ATE255109T1 - Imidazopyridinderivate als gaba rezeptor liganden - Google Patents

Imidazopyridinderivate als gaba rezeptor liganden

Info

Publication number
ATE255109T1
ATE255109T1 AT00956700T AT00956700T ATE255109T1 AT E255109 T1 ATE255109 T1 AT E255109T1 AT 00956700 T AT00956700 T AT 00956700T AT 00956700 T AT00956700 T AT 00956700T AT E255109 T1 ATE255109 T1 AT E255109T1
Authority
AT
Austria
Prior art keywords
receptor ligands
gaba receptor
imidazopyridine derivatives
derivatives
imidazopyridine
Prior art date
Application number
AT00956700T
Other languages
English (en)
Inventor
David James Hallett
Michael Rowley
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Application granted granted Critical
Publication of ATE255109T1 publication Critical patent/ATE255109T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Exhaust Gas Treatment By Means Of Catalyst (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
AT00956700T 1999-09-07 2000-08-30 Imidazopyridinderivate als gaba rezeptor liganden ATE255109T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9921150.0A GB9921150D0 (en) 1999-09-07 1999-09-07 Therapeutic agents
PCT/GB2000/003350 WO2001018000A1 (en) 1999-09-07 2000-08-30 Imidazo-pyridine derivatives as ligands for gaba receptors

Publications (1)

Publication Number Publication Date
ATE255109T1 true ATE255109T1 (de) 2003-12-15

Family

ID=10860524

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00956700T ATE255109T1 (de) 1999-09-07 2000-08-30 Imidazopyridinderivate als gaba rezeptor liganden

Country Status (10)

Country Link
US (1) US6723735B1 (de)
EP (1) EP1214319B1 (de)
JP (1) JP2003508530A (de)
AT (1) ATE255109T1 (de)
AU (1) AU776815B2 (de)
CA (1) CA2384048A1 (de)
DE (1) DE60006835T2 (de)
ES (1) ES2209963T3 (de)
GB (1) GB9921150D0 (de)
WO (1) WO2001018000A1 (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040077605A1 (en) * 2001-06-20 2004-04-22 Salvati Mark E. Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
EP1854798A3 (de) * 2000-09-19 2007-11-28 Bristol-Myers Squibb Company Kondensierte heterozyklische Succinimid-Verbindungen und Analoga daraus, Modulatoren der nuklearen Hormonrezeptorfunktion
GB0117277D0 (en) 2001-07-16 2001-09-05 Merck Sharp & Dohme Therapeutic agents
PA8535601A1 (es) 2000-12-21 2002-11-28 Pfizer Derivados benzimidazol y piridilimidazol como ligandos para gabaa
US20040087548A1 (en) 2001-02-27 2004-05-06 Salvati Mark E. Fused cyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
US7087636B2 (en) * 2001-12-19 2006-08-08 Bristol-Myers Squibb Company Fused heterocyclic compounds and analogs thereof, modulators of nuclear hormone receptor function
GB0208392D0 (en) * 2002-04-11 2002-05-22 Merck Sharp & Dohme Therapeutic compounds
EP2258357A3 (de) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenese mit Acetylcholinesterasehemmer
EP2275096A3 (de) 2005-08-26 2011-07-13 Braincells, Inc. Neurogenese durch modulation des Muscarinrezeptors
WO2007047978A2 (en) 2005-10-21 2007-04-26 Braincells, Inc. Modulation of neurogenesis by pde inhibition
EP2314289A1 (de) 2005-10-31 2011-04-27 Braincells, Inc. Gaba-rezeptor-vermittelte modulation von neurogenese
US7465795B2 (en) 2005-12-20 2008-12-16 Astrazeneca Ab Compounds and uses thereof
ES2391472T3 (es) 2005-12-20 2012-11-27 Astrazeneca Ab Derivados de cinnolina sustituidos como moduladores del receptor de GABAA y método para su síntesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
EP2021000A2 (de) 2006-05-09 2009-02-11 Braincells, Inc. Neurogenese mittels angiotensin-modulation
US7678808B2 (en) 2006-05-09 2010-03-16 Braincells, Inc. 5 HT receptor mediated neurogenesis
WO2008030651A1 (en) 2006-09-08 2008-03-13 Braincells, Inc. Combinations containing a 4-acylaminopyridine derivative
JP5442449B2 (ja) 2006-12-22 2014-03-12 アステックス、セラピューティックス、リミテッド 新規化合物
CN101679408B (zh) 2006-12-22 2016-04-27 Astex治疗学有限公司 作为fgfr抑制剂的双环杂环化合物
TW200911803A (en) * 2007-07-16 2009-03-16 Organon Nv 6-phenyl-1H-imidazo [4,5-c] pyridine-4-carbonitrile derivatives
GB0720041D0 (en) 2007-10-12 2007-11-21 Astex Therapeutics Ltd New Compounds
GB0720038D0 (en) 2007-10-12 2007-11-21 Astex Therapeutics Ltd New compounds
EP2307402B1 (de) * 2008-04-29 2012-11-07 Novartis AG Imidazo-pyridin-derivate als activin-like-rezeptorkinase (alk4 oder alk5)-hemmer
GB0810902D0 (en) 2008-06-13 2008-07-23 Astex Therapeutics Ltd New compounds
US20100216805A1 (en) 2009-02-25 2010-08-26 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
GB0906472D0 (en) 2009-04-15 2009-05-20 Astex Therapeutics Ltd New compounds
GB0906470D0 (en) 2009-04-15 2009-05-20 Astex Therapeutics Ltd New compounds
EP3154979B1 (de) 2014-06-12 2018-03-07 Pfizer Limited Imidazopyridazinderivate als modulatoren der gabaa-rezeptoraktivität
HUE060943T2 (hu) 2018-09-13 2023-04-28 Saniona As A gaba A receptor ligandum
AU2024411621A1 (en) 2023-12-27 2026-06-18 Saniona A/S A gabaa receptor ligand and the use thereof in medicine, in particular in the treatment of epilepsy

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK40192D0 (da) * 1992-03-26 1992-03-26 Neurosearch As Imidazolforbindelser, deres fremstilling og anvendelse
AU675484B2 (en) * 1993-03-24 1997-02-06 Neurosearch A/S Benzimidazole compounds, their use and preparation
GB9702524D0 (en) 1997-02-07 1997-03-26 Merck Sharp & Dohme Therapeutic agents

Also Published As

Publication number Publication date
WO2001018000A1 (en) 2001-03-15
JP2003508530A (ja) 2003-03-04
EP1214319A1 (de) 2002-06-19
US6723735B1 (en) 2004-04-20
ES2209963T3 (es) 2004-07-01
GB9921150D0 (en) 1999-11-10
CA2384048A1 (en) 2001-03-15
DE60006835T2 (de) 2004-09-02
EP1214319B1 (de) 2003-11-26
DE60006835D1 (de) 2004-01-08
AU6856700A (en) 2001-04-10
AU776815B2 (en) 2004-09-23

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Legal Events

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties