ATE255579T1 - Pyrrolidin-derivate die eine phospholipase-a2- hemmende wirkung haben - Google Patents
Pyrrolidin-derivate die eine phospholipase-a2- hemmende wirkung habenInfo
- Publication number
- ATE255579T1 ATE255579T1 AT98900741T AT98900741T ATE255579T1 AT E255579 T1 ATE255579 T1 AT E255579T1 AT 98900741 T AT98900741 T AT 98900741T AT 98900741 T AT98900741 T AT 98900741T AT E255579 T1 ATE255579 T1 AT E255579T1
- Authority
- AT
- Austria
- Prior art keywords
- phospholipase
- inhibiting effect
- optionally substituted
- pyrrolidine derivatives
- ch2nhco
- Prior art date
Links
- 102100037611 Lysophospholipase Human genes 0.000 title 1
- 108010058864 Phospholipases A2 Proteins 0.000 title 1
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical class C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 title 1
- 230000002401 inhibitory effect Effects 0.000 title 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Cosmetics (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1796297 | 1997-01-31 | ||
| PCT/JP1998/000307 WO1998033797A1 (en) | 1997-01-31 | 1998-01-27 | Pyrrolidine derivatives having phospholipase a2 inhibitory activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE255579T1 true ATE255579T1 (de) | 2003-12-15 |
Family
ID=11958379
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98900741T ATE255579T1 (de) | 1997-01-31 | 1998-01-27 | Pyrrolidin-derivate die eine phospholipase-a2- hemmende wirkung haben |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US6147100A (de) |
| EP (1) | EP0976748B1 (de) |
| JP (1) | JP3850450B2 (de) |
| KR (1) | KR100354358B1 (de) |
| CN (1) | CN1217942C (de) |
| AT (1) | ATE255579T1 (de) |
| AU (1) | AU719210B2 (de) |
| BR (1) | BR9807132A (de) |
| CA (1) | CA2277947C (de) |
| DE (1) | DE69820248T2 (de) |
| DK (1) | DK0976748T3 (de) |
| ES (1) | ES2210710T3 (de) |
| HU (1) | HUP0000965A3 (de) |
| NO (1) | NO313881B1 (de) |
| PL (1) | PL334915A1 (de) |
| PT (1) | PT976748E (de) |
| RU (1) | RU2198174C2 (de) |
| TR (1) | TR199901847T2 (de) |
| TW (1) | TW577875B (de) |
| WO (1) | WO1998033797A1 (de) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7291626B1 (en) | 1998-04-09 | 2007-11-06 | John Hopkins University School Of Medicine | Inhibitors of hedgehog signaling pathways, compositions and uses related thereto |
| US7026334B1 (en) | 1999-07-26 | 2006-04-11 | Shionogi & Co., Ltd. | Thiazolidine compounds and pharmaceutical compositions exhibiting thrombopoietin receptor agonism |
| JP5420128B2 (ja) | 1999-10-13 | 2014-02-19 | ジョンズ ホプキンス ユニバーシティ スクール オブ メディシン | ヘッジホッグ経路の調節物質、並びにそれに関する組成物及び利用法 |
| CA2388468C (en) * | 1999-10-14 | 2011-01-25 | Curis, Inc. | Mediators of hedgehog signalling pathways, compositions and uses related thereto |
| US6552016B1 (en) | 1999-10-14 | 2003-04-22 | Curis, Inc. | Mediators of hedgehog signaling pathways, compositions and uses related thereto |
| KR20020060207A (ko) | 1999-10-22 | 2002-07-16 | 시오노 요시히코 | 부정맥의 치료 또는 예방용 조성물 |
| AU2155001A (en) * | 1999-11-10 | 2001-06-06 | Aventis Pharma Deutschland Gmbh | N-acylpyrrolidin-2-ylalkylbenzamidine derivatives as inhibitors of factor xa |
| US7361663B2 (en) | 1999-11-10 | 2008-04-22 | Aventis Pharmaceuticals Inc. | N-acylpyrrolidin-2-ylalkylbenzamidine derivatives as inhibitors of factor Xa |
| KR20030074587A (ko) * | 2000-08-07 | 2003-09-19 | 악조 노벨 엔.브이. | 사이징 분산물 |
| CA2435143A1 (en) * | 2001-01-26 | 2002-08-01 | Shionogi & Co., Ltd. | Halogen compounds having thrombopoietin receptor agonism |
| US20030073945A1 (en) * | 2001-10-17 | 2003-04-17 | Liang-Kuang Diang | Ozone hemodiafiltration device |
| US6867320B2 (en) * | 2002-02-21 | 2005-03-15 | Asahi Kasei Pharma Corporation | Substituted phenylalkanoic acid derivatives and use thereof |
| WO2003101177A2 (en) * | 2002-06-04 | 2003-12-11 | Sequenom, Inc. | Diagnosing predisposition to fat deposition and therapeutic methods for reducing fat deposition and treatment of associated conditions |
| AUPS282602A0 (en) | 2002-06-07 | 2002-06-27 | Garvan Institute Of Medical Research | Method of inhibiting cell proliferation |
| US20050014158A1 (en) * | 2002-06-27 | 2005-01-20 | Adam Gail Isabel Reid | Therapeutic methods for reducing fat deposition and treating associated conditions |
| WO2004002295A2 (en) * | 2002-06-27 | 2004-01-08 | Sequenom, Inc. | Diagnosing predisposition to fat deposition and associated condition |
| WO2004043955A1 (en) * | 2002-11-13 | 2004-05-27 | Rigel Pharmaceuticals, Inc. | Rhodanine derivatives and pharmaceutical compositions containing them |
| WO2004050654A1 (ja) * | 2002-11-29 | 2004-06-17 | Shionogi & Co., Ltd. | ピロリジン化合物の合成とその塩 |
| US6794401B2 (en) * | 2003-01-17 | 2004-09-21 | Bexel Pharmaceuticals, Inc. | Amino acid phenoxy ethers |
| US7781464B2 (en) * | 2003-01-17 | 2010-08-24 | Bexel Pharmaceuticals, Inc. | Heterocyclic diphenyl ethers |
| US7521465B2 (en) * | 2003-01-17 | 2009-04-21 | Bexel Pharmaceuticals, Inc. | Diphenyl ether derivatives |
| WO2004089368A1 (ja) * | 2003-04-08 | 2004-10-21 | Shionogi & Co. Ltd. | 皮膚炎の治療または予防剤 |
| KR20060079190A (ko) * | 2003-08-14 | 2006-07-05 | 아사히 가세이 파마 가부시키가이샤 | 치환 아릴알칸산 유도체 및 그의 용도 |
| US7087576B2 (en) * | 2003-10-07 | 2006-08-08 | Bexel Pharmaceuticals, Inc. | Dipeptide phenyl ethers |
| US7207652B2 (en) * | 2003-10-17 | 2007-04-24 | Lexmark International, Inc. | Balanced satellite distributions |
| US20090215857A1 (en) * | 2005-09-13 | 2009-08-27 | Pfizer Products Inc. | Therapeutic Pyrrolidines |
| UY31952A (es) * | 2008-07-02 | 2010-01-29 | Astrazeneca Ab | 5-metilideno-1,3-tiazolidina-2,4-dionas sustituidas como inhibidores de quinasa pim |
| WO2010048014A1 (en) * | 2008-10-21 | 2010-04-29 | Merck Sharp & Dohme Corp. | 2,4-disubstituted pyrrolidine orexin receptor antagonists |
| JP6053675B2 (ja) | 2010-06-18 | 2016-12-27 | ホワイトヘッド・インスティチュート・フォア・バイオメディカル・リサーチ | 抗ウイルス化合物のためのターゲットとしてのｐｌａ２ｇ１６ |
| WO2013018929A1 (en) | 2011-08-04 | 2013-02-07 | Takeda Pharmaceutical Company Limited | Nitrogen-containing heterocyclic compound |
| USD804651S1 (en) | 2017-01-10 | 2017-12-05 | Howard Loonan | Syringe |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1986002073A1 (fr) * | 1984-10-03 | 1986-04-10 | Takeda Chemical Industries, Ltd. | Derives de thiazolidinedione, procede de preparation et composition pharmaceutique les contenant |
| US5420289A (en) * | 1989-10-27 | 1995-05-30 | American Home Products Corporation | Substituted indole-, indene-, pyranoindole- and tetrahydrocarbazole-alkanoic acid derivatives as inhibitors of PLA2 and lipoxygenase |
| JP2826379B2 (ja) * | 1990-01-22 | 1998-11-18 | 三共株式会社 | チアゾリジン誘導体を有効成分とする肥満性高血圧症治療剤 |
| US5317016A (en) * | 1991-08-20 | 1994-05-31 | Shionogi Seiyaku Kabushiki Kaisha | Pyrrolidylthiocarbapenem derivative |
| FR2680512B1 (fr) * | 1991-08-20 | 1995-01-20 | Adir | Nouveaux derives de 2,4-thiazolidinedione, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| JPH05306224A (ja) * | 1992-04-24 | 1993-11-19 | Wakamoto Pharmaceut Co Ltd | ドーパミン β−ヒドロキシラーゼ阻害剤 |
| EP0586229A1 (de) * | 1992-09-01 | 1994-03-09 | Zeneca Limited | 3-Hydroxy-3-(Subst.-Alkyl)-Pyrrolidine als 5-Lipoxygenase-Inhibitoren |
| TW245716B (de) * | 1992-12-28 | 1995-04-21 | Takeda Pharm Industry Co | |
| AU684316B2 (en) * | 1993-10-15 | 1997-12-11 | Shionogi & Co., Ltd. | Oxazolinone derivative having intracellular phospholipase A2 inhibitor activity |
| JPH07138258A (ja) * | 1993-11-16 | 1995-05-30 | Taiho Yakuhin Kogyo Kk | チアゾリジンジオン誘導体又はその塩 |
| CA2145257A1 (en) * | 1994-03-23 | 1995-09-24 | Takashi Fujita | Thiazolidine and oxazolidine derivatives, their preparation and their medical use |
| EP0848004B1 (de) * | 1995-07-31 | 2003-04-02 | Shionogi & Co., Ltd. | Pyrrolydin-derivate mit einer phospholipase a2 inhibierenden wirkung |
| JPH09176162A (ja) * | 1995-12-22 | 1997-07-08 | Toubishi Yakuhin Kogyo Kk | チアゾリジンジオン誘導体及びその製造法並びにそれを含む医薬組成物 |
| WO1997041120A1 (en) * | 1996-07-26 | 1997-11-06 | Dr. Reddy's Research Foundation | Thiazolidinedione compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions thereof |
| JP2001518069A (ja) * | 1997-05-02 | 2001-10-09 | ドクター・レディーズ・リサーチ・ファウンデーション | 低脂質性、抗高血圧性特性を有する新規な抗糖尿病化合物、それらの製造方法及びそれらを含有する薬学的組成物 |
| AU2823797A (en) * | 1997-05-02 | 1997-11-19 | Dr. Reddy's Research Foundation | Novel heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them |
-
1998
- 1998-01-26 TW TW087101064A patent/TW577875B/zh not_active IP Right Cessation
- 1998-01-27 CA CA002277947A patent/CA2277947C/en not_active Expired - Fee Related
- 1998-01-27 HU HU0000965A patent/HUP0000965A3/hu unknown
- 1998-01-27 WO PCT/JP1998/000307 patent/WO1998033797A1/ja not_active Ceased
- 1998-01-27 EP EP98900741A patent/EP0976748B1/de not_active Expired - Lifetime
- 1998-01-27 KR KR1019997006741A patent/KR100354358B1/ko not_active Expired - Fee Related
- 1998-01-27 AT AT98900741T patent/ATE255579T1/de not_active IP Right Cessation
- 1998-01-27 ES ES98900741T patent/ES2210710T3/es not_active Expired - Lifetime
- 1998-01-27 CN CN988038021A patent/CN1217942C/zh not_active Expired - Fee Related
- 1998-01-27 PL PL98334915A patent/PL334915A1/xx not_active Application Discontinuation
- 1998-01-27 BR BR9807132-7A patent/BR9807132A/pt not_active Application Discontinuation
- 1998-01-27 US US09/355,008 patent/US6147100A/en not_active Expired - Fee Related
- 1998-01-27 JP JP53270898A patent/JP3850450B2/ja not_active Expired - Fee Related
- 1998-01-27 RU RU99119481/04A patent/RU2198174C2/ru not_active IP Right Cessation
- 1998-01-27 DE DE69820248T patent/DE69820248T2/de not_active Expired - Lifetime
- 1998-01-27 DK DK98900741T patent/DK0976748T3/da active
- 1998-01-27 TR TR1999/01847T patent/TR199901847T2/xx unknown
- 1998-01-27 PT PT98900741T patent/PT976748E/pt unknown
- 1998-01-27 AU AU55775/98A patent/AU719210B2/en not_active Ceased
-
1999
- 1999-07-29 NO NO19993706A patent/NO313881B1/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU719210B2 (en) | 2000-05-04 |
| US6147100A (en) | 2000-11-14 |
| DE69820248T2 (de) | 2004-09-23 |
| KR100354358B1 (ko) | 2002-09-28 |
| CA2277947C (en) | 2004-09-21 |
| JP3850450B2 (ja) | 2006-11-29 |
| AU5577598A (en) | 1998-08-25 |
| HUP0000965A3 (en) | 2001-11-28 |
| RU2198174C2 (ru) | 2003-02-10 |
| NO993706L (no) | 1999-09-30 |
| EP0976748A1 (de) | 2000-02-02 |
| BR9807132A (pt) | 2000-01-25 |
| TW577875B (en) | 2004-03-01 |
| CN1251587A (zh) | 2000-04-26 |
| CA2277947A1 (en) | 1998-08-06 |
| EP0976748A4 (de) | 2001-08-08 |
| ES2210710T3 (es) | 2004-07-01 |
| EP0976748B1 (de) | 2003-12-03 |
| NO993706D0 (no) | 1999-07-29 |
| CN1217942C (zh) | 2005-09-07 |
| TR199901847T2 (xx) | 2000-06-21 |
| NO313881B1 (no) | 2002-12-16 |
| WO1998033797A1 (en) | 1998-08-06 |
| KR20000070497A (ko) | 2000-11-25 |
| HUP0000965A2 (hu) | 2001-04-28 |
| DK0976748T3 (da) | 2004-03-22 |
| PL334915A1 (en) | 2000-03-27 |
| PT976748E (pt) | 2004-03-31 |
| DE69820248D1 (de) | 2004-01-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 0976748 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |