ATE263145T1 - Verfahren zur herstellung von n-carbamat- geschütztem beta-aminoepoxid und beta- aminoalkohol - Google Patents

Verfahren zur herstellung von n-carbamat- geschütztem beta-aminoepoxid und beta- aminoalkohol

Info

Publication number
ATE263145T1
ATE263145T1 AT00307521T AT00307521T ATE263145T1 AT E263145 T1 ATE263145 T1 AT E263145T1 AT 00307521 T AT00307521 T AT 00307521T AT 00307521 T AT00307521 T AT 00307521T AT E263145 T1 ATE263145 T1 AT E263145T1
Authority
AT
Austria
Prior art keywords
carbamate
protected beta
aminoepoxide
beta
protected
Prior art date
Application number
AT00307521T
Other languages
English (en)
Inventor
Tomoyuki Onishi
Naoko Hirose
Yasuyuki Otake
Takashi Nakano
Yutaka Honda
Masakazu Nakazawa
Kunisuke Izawa
Original Assignee
Ajinomoto Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Kk filed Critical Ajinomoto Kk
Application granted granted Critical
Publication of ATE263145T1 publication Critical patent/ATE263145T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/08—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C07D263/24—Oxygen atoms attached in position 2 with hydrocarbon radicals, substituted by oxygen atoms, attached to other ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/36—Compounds containing oxirane rings with hydrocarbon radicals, substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Epoxy Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT00307521T 1999-08-31 2000-08-31 Verfahren zur herstellung von n-carbamat- geschütztem beta-aminoepoxid und beta- aminoalkohol ATE263145T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP24564599 1999-08-31
JP2000035074 2000-02-14
JP2000082895 2000-03-23
JP2000199234 2000-06-30

Publications (1)

Publication Number Publication Date
ATE263145T1 true ATE263145T1 (de) 2004-04-15

Family

ID=27478006

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00307521T ATE263145T1 (de) 1999-08-31 2000-08-31 Verfahren zur herstellung von n-carbamat- geschütztem beta-aminoepoxid und beta- aminoalkohol

Country Status (7)

Country Link
US (1) US6765100B2 (de)
EP (2) EP1081133B1 (de)
KR (2) KR100708221B1 (de)
AT (1) ATE263145T1 (de)
CA (1) CA2317198A1 (de)
DE (1) DE60009407T2 (de)
ES (1) ES2216828T3 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20020046948A (ko) * 2000-12-12 2002-06-21 에가시라 구니오 에폭사이드 결정의 제조방법
JP2002371044A (ja) 2001-04-11 2002-12-26 Ajinomoto Co Inc β−アミノ−α−ヒドロキシカルボン酸の製造方法
RS51073B (sr) 2003-12-23 2010-10-31 Tibotec Pharmaceuticals Ltd. Proces za pripremanje (3r,3as,6ar)-heksahidrofuro│2,3-b│ furan-3-il (1s,2r)-3-││(4-aminofenil) sulfonil│(izobutil) amino │-1-benzil-2-hidroksipropilkarbamata
US7582468B2 (en) * 2005-05-25 2009-09-01 Bristol-Myers Squibb Company Process for preparing (2R,3S)-1,2-epoxy-3-(protected)amino-4-substituted butane and intermediates thereof
JP2007112723A (ja) * 2005-10-18 2007-05-10 Ajinomoto Co Inc アミノクロロヒドリン硫酸塩の製造方法
ES2359949T3 (es) 2006-11-09 2011-05-30 Tibotec Pharmaceuticals Métodos para preparar hexhidrofuro(2,3-b)furan-3-ol.
BRPI0810609A2 (pt) 2007-04-27 2014-10-21 Tibotec Pharm Ltd Métodos para a preparação de derivados de n-isobutil-n-(2-hidróxi-a-amino-4-fenilbutil)-p-nitrobe nzenossulfonilamida
SI2170292T1 (sl) * 2007-06-22 2014-05-30 Bristol-Myers Squibb Holdings Ireland Tabletirani sestavki, ki vsebujejo atazanavir
JP2010530889A (ja) * 2007-06-22 2010-09-16 ブリストル−マイヤーズ スクイブ カンパニー アタザナビルを含む錠剤組成物
JP2010530892A (ja) * 2007-06-22 2010-09-16 ブリストル−マイヤーズ スクイブ カンパニー アタザナビルを含む錠剤組成物
ES2359770T3 (es) * 2007-06-22 2011-05-26 Bristol-Myers Squibb Company Composiciones en comprimidos que contienen atazanavir.
WO2009136365A1 (en) * 2008-05-08 2009-11-12 Ranbaxy Laboratories Limited Process for the preparation of 3,4-epoxy-2-amino-1-substituted butane derivatives and intermediate compounds thereof
AR073248A1 (es) 2008-09-01 2010-10-20 Tibotec Pharm Ltd Proceso para la preparacion de (1s, 2r)-3- ((4-aminofenil) sulfonil) ( isobutil) amino)-1- bencil-2- hidroxipropilcarbamato de (3r, 3as,6ar)- hexahidrofuro-(2,3-b) furan-3- ilo (darunavir) y compuestos intermediarios utiles en dicho proceso.
US8921415B2 (en) 2009-01-29 2014-12-30 Mapi Pharma Ltd. Polymorphs of darunavir
EP2528923B1 (de) 2010-01-28 2014-07-30 Mapi Pharma Limited Verfahren zur herstellung von darunavir und darunavir-zwischenprodukten
WO2013011485A1 (en) 2011-07-20 2013-01-24 Ranbaxy Laboratories Limited Process for the preparation of sulfonamides useful as retroviral protease inhibitors
CN102766074B (zh) * 2012-08-07 2014-05-07 江西东邦药业有限公司 抗艾滋病药物中间体的制备方法
CN103044361B (zh) * 2012-12-30 2014-08-06 江苏八巨药业有限公司 一种（2r,3s）-环氧化氨基苯丁烷的制备方法
CN105461662A (zh) * 2014-08-31 2016-04-06 复旦大学 一种抗hiv药物中间体的手性环氧化合物的合成方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0731088B1 (de) * 1990-11-19 2000-10-04 Monsanto Company Inhibitoren retroviraler Proteasen
EP0532466A3 (en) 1991-09-12 1993-06-16 Ciba-Geigy Ag Derivatives of 5-amino-4-hydroxy-hexanoic acid and their therapeutical use
US5559256A (en) 1992-07-20 1996-09-24 E. R. Squibb & Sons, Inc. Aminediol protease inhibitors
US5481011A (en) * 1994-12-13 1996-01-02 Bristol-Myers Squibb Company Process for preparing N-protected amino acid α-halomethyl ketones and alcohols from N-protected amino acid esters
KR100411856B1 (ko) * 1995-02-03 2004-05-20 카네카 코포레이션 α-할로케톤,α-할로히드린및에폭사이드의제조법
DE69619067T2 (de) * 1995-11-17 2002-10-02 Ajinomoto Co., Inc. Verfahren zur Herstellung von 3-Amino-2-oxo-1-Halogenpropan-Derivaten
JP4250335B2 (ja) 1998-01-28 2009-04-08 日本化薬株式会社 光学活性スレオ−３−アミノ−１，２−エポキシ体の製造法
EP1151992B1 (de) 1999-01-21 2003-09-17 Kaneka Corporation Methode zur reinigung und abtrennung von (2s,3s)- oder (2r,3s)-halohydrinderivaten
EP1067125B1 (de) 1999-01-29 2006-07-26 Kaneka Corporation VERFAHREN ZUR HERSTELLUNG VON threo-1,2-EPOXY-3-AMINO-4-PHENYLBUTAN-DERIVATEN
US6605732B1 (en) 1999-05-03 2003-08-12 Aerojet Fine Chemicals Llc Clean, high-yield preparation of S,S and R,S amino acid isosteres

Also Published As

Publication number Publication date
EP1428818A3 (de) 2004-11-03
KR100706567B1 (ko) 2007-04-13
KR100708221B1 (ko) 2007-04-17
US6765100B2 (en) 2004-07-20
DE60009407T2 (de) 2005-03-03
US20020072621A1 (en) 2002-06-13
DE60009407D1 (de) 2004-05-06
EP1428818A2 (de) 2004-06-16
EP1081133A1 (de) 2001-03-07
EP1081133B1 (de) 2004-03-31
ES2216828T3 (es) 2004-11-01
KR20060116182A (ko) 2006-11-14
CA2317198A1 (en) 2001-02-28
KR20010067130A (ko) 2001-07-12

Similar Documents

Publication Publication Date Title
DE60009407D1 (de) Verfahren zur Herstellung von N-carbamat-geschütztem beta-Aminoepoxid und beta-Aminoalkohol
ES2191628T3 (es) Procedimiento para extraccion y purificacion de paclitaxel a partir de fuentes naturales.
PT1025067E (pt) Processo para a cristalizacao de compostos impedidos estereoquimicamente
EP1602680A4 (de) Aromatisches polymer, folie, elektrolytmembran und separator
RU2006113122A (ru) Ацетоновый сольват диметоксидоцетаксела и способ его получения
YU63602A (sh) Postupak za prečišćavanje fermentacionog bujona
DE50206163D1 (de) Verfahren zur herstellung von (meth)acrylsäureestern
DK0652219T3 (da) Ny ekstraktionsmetode til udvinding af naturligt forekommende makrolider
ATE417036T1 (de) Verbessertes verfahren zur herstellung von 3- hydroxy-4-hydroxymethyl-pyrrolidin-verbindungen
ATE543793T1 (de) Verfahren zur herstellung von benzoesäureestern
DE60105113D1 (de) Verfahren zur Herstellung von einem Kristallepoxid
BR0012641A (pt) Processo para a separação e purificação de uma mistura aquosa a partir dos componentes principais ácido acético e ácido fórmico
RU2010115263A (ru) Способ получения ди- и полиаминов дифенилметанового ряда
BR0011815B1 (pt) processo para a purificação de poloxámeros que contêm impurezas de aldeìdo.
RU2003119451A (ru) Способ получения 1-(аминометил) циклогексануксусной кислоты
DE60005304D1 (de) Methode zur reinigung und abtrennung von (2s,3s)- oder (2r,3s)-halohydrinderivaten
DE60144358D1 (de) Enzymatisches Verfahren und Verfahren zur enzymatischen Herstellung von optisch aktivem Cyanhidrin
RU2006110205A (ru) Способ получения бисфенола а
PT992495E (pt) Processo pata obter cloridrato de quinapril e solvatos uteis para isolar e purificar o cloridrato de quinapril
Wright et al. First access to the spin-labelled β-amino acid POAC in an enantiopure state by resolution through its binaphthyl esters
ATE301637T1 (de) Verfahren zur herstellung von n-geschützten azetidin-2-carbonsäuren
DE60327813D1 (de) Verfahren zu herstellung von lovastatin.
ATE231485T1 (de) Verfahren zur herstellung von arylmalonaten
EP1219593A4 (de) Verfahren zur herstellung eines optisch aktiven aminalkoholes
DE602005013382D1 (de) Feste formen des magnesiumsalzes von (s)-omeprazol und verfahren zu deren herstellung

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties