ATE258992T1 - Mit stickstoffheterozyklen substituierte elektronenmangel-fluoresceinfarbstoffe - Google Patents
Mit stickstoffheterozyklen substituierte elektronenmangel-fluoresceinfarbstoffeInfo
- Publication number
- ATE258992T1 ATE258992T1 AT01907003T AT01907003T ATE258992T1 AT E258992 T1 ATE258992 T1 AT E258992T1 AT 01907003 T AT01907003 T AT 01907003T AT 01907003 T AT01907003 T AT 01907003T AT E258992 T1 ATE258992 T1 AT E258992T1
- Authority
- AT
- Austria
- Prior art keywords
- nitrogen heterocycles
- fluorescein dyes
- electron
- electron deficiency
- dyes substituted
- Prior art date
Links
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 title abstract 5
- 239000000975 dye Substances 0.000 title abstract 3
- 229910052757 nitrogen Inorganic materials 0.000 title abstract 3
- GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 title abstract 2
- 230000007812 deficiency Effects 0.000 title 1
- KYQCOXFCLRTKLS-UHFFFAOYSA-N Pyrazine Chemical compound C1=CN=CC=N1 KYQCOXFCLRTKLS-UHFFFAOYSA-N 0.000 abstract 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 2
- SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical compound N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 abstract 2
- 230000002950 deficient Effects 0.000 abstract 2
- 239000000758 substrate Substances 0.000 abstract 2
- PCNDJXKNXGMECE-UHFFFAOYSA-N Phenazine Natural products C1=CC=CC2=NC3=CC=CC=C3N=C21 PCNDJXKNXGMECE-UHFFFAOYSA-N 0.000 abstract 1
- 150000001720 carbohydrates Chemical class 0.000 abstract 1
- 235000014633 carbohydrates Nutrition 0.000 abstract 1
- 238000001514 detection method Methods 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000002777 nucleoside Substances 0.000 abstract 1
- 125000003835 nucleoside group Chemical group 0.000 abstract 1
- 239000002773 nucleotide Substances 0.000 abstract 1
- 125000003729 nucleotide group Chemical group 0.000 abstract 1
- 239000002157 polynucleotide Substances 0.000 abstract 1
- 102000040430 polynucleotide Human genes 0.000 abstract 1
- 108091033319 polynucleotide Proteins 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B11/00—Diaryl- or thriarylmethane dyes
- C09B11/04—Diaryl- or thriarylmethane dyes derived from triarylmethanes, i.e. central C-atom is substituted by amino, cyano, alkyl
- C09B11/06—Hydroxy derivatives of triarylmethanes in which at least one OH group is bound to an aryl nucleus and their ethers or esters
- C09B11/08—Phthaleins; Phenolphthaleins; Fluorescein
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/80—Fluorescent dyes, e.g. rhodamine
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Plural Heterocyclic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Pyrane Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Quinoline Compounds (AREA)
- Pyridine Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/498,702 US6221604B1 (en) | 2000-02-07 | 2000-02-07 | Electron-deficient nitrogen heterocycle-substituted fluorescein dyes |
| PCT/US2001/003772 WO2001057264A2 (en) | 2000-02-07 | 2001-02-05 | Electron-deficient nitrogen heterocycle-substituted fluorescein dyes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE258992T1 true ATE258992T1 (de) | 2004-02-15 |
Family
ID=23982139
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01907003T ATE258992T1 (de) | 2000-02-07 | 2001-02-05 | Mit stickstoffheterozyklen substituierte elektronenmangel-fluoresceinfarbstoffe |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US6221604B1 (de) |
| EP (1) | EP1196640B1 (de) |
| JP (5) | JP2003521571A (de) |
| AT (1) | ATE258992T1 (de) |
| AU (1) | AU772739B2 (de) |
| CA (1) | CA2368495C (de) |
| DE (1) | DE60101939T2 (de) |
| ES (1) | ES2211768T3 (de) |
| WO (1) | WO2001057264A2 (de) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6221604B1 (en) * | 2000-02-07 | 2001-04-24 | Pe Corporation | Electron-deficient nitrogen heterocycle-substituted fluorescein dyes |
| CA2425663C (en) * | 2000-10-11 | 2009-12-29 | Applera Corporation | Fluorescent nucleobase conjugates having anionic linkers |
| US6887690B2 (en) * | 2001-06-22 | 2005-05-03 | Pe Corporation | Dye-labeled ribonucleotide triphosphates |
| US8569516B2 (en) * | 2001-09-07 | 2013-10-29 | Elitech Holding B.V. | Compounds and methods for fluorescent labeling |
| US6972339B2 (en) * | 2001-09-07 | 2005-12-06 | Epoch Biosciences, Inc. | Compounds and methods for fluorescent labeling |
| WO2003040395A2 (en) * | 2001-11-07 | 2003-05-15 | Applera Corporation | Universal nucleotides for nucleic acid analysis |
| US20030148284A1 (en) * | 2001-12-17 | 2003-08-07 | Vision Todd J. | Solid phase detection of nucleic acid molecules |
| US7026166B2 (en) * | 2002-01-22 | 2006-04-11 | Chiron Corporation | Fluorogenic dyes |
| US7074597B2 (en) * | 2002-07-12 | 2006-07-11 | The Trustees Of Columbia University In The City Of New York | Multiplex genotyping using solid phase capturable dideoxynucleotides and mass spectrometry |
| US7704756B2 (en) * | 2003-01-21 | 2010-04-27 | Novartis Vaccines And Diagnostics, Inc. | Fluorogenic dyes |
| KR20070121853A (ko) | 2003-03-31 | 2007-12-27 | 에프. 호프만-라 로슈 아게 | 일본 뇌염 바이러스 혈청군의 구성원을 포함하는, 특정플라비바이러스 검출용 조성물 및 방법 |
| US7399639B2 (en) * | 2003-05-04 | 2008-07-15 | Massachusetts Institute Of Technology | Sensors, and methods of making and using the same |
| US7570443B2 (en) | 2003-09-19 | 2009-08-04 | Applied Biosystems, Llc | Optical camera alignment |
| US20060029948A1 (en) * | 2003-09-19 | 2006-02-09 | Gary Lim | Sealing cover and dye compatibility selection |
| US7417726B2 (en) * | 2003-09-19 | 2008-08-26 | Applied Biosystems Inc. | Normalization of data using controls |
| US7541454B2 (en) * | 2003-10-24 | 2009-06-02 | Epoch Biosciences, Inc. | Compounds and methods for fluorescent labeling |
| CA2547418A1 (en) * | 2003-12-08 | 2005-06-23 | The Research Foundation Of State University Of New York | Site selectively tagged and templated molecularly imprinted polymers for sensor applications |
| JP4127204B2 (ja) * | 2003-12-17 | 2008-07-30 | セイコーエプソン株式会社 | 液晶表示装置の製造方法 |
| US7598087B2 (en) * | 2004-01-07 | 2009-10-06 | The Research Foundation Of State University Of New York | Protein imprinted polymers with integrated emission sites |
| WO2005077125A2 (en) * | 2004-02-11 | 2005-08-25 | Applera Corporation | Methods and compositions for detecting nucleic acids |
| US7939251B2 (en) | 2004-05-06 | 2011-05-10 | Roche Molecular Systems, Inc. | SENP1 as a marker for cancer |
| US20050255485A1 (en) * | 2004-05-14 | 2005-11-17 | Livak Kenneth J | Detection of gene duplications |
| EP1748767B1 (de) | 2004-05-28 | 2011-12-28 | Unigen, Inc. | 1-(3-methyl-2,4-dimethoxyphenyl)-3-(2',4'-dihydroxyphenyl)-propan als hochwirksamer tyrosinase-inhibitor |
| EP1781675B1 (de) | 2004-08-13 | 2014-03-26 | Epoch Biosciences, Inc. | Fluoreszierende phosphonatfarbstoffe und konjugate |
| US7767834B2 (en) * | 2004-08-13 | 2010-08-03 | Elitech Holding B.V. | Phosphonylated fluorescent dyes and conjugates |
| EP1886145A2 (de) | 2005-05-03 | 2008-02-13 | Applera Corporation | Fluoreszenznachweissystem und farbstoffsatz zur verwendung damit |
| EP2674417A3 (de) * | 2007-11-21 | 2014-04-09 | Decode Genetics EHF | Biaryl-PDE4-Inhibitoren zur Behandlung von Entzündungen |
| KR101988329B1 (ko) * | 2008-07-21 | 2019-06-12 | 유니젠, 인크. | 일련의 피부-화이트닝(라이트닝) 화합물 |
| KR101718994B1 (ko) * | 2009-09-16 | 2017-03-23 | 포항공과대학교 산학협력단 | 무기 및 유기수은종을 형광을 통하여 감지하는 화학량계의 개발 |
| US20130078148A1 (en) | 2010-06-07 | 2013-03-28 | Konica Minolta Holdings, Inc. | Near field-enhanced fluorescence sensor chip |
| WO2012023391A1 (ja) | 2010-08-17 | 2012-02-23 | コニカミノルタホールディングス株式会社 | 非特異吸着の精製機構を備えたspfs用センサ |
| CN107326073A (zh) | 2010-12-29 | 2017-11-07 | 生命技术公司 | 作为荧光参考标准品的 ddao 化合物 |
| JP6216312B2 (ja) | 2011-03-24 | 2017-10-18 | ユニゲン・インコーポレーテッド | ジアリールプロパンを調製するための化合物及び方法 |
| DK2714939T3 (en) | 2011-05-24 | 2015-06-29 | Elitech Holding Bv | DETECTION OF METHICILLIN-RESISTENT STAPHYLOCOCCUS AUREUS |
| CN102321063B (zh) * | 2011-07-19 | 2015-07-01 | 华东理工大学 | 一种制备不对称罗丹明的方法 |
| WO2013015282A1 (ja) | 2011-07-28 | 2013-01-31 | コニカミノルタホールディングス株式会社 | アナライト量の測定方法およびspfs用装置 |
| CN103012354A (zh) * | 2012-12-24 | 2013-04-03 | 广州医药研究总院 | 5(6)-羧基荧光素异构体的制备方法 |
| WO2014164479A1 (en) | 2013-03-11 | 2014-10-09 | Elitech Holding B.V. | Methods for true isothermal strand displacement amplification |
| US9328384B2 (en) | 2013-05-13 | 2016-05-03 | Elitechgroup B.V. | Droplet digital PCR with short minor groove probes |
| CN103508941B (zh) * | 2013-10-29 | 2015-07-22 | 郑州大学 | 2,4-二苯基-5,6-二吡啶基-苯酚及其制备方法 |
| EP3230467A1 (de) | 2014-12-12 | 2017-10-18 | ELITechGroup B.V. | Verfahren und zusammensetzungen zum nachweis von antibiotikaresistenten bakterien |
| EP3230468B1 (de) | 2014-12-12 | 2020-09-16 | ELITechGroup, Inc. | Verfahren und kits zum nachweis von antibiotikaresistenten bakterien |
| EP3247797B1 (de) | 2015-01-12 | 2020-04-29 | Life Technologies Corporation | Verfahren, systeme und zusammensetzungen daraus zur kontrolle und quantifizierung der nukleinsäurebibliotheksqualität |
| JP6675758B2 (ja) * | 2015-02-20 | 2020-04-01 | 国立大学法人名古屋大学 | ホスファフルオレセイン化合物若しくはその塩、又はそれを用いた蛍光色素 |
| WO2019069885A1 (ja) | 2017-10-02 | 2019-04-11 | コニカミノルタ株式会社 | アナライトの検出方法 |
| CA3124333A1 (en) | 2018-12-20 | 2020-06-25 | Life Technologies Corporation | Modified rhodamine dye and use thereof in biological assays |
| MX2021007492A (es) | 2018-12-20 | 2021-10-13 | Life Technologies Corp | Colorante de rodamina asimétrica y uso de este en ensayos biológicos. |
| WO2021080629A1 (en) | 2019-10-23 | 2021-04-29 | Elitechgroup, Inc. | Methods for true isothermal strand displacement amplification |
| WO2021092408A1 (en) * | 2019-11-08 | 2021-05-14 | The University Of North Carolina At Charlotte | Asymmetric donor-acceptor molecular dyes |
| JP7570350B2 (ja) | 2019-12-06 | 2024-10-21 | 大塚製薬株式会社 | Psa定量用標準物質、その調製方法、psa定量用標準液及びpsa定量方法 |
| CA3186955A1 (en) | 2020-07-23 | 2022-01-27 | Scott Benson | Energy transfer dye conjugates for use in biological assays |
| US20230304932A1 (en) | 2020-07-23 | 2023-09-28 | Life Technologies Corporation | Compositions, systems and methods for biological analysis involving energy transfer dye conjugates and analytes comprising the same |
| CN113563360A (zh) * | 2021-08-16 | 2021-10-29 | 中国科学技术大学 | 一种两亲性荧光染料及其合成方法和应用 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4318846A (en) | 1979-09-07 | 1982-03-09 | Syva Company | Novel ether substituted fluorescein polyamino acid compounds as fluorescers and quenchers |
| CA1340806C (en) | 1986-07-02 | 1999-11-02 | James Merrill Prober | Method, system and reagents for dna sequencing |
| US5047519A (en) | 1986-07-02 | 1991-09-10 | E. I. Du Pont De Nemours And Company | Alkynylamino-nucleotides |
| US5654442A (en) * | 1989-11-14 | 1997-08-05 | The Perkin-Elmer Corporation | 4,7-dichlorofluorescein dyes as molecular probes |
| US5188934A (en) | 1989-11-14 | 1993-02-23 | Applied Biosystems, Inc. | 4,7-dichlorofluorescein dyes as molecular probes |
