ATE508107T1 - Verfahren zur herstellung von gabapentin - Google Patents

Verfahren zur herstellung von gabapentin

Info

Publication number: ATE508107T1
Authority: AT; Austria
Prior art keywords: gabapentin; relates; producing gabapentin; producing; acidification
Prior art date: 2004-03-25

Application number

AT05729552T

Other languages

English (en)

Inventor

Roberto Giovanetti

Andrea Nicoli

Massimo Verzini

Giorgio Soriato

Livius Cotarca

Original Assignee

Zach System Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-03-25

Filing date

2005-03-21

Publication date

2011-05-15

2005-03-21 Application filed by Zach System Spa filed Critical Zach System Spa

2011-05-15 Application granted granted Critical

2011-05-15 Publication of ATE508107T1 publication Critical patent/ATE508107T1/de

Links

UGJMXCAKCUNAIE-UHFFFAOYSA-N Gabapentin Chemical compound OC(=O)CC1(CN)CCCCC1 UGJMXCAKCUNAIE-UHFFFAOYSA-N 0.000 title abstract 6
229960002870 gabapentin Drugs 0.000 title abstract 3
238000004519 manufacturing process Methods 0.000 title 1
238000000034 method Methods 0.000 abstract 2
QJGSJXLCJRXTRY-UHFFFAOYSA-N 2-[1-(2-amino-2-oxoethyl)cyclohexyl]acetic acid Chemical compound NC(=O)CC1(CC(O)=O)CCCCC1 QJGSJXLCJRXTRY-UHFFFAOYSA-N 0.000 abstract 1
238000007167 Hofmann rearrangement reaction Methods 0.000 abstract 1
239000007864 aqueous solution Substances 0.000 abstract 1
230000020477 pH reduction Effects 0.000 abstract 1
238000001556 precipitation Methods 0.000 abstract 1
238000002360 preparation method Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/38—Separation; Purification; Stabilisation; Use of additives
- C07C227/40—Separation; Purification
- C07C227/42—Crystallisation
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/04—Formation of amino groups in compounds containing carboxyl groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Crystallography & Structural Chemistry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT05729552T 2004-03-25 2005-03-21 Verfahren zur herstellung von gabapentin ATE508107T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT000579A ITMI20040579A1 (it)	2004-03-25	2004-03-25	Processo di preparazione di gabapentina
PCT/EP2005/051297 WO2005092837A2 (en)	2004-03-25	2005-03-21	Process for the preparation of gabapentin

Publications (1)

Publication Number	Publication Date
ATE508107T1 true ATE508107T1 (de)	2011-05-15

Family

ID=34963314

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT05729552T ATE508107T1 (de)	2004-03-25	2005-03-21	Verfahren zur herstellung von gabapentin

Country Status (15)

Country	Link
US (1)	US7417166B2 (de)
EP (1)	EP1919856B1 (de)
JP (1)	JP4801043B2 (de)
AT (1)	ATE508107T1 (de)
CA (1)	CA2560698C (de)
CY (1)	CY1111730T1 (de)
DE (1)	DE602005027911D1 (de)
DK (1)	DK1919856T3 (de)
ES (1)	ES2364273T3 (de)
HR (1)	HRP20110401T1 (de)
IL (1)	IL178154A (de)
IT (1)	ITMI20040579A1 (de)
PT (1)	PT1919856E (de)
SI (1)	SI1919856T1 (de)
WO (1)	WO2005092837A2 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ITMI20042418A1 (it) *	2004-12-17	2005-03-17	Zambon Spa	Processo per la purificazione della gabapentina
US8143443B2 (en) *	2006-06-30	2012-03-27	Zach System S.P.A.	Process for preparing gabapentin
WO2009147528A1 (en) *	2008-06-02	2009-12-10	Actavis Group Ptc Ehf	Improved process for preparing pregabalin
PT2358851E (pt) *	2008-11-17	2014-04-02	Basf Se	Utilização de ácido metanossulfónico para a preparação de ésteres de ácidos gordos
ITMI20131757A1 (it) *	2013-10-22	2015-04-23	Zach System Spa	Processo di preparazione di gabapentina

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2460891C2 (de)	1974-12-21	1982-09-23	Gödecke AG, 1000 Berlin	1-Aminomethyl-1-cycloalkanessigsäuren und deren Ester, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
US4894476A (en) *	1988-05-02	1990-01-16	Warner-Lambert Company	Gabapentin monohydrate and a process for producing the same
DE3928182A1 (de)	1989-08-25	1991-02-28	Goedecke Ag	Verfahren zur herstellung von gabapentin
DE3928184A1 (de)	1989-08-25	1991-02-28	Goedecke Ag	Verfahren zur herstellung von cyclischen aminosaeurederivaten sowie zwischenprodukte
US5084479A (en) *	1990-01-02	1992-01-28	Warner-Lambert Company	Novel methods for treating neurodegenerative diseases
IL119890A (en)	1996-12-24	2002-03-10	Teva Pharma	Gabapentin form iii and preparation of gabapentin form ii
IT1311984B1 (it)	1999-03-26	2002-03-22	Bioindustria Lab Italiano Medi	Procedimento per la preparzione di gabapentin.
IT1319234B1 (it) *	2000-10-23	2003-09-26	Zambon Spa	Processo di preparazione di gabapentina.
US6800782B2 (en) *	2001-10-09	2004-10-05	Warner-Lambert Co.	Anhydrous crystalline forms of gabapentin
AU2002246303A1 (en) *	2002-02-22	2003-09-09	Shasun Chemicals And Drugs Limited	Preparation of new mineral acid addition salts of gabapentin
EP1494996A1 (de) *	2002-04-16	2005-01-12	Taro Pharmaceutical Industries Limited	Verfahren zur herstellung von gabapentin
ITMI20022071A1 (it) *	2002-10-01	2004-04-02	Erregierre Spa	Processo di sintesi dell'acido 1-(aminometil)cicloesanacetico cloridato.
WO2004110981A1 (en) *	2003-06-12	2004-12-23	Matrix Laboratories Ltd	A process for the preparation of gabapentin form-ii

2004
- 2004-03-25 IT IT000579A patent/ITMI20040579A1/it unknown
2005
- 2005-03-21 JP JP2007504412A patent/JP4801043B2/ja not_active Expired - Lifetime
- 2005-03-21 CA CA2560698A patent/CA2560698C/en not_active Expired - Lifetime
- 2005-03-21 WO PCT/EP2005/051297 patent/WO2005092837A2/en not_active Ceased
- 2005-03-21 ES ES05729552T patent/ES2364273T3/es not_active Expired - Lifetime
- 2005-03-21 DE DE602005027911T patent/DE602005027911D1/de not_active Expired - Lifetime
- 2005-03-21 AT AT05729552T patent/ATE508107T1/de active
- 2005-03-21 EP EP05729552A patent/EP1919856B1/de not_active Expired - Lifetime
- 2005-03-21 SI SI200531331T patent/SI1919856T1/sl unknown
- 2005-03-21 HR HR20110401T patent/HRP20110401T1/hr unknown
- 2005-03-21 US US10/593,813 patent/US7417166B2/en not_active Expired - Fee Related
- 2005-03-21 PT PT05729552T patent/PT1919856E/pt unknown
- 2005-03-21 DK DK05729552.9T patent/DK1919856T3/da active
2006
- 2006-09-18 IL IL178154A patent/IL178154A/en active IP Right Grant
2011
- 2011-07-22 CY CY20111100724T patent/CY1111730T1/el unknown

Also Published As

Publication number	Publication date
DK1919856T3 (da)	2011-08-08
JP4801043B2 (ja)	2011-10-26
PT1919856E (pt)	2011-07-08
DE602005027911D1 (de)	2011-06-16
WO2005092837A3 (en)	2005-12-22
CA2560698A1 (en)	2005-10-06
JP2007530504A (ja)	2007-11-01
ES2364273T3 (es)	2011-08-30
US20070293700A1 (en)	2007-12-20
SI1919856T1 (sl)	2011-10-28
HRP20110401T1 (hr)	2011-06-30
CY1111730T1 (el)	2015-10-07
WO2005092837A2 (en)	2005-10-06
ITMI20040579A1 (it)	2004-06-25
CA2560698C (en)	2012-02-07
US7417166B2 (en)	2008-08-26
IL178154A (en)	2013-09-30
EP1919856B1 (de)	2011-05-04
EP1919856A2 (de)	2008-05-14
IL178154A0 (en)	2006-12-31

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Legal Events

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Title

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2011-12-15

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