ATE252094T1 - Imidazol derivate mit proteinkinase, insbesondere egf-r tyrosinkinase, inhibierender wirkung - Google Patents

Imidazol derivate mit proteinkinase, insbesondere egf-r tyrosinkinase, inhibierender wirkung

Info

Publication number
ATE252094T1
ATE252094T1 AT95941646T AT95941646T ATE252094T1 AT E252094 T1 ATE252094 T1 AT E252094T1 AT 95941646 T AT95941646 T AT 95941646T AT 95941646 T AT95941646 T AT 95941646T AT E252094 T1 ATE252094 T1 AT E252094T1
Authority
AT
Austria
Prior art keywords
inhibiting effect
imidazole derivatives
kinase
protein kinase
tyrosine kinase
Prior art date
Application number
AT95941646T
Other languages
English (en)
Inventor
Charles Stanford Harmon
Markus Kamber
Anna Krasso
Wolfang Pirson
Pierre-Charles Wyss
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of ATE252094T1 publication Critical patent/ATE252094T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Cosmetics (AREA)
AT95941646T 1994-12-13 1995-12-01 Imidazol derivate mit proteinkinase, insbesondere egf-r tyrosinkinase, inhibierender wirkung ATE252094T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH376894 1994-12-13
PCT/EP1995/004741 WO1996018626A1 (en) 1994-12-13 1995-12-01 Imidazole derivatives as protein kinase inhibitors in particular egf-r tyrosine kinase

Publications (1)

Publication Number Publication Date
ATE252094T1 true ATE252094T1 (de) 2003-11-15

Family

ID=4263074

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95941646T ATE252094T1 (de) 1994-12-13 1995-12-01 Imidazol derivate mit proteinkinase, insbesondere egf-r tyrosinkinase, inhibierender wirkung

Country Status (16)

Country Link
US (1) US5959113A (de)
EP (1) EP0797575B1 (de)
JP (1) JPH10510281A (de)
CN (1) CN1145623C (de)
AR (1) AR003406A1 (de)
AT (1) ATE252094T1 (de)
AU (1) AU4301096A (de)
BR (1) BR9509998A (de)
CA (1) CA2207404C (de)
DE (1) DE69531956T2 (de)
DK (1) DK0797575T3 (de)
ES (1) ES2208698T3 (de)
FI (1) FI972492A0 (de)
PT (1) PT797575E (de)
TR (1) TR199501561A2 (de)
WO (1) WO1996018626A1 (de)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6083949A (en) * 1995-10-06 2000-07-04 Merck & Co., Inc. Substituted imidazoles having anti-cancer and cytokine inhibitory activity
WO1998021957A1 (en) * 1996-11-20 1998-05-28 Merck & Co., Inc. Triaryl substituted imidazoles, compositions containing such compounds and methods of use
US5880139A (en) * 1996-11-20 1999-03-09 Merck & Co., Inc. Triaryl substituted imidazoles as glucagon antagonists
CA2271893A1 (en) * 1996-11-20 1998-05-28 Linda L. Chang Triaryl substituted imidazoles as glucagon antagonists
US6022884A (en) 1997-11-07 2000-02-08 Amgen Inc. Substituted pyridine compounds and methods of use
WO1999064418A1 (en) * 1998-06-05 1999-12-16 Novartis Ag Aryl pyridinyl thiazoles
AU4395399A (en) * 1998-07-02 2000-01-24 Sankyo Company Limited Five-membered heteroaryl compounds
JP3850596B2 (ja) 1999-02-25 2006-11-29 本州化学工業株式会社 新規な部分保護トリスフェノール類とその製造方法
WO2003024447A1 (en) * 2001-09-20 2003-03-27 Smithkline Beecham Corporation Inhibitors of glycogen synthase kinase-3
AR039241A1 (es) 2002-04-04 2005-02-16 Biogen Inc Heteroarilos trisustituidos y metodos para su produccion y uso de los mismos
US6790852B2 (en) * 2002-04-18 2004-09-14 Hoffmann-La Roche Inc. 2-(2,6-dichlorophenyl)-diarylimidazoles
CN101870691A (zh) 2002-08-19 2010-10-27 劳洛斯治疗公司 2,4,5-三取代的咪唑及其作为抗菌剂的用途
CN100436450C (zh) * 2003-10-16 2008-11-26 霍夫曼-拉罗奇有限公司 三芳基咪唑
US7144889B2 (en) * 2003-10-16 2006-12-05 Hoffman-La Roche Inc. Triarylimidazoles
US7169781B2 (en) 2003-10-17 2007-01-30 Hoffmann-La Roche Inc. Imidazole derivatives and their use as pharmaceutical agents
AU2004289539C1 (en) 2003-11-14 2012-06-07 Lorus Therapeutics Inc. Aryl imidazoles and their use as anti-cancer agents
EP1849778B1 (de) * 2005-02-18 2013-04-24 Japan Science and Technology Agency Verfahren zur herstellung einer optisch aktiven epoxyverbindung, komplex zur verwendung in dem verfahren und verfahren zu dessen herstellung
CA2611032C (en) 2005-05-25 2012-01-17 Genesense Technologies Inc. 2-indolyl imidazo[4,5-d]phenanthroline derivatives and their use in the treatment of cancer
JP5283872B2 (ja) * 2006-09-27 2013-09-04 シスメックス株式会社 腫瘍細胞に対する阻害剤の増殖抑制効果を評価する方法、及び腫瘍細胞の増殖を阻害する化合物をスクリーニングする方法
JP2010504974A (ja) * 2006-09-28 2010-02-18 フォリカ，インコーポレーテッド 新しい毛嚢を生成させ毛髪を成長させる方法、キット、及び組成物
WO2014153464A2 (en) 2013-03-20 2014-09-25 Lorus Therapeutics Inc. 2-substituted imidazo[4,5-d]phenanthroline derivatives and their use in the treatment of cancer
EP3052102B1 (de) 2013-10-04 2019-12-04 Aptose Biosciences Inc. Zusammensetzungen zur behandlung von krebs
EP3102195B1 (de) 2014-02-03 2021-10-06 Quadriga Biosciences, Inc. Beta-substituierte beta-aminosäuren und analoga als chemotherapeutika
EP3102194A1 (de) 2014-02-03 2016-12-14 Quadriga Biosciences, Inc. Beta-substituierte gamma-aminosäuren und analoga als chemotherapeutika
SG11201606427SA (en) * 2014-02-07 2016-09-29 Agency Science Tech & Res 2,4,5-tri-substituted azole-based casein kinase 1 inhibitors as inducers for cardiomyogenesis
AR105592A1 (es) 2015-08-03 2017-10-18 Quadriga Biosciences Inc b-AMINOÁCIDOS b-SUSTITUIDOS Y ANÁLOGOS COMO AGENTES QUIMIOTERAPÉUTICOS Y USOS DE LOS MISMOS
CN109212045A (zh) * 2017-07-04 2019-01-15 万全万特制药（厦门）有限公司 草酸艾司西酞普兰残留溶剂和杂质的分离测定方法
JP2021501203A (ja) 2017-10-30 2021-01-14 アプトース バイオサイエンシズ インコーポレイテッド がん治療用のアリールイミダゾール
CN114262298B (zh) * 2021-12-03 2023-09-26 郑州轻工业大学 2-溴-4-n,n-二甲氨基咪唑及其制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3707475A (en) * 1970-11-16 1972-12-26 Pfizer Antiinflammatory imidazoles
US3940486A (en) * 1971-05-10 1976-02-24 Ciba-Geigy Corporation Imidazole derivatives in the treatment of pain
CH561202A5 (de) * 1971-05-10 1975-04-30 Ciba Geigy Ag
MC2096A1 (fr) * 1989-02-23 1991-02-15 Hoffmann La Roche Pyrroles substitues
JP3264492B2 (ja) * 1992-01-13 2002-03-11 スミスクライン・ビーチャム・コーポレイション ピリジル置換イミダゾール
IL104369A0 (en) * 1992-01-13 1993-05-13 Smithkline Beecham Corp Novel compounds and compositions
EP0654024A1 (de) * 1992-08-06 1995-05-24 Warner-Lambert Company 2-thioindole (selenoindole) und verwandte disulfide (selenide), die tyrosin proteinkinase inhibitoren sind, und ihre verwendung als anti-tumor mittel
AU7629594A (en) * 1993-07-21 1995-02-20 Smithkline Beecham Corporation Imidazoles for treating cytokine mediated disease
US5871934A (en) * 1993-09-17 1999-02-16 Smithkline Beecham Corporation Screening methods using cytokine suppressive anti-inflammatory drug (CSAID) binding proteins

Also Published As

Publication number Publication date
TR199501561A2 (tr) 1996-07-21
CA2207404C (en) 2004-06-29
FI972492L (fi) 1997-06-12
PT797575E (pt) 2004-02-27
DK0797575T3 (da) 2004-02-16
US5959113A (en) 1999-09-28
CA2207404A1 (en) 1996-06-20
EP0797575A1 (de) 1997-10-01
AR003406A1 (es) 1998-08-05
JPH10510281A (ja) 1998-10-06
AU4301096A (en) 1996-07-03
FI972492A7 (fi) 1997-06-12
DE69531956D1 (de) 2003-11-20
CN1145623C (zh) 2004-04-14
WO1996018626A1 (en) 1996-06-20
DE69531956T2 (de) 2004-07-29
MX9704263A (es) 1997-09-30
FI972492A0 (fi) 1997-06-12
BR9509998A (pt) 1997-12-30
ES2208698T3 (es) 2004-06-16
EP0797575B1 (de) 2003-10-15
CN1175252A (zh) 1998-03-04

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