ATE258984T1 - Bmp-11 zusammensetzungen - Google Patents
Bmp-11 zusammensetzungenInfo
- Publication number
- ATE258984T1 ATE258984T1 AT94917361T AT94917361T ATE258984T1 AT E258984 T1 ATE258984 T1 AT E258984T1 AT 94917361 T AT94917361 T AT 94917361T AT 94917361 T AT94917361 T AT 94917361T AT E258984 T1 ATE258984 T1 AT E258984T1
- Authority
- AT
- Austria
- Prior art keywords
- proteins
- bmp
- useful
- disclosed
- compositions
- Prior art date
Links
- 102100040898 Growth/differentiation factor 11 Human genes 0.000 title abstract 3
- 101710194452 Growth/differentiation factor 11 Proteins 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 102000012673 Follicle Stimulating Hormone Human genes 0.000 abstract 1
- 108010079345 Follicle Stimulating Hormone Proteins 0.000 abstract 1
- 108020004511 Recombinant DNA Proteins 0.000 abstract 1
- 210000000988 bone and bone Anatomy 0.000 abstract 1
- 210000000845 cartilage Anatomy 0.000 abstract 1
- 210000002808 connective tissue Anatomy 0.000 abstract 1
- 229940028334 follicle stimulating hormone Drugs 0.000 abstract 1
- 230000006698 induction Effects 0.000 abstract 1
- 230000001105 regulatory effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1875—Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0619—Neurons
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/12—Growth hormone, growth factor other than t-cell or b-cell growth factor, and growth hormone releasing factor; related peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Neurology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Neurosurgery (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Endocrinology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Reproductive Health (AREA)
- Physical Education & Sports Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Gynecology & Obstetrics (AREA)
- Hematology (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6146493A | 1993-05-12 | 1993-05-12 | |
| PCT/US1994/005288 WO1994026892A1 (en) | 1993-05-12 | 1994-05-12 | Bmp-11 compositions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE258984T1 true ATE258984T1 (de) | 2004-02-15 |
Family
ID=22035966
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03021107T ATE343635T1 (de) | 1993-05-12 | 1994-05-12 | Bmp-11 zusammenstellungen |
| AT94917361T ATE258984T1 (de) | 1993-05-12 | 1994-05-12 | Bmp-11 zusammensetzungen |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03021107T ATE343635T1 (de) | 1993-05-12 | 1994-05-12 | Bmp-11 zusammenstellungen |
Country Status (16)
| Country | Link |
|---|---|
| US (7) | US5639638A (de) |
| EP (4) | EP0698094B1 (de) |
| JP (2) | JP3681069B2 (de) |
| KR (1) | KR100227406B1 (de) |
| AT (2) | ATE343635T1 (de) |
| AU (1) | AU678582B2 (de) |
| BR (1) | BR9406715A (de) |
| CA (1) | CA2161808C (de) |
| DE (2) | DE69433530T2 (de) |
| DK (2) | DK0698094T3 (de) |
| ES (2) | ES2274157T3 (de) |
| FI (1) | FI119696B (de) |
| NO (1) | NO320119B1 (de) |
| OA (1) | OA10191A (de) |
| PT (2) | PT1378572E (de) |
| WO (1) | WO1994026892A1 (de) |
Families Citing this family (137)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE20004692U1 (de) | 2000-03-14 | 2001-07-26 | Sofamor Danek GmbH, 94469 Deggendorf | Wirbelimplantat zum Einschrauben in einen Wirbelzwischenraum |
| US6150328A (en) | 1986-07-01 | 2000-11-21 | Genetics Institute, Inc. | BMP products |
| US20080139474A1 (en) * | 1991-11-04 | 2008-06-12 | David Israel | Recombinant bone morphogenetic protein heterodimers, compositions and methods of use |
| DE69233022T2 (de) * | 1991-11-04 | 2004-02-12 | Genetics Institute, LLC, Cambridge | Rekombinante knochenmorphogenetische protein heterodimere, zusammensetzungen und verfahren zur verwendung |
| US7393682B1 (en) * | 1993-03-19 | 2008-07-01 | The Johns Hopkins University School Of Medicine | Polynucleotides encoding promyostatin polypeptides |
| US20030074680A1 (en) * | 1993-03-19 | 2003-04-17 | Johns Hopkins University School Of Medicine | Growth differentiation factor-8 |
| US6465239B1 (en) * | 1993-03-19 | 2002-10-15 | The John Hopkins University School Of Medicine | Growth differentiation factor-8 nucleic acid and polypeptides from aquatic species and non-human transgenic aquatic species |
| DK0698094T3 (da) * | 1993-05-12 | 2004-05-03 | Inst Genetics Llc | BMP-11-sammensætninger |
| US6291206B1 (en) | 1993-09-17 | 2001-09-18 | Genetics Institute, Inc. | BMP receptor proteins |
| DE69434651T2 (de) | 1993-12-07 | 2007-03-08 | Genetics Institute, Inc., Cambridge | Bmp-12, bmp-13 und diese enthaltende sehne-induzierende zusammensetzungen |
| US5942496A (en) | 1994-02-18 | 1999-08-24 | The Regent Of The University Of Michigan | Methods and compositions for multiple gene transfer into bone cells |
| US6551618B2 (en) | 1994-03-15 | 2003-04-22 | University Of Birmingham | Compositions and methods for delivery of agents for neuronal regeneration and survival |
| US7332575B2 (en) * | 1994-03-18 | 2008-02-19 | The Johns Hopkins University School Of Medicine | Growth differentiation factor-8 nucleic acid and polypeptide from aquatic species, and transgenic aquatic species |
| US5906827A (en) * | 1994-06-03 | 1999-05-25 | Creative Biomolecules, Inc. | Matrix for the manufacture of autogenous replacement body parts |
| US6008434A (en) | 1994-07-08 | 1999-12-28 | Johns Hopkins University School Of Medicine | Growth differentiation factor-11 transgenic mice |
| US20030167492A1 (en) | 1994-07-08 | 2003-09-04 | Johns Hopkins University School Of Medicine | Transgenic non-human animals expressing a gdf-11 dominant negative polypeptide, and methods of making and using same |
| WO1996001845A1 (en) * | 1994-07-08 | 1996-01-25 | The Johns Hopkins University School Of Medicine | Growth differentiation factor-11 |
| US5846770A (en) * | 1994-11-22 | 1998-12-08 | Genetics Institute, Inc. | DNA molecules encoding human chordin |
| US5645084A (en) * | 1995-06-07 | 1997-07-08 | Danek Medical, Inc. | Method for spinal fusion without decortication |
| US5635372A (en) * | 1995-05-18 | 1997-06-03 | Genetics Institute, Inc. | BMP-15 compositions |
| DE69629294T2 (de) | 1995-06-05 | 2004-04-29 | Genetics Institute, LLC, Cambridge | Verwendung von knochenmorphogeneseproteinen zur heilung und reparatur von bindegewebebefestigung |
| US5902785A (en) * | 1995-06-06 | 1999-05-11 | Genetics Institute, Inc. | Cartilage induction by bone morphogenetic proteins |
| US5700774A (en) * | 1996-03-26 | 1997-12-23 | Genetics Institute, Inc. | Compositions comprising bone morphogenic proteins and truncated parathyroid hormone related peptide, and methods of inducing cartilage by administration of same |
| US5965403A (en) * | 1996-09-18 | 1999-10-12 | Genetics Institute, Inc. | Nucleic acids encoding bone morphogenic protein-16 (BMP-16) |
| US6037519A (en) * | 1997-10-20 | 2000-03-14 | Sdgi Holdings, Inc. | Ceramic fusion implants and compositions |
| EP0973926A1 (de) * | 1997-03-14 | 2000-01-26 | Selective Genetics, Inc. | Adenovirale vektoren mit verändertem tropismus |
| US7041641B2 (en) | 1997-03-20 | 2006-05-09 | Stryker Corporation | Osteogenic devices and methods of use thereof for repair of endochondral bone and osteochondral defects |
| US20010016646A1 (en) | 1998-03-20 | 2001-08-23 | David C. Rueger | Osteogenic devices and methods of use thereof for repair of endochondral bone, osteochondral and chondral defects |
| CA2291514C (en) | 1997-05-30 | 2011-07-12 | Mariel Therapeutics, Inc. | Methods for evaluating tissue morphogenesis and activity |
| US5972368A (en) | 1997-06-11 | 1999-10-26 | Sdgi Holdings, Inc. | Bone graft composites and spacers |
| US7923250B2 (en) | 1997-07-30 | 2011-04-12 | Warsaw Orthopedic, Inc. | Methods of expressing LIM mineralization protein in non-osseous cells |
| ES2320603T3 (es) | 1997-07-30 | 2009-05-25 | Emory University | Sistemas de expresion, vectores, adn, proteinas de mineralizacion osea novedosos. |
| AU8666398A (en) * | 1997-08-01 | 1999-02-22 | Johns Hopkins University School Of Medicine, The | Methods to identify growth differentiation factor (gdf) receptors |
| US6891082B2 (en) * | 1997-08-01 | 2005-05-10 | The Johns Hopkins University School Of Medicine | Transgenic non-human animals expressing a truncated activintype II receptor |
| US6696260B1 (en) * | 1997-08-01 | 2004-02-24 | The Johns Hopkins University School Of Medicine | Methods to identify growth differentiation factor (GDF) binding proteins |
| US20020052026A1 (en) | 1997-10-08 | 2002-05-02 | Steven M. Vicik | Methods of refolding proteins |
| US6511509B1 (en) | 1997-10-20 | 2003-01-28 | Lifenet | Textured bone allograft, method of making and using same |
| WO1999024057A2 (en) * | 1997-11-07 | 1999-05-20 | Genetics Inst | Neuronal uses of bmp-11 |
| US6027917A (en) | 1997-12-10 | 2000-02-22 | Genetics Institute, Inc. | Bone morphogenetic protein (BMP)-17 and BMP-18 compositions |
| US20030036629A1 (en) * | 1997-12-12 | 2003-02-20 | Barry Foster | Novel tgf-beta protein purification methods |
| US6004937A (en) * | 1998-03-09 | 1999-12-21 | Genetics Institute, Inc. | Use of follistatin to modulate growth and differentiation factor 8 [GDF-8] and bone morphogenic protein 11 [BMP-11] |
| US7147839B2 (en) | 1998-05-29 | 2006-12-12 | Curis, Inc. | Methods for evaluating tissue morphogenesis and activity |
| AU765832B2 (en) * | 1998-07-28 | 2003-10-02 | Johns Hopkins University School Of Medicine, The | Growth differentiation factor-11 |
| JP4156197B2 (ja) | 1998-08-06 | 2008-09-24 | ウォーソー・オーソペディック・インコーポレーテッド | 複合型椎骨間スペーサ |
| US6849255B2 (en) * | 1998-08-18 | 2005-02-01 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Methods and compositions for enhancing cartilage repair |
| US6727224B1 (en) | 1999-02-01 | 2004-04-27 | Genetics Institute, Llc. | Methods and compositions for healing and repair of articular cartilage |
| WO2000066620A2 (en) * | 1999-04-30 | 2000-11-09 | Curis, Inc. | Morphogen-induced enhancement of fertility |
| ATE271886T1 (de) | 1999-10-15 | 2004-08-15 | Inst Genetics Llc | Hyaluronsäure enthaltende zusammensetzungen zur abgabe osteogener proteine |
| JP4672947B2 (ja) | 1999-12-06 | 2011-04-20 | ウォーソー・オーソペディック・インコーポレーテッド | 椎間板の治療装置及び方法 |
| US20030082233A1 (en) * | 2000-12-01 | 2003-05-01 | Lyons Karen M. | Method and composition for modulating bone growth |
| US6752831B2 (en) | 2000-12-08 | 2004-06-22 | Osteotech, Inc. | Biocompatible osteogenic band for repair of spinal disorders |
| US8758438B2 (en) | 2000-12-08 | 2014-06-24 | Warsaw Orthopedic, Inc. | Implant for orthopedic applications |
| GB0100551D0 (en) * | 2001-01-09 | 2001-02-21 | Queen Mary & Westfield College | Protein |
| US7141392B2 (en) | 2001-01-09 | 2006-11-28 | Queen Mary And Westfield College | Latent fusion protein |
| EP1790726B1 (de) * | 2001-02-08 | 2013-07-03 | Wyeth LLC | Modifizierte und stabilisierte GDF-Propeptide und ihre Verwendung |
| TWI329129B (en) | 2001-02-08 | 2010-08-21 | Wyeth Corp | Modified and stabilized gdf propeptides and uses thereof |
| KR100420798B1 (ko) * | 2001-02-10 | 2004-03-02 | (주)알에이싸이언스 | 펩타이드 벡터 |
| WO2002099037A2 (en) | 2001-06-01 | 2002-12-12 | Wyeth | Compositions and methods for systemic administration of sequences encoding bone morphogenetic proteins |
| TWI267378B (en) | 2001-06-08 | 2006-12-01 | Wyeth Corp | Calcium phosphate delivery vehicles for osteoinductive proteins |
| US7320789B2 (en) | 2001-09-26 | 2008-01-22 | Wyeth | Antibody inhibitors of GDF-8 and uses thereof |
| US6798160B2 (en) * | 2001-11-02 | 2004-09-28 | Honda Giken Kogyo Kabushiki Kaisha | Electric working machine |
| CN1301757C (zh) * | 2001-11-27 | 2007-02-28 | 多喜兰株式会社 | 植入物材料及其生产方法 |
| CH695985A5 (de) * | 2002-01-21 | 2006-11-15 | Straumann Holding Ag | Oberflächenmodifizierte Implantate. |
| JP4429728B2 (ja) * | 2002-02-21 | 2010-03-10 | ワイス エルエルシー | フォリスタチン(follistatin)ドメイン含有タンパク質 |
| BR0307907A2 (pt) | 2002-02-21 | 2011-07-05 | Wyeth Corp | gasp1: proteìna contendo domìnio de folistatina |
| TW200638946A (en) * | 2002-05-17 | 2006-11-16 | Wyeth Corp | Injectable solid hyaluronic acid carriers for delivery of osteogenic proteins |
| JP2006508049A (ja) | 2002-08-13 | 2006-03-09 | ワイエス | 増殖因子βタンパク質を形質転換するための可溶化賦形剤としてのペプチド |
| EP1578928B1 (de) * | 2002-09-16 | 2010-03-17 | The Johns Hopkins University | Metalloproteaseaktivierung von myostatin und verfahren zur modulation der myostatinaktivität |
| US7261893B2 (en) | 2002-10-22 | 2007-08-28 | Wyeth | Neutralizing antibodies against GDF-8 and uses therefor |
| US20040223966A1 (en) * | 2002-10-25 | 2004-11-11 | Wolfman Neil M. | ActRIIB fusion polypeptides and uses therefor |
| JP5110877B2 (ja) | 2003-06-02 | 2012-12-26 | ワイス・エルエルシー | 神経筋障害を処置するための、コルチコステロイドと組み合わせたミオスタチン(gdf8)インヒビターの使用 |
| DE602004005477T2 (de) * | 2003-09-12 | 2007-12-13 | Wyeth | Injizierbare feste Calciumphosphat-Stäbe zur Abgabe von osteogenen Proteinen |
| PL1737734T3 (pl) | 2004-03-10 | 2011-02-28 | Scil Tech Gmbh | Powlekane implanty, ich wytwarzanie i zastosowanie |
| WO2005116052A2 (en) | 2004-04-27 | 2005-12-08 | Research Development Foundation | ANTAGONISM OF TGF-β SUPERFAMILY RECEPTOR SIGNALING |
| ES2369629T3 (es) | 2004-05-25 | 2011-12-02 | Stryker Corporation | Uso de op-1 para tratar defectos del cartílago. |
| US7749268B2 (en) | 2004-05-26 | 2010-07-06 | Warsaw Orthopedic, Inc. | Methods for treating the spine |
| MX2007000976A (es) * | 2004-08-12 | 2007-04-10 | Wyeth Corp | Tratamiento combinado para diabetes, obesidad y enfermedades cardiovasculares utilizando inhibidores del factor 8 de crecimiento y diferenciacion. |
| US7473678B2 (en) | 2004-10-14 | 2009-01-06 | Biomimetic Therapeutics, Inc. | Platelet-derived growth factor compositions and methods of use thereof |
| US20060166251A1 (en) * | 2005-01-26 | 2006-07-27 | Archambault Joanne M | Use of sFRPs as markers of BMP activity |
| CN101137906A (zh) * | 2005-03-23 | 2008-03-05 | 惠氏公司 | 对gdf-8调节剂的免疫应答的检测 |
| EP1863518A2 (de) * | 2005-03-30 | 2007-12-12 | Wyeth | VERFAHREN ZUR STIMULATION DES WAARWACHSTUMS MITTELS VERABREICHUNG VON BMPs |
| US8506646B2 (en) | 2005-04-29 | 2013-08-13 | Warsaw Orthopedic, Inc. | Multi-purpose medical implant devices |
| US20060247790A1 (en) * | 2005-04-30 | 2006-11-02 | Mckay William F | Shaped osteochondral grafts and methods of using same |
| ES2533464T3 (es) | 2005-10-06 | 2015-04-10 | Eli Lilly And Company | Anticuerpos anti-miostatina |
| UA92504C2 (en) | 2005-10-12 | 2010-11-10 | Эли Лилли Энд Компани | Anti-myostatin monoclonal antibody |
| US8147860B2 (en) | 2005-12-06 | 2012-04-03 | Etex Corporation | Porous calcium phosphate bone material |
| EP1991282B1 (de) | 2006-02-09 | 2013-06-19 | BioMimetic Therapeutics, LLC | Zusammensetzungen und verfahren zur behandlung von knochen |
| AU2007257208B2 (en) | 2006-05-17 | 2013-05-02 | Stryker Corporation | Use of a soluble morphogenic protein complex for treating cartilage defects |
| US9161967B2 (en) | 2006-06-30 | 2015-10-20 | Biomimetic Therapeutics, Llc | Compositions and methods for treating the vertebral column |
| CA2656278C (en) | 2006-06-30 | 2016-02-09 | Biomimetic Therapeutics, Inc. | Compositions and methods for treating rotator cuff injuries |
| US8524265B2 (en) | 2006-08-17 | 2013-09-03 | Warsaw Orthopedic, Inc. | Medical implant sheets useful for tissue regeneration |
| PL2066695T3 (pl) | 2006-09-05 | 2013-08-30 | Lilly Co Eli | Przeciwciała przeciwko miostatynie |
| JP2008104401A (ja) * | 2006-10-25 | 2008-05-08 | Kyoto Univ | 精原幹細胞のインビトロ増殖方法 |
| AU2007234612B2 (en) | 2006-12-14 | 2013-06-27 | Johnson & Johnson Regenerative Therapeutics, Llc | Protein stabilization formulations |
| US20100184659A1 (en) | 2006-12-21 | 2010-07-22 | Warren Jaworowicz | Sustained-Release Formulations Comprising Crystals, Macromolecular Gels, and Particulate Suspensions of Biologic Agents |
| US7678764B2 (en) | 2007-06-29 | 2010-03-16 | Johnson & Johnson Regenerative Therapeutics, Llc | Protein formulations for use at elevated temperatures |
| WO2009020744A1 (en) | 2007-08-07 | 2009-02-12 | Johnson & Johnson Regenerative Therapeutics, Llc | Protein formulations comprising gdf-5 in aqueous acidic solution |
| AU2009214629A1 (en) | 2008-02-13 | 2009-08-20 | Eric T. Choi | BMP-7 for use in treating vascular sclerosis |
| BRPI0911048A2 (pt) | 2008-04-14 | 2015-12-29 | Atrm Llc | formulações líquidas tamponadas de gdf-5 |
| KR20110067035A (ko) | 2008-09-09 | 2011-06-20 | 바이오미메틱 세라퓨틱스, 인크. | 건 및 인대 손상의 치료를 위한 혈소판-유래 성장 인자 조성물 및 방법 |
| WO2010093925A2 (en) | 2009-02-12 | 2010-08-19 | Stryker Corporation | PERIPHERAL ADMINISTRATION OF PROTEINS INCLUDING TGF-β SUPERFAMILY MEMBERS FOR TREATMENT OF SYSTEMIC DISORDERS AND DISEASE |
| US20100204124A1 (en) | 2009-02-12 | 2010-08-12 | Mary Elizabeth Pecquet Goad | Compositions and Methods for Minimally-Invasive Systemic Delivery of Proteins Including TGF-Beta Superfamily Members |
| WO2010110974A1 (en) | 2009-03-24 | 2010-09-30 | Stryker Corporation | Methods and compositions for tissue engineering |
| US8609127B2 (en) | 2009-04-03 | 2013-12-17 | Warsaw Orthopedic, Inc. | Medical implant with bioactive material and method of making the medical implant |
| WO2010144696A1 (en) | 2009-06-11 | 2010-12-16 | Burnham Institute For Medical Research | Directed differentiation of stem cells |
| US9399086B2 (en) | 2009-07-24 | 2016-07-26 | Warsaw Orthopedic, Inc | Implantable medical devices |
| WO2011031856A1 (en) | 2009-09-09 | 2011-03-17 | Stryker Corporation | Bmp -7 for use in treating pain induced by injuries and diseases of an articular joint |
| US20110224410A1 (en) | 2009-09-17 | 2011-09-15 | Hile David | Buffers for Controlling the pH of Bone Morphogenetic Proteins |
| CA2785038A1 (en) | 2009-12-22 | 2011-07-21 | Stryker Corporation | Bmp-7 variants with reduced immunogenicity |
| CN107080834A (zh) | 2010-02-22 | 2017-08-22 | 生物模拟治疗有限责任公司 | 用于治疗腱病的血小板衍生生长因子组合物和方法 |
| WO2011139594A2 (en) | 2010-04-27 | 2011-11-10 | Medtronic, Inc. | Artificial bursa for intra-articular drug delivery |
| WO2012023113A2 (en) | 2010-08-20 | 2012-02-23 | Wyeth Llc | Designer osteogenic proteins |
| US9688735B2 (en) | 2010-08-20 | 2017-06-27 | Wyeth Llc | Designer osteogenic proteins |
| US8998925B2 (en) | 2011-06-20 | 2015-04-07 | Rdc Holdings, Llc | Fixation system for orthopedic devices |
| WO2012177759A1 (en) | 2011-06-20 | 2012-12-27 | Rdc Holdings, Llc | System and method for repairing joints |
| US9434779B2 (en) * | 2012-03-19 | 2016-09-06 | The Brigham And Women's Hospital, Inc. | Growth differentiation factor 11 (GDF-11) for treatment of diastolic heart failure |
| WO2014012101A1 (en) | 2012-07-13 | 2014-01-16 | Trustees Of Tufts College | Silk powder compaction for production of constructs with high mechanical strength and stiffness |
| EP2956545A4 (de) * | 2013-02-15 | 2016-07-20 | Joslin Diabetes Ct | Thymusregeneration |
| US10092627B2 (en) | 2013-04-08 | 2018-10-09 | President And Fellows Of Harvard College | Methods and compositions for rejuvenating skeletal muscle stem cells |
| AU2014253753B2 (en) | 2013-04-19 | 2017-03-30 | Arteriocyte Medical Systems, Inc. | Demineralized bone fibers having controlled geometry and shapes and methods thereof |
| US20160287667A1 (en) * | 2013-11-08 | 2016-10-06 | President And Fellows Of Harvard College | Methods and compositions for rejuvenating neuromuscular junctions |
| WO2015073396A1 (en) | 2013-11-12 | 2015-05-21 | The Brigham And Women's Hospital, Inc. | Growth differentiation factor (gdf) for treatment of diastolic heart failure |
| WO2016123583A1 (en) | 2015-01-29 | 2016-08-04 | Theracell, Inc. | Demineralized bone fiber composition for use in minimally invasive surgery |
| EP3271380B1 (de) | 2015-03-17 | 2021-08-11 | ISTITUTO BIOCHIMICO ITALIANO GIOVANNI LORENZINI S.p.A. | Verfahren zur reinigung knochenmorphogenetischer proteine |
| CN107683130B (zh) | 2015-06-17 | 2022-03-04 | 华沙整形外科股份有限公司 | 包括氧固醇的植入物和使用方法 |
| CN108430458B (zh) | 2015-10-26 | 2022-05-10 | 哈佛学院院长等 | 还原和氧化的多糖及其使用方法 |
| ES2893813T3 (es) | 2016-01-06 | 2022-02-10 | Harvard College | El tratamiento con GDF11 previene el aumento de peso, mejora la tolerancia a la glucosa y reduce la hepatoesteatosis |
| KR101810385B1 (ko) * | 2016-02-04 | 2017-12-20 | 주식회사 강스템바이오텍 | Gdf11을 포함하는 조성물 및 그의 용도 |
| US10688222B2 (en) | 2016-11-21 | 2020-06-23 | Warsaw Orthopedic, Inc. | Lyophilized moldable implants containing an oxysterol |
| US10639157B2 (en) | 2017-03-14 | 2020-05-05 | Theracell, Inc. | Demineralized bone fiber composition for use in minimally invasive surgery |
| US11464888B2 (en) | 2017-06-12 | 2022-10-11 | Warsaw Orthopedic, Inc. | Moldable formulations containing an oxysterol in an acellular tissue matrix |
| WO2019033082A1 (en) | 2017-08-11 | 2019-02-14 | Theracell, Inc. | DEMINERALIZED BONE FIBER COMPOSITION FOR INCREASED FASTENING |
| KR101893339B1 (ko) * | 2017-09-19 | 2018-08-31 | 주식회사 강스템바이오텍 | Gdf11을 포함하는 조성물 및 그의 용도 |
| US11103618B2 (en) | 2018-02-22 | 2021-08-31 | Warsaw Orthopedic, Inc. | Demineralized bone matrix having improved handling characteristics |
| CN109097425B (zh) * | 2018-08-28 | 2022-06-07 | 浙江康嘉基因技术有限公司 | 一种多肽及用作流感疫苗免疫佐剂的用途 |
| JP7531772B2 (ja) | 2019-02-09 | 2024-08-13 | セラセル,エルエルシー | 骨修復における固定を増強するための脱灰骨線維インプラント構成物及び方法 |
| US11498880B2 (en) | 2019-07-26 | 2022-11-15 | Warsaw Orthopedic, Inc. | Calcium phosphate granules and methods of making them |
Family Cites Families (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4419446A (en) | 1980-12-31 | 1983-12-06 | The United States Of America As Represented By The Department Of Health And Human Services | Recombinant DNA process utilizing a papilloma virus DNA as a vector |
| EP0105014B1 (de) | 1982-09-24 | 1992-05-20 | THE UNITED STATES OF AMERICA as represented by the Secretary United States Department of Commerce | Wiederherstellung von Gewebe bei Tieren |
| US4588684A (en) | 1983-04-26 | 1986-05-13 | Chiron Corporation | a-Factor and its processing signals |
| NZ210699A (en) | 1984-01-04 | 1989-06-28 | Int Genetic Eng | Isolation of an osteogenic protein of the p3 immunologically related family |
| DK518384A (da) | 1984-01-31 | 1985-07-01 | Idaho Res Found | Vektor til fremstilling af et gen-produkt i insektceller, fremgangsmaade til dens fremstilling samt dens anvendelse |
| CA1341617C (en) | 1984-06-08 | 2011-06-28 | Henry George Burger | Inhibin isolated from ovarian follicular fluid |
| NZ212645A (en) | 1984-07-06 | 1990-02-26 | Sandoz Ltd | Method for producing primate granulocyte-macrophage colony stimulating factor (gm-csf) |
| EP0169016B2 (de) | 1984-07-16 | 2004-04-28 | Celtrix Pharmaceuticals, Inc. | Knorpel-induzierende Polypeptid-Faktoren aus Knochen |
| DE3586386T2 (de) | 1984-10-05 | 1993-01-14 | Genentech Inc | Dna, zellkulturen und verfahren zur sekretion von heterologen proteinen und periplasmische proteinrueckgewinnung. |
| US4740587A (en) * | 1985-07-18 | 1988-04-26 | The Salk Institute For Biological Studies | Inhibin and method of purifying same |
| US5089396A (en) * | 1985-10-03 | 1992-02-18 | Genentech, Inc. | Nucleic acid encoding β chain prodomains of inhibin and method for synthesizing polypeptides using such nucleic acid |
| US5215893A (en) * | 1985-10-03 | 1993-06-01 | Genentech, Inc. | Nucleic acid encoding the ba chain prodomains of inhibin and method for synthesizing polypeptides using such nucleic acid |
| US4798885A (en) | 1986-02-07 | 1989-01-17 | Genentech, Inc. | Compositions of hormonally active human and porcine inhibin containing an α chain and 62 chain |
| NZ231899A (en) * | 1985-10-03 | 1991-07-26 | Genentech Inc | Human or porcine inhibin peptide compositions and dna encoding them |
| US4737578A (en) * | 1986-02-10 | 1988-04-12 | The Salk Institute For Biological Studies | Human inhibin |
| US5108922A (en) | 1986-07-01 | 1992-04-28 | Genetics Institute, Inc. | DNA sequences encoding BMP-1 products |
| ZA874681B (en) | 1986-07-01 | 1988-04-27 | Genetics Inst | Novel osteoinductive factors |
| US5013649A (en) | 1986-07-01 | 1991-05-07 | Genetics Institute, Inc. | DNA sequences encoding osteoinductive products |
| US5187076A (en) * | 1986-07-01 | 1993-02-16 | Genetics Institute, Inc. | DNA sequences encoding BMP-6 proteins |
| US5106748A (en) | 1986-07-01 | 1992-04-21 | Genetics Institute, Inc. | Dna sequences encoding 5 proteins |
| IL83003A (en) * | 1986-07-01 | 1995-07-31 | Genetics Inst | Osteoinductive factors |
| US5041538A (en) * | 1987-08-28 | 1991-08-20 | The Salk Institute For Biological Studies | Mammalian follistatin |
| US5168150A (en) | 1988-03-17 | 1992-12-01 | Electronique Serge Dassault | Device for the processing of a magnetic-track ticket, especially an air transport ticket |
| US5071834A (en) | 1988-09-16 | 1991-12-10 | Genentech, Inc. | Purified activin B composition |
| US5166190A (en) * | 1990-01-08 | 1992-11-24 | Genentech, Inc. | Method for increasing fertility in males |
| DE69132823T2 (de) * | 1990-05-16 | 2002-07-18 | Genetics Institute, Inc. | Knochen- und knorpel-bildung hervorrufende proteine |
| US5168050A (en) * | 1990-05-24 | 1992-12-01 | Genentech, Inc. | Mammalian expression of the bone morphogenetic protein-2b using bmp2a/bmp2b fusion |
| DE69133338T2 (de) * | 1990-09-26 | 2004-04-15 | Genetics Institute, LLC, Cambridge | Bmp-5-derivate |
| EP0513334A4 (en) * | 1990-11-30 | 1993-08-04 | Celtrix Laboratories, Inc. | Use of a bone morphogenetic protein in synergistic combination with tgf--g(b) for bone repair |
| US5208219A (en) * | 1991-02-14 | 1993-05-04 | Celtrix Pharmaceuticals Inc. | Method for inducing bone growth |
| AU662155B2 (en) * | 1991-05-10 | 1995-08-24 | Celtrix Pharmaceuticals, Inc. | Targeted delivery of bone growth factors |
| KR100255415B1 (ko) | 1991-06-25 | 2000-05-01 | 브루스 엠. 에이센 | 비엠피-9 조성물 |
| US5171579A (en) * | 1991-10-11 | 1992-12-15 | Genetics Institute, Inc. | Formulations of blood clot-polymer matrix for delivery of osteogenic proteins |
| DE69233022T2 (de) * | 1991-11-04 | 2004-02-12 | Genetics Institute, LLC, Cambridge | Rekombinante knochenmorphogenetische protein heterodimere, zusammensetzungen und verfahren zur verwendung |
| EP0653942B2 (de) | 1992-07-31 | 2007-03-07 | Curis, Inc. | Morphogen induzierte nerven wiederherstellung und wiedergutmachung. |
| ES2201076T3 (es) * | 1993-03-19 | 2004-03-16 | The Johns Hopkins University School Of Medicine | Factor-8 de diferenciacion del crecimiento. |
| DE69433742T2 (de) * | 1993-05-12 | 2005-07-07 | Genetics Institute, LLC, Cambridge | Bmp-10 zusammensetzungen |
| DK0698094T3 (da) * | 1993-05-12 | 2004-05-03 | Inst Genetics Llc | BMP-11-sammensætninger |
| EP1716864A1 (de) * | 1993-08-26 | 2006-11-02 | Genetics Institute, LLC | Neuronale Regeneration mit menschlichen morphogenischen Knochenproteinen |
| WO1996001845A1 (en) * | 1994-07-08 | 1996-01-25 | The Johns Hopkins University School Of Medicine | Growth differentiation factor-11 |
| US5545616A (en) * | 1994-09-22 | 1996-08-13 | Genentech, Inc. | Method for predicting and/or preventing preterm labor |
| DE69723429T3 (de) | 1996-03-22 | 2007-09-20 | Curis, Inc., Cambridge | Verfahren zur verbesserten funktionellen Erholung der motorischen Koordination, der Sprache oder Sinneswahrnehmung nach Trauma oder Ischämie des ZNS |
| JP3361278B2 (ja) | 1997-12-26 | 2003-01-07 | シャープ株式会社 | 反射型液晶表示装置とその製造方法、ならびに回路基板の製造方法 |
| US6004937A (en) * | 1998-03-09 | 1999-12-21 | Genetics Institute, Inc. | Use of follistatin to modulate growth and differentiation factor 8 [GDF-8] and bone morphogenic protein 11 [BMP-11] |
-
1994
- 1994-05-12 DK DK94917361T patent/DK0698094T3/da active
- 1994-05-12 ES ES03021107T patent/ES2274157T3/es not_active Expired - Lifetime
- 1994-05-12 DE DE69433530T patent/DE69433530T2/de not_active Expired - Lifetime
- 1994-05-12 PT PT03021107T patent/PT1378572E/pt unknown
- 1994-05-12 KR KR1019950704836A patent/KR100227406B1/ko not_active Expired - Fee Related
- 1994-05-12 DK DK03021107T patent/DK1378572T3/da active
- 1994-05-12 PT PT94917361T patent/PT698094E/pt unknown
- 1994-05-12 AU AU69105/94A patent/AU678582B2/en not_active Ceased
- 1994-05-12 EP EP94917361A patent/EP0698094B1/de not_active Expired - Lifetime
- 1994-05-12 EP EP03021107A patent/EP1378572B1/de not_active Expired - Lifetime
- 1994-05-12 AT AT03021107T patent/ATE343635T1/de active
- 1994-05-12 DE DE69434875T patent/DE69434875T2/de not_active Expired - Lifetime
- 1994-05-12 CA CA002161808A patent/CA2161808C/en not_active Expired - Fee Related
- 1994-05-12 EP EP10181708A patent/EP2272959A1/de not_active Withdrawn
- 1994-05-12 BR BR9406715A patent/BR9406715A/pt not_active Application Discontinuation
- 1994-05-12 AT AT94917361T patent/ATE258984T1/de active
- 1994-05-12 EP EP06022258A patent/EP1770161A3/de not_active Withdrawn
- 1994-05-12 JP JP52569894A patent/JP3681069B2/ja not_active Expired - Fee Related
- 1994-05-12 ES ES94917361T patent/ES2213745T3/es not_active Expired - Lifetime
- 1994-05-12 WO PCT/US1994/005288 patent/WO1994026892A1/en not_active Ceased
- 1994-05-20 US US08/247,907 patent/US5639638A/en not_active Expired - Lifetime
-
1995
- 1995-05-30 US US08/452,772 patent/US5700911A/en not_active Expired - Lifetime
- 1995-11-08 NO NO19954492A patent/NO320119B1/no not_active IP Right Cessation
- 1995-11-10 OA OA60735A patent/OA10191A/en unknown
- 1995-11-10 FI FI955419A patent/FI119696B/fi not_active IP Right Cessation
-
1997
- 1997-08-28 US US08/919,850 patent/US6437111B1/en not_active Expired - Fee Related
-
1999
- 1999-10-07 US US09/414,234 patent/US6340668B1/en not_active Expired - Fee Related
-
2001
- 2001-12-20 US US10/029,016 patent/US20030083252A1/en not_active Abandoned
-
2002
- 2002-07-05 US US10/188,886 patent/US7175997B2/en not_active Expired - Fee Related
-
2004
- 2004-08-24 JP JP2004243948A patent/JP2005046155A/ja active Pending
-
2006
- 2006-04-11 US US11/401,228 patent/US20060172391A1/en not_active Abandoned
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK1378572T3 (da) | BMP-11-sammensætninger | |
| ATE265529T1 (de) | Bmp-10 zusammensetzungen | |
| CA2030518A1 (en) | Osteoinductive compositions | |
| DE69821793D1 (de) | Neuronale verwendungen des bmp-11 | |
| AU2817095A (en) | Bmp-9 compositions | |
| DE60039450D1 (de) | Zusammensetzungen und methoden zur stabilisierung von biologischen molekülen nach lyophilisierung | |
| EP0787802A3 (de) | ||
| CA2108770A1 (en) | Bmp-9 compositions | |
| ATE328896T1 (de) | Faktor viii vom schwein und hybriden | |
| DK0409472T3 (da) | Knoglemorfogenetisk protein | |
| DE69233022D1 (de) | Rekombinante knochenmorphogenetische protein heterodimere, zusammensetzungen und verfahren zur verwendung | |
| EP1719531A3 (de) | Osteogene Artikel und ihre Verwendung zur Knochenreparatur | |
| ATE141928T1 (de) | Osteoinduktive mittel | |
| DE69726884D1 (de) | Menschliches sdf-5 protein und diesbezügliche zusammensetzungen | |
| DK1431391T3 (da) | RANTES-mutanter og terapeutiske anvendelser heraf | |
| GR3033698T3 (en) | Use of a hymenoptera venom for the manufacture of a medicament for treating dna virus infections. | |
| EP0723016A3 (de) | Leukocyten-aktivierender Faktor |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 0698094 Country of ref document: EP |