ATE251448T1 - Polyol/öl-suspensionen zur verzörgerten freisetzung von proteinen - Google Patents
Polyol/öl-suspensionen zur verzörgerten freisetzung von proteinenInfo
- Publication number
- ATE251448T1 ATE251448T1 AT99968164T AT99968164T ATE251448T1 AT E251448 T1 ATE251448 T1 AT E251448T1 AT 99968164 T AT99968164 T AT 99968164T AT 99968164 T AT99968164 T AT 99968164T AT E251448 T1 ATE251448 T1 AT E251448T1
- Authority
- AT
- Austria
- Prior art keywords
- oil suspensions
- polyol
- proteins
- delayed release
- active agent
- Prior art date
Links
- 239000012053 oil suspension Substances 0.000 title abstract 3
- 102000004169 proteins and genes Human genes 0.000 title abstract 3
- 108090000623 proteins and genes Proteins 0.000 title abstract 3
- 229920005862 polyol Polymers 0.000 title abstract 2
- 150000003077 polyols Chemical class 0.000 title abstract 2
- 230000003111 delayed effect Effects 0.000 title 1
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 abstract 3
- 239000013543 active substance Substances 0.000 abstract 2
- 102000004269 Granulocyte Colony-Stimulating Factor Human genes 0.000 abstract 1
- 108010017080 Granulocyte Colony-Stimulating Factor Proteins 0.000 abstract 1
- -1 e.g. Proteins 0.000 abstract 1
- 230000002459 sustained effect Effects 0.000 abstract 1
- 238000013268 sustained release Methods 0.000 abstract 1
- 239000012730 sustained-release form Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Fats And Perfumes (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/221,181 US6245740B1 (en) | 1998-12-23 | 1998-12-23 | Polyol:oil suspensions for the sustained release of proteins |
| US44820599A | 1999-11-23 | 1999-11-23 | |
| PCT/US1999/030527 WO2000038652A1 (en) | 1998-12-23 | 1999-12-20 | Polyol/oil suspensions for the sustained release of proteins |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE251448T1 true ATE251448T1 (de) | 2003-10-15 |
Family
ID=26915566
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99968164T ATE251448T1 (de) | 1998-12-23 | 1999-12-20 | Polyol/öl-suspensionen zur verzörgerten freisetzung von proteinen |
Country Status (16)
| Country | Link |
|---|---|
| EP (1) | EP1140018B1 (de) |
| JP (1) | JP2002533378A (de) |
| KR (1) | KR100491815B1 (de) |
| CN (1) | CN1158068C (de) |
| AT (1) | ATE251448T1 (de) |
| AU (1) | AU769610B2 (de) |
| CA (1) | CA2355618C (de) |
| DE (1) | DE69911993T2 (de) |
| DK (1) | DK1140018T3 (de) |
| ES (1) | ES2204187T3 (de) |
| HU (1) | HUP0104756A3 (de) |
| IL (2) | IL143706A0 (de) |
| PT (1) | PT1140018E (de) |
| SI (1) | SI1140018T1 (de) |
| TW (1) | TWI221777B (de) |
| WO (1) | WO2000038652A1 (de) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7022674B2 (en) | 1999-12-16 | 2006-04-04 | Eli Lilly And Company | Polypeptide compositions with improved stability |
| JP4361710B2 (ja) | 2000-04-19 | 2009-11-11 | ジェネンテック・インコーポレーテッド | 徐放製剤 |
| BR0115392A (pt) | 2000-11-03 | 2004-06-15 | Biomedicines Inc | Método para o tratamento de uma doença sensìvel a interferona em um animal de sangue quente, método para individualizar as dosagens de uma interferona no tratamento, método para a fabricação de um dispositivo de liberação de efeito terapêutico de longa duração de uma droga ao longo de um perìodo de tempo, e conjunto útil para a ministração de uma quantidade relativamente constante de uma droga |
| DK1397155T3 (en) * | 2001-06-21 | 2015-12-07 | Genentech Inc | Prolonged release formulation |
| US7731947B2 (en) | 2003-11-17 | 2010-06-08 | Intarcia Therapeutics, Inc. | Composition and dosage form comprising an interferon particle formulation and suspending vehicle |
| FR2868704B1 (fr) * | 2004-04-07 | 2007-09-14 | Ethypharm Sa | Utilisation de lipides pour ameliorer la biodisponibilite de principes actifs proteiques en formulations injectables sous cutanees ou intra-musculaires |
| US7772182B2 (en) * | 2004-08-05 | 2010-08-10 | Alza Corporation | Stable suspension formulations of erythropoietin receptor agonists |
| US11246913B2 (en) | 2005-02-03 | 2022-02-15 | Intarcia Therapeutics, Inc. | Suspension formulation comprising an insulinotropic peptide |
| WO2006083761A2 (en) | 2005-02-03 | 2006-08-10 | Alza Corporation | Solvent/polymer solutions as suspension vehicles |
| US8008453B2 (en) | 2005-08-12 | 2011-08-30 | Amgen Inc. | Modified Fc molecules |
| WO2007140416A2 (en) | 2006-05-30 | 2007-12-06 | Intarcia Therapeutics, Inc. | Two-piece, internal-channel osmotic delivery system flow modulator |
| PT2359808E (pt) | 2006-08-09 | 2013-08-28 | Intarcia Therapeutics Inc | Sistemas de entrega osmótica e montagens de pistão |
| PE20081140A1 (es) | 2006-10-25 | 2008-09-22 | Amgen Inc | Agentes terapeuticos a base de peptidos derivados de toxinas |
| AU2008215659B2 (en) * | 2007-02-16 | 2012-11-01 | Aska Pharmaceutical Co., Ltd. | Pharmaceutical composition comprising microparticle oily suspension |
| WO2008106571A2 (en) | 2007-02-28 | 2008-09-04 | Abbott Laboratories | Sustained release parenteral formulations of buprenorphine |
| ES2402172T3 (es) | 2007-04-23 | 2013-04-29 | Intarcia Therapeutics, Inc | Formulación en suspensión de péptidos insulinotrópicos y usos de los mismos |
| JP5591691B2 (ja) | 2007-05-22 | 2014-09-17 | アムジエン・インコーポレーテツド | 生物活性を有する融合タンパク質を作製するための組成物及び方法 |
| WO2009102467A2 (en) | 2008-02-13 | 2009-08-20 | Intarcia Therapeutics, Inc. | Devices, formulations, and methods for delivery of multiple beneficial agents |
| EP3735944A1 (de) | 2009-09-28 | 2020-11-11 | Intarcia Therapeutics, Inc. | Schnelle initiierung und/oder beendigung der verabreichung substantiell stabiler arzneimittel |
| US20120208755A1 (en) | 2011-02-16 | 2012-08-16 | Intarcia Therapeutics, Inc. | Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers |
| SG10201601789TA (en) | 2011-03-16 | 2016-04-28 | Amgen Inc | Potent And Selective Inhibitors Of Nav1.3 And Nav1.7 |
| US20160067347A1 (en) | 2012-12-20 | 2016-03-10 | Amgen Inc. | Apj receptor agonists and uses thereof |
| US10344060B2 (en) | 2013-03-12 | 2019-07-09 | Amgen Inc. | Potent and selective inhibitors of Nav1.7 |
| AU2015274574B2 (en) | 2014-06-10 | 2019-10-10 | Amgen Inc. | Apelin polypeptides |
| US9889085B1 (en) | 2014-09-30 | 2018-02-13 | Intarcia Therapeutics, Inc. | Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c |
| KR102650751B1 (ko) | 2015-06-03 | 2024-03-22 | 인타르시아 세라퓨틱스 인코포레이티드 | 임플란트 배치 및 제거 시스템들 |
| CN109310743A (zh) | 2016-05-16 | 2019-02-05 | 因塔西亚制药公司 | 胰高血糖素受体选择性多肽及其使用方法 |
| USD860451S1 (en) | 2016-06-02 | 2019-09-17 | Intarcia Therapeutics, Inc. | Implant removal tool |
| USD840030S1 (en) | 2016-06-02 | 2019-02-05 | Intarcia Therapeutics, Inc. | Implant placement guide |