| EP0658167B1 (de) | 1992-09-03 | 1999-04-14 | The Perkin-Elmer Corporation | 4,7-dichlorofluoroszein-farbestoffe als molekulare sonden |
| US5538848A (en) | 1994-11-16 | 1996-07-23 | Applied Biosystems Division, Perkin-Elmer Corp. | Method for detecting nucleic acid amplification using self-quenching fluorescence probe |
| US5654419A (en) | 1994-02-01 | 1997-08-05 | The Regents Of The University Of California | Fluorescent labels and their use in separations |
| US5453505A (en) | 1994-06-30 | 1995-09-26 | Biometric Imaging, Inc. | N-heteroaromatic ion and iminium ion substituted cyanine dyes for use as fluorescence labels |
| US6020481A (en) | 1996-04-01 | 2000-02-01 | The Perkin-Elmer Corporation | Asymmetric benzoxanthene dyes |
| US5863727A (en) | 1996-05-03 | 1999-01-26 | The Perkin-Elmer Corporation | Energy transfer dyes with enhanced fluorescence |
| US5945526A (en) | 1996-05-03 | 1999-08-31 | Perkin-Elmer Corporation | Energy transfer dyes with enhanced fluorescence |
| US5800996A (en) * | 1996-05-03 | 1998-09-01 | The Perkin Elmer Corporation | Energy transfer dyes with enchanced fluorescence |
| US5821356A (en) | 1996-08-12 | 1998-10-13 | The Perkin Elmer Corporation | Propargylethoxyamino nucleotides |
| US5770716A (en) | 1997-04-10 | 1998-06-23 | The Perkin-Elmer Corporation | Substituted propargylethoxyamido nucleosides, oligonucleotides and methods for using same |
| US6130101A (en) * | 1997-09-23 | 2000-10-10 | Molecular Probes, Inc. | Sulfonated xanthene derivatives |
| US6008379A (en) * | 1997-10-01 | 1999-12-28 | The Perkin-Elmer Corporation | Aromatic-substituted xanthene dyes |
| US6221604B1 (en) * | 2000-02-07 | 2001-04-24 | Pe Corporation | Electron-deficient nitrogen heterocycle-substituted fluorescein dyes |
-
2000
- 2000-02-07 US US09/498,702 patent/US6221604B1/en not_active Ceased
-
2001
- 2001-02-05 AT AT01907003T patent/ATE258992T1/de not_active IP Right Cessation
- 2001-02-05 WO PCT/US2001/003772 patent/WO2001057264A2/en not_active Ceased
- 2001-02-05 DE DE60101939T patent/DE60101939T2/de not_active Expired - Lifetime
- 2001-02-05 CA CA002368495A patent/CA2368495C/en not_active Expired - Lifetime
- 2001-02-05 AU AU34839/01A patent/AU772739B2/en not_active Expired
- 2001-02-05 ES ES01907003T patent/ES2211768T3/es not_active Expired - Lifetime
- 2001-02-05 EP EP01907003A patent/EP1196640B1/de not_active Expired - Lifetime
- 2001-02-05 JP JP2001555887A patent/JP2003521571A/ja active Pending
-
2004
- 2004-04-06 US US10/819,078 patent/USRE39663E1/en not_active Expired - Lifetime
-
2005
- 2005-09-02 JP JP2005255770A patent/JP2006070270A/ja not_active Withdrawn
-
2006
- 2006-03-20 JP JP2006077798A patent/JP4942150B2/ja not_active Expired - Lifetime
-
2007
- 2007-05-08 JP JP2007124004A patent/JP2007277564A/ja active Pending
- 2007-05-08 JP JP2007124005A patent/JP2007277565A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| ES2211768T3 (es) | 2004-07-16 |
| JP4942150B2 (ja) | 2012-05-30 |
| JP2007277564A (ja) | 2007-10-25 |
| WO2001057264A3 (en) | 2002-02-21 |
| EP1196640B1 (de) | 2004-02-04 |
| WO2001057264A2 (en) | 2001-08-09 |
| CA2368495A1 (en) | 2001-08-09 |
| CA2368495C (en) | 2009-09-29 |
| JP2006257427A (ja) | 2006-09-28 |
| JP2007277565A (ja) | 2007-10-25 |
| DE60101939D1 (de) | 2004-03-11 |
| EP1196640A2 (de) | 2002-04-17 |
| US6221604B1 (en) | 2001-04-24 |
| AU3483901A (en) | 2001-08-14 |
| AU772739B2 (en) | 2004-05-06 |
| USRE39663E1 (en) | 2007-05-29 |
| JP2003521571A (ja) | 2003-07-15 |
| JP2006070270A (ja) | 2006-03-16 |
| DE60101939T2 (de) | 2005-01-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |