ATE253066T1 - Imidazotriazinderivate als gaba rezeptor-liganden - Google Patents

Imidazotriazinderivate als gaba rezeptor-liganden

Info

Publication number
ATE253066T1
ATE253066T1 AT00954717T AT00954717T ATE253066T1 AT E253066 T1 ATE253066 T1 AT E253066T1 AT 00954717 T AT00954717 T AT 00954717T AT 00954717 T AT00954717 T AT 00954717T AT E253066 T1 ATE253066 T1 AT E253066T1
Authority
AT
Austria
Prior art keywords
receptor ligands
gaba receptor
optionally substituted
derivatives
imidazotriazine
Prior art date
Application number
AT00954717T
Other languages
English (en)
Inventor
William Robert Terling Carling
Alexander Richard Guiblin
Kevin William Moore
Christopher Richard Moyes
Michael Rowley
Leslie Joseph Street
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Application granted granted Critical
Publication of ATE253066T1 publication Critical patent/ATE253066T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
AT00954717T 1999-08-23 2000-08-17 Imidazotriazinderivate als gaba rezeptor-liganden ATE253066T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9919957.2A GB9919957D0 (en) 1999-08-23 1999-08-23 Therapeutic agents
PCT/GB2000/003199 WO2001014377A1 (en) 1999-08-23 2000-08-17 Imidazo-triazine derivatives as ligands for gaba receptors

Publications (1)

Publication Number Publication Date
ATE253066T1 true ATE253066T1 (de) 2003-11-15

Family

ID=10859670

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00954717T ATE253066T1 (de) 1999-08-23 2000-08-17 Imidazotriazinderivate als gaba rezeptor-liganden

Country Status (10)

Country Link
US (1) US6608062B1 (de)
EP (1) EP1212324B1 (de)
JP (1) JP2003507479A (de)
AT (1) ATE253066T1 (de)
AU (1) AU775008B2 (de)
CA (1) CA2380452C (de)
DE (1) DE60006260T2 (de)
ES (1) ES2208404T3 (de)
GB (1) GB9919957D0 (de)
WO (1) WO2001014377A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9923078D0 (en) * 1999-09-29 1999-12-01 Phytopharm Plc Sapogenin derivatives and their use
GB0210127D0 (en) * 2002-05-02 2002-06-12 Merck Sharp & Dohme Therapeutic agents
JPWO2004006956A1 (ja) * 2002-07-12 2005-11-10 独立行政法人科学技術振興機構 脳損傷の予後改善薬とそのスクリーニング方法
EP2258357A3 (de) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenese mit Acetylcholinesterasehemmer
EP2275096A3 (de) 2005-08-26 2011-07-13 Braincells, Inc. Neurogenese durch modulation des Muscarinrezeptors
WO2007047978A2 (en) 2005-10-21 2007-04-26 Braincells, Inc. Modulation of neurogenesis by pde inhibition
EP2314289A1 (de) 2005-10-31 2011-04-27 Braincells, Inc. Gaba-rezeptor-vermittelte modulation von neurogenese
US7465795B2 (en) 2005-12-20 2008-12-16 Astrazeneca Ab Compounds and uses thereof
ES2391472T3 (es) 2005-12-20 2012-11-27 Astrazeneca Ab Derivados de cinnolina sustituidos como moduladores del receptor de GABAA y método para su síntesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
US7678808B2 (en) 2006-05-09 2010-03-16 Braincells, Inc. 5 HT receptor mediated neurogenesis
EP2021000A2 (de) 2006-05-09 2009-02-11 Braincells, Inc. Neurogenese mittels angiotensin-modulation
WO2008030651A1 (en) 2006-09-08 2008-03-13 Braincells, Inc. Combinations containing a 4-acylaminopyridine derivative
GB0622472D0 (en) * 2006-11-10 2006-12-20 Addex Pharmaceuticals Sa Novel heterocyclic derivatives
US20100216805A1 (en) 2009-02-25 2010-08-26 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
JP2024529839A (ja) * 2021-06-29 2024-08-14 ズーマゲン バイオサイエンシーズ エルティーディー Ｎｌｒｐ３モジュレーター
IL310992A (en) * 2021-08-25 2024-04-01 Ptc Therapeutics Inc NLRP3 inhibitors

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3422194A (en) 1967-08-15 1969-01-14 Smithkline Corp The treatment of depression with imidazo(1,2-b)-as-triazines and compositions thereof
EP0915875B1 (de) * 1996-07-25 2003-04-09 MERCK SHARP & DOHME LTD. Substituierte Triazolo-Pyridazin-Derivate als Liganden von GABA-Rezeptoren
DE69936998T2 (de) * 1998-10-16 2008-05-21 Merck Sharp & Dohme Ltd., Hoddesdon Pyrazolotriazinderivate als gaba-rezeptorliganden

Also Published As

Publication number Publication date
ES2208404T3 (es) 2004-06-16
US6608062B1 (en) 2003-08-19
WO2001014377A1 (en) 2001-03-01
GB9919957D0 (en) 1999-10-27
AU775008B2 (en) 2004-07-15
DE60006260T2 (de) 2004-07-29
EP1212324B1 (de) 2003-10-29
CA2380452A1 (en) 2001-03-01
DE60006260D1 (de) 2003-12-04
CA2380452C (en) 2008-10-28
JP2003507479A (ja) 2003-02-25
EP1212324A1 (de) 2002-06-12
AU6707700A (en) 2001-03-19

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