ATE263145T1 - Verfahren zur herstellung von n-carbamat- geschütztem beta-aminoepoxid und beta- aminoalkohol - Google Patents

Verfahren zur herstellung von n-carbamat- geschütztem beta-aminoepoxid und beta- aminoalkohol

Info

Publication number
ATE263145T1
ATE263145T1 AT00307521T AT00307521T ATE263145T1 AT E263145 T1 ATE263145 T1 AT E263145T1 AT 00307521 T AT00307521 T AT 00307521T AT 00307521 T AT00307521 T AT 00307521T AT E263145 T1 ATE263145 T1 AT E263145T1
Authority
AT
Austria
Prior art keywords
carbamate
protected beta
aminoepoxide
beta
protected
Prior art date
Application number
AT00307521T
Other languages
English (en)
Inventor
Tomoyuki Onishi
Naoko Hirose
Yasuyuki Otake
Takashi Nakano
Yutaka Honda
Masakazu Nakazawa
Kunisuke Izawa
Original Assignee
Ajinomoto Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Kk filed Critical Ajinomoto Kk
Application granted granted Critical
Publication of ATE263145T1 publication Critical patent/ATE263145T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/08—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C07D263/24—Oxygen atoms attached in position 2 with hydrocarbon radicals, substituted by oxygen atoms, attached to other ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/36—Compounds containing oxirane rings with hydrocarbon radicals, substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
AT00307521T 1999-08-31 2000-08-31 Verfahren zur herstellung von n-carbamat- geschütztem beta-aminoepoxid und beta- aminoalkohol ATE263145T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP24564599 1999-08-31
JP2000035074 2000-02-14
JP2000082895 2000-03-23
JP2000199234 2000-06-30

Publications (1)

Publication Number Publication Date
ATE263145T1 true ATE263145T1 (de) 2004-04-15

Family

ID=27478006

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00307521T ATE263145T1 (de) 1999-08-31 2000-08-31 Verfahren zur herstellung von n-carbamat- geschütztem beta-aminoepoxid und beta- aminoalkohol

Country Status (7)

