003-08-05
EP1127154A1 (de) 2001-08-29
DE69939548D1 (de) 2008-10-23
JP4463988B2 (ja) 2010-05-19
US6329176B1 (en) 2001-12-11
WO2000028065A1 (en) 2000-05-18
US20020160458A1 (en) 2002-10-31
EP1127154B1 (de) 2008-09-10

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