ATE417036T1 - Verbessertes verfahren zur herstellung von 3- hydroxy-4-hydroxymethyl-pyrrolidin-verbindungen - Google Patents
Verbessertes verfahren zur herstellung von 3- hydroxy-4-hydroxymethyl-pyrrolidin-verbindungenInfo
- Publication number
- ATE417036T1 ATE417036T1 AT05757531T AT05757531T ATE417036T1 AT E417036 T1 ATE417036 T1 AT E417036T1 AT 05757531 T AT05757531 T AT 05757531T AT 05757531 T AT05757531 T AT 05757531T AT E417036 T1 ATE417036 T1 AT E417036T1
- Authority
- AT
- Austria
- Prior art keywords
- hydroxy
- hydroxymethyl
- producing
- improved method
- pyrrolidine compounds
- Prior art date
Links
- BSQXZHMREYHKOM-UHFFFAOYSA-N 4-(hydroxymethyl)pyrrolidin-3-ol Chemical class OCC1CNCC1O BSQXZHMREYHKOM-UHFFFAOYSA-N 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- BSQXZHMREYHKOM-UHNVWZDZSA-N (3r,4r)-4-(hydroxymethyl)pyrrolidin-3-ol Chemical compound OC[C@H]1CNC[C@@H]1O BSQXZHMREYHKOM-UHNVWZDZSA-N 0.000 abstract 1
- BSQXZHMREYHKOM-CRCLSJGQSA-N (3s,4s)-4-(hydroxymethyl)pyrrolidin-3-ol Chemical compound OC[C@@H]1CNC[C@H]1O BSQXZHMREYHKOM-CRCLSJGQSA-N 0.000 abstract 1
- -1 3,4-trans-disubstituted pyrrolidinone compound Chemical class 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NZ533360A NZ533360A (en) | 2004-06-04 | 2004-06-04 | Improved method for preparing 3-hydroxy-4-hydroxymethyl-pyrrolidine compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE417036T1 true ATE417036T1 (de) | 2008-12-15 |
Family
ID=35462865
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05757531T ATE417036T1 (de) | 2004-06-04 | 2005-06-03 | Verbessertes verfahren zur herstellung von 3- hydroxy-4-hydroxymethyl-pyrrolidin-verbindungen |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US8183019B2 (de) |
| EP (1) | EP1756052B1 (de) |
| JP (2) | JP5219506B2 (de) |
| KR (1) | KR101294732B1 (de) |
| CN (1) | CN101018768B (de) |
| AT (1) | ATE417036T1 (de) |
| AU (1) | AU2005250308B2 (de) |
| CA (1) | CA2568836C (de) |
| CY (1) | CY1108866T1 (de) |
| DE (1) | DE602005011609D1 (de) |
| DK (1) | DK1756052T3 (de) |
| ES (1) | ES2318504T3 (de) |
| IL (1) | IL179749A (de) |
| MX (1) | MXPA06014139A (de) |
| NZ (1) | NZ533360A (de) |
| PL (1) | PL1756052T3 (de) |
| PT (1) | PT1756052E (de) |
| SI (1) | SI1756052T1 (de) |
| WO (1) | WO2005118532A1 (de) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5985848A (en) | 1997-10-14 | 1999-11-16 | Albert Einstein College Of Medicine Of Yeshiva University | Inhibitors of nucleoside metabolism |
| PT1165564E (pt) | 1999-04-08 | 2009-04-16 | Einstein Coll Med | Processo para a preparação de inibidores do metabolismo de nucleósidos |
| US7553839B2 (en) | 2002-08-21 | 2009-06-30 | Industrial Research Limited | 5h-pyrrolo[3,2-D] pyrimidine inhibitors of nucleoside phosphorylases and nucleosidases |
| NZ523970A (en) | 2003-02-04 | 2005-02-25 | Ind Res Ltd | Process for preparing inhibitors of nucleoside phoshorylases and nucleosidases |
| CN1329374C (zh) * | 2004-06-09 | 2007-08-01 | 上海靶点药物有限公司 | 作为ccr5拮抗剂的化合物 |
| WO2007016291A2 (en) * | 2005-07-27 | 2007-02-08 | Albert Einstein College Of Medicine Of Yeshiva University | Transition state structure of 5'-methylthioadenosine/s-adenosylhomocysteine nucleosidases |
| NZ544187A (en) * | 2005-12-15 | 2008-07-31 | Ind Res Ltd | Deazapurine analogs of 1'-aza-l-nucleosides |
| WO2007097643A1 (en) | 2006-02-22 | 2007-08-30 | Industrial Research Limited | Analogues of coformycin and their use for treating protozoan parasite infections |
| WO2007097647A1 (en) | 2006-02-24 | 2007-08-30 | Albert Einstein College Of Medicine Of Yeshiva University | Methods of treating cancer |
| JP2009528996A (ja) * | 2006-02-24 | 2009-08-13 | インダストリアル リサーチ リミテッド | ヌクレオシドホスホリラーゼ及びヌクレオシダーゼの阻害剤を用いて疾患を処置する方法 |
| CN101094080B (zh) * | 2006-06-22 | 2012-06-20 | 华为技术有限公司 | 一种即按即通系统中的计费方法 |
| ES2362805T3 (es) | 2006-09-07 | 2011-07-13 | Industrial Research Limited | Inhibidores aminoacíclicos de nucleósido fosforilasas e hidrolasas. |
| US8383636B2 (en) | 2006-09-07 | 2013-02-26 | Industrial Research Limited | Acyclic amine inhibitors of 5-methytioadenosine phosphorylase and nucleosidase |
| DK2114925T3 (da) | 2006-12-22 | 2012-05-29 | Ind Res Ltd | Azetidin-analoger af nucleosidase- og phosphorylase-inhibitorer |
| CA2710538A1 (en) * | 2008-01-25 | 2009-07-30 | Xenoport, Inc. | Crystalline form of a (3s)-aminomethyl-5-methyl-hexanoic acid prodrug and methods of use |
| WO2010033236A2 (en) * | 2008-09-22 | 2010-03-25 | Albert Einstein College Of Medicine Of Yeshiva University | Methods and compositions for treating bacterial infections by inhibiting quorum sensing |
| JP5861243B2 (ja) | 2009-07-17 | 2016-02-16 | アルバート アインシュタイン カレッジ オブ メディシン オブ イエシバ ユニバーシティ | ５’−メチルチオアデノシンホスホリラーゼ及びヌクレオシダーゼの３−ヒドロキシピロリジン阻害剤 |
| US9290501B2 (en) | 2010-11-29 | 2016-03-22 | Albert Einstein College Of Medicine, Inc. | Methods, assays and compounds for treating bacterial infections by inhibiting methylthioinosine phosphorylase |
| JP6063571B2 (ja) | 2012-08-07 | 2017-01-18 | アルバート アインシュタイン カレッジ オブ メディシン，インコーポレイティド | ヘリコバクター・ピロリ感染の治療 |
| WO2014073989A1 (en) | 2012-11-12 | 2014-05-15 | Callaghan Innovation Research Limited | Salt and polymorphic forms of (3r,4s)-l-((4-amino-5h-pyrrolo[3,2-d]pyrimidin-7-yl)methyl)-4(methylthiomethyl)pyrodin-3-ol(mtdia) |
| EP3104707B1 (de) | 2014-02-12 | 2020-07-15 | Albert Einstein College of Medicine, Inc. | Behandlung von infektionen mit h. pylori mittels mtan-inhibitoren |
| CN104529814A (zh) * | 2014-12-15 | 2015-04-22 | 上海同昌生物医药科技有限公司 | 一种合成n-苄基羟胺盐酸盐的方法 |
| CN111793017B (zh) * | 2019-04-04 | 2024-01-16 | 广东东阳光药业股份有限公司 | 一种内酰胺化合物的制备方法 |
| CN120136758A (zh) * | 2025-03-14 | 2025-06-13 | 宏济堂制药(商河)有限公司 | 一种氯马斯汀中间体的合成方法 |
| CN121736008B (zh) * | 2026-02-28 | 2026-05-01 | 苏州大学 | 一种催化合成1-芳甲基-4-芳甲基-3-羟基吡咯-2(5h)-酮及其衍生物的方法 |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3504026B2 (ja) | 1995-06-16 | 2004-03-08 | 株式会社トクヤマ | ピロリジン誘導体の製造方法 |
| US6379911B2 (en) | 1996-02-23 | 2002-04-30 | Albert Einstein College Of Medicine Of Yeshiva University | Enzyme detection/assay method and substrates |
| US5985848A (en) | 1997-10-14 | 1999-11-16 | Albert Einstein College Of Medicine Of Yeshiva University | Inhibitors of nucleoside metabolism |
| US6239163B1 (en) | 1999-03-15 | 2001-05-29 | Novo Nordisk A/S | Salt of (2R,3R,4R)-3,4-dihydroxy-2-hydroxymethylpyrrolidine |
| AU3147900A (en) | 1999-03-15 | 2000-10-04 | Novo Nordisk A/S | New salt of (2r,3r,4r)-3,4-dihydroxy-2-hydroxymethylpyrrolidine |
| PT1165564E (pt) | 1999-04-08 | 2009-04-16 | Einstein Coll Med | Processo para a preparação de inibidores do metabolismo de nucleósidos |
| US6448799B1 (en) * | 1999-09-30 | 2002-09-10 | Hitachi Electronics Engineering Co., Ltd. | Timing adjustment method and apparatus for semiconductor IC tester |
| WO2002018371A1 (en) | 2000-08-29 | 2002-03-07 | Industrial Research Limited | Nucleoside metabolism inhibitors |
| US6458799B1 (en) | 2000-08-31 | 2002-10-01 | Biocryst Pharmaceuticals, Inc. | Deazaguanine analog, preparation thereof and use thereof |
| US7153851B2 (en) | 2002-03-18 | 2006-12-26 | Kyorin Pharmaceutical Co., Ltd. | 10-(3-cyclopropylaminomethyl-1-pyrrolidinyl)pyridobenzoxazinecarboxylic acid derivative effective against resistant bacterium |
| US7098334B2 (en) | 2002-03-25 | 2006-08-29 | Industrial Research Limited | 4-amino-5H-pyrrolo[3,2-d]pyrimidine inhibitors of nucleoside phosphorylases and nucleosidases |
| US7553839B2 (en) | 2002-08-21 | 2009-06-30 | Industrial Research Limited | 5h-pyrrolo[3,2-D] pyrimidine inhibitors of nucleoside phosphorylases and nucleosidases |
| NZ523970A (en) | 2003-02-04 | 2005-02-25 | Ind Res Ltd | Process for preparing inhibitors of nucleoside phoshorylases and nucleosidases |
| WO2005003307A2 (en) | 2003-06-17 | 2005-01-13 | The Regents Of The University Of California | Compositions and methods for analysis and manipulation of enzymes in biosynthetic proteomes |
| CA2538169A1 (en) * | 2003-09-09 | 2005-03-17 | Albert Einstein College Of Medicine Of Yeshiva University | Transition state analog inhibitors of ricin a-chain |
| CN1329374C (zh) | 2004-06-09 | 2007-08-01 | 上海靶点药物有限公司 | 作为ccr5拮抗剂的化合物 |
| WO2006014913A2 (en) | 2004-07-27 | 2006-02-09 | Biocryst Pharmaceuticals, Inc. | Inhibitors of 5'-methylthioadenosine phosphorylase and 5'methylthioadenosine/s-adenosylhomocysteine nucleosidase |
| NZ540160A (en) | 2005-05-20 | 2008-03-28 | Einstein Coll Med | Inhibitors of nucleoside phosphorylases |
| WO2007016291A2 (en) | 2005-07-27 | 2007-02-08 | Albert Einstein College Of Medicine Of Yeshiva University | Transition state structure of 5'-methylthioadenosine/s-adenosylhomocysteine nucleosidases |
| NZ544187A (en) | 2005-12-15 | 2008-07-31 | Ind Res Ltd | Deazapurine analogs of 1'-aza-l-nucleosides |
| WO2007097647A1 (en) | 2006-02-24 | 2007-08-30 | Albert Einstein College Of Medicine Of Yeshiva University | Methods of treating cancer |
| JP2009528996A (ja) | 2006-02-24 | 2009-08-13 | インダストリアル リサーチ リミテッド | ヌクレオシドホスホリラーゼ及びヌクレオシダーゼの阻害剤を用いて疾患を処置する方法 |
| AR060216A1 (es) * | 2006-03-29 | 2008-06-04 | Medichem Sa | Procesos para preparar ezetimibe y compuestos intermediarios utiles para su preparacion |
| ES2362805T3 (es) | 2006-09-07 | 2011-07-13 | Industrial Research Limited | Inhibidores aminoacíclicos de nucleósido fosforilasas e hidrolasas. |
| US8383636B2 (en) | 2006-09-07 | 2013-02-26 | Industrial Research Limited | Acyclic amine inhibitors of 5-methytioadenosine phosphorylase and nucleosidase |
| EP2066671A1 (de) | 2006-09-26 | 2009-06-10 | Albert Einstein College Of Medicine Of Yeshiva University | Übergangsstatus-struktur menschlicher 5'-methylthioadenosin-phosphorylase |
| DK2114925T3 (da) | 2006-12-22 | 2012-05-29 | Ind Res Ltd | Azetidin-analoger af nucleosidase- og phosphorylase-inhibitorer |
| WO2009082247A1 (en) | 2007-12-21 | 2009-07-02 | Industrial Research Limited | Process for preparing immucillins having a methylene link |
| WO2010033236A2 (en) | 2008-09-22 | 2010-03-25 | Albert Einstein College Of Medicine Of Yeshiva University | Methods and compositions for treating bacterial infections by inhibiting quorum sensing |
| JP5861243B2 (ja) | 2009-07-17 | 2016-02-16 | アルバート アインシュタイン カレッジ オブ メディシン オブ イエシバ ユニバーシティ | ５’−メチルチオアデノシンホスホリラーゼ及びヌクレオシダーゼの３−ヒドロキシピロリジン阻害剤 |
-
2004
- 2004-06-04 NZ NZ533360A patent/NZ533360A/en not_active IP Right Cessation
-
2005
- 2005-06-03 SI SI200530574T patent/SI1756052T1/sl unknown
- 2005-06-03 AU AU2005250308A patent/AU2005250308B2/en not_active Ceased
- 2005-06-03 US US11/628,427 patent/US8183019B2/en active Active
- 2005-06-03 DK DK05757531T patent/DK1756052T3/da active
- 2005-06-03 AT AT05757531T patent/ATE417036T1/de active
- 2005-06-03 WO PCT/NZ2005/000114 patent/WO2005118532A1/en not_active Ceased
- 2005-06-03 MX MXPA06014139A patent/MXPA06014139A/es active IP Right Grant
- 2005-06-03 EP EP05757531A patent/EP1756052B1/de not_active Expired - Lifetime
- 2005-06-03 PL PL05757531T patent/PL1756052T3/pl unknown
- 2005-06-03 PT PT05757531T patent/PT1756052E/pt unknown
- 2005-06-03 JP JP2007514966A patent/JP5219506B2/ja not_active Expired - Fee Related
- 2005-06-03 ES ES05757531T patent/ES2318504T3/es not_active Expired - Lifetime
- 2005-06-03 CN CN2005800234431A patent/CN101018768B/zh not_active Expired - Fee Related
- 2005-06-03 CA CA2568836A patent/CA2568836C/en not_active Expired - Fee Related
- 2005-06-03 DE DE602005011609T patent/DE602005011609D1/de not_active Expired - Lifetime
- 2005-06-03 KR KR1020077000157A patent/KR101294732B1/ko not_active Expired - Fee Related
-
2006
- 2006-11-30 IL IL179749A patent/IL179749A/en not_active IP Right Cessation
-
2009
- 2009-03-10 CY CY20091100263T patent/CY1108866T1/el unknown
-
2012
- 2012-05-10 JP JP2012108801A patent/JP2012211136A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| PL1756052T3 (pl) | 2009-05-29 |
| CN101018768A (zh) | 2007-08-15 |
| IL179749A0 (en) | 2007-05-15 |
| US20080280334A1 (en) | 2008-11-13 |
| KR101294732B1 (ko) | 2013-08-12 |
| JP5219506B2 (ja) | 2013-06-26 |
| KR20070050037A (ko) | 2007-05-14 |
| CN101018768B (zh) | 2012-11-21 |
| AU2005250308A1 (en) | 2005-12-15 |
| IL179749A (en) | 2011-07-31 |
| US8183019B2 (en) | 2012-05-22 |
| DE602005011609D1 (de) | 2009-01-22 |
| EP1756052A1 (de) | 2007-02-28 |
| ES2318504T3 (es) | 2009-05-01 |
| EP1756052B1 (de) | 2008-12-10 |
| PT1756052E (pt) | 2009-02-11 |
| SI1756052T1 (sl) | 2009-04-30 |
| EP1756052A4 (de) | 2007-08-22 |
| CY1108866T1 (el) | 2014-07-02 |
| JP2008501682A (ja) | 2008-01-24 |
| NZ533360A (en) | 2007-02-23 |
| AU2005250308B2 (en) | 2012-04-26 |
| HK1106518A1 (en) | 2008-03-14 |
| CA2568836C (en) | 2013-04-16 |
| WO2005118532A1 (en) | 2005-12-15 |
| DK1756052T3 (da) | 2009-03-09 |
| MXPA06014139A (es) | 2007-05-09 |
| JP2012211136A (ja) | 2012-11-01 |
| CA2568836A1 (en) | 2005-12-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CY1108866T1 (el) | Βελτιωμενη μεθοδος για την παρασκευη ενωσεων 3-υδροξυ-4-υδροξυμεθυλ-πυρρολιδινης | |
| ATE466015T1 (de) | Verfahren zur herstellung von phenserin und dessen analogon | |
| DE602006021411D1 (de) | Verfahren zur herstellung von optional 2-substituierten 1,6-dihydro-6-oxo-4-pyrimidincarboxylsäuren | |
| ATE437869T1 (de) | Verfahren zur herstellung von pyridinylmethyl-1h- benzimidazolverbindungen in enantiomerenangereicherter form oder als einzelne enantiomere | |
| ATE407130T1 (de) | Verfahren zur herstellung von 2- azetidinonderivaten | |
| ATE424392T1 (de) | Verfahren zur herstellung von enantiomerenreinen aminoalkoholen | |
| ATE440815T1 (de) | Verfahren zur herstellung von dialkylcarbonaten | |
| DE60015563D1 (de) | Verfahren zur herstellung von benzoperhydroisoindolen | |
| ATE368661T1 (de) | Verfahren zur herstellung von 5-(4-fluorphenyl)-1- 2-((2r,4r)-4-hydroxy-6-oxo etrahydropyran-2- yl)ethylö-2-isopropyl-4-phenyl-1h-pyrrol-3- carbonsäurephenylamid | |
| ATE459723T1 (de) | Verfahren zur herstellung von (4s)-3,4-dihydroxy- 2,6,6-trimethyl-cyclohex-2-enon und derivaten davon unter verwendung der azoarcus phenylethanol dehydrogenase | |
| ATE489352T1 (de) | Verfahren zur herstellung von brenztraubensäure | |
| ATE370950T1 (de) | Verfahren zur herstellung von (1s,4r)-cis-4-(2- amino-6-chlor-9h-purin-9-yl)-2-cyclopenten-1- methanol | |
| ATE445601T1 (de) | Verfahren zur herstellung von carvedilol und seinen enantiomeren | |
| GB0417063D0 (en) | Process for the preparation of optically-active compounds | |
| ATE457356T1 (de) | Verfahren zur herstellung von vorwiegend ein enantiomer enthaltendes 1,1,1-trifluorisopropanol | |
| DE602004006021D1 (de) | Verfahren zur racematspaltung von nefopam | |
| WO2006034812A3 (de) | Verfahren zur herstellung von optisch aktiven 2-methylalkan-1-ols aus dem entsprechenden 2-methylalk-2-en-1-al, umfassend eine carbonylselektive reduktion, eine enantioselektive hydrierung und eine lipase-katalysierte, stereoselektive acylierung zwecks anreicherung des gewünschten enatiomers | |
| ATE326545T1 (de) | Verfahren zur herstellung von d- oder l-menthol | |
| DE602005013007D1 (de) | Verfahren zur herstellung von lactonen | |
| ATE439333T1 (de) | Verfahren zur herstellung optisch aktiver propoxyanilinderivate | |
| DE602004030091D1 (de) | Verfahren zur reduktiven deshalogenierung | |
| ATE454388T1 (de) | Verfahren zur herstellung von estern von 2-diazo- 3-trimethylsilyloxy-3-butensäure | |
| ATE375355T1 (de) | Verfahren zur herstellung von cefpodoxim-proxetil | |
| WO2003106432A8 (de) | Verfahren zur herstellung von 4,6-dichlor-5-fluorpyrimidin | |
| DE50311960D1 (de) | Verfahren zur Racematsspaltung von 3-Aminopentannitril |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1756052 Country of ref document: EP |