Country Link
US (1) US6765100B2 (de)
EP (2) EP1428818A3 (de)
KR (2) KR100708221B1 (de)
AT (1) ATE263145T1 (de)
CA (1) CA2317198A1 (de)
DE (1) DE60009407T2 (de)
ES (1) ES2216828T3 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6764545B2 (en) * 2000-12-12 2004-07-20 Ajinomoto Co., Inc. Production method of epoxide crystal
JP2002371044A (ja) * 2001-04-11 2002-12-26 Ajinomoto Co Inc β−アミノ−α−ヒドロキシカルボン酸の製造方法
JP4818124B2 (ja) 2003-12-23 2011-11-16 テイボテク・フアーマシユーチカルズ・リミテツド （３Ｒ，３ａＳ，６ａＲ）−ヘキサヒドロフロ〔２，３−ｂ〕フラン−３−イル（１Ｓ，１Ｒ）−３−〔〔（４−アミノフェニル）スルホニル〕（イソブチル）アミノ〕−１−ベンジル−２−ヒドロキシプロピルカルバマートの製造方法
US7582468B2 (en) * 2005-05-25 2009-09-01 Bristol-Myers Squibb Company Process for preparing (2R,3S)-1,2-epoxy-3-(protected)amino-4-substituted butane and intermediates thereof
JP2007112723A (ja) * 2005-10-18 2007-05-10 Ajinomoto Co Inc アミノクロロヒドリン硫酸塩の製造方法
CN102432621B (zh) 2006-11-09 2016-02-17 爱尔兰詹森科学公司 六氢呋喃并[2,3-b]呋喃-3-醇的制备方法
WO2008132154A1 (en) 2007-04-27 2008-11-06 Tibotec Pharmaceuticals Ltd. Methods for the preparation of n-isobutyl-n-(2-hydroxy-3-amino-4-phenylbutyl)-p-nitrobenzenesulfonylamide derivatives
MX2009013499A (es) * 2007-06-22 2010-01-18 Bristol Myers Squibb Co Composiciones comprimidas que contienen atazanavir.
JP2010530892A (ja) * 2007-06-22 2010-09-16 ブリストル−マイヤーズ スクイブ カンパニー アタザナビルを含む錠剤組成物
DE602008005316D1 (de) * 2007-06-22 2011-04-14 Bristol Myers Squibb Co Tablettierte atazanavirhaltige zusammensetzungen
CN101778624A (zh) * 2007-06-22 2010-07-14 百时美施贵宝公司 含有阿扎那韦的压片组合物
US20110178305A1 (en) * 2008-05-08 2011-07-21 Ranbaxy Laboratories Limited Process for the preparation of 3,4-epoxy-2-amino-1-substituted butane derivatives and intermediate compounds thereof
TWI482775B (zh) 2008-09-01 2015-05-01 Tibotec Pharm Ltd 用於製備（３ｒ，３ａｓ，６ａｒ）－六氫呋喃并〔２，３－ｂ〕呋喃－３－基（１ｓ，２ｒ）－３－〔〔（４－胺基苯基）磺醯基〕（異丁基）胺基〕－１－苯甲基－２－羥基丙基胺基甲酸酯之方法
US8921415B2 (en) 2009-01-29 2014-12-30 Mapi Pharma Ltd. Polymorphs of darunavir
EP2528923B1 (de) 2010-01-28 2014-07-30 Mapi Pharma Limited Verfahren zur herstellung von darunavir und darunavir-zwischenprodukten
WO2013011485A1 (en) 2011-07-20 2013-01-24 Ranbaxy Laboratories Limited Process for the preparation of sulfonamides useful as retroviral protease inhibitors
CN102766074B (zh) * 2012-08-07 2014-05-07 江西东邦药业有限公司 抗艾滋病药物中间体的制备方法
CN103044361B (zh) * 2012-12-30 2014-08-06 江苏八巨药业有限公司 一种（2r,3s）-环氧化氨基苯丁烷的制备方法
CN105461662A (zh) * 2014-08-31 2016-04-06 复旦大学 一种抗hiv药物中间体的手性环氧化合物的合成方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE196759T1 (de) * 1990-11-19 2000-10-15 Monsanto Co Inhibitoren retroviraler proteasen
EP0532466A3 (en) 1991-09-12 1993-06-16 Ciba-Geigy Ag Derivatives of 5-amino-4-hydroxy-hexanoic acid and their therapeutical use
US5559256A (en) 1992-07-20 1996-09-24 E. R. Squibb & Sons, Inc. Aminediol protease inhibitors
US5481011A (en) * 1994-12-13 1996-01-02 Bristol-Myers Squibb Company Process for preparing N-protected amino acid α-halomethyl ketones and alcohols from N-protected amino acid esters
DE69616446T2 (de) * 1995-02-03 2002-05-16 Kaneka Corp., Osaka Verfahren zur herstellung von alpha-haloketonen, alpha-halohydrinen und epoxiden
US5767316A (en) * 1995-11-17 1998-06-16 Ajinomoto Co., Inc. Process for producing 3-amino-2-oxo-1-halogenopropane derivatives
US6376685B1 (en) 1998-01-28 2002-04-23 Nippon Kayaku Kabushiki Kaisha Process for producing optically active threo-3-amino-1,2-epoxy compounds
ATE250024T1 (de) 1999-01-21 2003-10-15 Kaneka Corp Methode zur reinigung und abtrennung von (2s,3s)- oder (2r,3s)-halohydrinderivaten
AU2322600A (en) 1999-01-29 2000-08-18 Kaneka Corporation Processes for the preparation of (threo)-1,2-epoxy-3-amino-4-phenylbutane derivatives
US6605732B1 (en) 1999-05-03 2003-08-12 Aerojet Fine Chemicals Llc Clean, high-yield preparation of S,S and R,S amino acid isosteres

Also Published As

Publication number Publication date
DE60009407T2 (de) 2005-03-03
CA2317198A1 (en) 2001-02-28
US20020072621A1 (en) 2002-06-13
EP1081133A1 (de) 2001-03-07
ES2216828T3 (es) 2004-11-01
EP1081133B1 (de) 2004-03-31
EP1428818A2 (de) 2004-06-16
EP1428818A3 (de) 2004-11-03
KR20060116182A (ko) 2006-11-14
US6765100B2 (en) 2004-07-20
KR100706567B1 (ko) 2007-04-13
KR100708221B1 (ko) 2007-04-17
DE60009407D1 (de) 2004-05-06
KR20010067130A (ko) 2001-07-12

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