ATE255579T1 - Pyrrolidin-derivate die eine phospholipase-a2- hemmende wirkung haben - Google Patents
Pyrrolidin-derivate die eine phospholipase-a2- hemmende wirkung habenInfo
- Publication number
- ATE255579T1 ATE255579T1 AT98900741T AT98900741T ATE255579T1 AT E255579 T1 ATE255579 T1 AT E255579T1 AT 98900741 T AT98900741 T AT 98900741T AT 98900741 T AT98900741 T AT 98900741T AT E255579 T1 ATE255579 T1 AT E255579T1
- Authority
- AT
- Austria
- Prior art keywords
- phospholipase
- inhibiting effect
- optionally substituted
- pyrrolidine derivatives
- ch2nhco
- Prior art date
Links
- 102100037611 Lysophospholipase Human genes 0.000 title 1
- 108010058864 Phospholipases A2 Proteins 0.000 title 1
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical class C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 title 1
- 230000002401 inhibitory effect Effects 0.000 title 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rheumatology (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1796297 | 1997-01-31 | ||
| PCT/JP1998/000307 WO1998033797A1 (en) | 1997-01-31 | 1998-01-27 | Pyrrolidine derivatives having phospholipase a2 inhibitory activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE255579T1 true ATE255579T1 (de) | 2003-12-15 |
Family
ID=11958379
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98900741T ATE255579T1 (de) | 1997-01-31 | 1998-01-27 | Pyrrolidin-derivate die eine phospholipase-a2- hemmende wirkung haben |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US6147100A (de) |
| EP (1) | EP0976748B1 (de) |
| JP (1) | JP3850450B2 (de) |
| KR (1) | KR100354358B1 (de) |
| CN (1) | CN1217942C (de) |
| AT (1) | ATE255579T1 (de) |
| AU (1) | AU719210B2 (de) |
| BR (1) | BR9807132A (de) |
| CA (1) | CA2277947C (de) |
| DE (1) | DE69820248T2 (de) |
| DK (1) | DK0976748T3 (de) |
| ES (1) | ES2210710T3 (de) |
| HU (1) | HUP0000965A3 (de) |
| NO (1) | NO313881B1 (de) |
| PL (1) | PL334915A1 (de) |
| PT (1) | PT976748E (de) |
| RU (1) | RU2198174C2 (de) |
| TR (1) | TR199901847T2 (de) |
| TW (1) | TW577875B (de) |
| WO (1) | WO1998033797A1 (de) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7291626B1 (en) | 1998-04-09 | 2007-11-06 | John Hopkins University School Of Medicine | Inhibitors of hedgehog signaling pathways, compositions and uses related thereto |
| CA2380206A1 (en) | 1999-07-26 | 2001-02-01 | Shionogi & Co., Ltd. | Pharmaceutical compositions exhibiting thrombopoietin receptor agonism |
| CA2386190C (en) | 1999-10-13 | 2009-04-14 | Johns Hopkins University School Of Medicine | Regulators of the hedgehog pathway, compositions and uses related thereto |
| WO2001026644A2 (en) * | 1999-10-14 | 2001-04-19 | Curis, Inc. | Mediators of hedgehog signaling pathways, compositions and uses related thereto |
| US6552016B1 (en) | 1999-10-14 | 2003-04-22 | Curis, Inc. | Mediators of hedgehog signaling pathways, compositions and uses related thereto |
| WO2001030387A1 (en) * | 1999-10-22 | 2001-05-03 | Shionogi & Co., Ltd. | Preventives or remedies for arrhythmia |
| US7361663B2 (en) * | 1999-11-10 | 2008-04-22 | Aventis Pharmaceuticals Inc. | N-acylpyrrolidin-2-ylalkylbenzamidine derivatives as inhibitors of factor Xa |
| DE60036568T2 (de) * | 1999-11-10 | 2008-06-26 | Sanofi-Aventis Deutschland Gmbh | N-acylpyrrolidin-2-ylalkylbenzamidin-derivate als inhibitoren von factor xa |
| BR0112906B1 (pt) * | 2000-08-07 | 2012-03-20 | "processo para produção de papel". | |
| MXPA03006510A (es) * | 2001-01-26 | 2003-10-15 | Shionogi & Co | Compuestos halogenados que muestran agonismo del receptor de trombopoyetina. |
| US20030073945A1 (en) * | 2001-10-17 | 2003-04-17 | Liang-Kuang Diang | Ozone hemodiafiltration device |
| US6867320B2 (en) * | 2002-02-21 | 2005-03-15 | Asahi Kasei Pharma Corporation | Substituted phenylalkanoic acid derivatives and use thereof |
| US20040018533A1 (en) * | 2002-06-04 | 2004-01-29 | Adam Gail Isabel Reid | Diagnosing predisposition to fat deposition and therapeutic methods for reducing fat deposition and treatment of associated conditions |
| AUPS282602A0 (en) | 2002-06-07 | 2002-06-27 | Garvan Institute Of Medical Research | Method of inhibiting cell proliferation |
| WO2004002295A2 (en) * | 2002-06-27 | 2004-01-08 | Sequenom, Inc. | Diagnosing predisposition to fat deposition and associated condition |
| AU2003248794B2 (en) * | 2002-06-27 | 2007-10-04 | Harkness Pharmaceuticals, Inc. | Therapeutic methods for reducing fat deposition and treating associated conditions |
| AU2003291024A1 (en) * | 2002-11-13 | 2004-06-03 | Rigel Pharmaceuticals, Inc. | Rhodanine derivatives and pharmaceutical compositions containing them |
| WO2004050654A1 (ja) * | 2002-11-29 | 2004-06-17 | Shionogi & Co., Ltd. | ピロリジン化合物の合成とその塩 |
| US7521465B2 (en) * | 2003-01-17 | 2009-04-21 | Bexel Pharmaceuticals, Inc. | Diphenyl ether derivatives |
| US7781464B2 (en) * | 2003-01-17 | 2010-08-24 | Bexel Pharmaceuticals, Inc. | Heterocyclic diphenyl ethers |
| US6794401B2 (en) * | 2003-01-17 | 2004-09-21 | Bexel Pharmaceuticals, Inc. | Amino acid phenoxy ethers |
| TW200503698A (en) * | 2003-04-08 | 2005-02-01 | Shionogi & Co | Composition for treating or preventing dermatitis |
| KR20060079190A (ko) * | 2003-08-14 | 2006-07-05 | 아사히 가세이 파마 가부시키가이샤 | 치환 아릴알칸산 유도체 및 그의 용도 |
| US7087576B2 (en) * | 2003-10-07 | 2006-08-08 | Bexel Pharmaceuticals, Inc. | Dipeptide phenyl ethers |
| US7207652B2 (en) * | 2003-10-17 | 2007-04-24 | Lexmark International, Inc. | Balanced satellite distributions |
| US20090215857A1 (en) * | 2005-09-13 | 2009-08-27 | Pfizer Products Inc. | Therapeutic Pyrrolidines |
| UY31952A (es) * | 2008-07-02 | 2010-01-29 | Astrazeneca Ab | 5-metilideno-1,3-tiazolidina-2,4-dionas sustituidas como inhibidores de quinasa pim |
| AU2009307918A1 (en) * | 2008-10-21 | 2010-04-29 | Merck Sharp & Dohme Corp. | 2,4-disubstituted pyrrolidine orexin receptor antagonists |
| EP2583099B1 (de) | 2010-06-18 | 2016-11-02 | Whitehead Institute for Biomedical Research | Pla2g16 als target für antivirusverbindungen |
| TW201311679A (zh) | 2011-08-04 | 2013-03-16 | Takeda Pharmaceutical | 含氮雜環化合物 |
| USD804651S1 (en) | 2017-01-10 | 2017-12-05 | Howard Loonan | Syringe |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1986002073A1 (fr) * | 1984-10-03 | 1986-04-10 | Takeda Chemical Industries, Ltd. | Derives de thiazolidinedione, procede de preparation et composition pharmaceutique les contenant |
| US5420289A (en) * | 1989-10-27 | 1995-05-30 | American Home Products Corporation | Substituted indole-, indene-, pyranoindole- and tetrahydrocarbazole-alkanoic acid derivatives as inhibitors of PLA2 and lipoxygenase |
| JP2826379B2 (ja) * | 1990-01-22 | 1998-11-18 | 三共株式会社 | チアゾリジン誘導体を有効成分とする肥満性高血圧症治療剤 |
| US5317016A (en) * | 1991-08-20 | 1994-05-31 | Shionogi Seiyaku Kabushiki Kaisha | Pyrrolidylthiocarbapenem derivative |
| FR2680512B1 (fr) * | 1991-08-20 | 1995-01-20 | Adir | Nouveaux derives de 2,4-thiazolidinedione, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| JPH05306224A (ja) * | 1992-04-24 | 1993-11-19 | Wakamoto Pharmaceut Co Ltd | ドーパミン β−ヒドロキシラーゼ阻害剤 |
| EP0586229A1 (de) * | 1992-09-01 | 1994-03-09 | Zeneca Limited | 3-Hydroxy-3-(Subst.-Alkyl)-Pyrrolidine als 5-Lipoxygenase-Inhibitoren |
| WO1995010508A1 (en) * | 1993-10-15 | 1995-04-20 | Shionogi & Co., Ltd. | Oxazolinone derivative having intracellular phospholipase a2 inhibitor activity |
| TW245716B (de) * | 1992-12-28 | 1995-04-21 | Takeda Pharm Industry Co | |
| JPH07138258A (ja) * | 1993-11-16 | 1995-05-30 | Taiho Yakuhin Kogyo Kk | チアゾリジンジオン誘導体又はその塩 |
| TW363959B (en) * | 1994-03-23 | 1999-07-11 | Sankyo Co | Thiazolidine and oxazolidine derivatives, their preparation and their medical use |
| BR9609744A (pt) * | 1995-07-31 | 1999-03-02 | Shionogi & Co | Derivados de pirrolidina tendo atividade inibitória de fosfolipase a2 |
| JPH09176162A (ja) * | 1995-12-22 | 1997-07-08 | Toubishi Yakuhin Kogyo Kk | チアゾリジンジオン誘導体及びその製造法並びにそれを含む医薬組成物 |
| EP0923580A1 (de) * | 1996-07-26 | 1999-06-23 | Dr. Reddy's Research Foundation | Thiazolidindione mit antidiabetischen, hypolipidaemischen, antihypertensiven eigenschaften, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen sie enthaltend |
| WO1997041121A1 (en) * | 1997-05-02 | 1997-11-06 | Dr. Reddy's Research Foundation | Novel heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them |
| JP2001518069A (ja) * | 1997-05-02 | 2001-10-09 | ドクター・レディーズ・リサーチ・ファウンデーション | 低脂質性、抗高血圧性特性を有する新規な抗糖尿病化合物、それらの製造方法及びそれらを含有する薬学的組成物 |
-
1998
- 1998-01-26 TW TW087101064A patent/TW577875B/zh not_active IP Right Cessation
- 1998-01-27 PT PT98900741T patent/PT976748E/pt unknown
- 1998-01-27 RU RU99119481/04A patent/RU2198174C2/ru not_active IP Right Cessation
- 1998-01-27 JP JP53270898A patent/JP3850450B2/ja not_active Expired - Fee Related
- 1998-01-27 WO PCT/JP1998/000307 patent/WO1998033797A1/ja not_active Ceased
- 1998-01-27 PL PL98334915A patent/PL334915A1/xx not_active Application Discontinuation
- 1998-01-27 CA CA002277947A patent/CA2277947C/en not_active Expired - Fee Related
- 1998-01-27 CN CN988038021A patent/CN1217942C/zh not_active Expired - Fee Related
- 1998-01-27 AU AU55775/98A patent/AU719210B2/en not_active Ceased
- 1998-01-27 US US09/355,008 patent/US6147100A/en not_active Expired - Fee Related
- 1998-01-27 EP EP98900741A patent/EP0976748B1/de not_active Expired - Lifetime
- 1998-01-27 ES ES98900741T patent/ES2210710T3/es not_active Expired - Lifetime
- 1998-01-27 HU HU0000965A patent/HUP0000965A3/hu unknown
- 1998-01-27 DE DE69820248T patent/DE69820248T2/de not_active Expired - Lifetime
- 1998-01-27 TR TR1999/01847T patent/TR199901847T2/xx unknown
- 1998-01-27 AT AT98900741T patent/ATE255579T1/de not_active IP Right Cessation
- 1998-01-27 BR BR9807132-7A patent/BR9807132A/pt not_active Application Discontinuation
- 1998-01-27 KR KR1019997006741A patent/KR100354358B1/ko not_active Expired - Fee Related
- 1998-01-27 DK DK98900741T patent/DK0976748T3/da active
-
1999
- 1999-07-29 NO NO19993706A patent/NO313881B1/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BR9807132A (pt) | 2000-01-25 |
| RU2198174C2 (ru) | 2003-02-10 |
| ES2210710T3 (es) | 2004-07-01 |
| NO993706L (no) | 1999-09-30 |
| CN1217942C (zh) | 2005-09-07 |
| JP3850450B2 (ja) | 2006-11-29 |
| DK0976748T3 (da) | 2004-03-22 |
| CA2277947C (en) | 2004-09-21 |
| NO313881B1 (no) | 2002-12-16 |
| EP0976748A1 (de) | 2000-02-02 |
| EP0976748A4 (de) | 2001-08-08 |
| WO1998033797A1 (en) | 1998-08-06 |
| PT976748E (pt) | 2004-03-31 |
| US6147100A (en) | 2000-11-14 |
| HUP0000965A3 (en) | 2001-11-28 |
| NO993706D0 (no) | 1999-07-29 |
| CN1251587A (zh) | 2000-04-26 |
| DE69820248D1 (de) | 2004-01-15 |
| TR199901847T2 (xx) | 2000-06-21 |
| CA2277947A1 (en) | 1998-08-06 |
| PL334915A1 (en) | 2000-03-27 |
| KR100354358B1 (ko) | 2002-09-28 |
| DE69820248T2 (de) | 2004-09-23 |
| EP0976748B1 (de) | 2003-12-03 |
| HUP0000965A2 (hu) | 2001-04-28 |
| AU5577598A (en) | 1998-08-25 |
| TW577875B (en) | 2004-03-01 |
| KR20000070497A (ko) | 2000-11-25 |
| AU719210B2 (en) | 2000-05-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 0976748 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |