ATE249471T1 - 3'-substuierte nukleosidderivate - Google Patents

3'-substuierte nukleosidderivate

Info

Publication number: ATE249471T1
Authority: AT; Austria
Prior art keywords: group; chem; ester; living body; substituted
Prior art date: 1994-12-13

Application number

AT95940427T

Other languages

English (en)

Inventor

Akira Matsuda

Takuma Sasaki

Original Assignee

Taiho Pharmaceutical Co Ltd

Akira Matsuda

Takuma Sasaki

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-12-13

Filing date

1995-12-13

Publication date

2003-09-15

1995-12-13 Application filed by Taiho Pharmaceutical Co Ltd, Akira Matsuda, Takuma Sasaki filed Critical Taiho Pharmaceutical Co Ltd

2003-09-15 Application granted granted Critical

2003-09-15 Publication of ATE249471T1 publication Critical patent/ATE249471T1/de

Links

150000003833 nucleoside derivatives Chemical class 0.000 title abstract 3
125000000217 alkyl group Chemical group 0.000 abstract 2
206010028980 Neoplasm Diseases 0.000 abstract 1
PYMYPHUHKUWMLA-LMVFSUKVSA-N Ribose Natural products OC[C@@H](O)[C@@H](O)[C@@H](O)C=O PYMYPHUHKUWMLA-LMVFSUKVSA-N 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000000304 alkynyl group Chemical group 0.000 abstract 1
HMFHBZSHGGEWLO-UHFFFAOYSA-N alpha-D-Furanose-Ribose Natural products OCC1OC(O)C(O)C1O HMFHBZSHGGEWLO-UHFFFAOYSA-N 0.000 abstract 1
230000000259 anti-tumor effect Effects 0.000 abstract 1
150000007523 nucleic acids Chemical class 0.000 abstract 1
102000039446 nucleic acids Human genes 0.000 abstract 1
108020004707 nucleic acids Proteins 0.000 abstract 1
125000000466 oxiranyl group Chemical group 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
229920000137 polyphosphoric acid Polymers 0.000 abstract 1
230000002265 prevention Effects 0.000 abstract 1
125000000548 ribosyl group Chemical group C1([C@H](O)[C@H](O)[C@H](O1)CO)* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT95940427T 1994-12-13 1995-12-13 3'-substuierte nukleosidderivate ATE249471T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
JP30891294		1994-12-13
JP20864595		1995-08-16
PCT/JP1995/002554 WO1996018636A1 (en)	1994-12-13	1995-12-13	3'-substituted nucleoside derivatives

Publications (1)

Publication Number	Publication Date
ATE249471T1 true ATE249471T1 (de)	2003-09-15

Family

ID=26516961

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT95940427T ATE249471T1 (de)	1994-12-13	1995-12-13	3'-substuierte nukleosidderivate

Country Status (18)

Country	Link
US (2)	US5763418A (de)
EP (1)	EP0747389B1 (de)
JP (1)	JP3142874B2 (de)
KR (1)	KR0177372B1 (de)
CN (1)	CN1195768C (de)
AT (1)	ATE249471T1 (de)
AU (1)	AU674639B2 (de)
CA (1)	CA2182707C (de)
DE (1)	DE69531729T2 (de)
DK (1)	DK0747389T3 (de)
ES (1)	ES2206522T3 (de)
FI (1)	FI118967B (de)
HU (1)	HU217772B (de)
NO (1)	NO305702B1 (de)
NZ (1)	NZ297100A (de)
PT (1)	PT747389E (de)
RU (1)	RU2130029C1 (de)
WO (1)	WO1996018636A1 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP3142874B2 (ja) *	1994-12-13	2001-03-07	彰松田	３´−置換ヌクレオシド誘導体
CA2172471C (en) *	1995-03-29	1999-01-26	Hua Qi	Apparatus for and method of simulating ocular optical system
US6235782B1 (en)	1998-11-12	2001-05-22	Rifat Pamukcu	Method for treating a patient with neoplasia by treatment with a platinum coordination complex
US6235776B1 (en)	1998-11-12	2001-05-22	Cell Pathways, Inc.	Method for treating a patient with neoplasia by treatment with a paclitaxel derivative
MY164523A (en) *	2000-05-23	2017-12-29	Univ Degli Studi Cagliari	Methods and compositions for treating hepatitis c virus
JP5230052B2 (ja)	2000-05-26	2013-07-10	イデニクス（ケイマン）リミテツド	フラビウイルスおよびペスチウイルス治療のための方法および組成物
WO2003026589A2 (en)	2001-09-28	2003-04-03	Idenix (Cayman) Limited	Methods and compositions for treating hepatitis c virus using 4'-modified nucleosides
US7012100B1 (en)	2002-06-04	2006-03-14	Avolix Pharmaceuticals, Inc.	Cell migration inhibiting compositions and methods and compositions for treating cancer
NZ537662A (en) *	2002-06-28	2007-10-26	Idenix Cayman Ltd	2'-C-methyl-3'-O-L-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections
WO2004003000A2 (en) *	2002-06-28	2004-01-08	Idenix (Cayman) Limited	1’-, 2'- and 3'- modified nucleoside derivatives for treating flaviviridae infections
AP2005003213A0 (en) *	2002-06-28	2005-03-31	Univ Cagliari	2'-C-methyl-3'-O-L-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections.
US7608600B2 (en) *	2002-06-28	2009-10-27	Idenix Pharmaceuticals, Inc.	Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
US7824851B2 (en)	2002-11-15	2010-11-02	Idenix Pharmaceuticals, Inc.	2′-branched nucleosides and Flaviviridae mutation
MXPA05006230A (es)	2002-12-12	2005-09-20	Idenix Cayman Ltd	Proceso para la produccion de nucleosidos ramificados-2'.
CA2514466C (en) *	2003-02-19	2015-05-26	Yale University	Anti-viral nucleoside analogs and methods for treating viral infections, especially hiv infections
AU2005256963A1 (en) *	2004-06-23	2006-01-05	Centre National De La Recherche Scientifique	5-aza-7-deazapurine derivatives for treating infections with flaviviridae
JP4516863B2 (ja) *	2005-03-11	2010-08-04	株式会社ケンウッド	音声合成装置、音声合成方法及びプログラム
ES2422290T3 (es) *	2005-12-23	2013-09-10	Idenix Pharmaceuticals Inc	Procedimiento para preparar un producto intermedio sintético para la preparación de nucleósidos ramificados
US8058261B2 (en)	2006-07-24	2011-11-15	Taiho Pharmaceutical Co., Ltd.	3′-ethynylcytidine derivative
JP5066737B2 (ja)	2007-04-06	2012-11-07	大鵬薬品工業株式会社	シチジン誘導体を含有する持続静脈内投与用抗腫瘍剤
JP4954004B2 (ja)	2007-08-09	2012-06-13	株式会社バイオダイナミクス研究所	任意の化合物が導入された新規核酸誘導体、及びその製造方法
RU2482855C2 (ru) *	2008-03-27	2013-05-27	Тайхо Фармасьютикал Ко., Лтд.	Противоопухолевое средство, включающее производное цитидина и карбоплатин
WO2014033617A1 (en)	2012-08-31	2014-03-06	Novartis Ag	2'-ethynyl nucleoside derivatives for treatment of viral infections
EP3558998A4 (de) *	2016-12-22	2020-06-10	Calithera Biosciences, Inc.	Ektonukleotidasehemmer und verfahren zur verwendung davon

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3480613A (en) *	1967-07-03	1969-11-25	Merck & Co Inc	2-c or 3-c-alkylribofuranosyl - 1-substituted compounds and the nucleosides thereof
BE739821A (de) *	1968-10-04	1970-03-16
GB8629892D0 (en) *	1986-12-15	1987-01-28	Wellcome Found	Antiviral compounds
DE3924424A1 (de) *	1989-07-24	1991-01-31	Boehringer Mannheim Gmbh	Nucleosid-derivate, verfahren zu deren herstellung, deren verwendung als arzneimittel sowie deren verwendung bei der nucleinsaeure-sequenzierung
DE4204032A1 (de) *	1992-02-12	1993-08-19	Boehringer Mannheim Gmbh	Neue liponucleotide, deren herstellunmg sowie deren verwendung als antivirale arzneimittel
WO1993018051A1 (fr) *	1992-03-11	1993-09-16	Japan Tobacco Inc.	Procede de production de derive de nucleosides
DE4418690A1 (de) *	1994-05-28	1996-01-11	Boehringer Mannheim Gmbh	Neue Lipidester von Nucleosid-Monophosphaten und deren Verwendung als immunsuppressive Arzneimittel
US5681940A (en) *	1994-11-02	1997-10-28	Icn Pharmaceuticals	Sugar modified nucleosides and oligonucleotides
JP3142874B2 (ja) *	1994-12-13	2001-03-07	彰松田	３´−置換ヌクレオシド誘導体

1995
- 1995-12-13 JP JP08518600A patent/JP3142874B2/ja not_active Expired - Lifetime
- 1995-12-13 DK DK95940427T patent/DK0747389T3/da active
- 1995-12-13 US US08/693,161 patent/US5763418A/en not_active Ceased
- 1995-12-13 KR KR1019960704407A patent/KR0177372B1/ko not_active Expired - Lifetime
- 1995-12-13 ES ES95940427T patent/ES2206522T3/es not_active Expired - Lifetime
- 1995-12-13 AU AU41884/96A patent/AU674639B2/en not_active Expired
- 1995-12-13 PT PT95940427T patent/PT747389E/pt unknown
- 1995-12-13 NZ NZ297100A patent/NZ297100A/en not_active IP Right Cessation
- 1995-12-13 RU RU96118248A patent/RU2130029C1/ru active
- 1995-12-13 CN CNB95191605XA patent/CN1195768C/zh not_active Expired - Lifetime
- 1995-12-13 CA CA002182707A patent/CA2182707C/en not_active Expired - Lifetime
- 1995-12-13 DE DE69531729T patent/DE69531729T2/de not_active Expired - Lifetime
- 1995-12-13 HU HU9602214A patent/HU217772B/hu unknown
- 1995-12-13 US US09/584,171 patent/USRE38090E1/en not_active Expired - Lifetime
- 1995-12-13 EP EP95940427A patent/EP0747389B1/de not_active Expired - Lifetime
- 1995-12-13 WO PCT/JP1995/002554 patent/WO1996018636A1/ja not_active Ceased
- 1995-12-13 AT AT95940427T patent/ATE249471T1/de active
1996
- 1996-08-12 FI FI963148A patent/FI118967B/fi not_active IP Right Cessation
- 1996-08-12 NO NO963350A patent/NO305702B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
HU217772B (hu)	2000-04-28
WO1996018636A1 (en)	1996-06-20
HU9602214D0 (en)	1996-11-28
EP0747389A1 (de)	1996-12-11
DE69531729T2 (de)	2004-08-05
CA2182707C (en)	2000-05-30
NO963350L (no)	1996-10-11
EP0747389A4 (de)	1998-12-30
EP0747389B1 (de)	2003-09-10
ES2206522T3 (es)	2004-05-16
US5763418A (en)	1998-06-09
AU4188496A (en)	1996-07-03
CN1140453A (zh)	1997-01-15
NO305702B1 (no)	1999-07-12
KR0177372B1 (ko)	1999-04-01
DK0747389T3 (da)	2004-01-26
JP3142874B2 (ja)	2001-03-07
AU674639B2 (en)	1997-01-02
FI118967B (fi)	2008-05-30
KR970701198A (ko)	1997-03-17
HUT75227A (en)	1997-04-28
FI963148L (fi)	1996-08-12
FI963148A0 (fi)	1996-08-12
NZ297100A (en)	1997-10-24
RU2130029C1 (ru)	1999-05-10
NO963350D0 (no)	1996-08-12
CN1195768C (zh)	2005-04-06
PT747389E (pt)	2003-12-31
DE69531729D1 (de)	2003-10-16
USRE38090E1 (en)	2003-04-22

Legal Events

Date

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Title

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2004-05-15

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Publication of translation of european patent specification

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