| AU2018206539A1 (en) | 2017-01-03 | 2019-07-18 | Intarcia Therapeutics, Inc. | Methods comprising continuous administration of a GLP-1 receptor agonist and co-administration of a drug |
| US11318190B2 (en) | 2017-05-05 | 2022-05-03 | United States Government As Represented By The Department Of Veterans Affairs | Methods and compositions for treating liver disease |
| JP7670390B2 (ja) * | 2021-04-08 | 2025-04-30 | ティオンラボ・セラピューティクス | 徐放性脂質前駆製剤 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3482657D1 (de) * | 1983-11-21 | 1990-08-09 | Univ Minnesota | Gepuffertes polyol-hormones gemisch zur verwendung bei chronischer parenteraler hormonverabreichung. |
| US5411951A (en) * | 1984-10-04 | 1995-05-02 | Monsanto Company | Prolonged release of biologically active somatotropin |
| EP0374120A3 (de) * | 1988-12-13 | 1991-07-31 | Monsanto Company | Zusammensetzung mit kontrollierter Wirkstoffabgabe von Polypeptiden |
| US5114929A (en) * | 1989-03-21 | 1992-05-19 | Beecham Group P.L.C. | Pharmaceutical formulation |
| US6004549A (en) * | 1994-12-14 | 1999-12-21 | Schering Corporation | Crystalline protein controlled release compositions |
-
1999
- 1999-12-20 AT AT99968164T patent/ATE251448T1/de not_active IP Right Cessation
- 1999-12-20 EP EP99968164A patent/EP1140018B1/de not_active Expired - Lifetime
- 1999-12-20 PT PT99968164T patent/PT1140018E/pt unknown
- 1999-12-20 WO PCT/US1999/030527 patent/WO2000038652A1/en not_active Ceased
- 1999-12-20 KR KR10-2001-7007843A patent/KR100491815B1/ko not_active Expired - Fee Related
- 1999-12-20 JP JP2000590606A patent/JP2002533378A/ja not_active Withdrawn
- 1999-12-20 DE DE69911993T patent/DE69911993T2/de not_active Expired - Fee Related
- 1999-12-20 CN CNB99816271XA patent/CN1158068C/zh not_active Expired - Fee Related
- 1999-12-20 AU AU24838/00A patent/AU769610B2/en not_active Ceased
- 1999-12-20 ES ES99968164T patent/ES2204187T3/es not_active Expired - Lifetime
- 1999-12-20 IL IL14370699A patent/IL143706A0/xx active IP Right Grant
- 1999-12-20 CA CA002355618A patent/CA2355618C/en not_active Expired - Fee Related
- 1999-12-20 SI SI9930434T patent/SI1140018T1/xx unknown
- 1999-12-20 DK DK99968164T patent/DK1140018T3/da active
- 1999-12-20 HU HU0104756A patent/HUP0104756A3/hu unknown
- 1999-12-21 TW TW088122540A patent/TWI221777B/zh active
-
2001
- 2001-06-12 IL IL143706A patent/IL143706A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ES2204187T3 (es) | 2004-04-16 |
| HUP0104756A2 (hu) | 2002-04-29 |
| JP2002533378A (ja) | 2002-10-08 |
| CN1335765A (zh) | 2002-02-13 |
| KR100491815B1 (ko) | 2005-05-27 |
| PT1140018E (pt) | 2004-02-27 |
| CA2355618C (en) | 2007-03-13 |
| SI1140018T1 (en) | 2003-12-31 |
| WO2000038652A1 (en) | 2000-07-06 |
| DE69911993T2 (de) | 2004-05-19 |
| DK1140018T3 (da) | 2004-02-02 |
| IL143706A0 (en) | 2002-04-21 |
| IL143706A (en) | 2008-04-13 |
| AU2483800A (en) | 2000-07-31 |
| EP1140018A1 (de) | 2001-10-10 |
| DE69911993D1 (de) | 2003-11-13 |
| TWI221777B (en) | 2004-10-11 |
| KR20010099864A (ko) | 2001-11-09 |
| HUP0104756A3 (en) | 2006-04-28 |
| EP1140018B1 (de) | 2003-10-08 |
| AU769610B2 (en) | 2004-01-29 |
| CA2355618A1 (en) | 2000-07-06 |
| CN1158068C (zh) | 2004-07-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1140018 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |