ATE256458T1 - Verfahren zur mikroverkapselung von wasserlöslichen substanzen - Google Patents

Verfahren zur mikroverkapselung von wasserlöslichen substanzen

Info

Publication number
ATE256458T1
ATE256458T1 AT00915076T AT00915076T ATE256458T1 AT E256458 T1 ATE256458 T1 AT E256458T1 AT 00915076 T AT00915076 T AT 00915076T AT 00915076 T AT00915076 T AT 00915076T AT E256458 T1 ATE256458 T1 AT E256458T1
Authority
AT
Austria
Prior art keywords
micro
soluble substances
present
encapsulating water
microparticles
Prior art date
Application number
AT00915076T
Other languages
English (en)
Inventor
Evelyne Vuaridel
Piero Orsolini
Original Assignee
Debio Rech Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Debio Rech Pharma Sa filed Critical Debio Rech Pharma Sa
Application granted granted Critical
Publication of ATE256458T1 publication Critical patent/ATE256458T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
AT00915076T 1999-04-15 2000-04-14 Verfahren zur mikroverkapselung von wasserlöslichen substanzen ATE256458T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP99107570A EP1044683A1 (de) 1999-04-15 1999-04-15 Einschrittdispersionsverfahren zur Mikroverkapselung von wasserlöslichen Substanzen
PCT/CH2000/000218 WO2000062761A1 (en) 1999-04-15 2000-04-14 Process for microencapsulation of water soluble substances

Publications (1)

Publication Number Publication Date
ATE256458T1 true ATE256458T1 (de) 2004-01-15

Family

ID=8237970

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00915076T ATE256458T1 (de) 1999-04-15 2000-04-14 Verfahren zur mikroverkapselung von wasserlöslichen substanzen

Country Status (11)

Country Link
US (1) US6777002B1 (de)
EP (2) EP1044683A1 (de)
JP (1) JP2002542184A (de)
AT (1) ATE256458T1 (de)
AU (1) AU779712B2 (de)
CA (1) CA2369808A1 (de)
DE (1) DE60007316T2 (de)
DK (1) DK1196148T3 (de)
ES (1) ES2213572T3 (de)
PT (1) PT1196148E (de)
WO (1) WO2000062761A1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL363716A1 (en) * 2000-12-13 2004-11-29 Merckle Gmbh Microparticles with an improved release profile and method for the production thereof
US20050048126A1 (en) 2000-12-22 2005-03-03 Barrett Rabinow Formulation to render an antimicrobial drug potent against organisms normally considered to be resistant to the drug
WO2002058671A1 (en) * 2001-01-26 2002-08-01 Debio Recherche Pharmaceutique S.A. Burst free pharmaceutical microparticules
WO2002058672A2 (en) * 2001-01-26 2002-08-01 Debio Recherche Pharmaceutique S.A. Microparticles of biodegradable polymer encapsulating a biologically active substance
CA2463358C (fr) * 2001-10-10 2012-03-13 Pierre Fabre Medicament Microspheres biodegradables a liberation prolongee et leur procede de preparation
ES2427092T3 (es) 2003-04-10 2013-10-28 Evonik Corporation Un método para la producción de micropartículas a base de emulsión
CN1852687B (zh) * 2003-07-15 2014-01-22 赢创有限公司 控释组合物的制备方法
JP5165240B2 (ja) 2003-07-23 2013-03-21 ピーアール ファーマシューティカルズ， インコーポレイテッド 徐放組成物
ES2424255T3 (es) * 2004-11-08 2013-09-30 Baxter International Inc. Composiciones particuladas de inhibidores de tubulina
US20060233849A1 (en) * 2005-04-13 2006-10-19 Simon Bruce J Composite bone graft material
US7621963B2 (en) * 2005-04-13 2009-11-24 Ebi, Llc Composite bone graft material
JP2007002197A (ja) * 2005-06-27 2007-01-11 Kuraray Co Ltd コーティング剤及びコーティング皮膜
GB0711007D0 (en) * 2007-06-07 2007-07-18 Isis Innovation Polymeric microparticles
WO2009085952A1 (en) 2007-12-20 2009-07-09 Brookwood Pharmaceuticals, Inc. Process for preparing microparticles having a low residual solvent volume
US8236350B2 (en) * 2008-08-01 2012-08-07 The Regents Of The University Of Michigan Polymer for tissue engineering applications and drug delivery
JP5769626B2 (ja) * 2008-09-18 2015-08-26 エボニック コーポレイションＥｖｏｎｉｋ Ｃｏｒｐｏｒａｔｉｏｎ 溶媒および塩を用いるマイクロカプセル封入プロセス
US20100189800A1 (en) * 2009-01-23 2010-07-29 Peter Markland Continous double emulsion process for making microparticles
US8927619B2 (en) 2011-12-21 2015-01-06 Jorg Thomas Wilken Color-stabilized iodopropynyl butylcarbamate
US9308172B2 (en) * 2012-10-26 2016-04-12 Board Of Trustees Of Michigan State University Device and method for encapsulation of hydrophilic materials
US12263252B2 (en) 2019-06-05 2025-04-01 The Florida International University Board Of Trustees Biotherapy for viral infections using biopolymer based micro/nanogels
US20200383932A1 (en) * 2019-06-05 2020-12-10 The Florida International University Board Of Trustees Biotherapy for viral infections using biopolymer based micro/nanogels

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE744162A (fr) * 1969-01-16 1970-06-15 Fuji Photo Film Co Ltd Procede d'encapsulage
DE2010116A1 (de) * 1970-03-04 1971-09-16 Farbenfabriken Bayer Ag, 5090 Leverkusen Verfahren zur Herstellung von Mikrogranulaten
GB1413186A (en) * 1973-06-27 1975-11-12 Toyo Jozo Kk Process for encapsulation of medicaments
DK0471036T4 (da) * 1989-05-04 2004-07-19 Southern Res Inst Indkapslingsfremgangsmåde
HU221294B1 (en) * 1989-07-07 2002-09-28 Novartis Ag Process for producing retarde compositions containing the active ingredient in a polymeric carrier
US5238714A (en) * 1990-10-02 1993-08-24 Board Of Regents, The University Of Texas System Efficient microcapsule preparation and method of use
CH683149A5 (fr) * 1991-07-22 1994-01-31 Debio Rech Pharma Sa Procédé pour la préparation de microsphères en matériau polymère biodégradable.
FR2693905B1 (fr) * 1992-07-27 1994-09-02 Rhone Merieux Procédé de préparation de microsphères pour la libération prolongée de l'hormone LHRH et ses analogues, microsphères et formulations obtenues.
US6090925A (en) * 1993-03-09 2000-07-18 Epic Therapeutics, Inc. Macromolecular microparticles and methods of production and use
EP2283821A1 (de) * 1993-11-19 2011-02-16 Alkermes, Inc. Herstellung biodegradierbarer Mikroteilchen, die ein biologisch aktives Mittel enthalten
KR0162872B1 (ko) * 1996-04-01 1998-12-01 김은영 용매추출법을 이용한 생분해성 고분자 미립구의 개선된 제조방법 및 이를 이용한 국소염증 질환 치료용 미립구의 제조방법
US5792477A (en) * 1996-05-07 1998-08-11 Alkermes Controlled Therapeutics, Inc. Ii Preparation of extended shelf-life biodegradable, biocompatible microparticles containing a biologically active agent

Also Published As

Publication number Publication date
AU779712B2 (en) 2005-02-10
AU3651800A (en) 2000-11-02
WO2000062761A1 (en) 2000-10-26
PT1196148E (pt) 2004-05-31
DK1196148T3 (da) 2004-04-13
EP1044683A1 (de) 2000-10-18
CA2369808A1 (en) 2000-10-26
EP1196148B1 (de) 2003-12-17
US6777002B1 (en) 2004-08-17
JP2002542184A (ja) 2002-12-10
ES2213572T3 (es) 2004-09-01
EP1196148A1 (de) 2002-04-17
DE60007316D1 (de) 2004-01-29
DE60007316T2 (de) 2004-09-30

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