ATE263550T1 - Orale cyclosporinformulierungen - Google Patents

Orale cyclosporinformulierungen

Info

Publication number
ATE263550T1
ATE263550T1 AT96926214T AT96926214T ATE263550T1 AT E263550 T1 ATE263550 T1 AT E263550T1 AT 96926214 T AT96926214 T AT 96926214T AT 96926214 T AT96926214 T AT 96926214T AT E263550 T1 ATE263550 T1 AT E263550T1
Authority
AT
Austria
Prior art keywords
oral cyclosporine
cyclosporine formulations
formulations
oral
cyclosporine
Prior art date
Application number
AT96926214T
Other languages
English (en)
Inventor
Moo J Cho
Ralph E Levy
Philippe J Pouletty
H Robert Floc
Christian Merle
Original Assignee
Sangstat Medical Corp
Univ North Carolina
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/519,689 external-priority patent/US5834017A/en
Priority claimed from US08/620,021 external-priority patent/US5766629A/en
Priority claimed from US08/622,516 external-priority patent/US5827822A/en
Application filed by Sangstat Medical Corp, Univ North Carolina filed Critical Sangstat Medical Corp
Application granted granted Critical
Publication of ATE263550T1 publication Critical patent/ATE263550T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
AT96926214T 1995-08-25 1996-07-31 Orale cyclosporinformulierungen ATE263550T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US08/519,689 US5834017A (en) 1995-08-25 1995-08-25 Oral cyclopsporin formulations
US08/620,021 US5766629A (en) 1995-08-25 1996-03-21 Oral cyclosporin formulations
US08/622,516 US5827822A (en) 1996-03-25 1996-03-25 Cyclosporin a formulations as nanoparticles
PCT/US1996/012569 WO1997007787A1 (en) 1995-08-25 1996-07-31 Oral cyclosporin formulations

Publications (1)

Publication Number Publication Date
ATE263550T1 true ATE263550T1 (de) 2004-04-15

Family

ID=27414735

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96926214T ATE263550T1 (de) 1995-08-25 1996-07-31 Orale cyclosporinformulierungen

Country Status (26)

Country Link
EP (1) EP0789561B1 (de)
JP (1) JP3009742B2 (de)
KR (1) KR100294935B1 (de)
CN (1) CN1164828A (de)
AR (1) AR001985A1 (de)
AT (1) ATE263550T1 (de)
AU (1) AU709548B2 (de)
BG (1) BG62875B1 (de)
BR (1) BR9606603A (de)
CA (1) CA2202887A1 (de)
CZ (1) CZ124897A3 (de)
DE (2) DE69632125T2 (de)
ES (1) ES2129381T1 (de)
GE (1) GEP20012547B (de)
HU (1) HUP9801052A3 (de)
IL (1) IL120673A0 (de)
IS (1) IS4460A (de)
MX (1) MX9702809A (de)
NO (1) NO971890L (de)
NZ (1) NZ313899A (de)
PL (1) PL319898A1 (de)
RO (1) RO119815B1 (de)
SI (1) SI9620014A (de)
SK (1) SK53697A3 (de)
TW (1) TW460287B (de)
WO (1) WO1997007787A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5962019A (en) * 1995-08-25 1999-10-05 Sangstat Medical Corporation Oral cyclosporin formulations
NZ337316A (en) * 1997-03-12 2001-06-29 Abbott Lab Hydrophilic binary systems comprising cyclosporine, hydrophilic phase and a surfactant for the administration of cyclosporine
US6673768B1 (en) 1997-10-16 2004-01-06 Board Of Regents, The University Of Texas System Transgenic animal models for cardiac hypertrophy and methods of use thereof (treating)
ATE404172T1 (de) 1998-12-30 2008-08-15 Dexcel Ltd Dispergierbares konzentrat zur verabreichung von cyclosporin
US6656504B1 (en) * 1999-09-09 2003-12-02 Elan Pharma International Ltd. Nanoparticulate compositions comprising amorphous cyclosporine and methods of making and using such compositions
IL160761A0 (en) * 2001-10-19 2004-08-31 Isotechnika Inc Novel cyclosporin analog microemulsion preconcentrates
ES2393814T3 (es) 2007-04-04 2012-12-28 Sigmoid Pharma Limited Una composición farmacéutica oral
CA2685118C (en) 2007-04-26 2016-11-01 Sigmoid Pharma Limited Manufacture of multiple minicapsules
US20090130198A1 (en) * 2007-11-21 2009-05-21 Innopharmax Inc. Pharmaceutical composition with enhanced bioavailability
ES2530049T3 (es) 2009-05-18 2015-02-26 Sigmoid Pharma Limited Composición que comprende gotas de aceite
CN102573802A (zh) 2009-08-12 2012-07-11 希格默伊德药业有限公司 包含聚合物基质和油相的免疫调节组合物
GB201020032D0 (en) 2010-11-25 2011-01-12 Sigmoid Pharma Ltd Composition
GB201212010D0 (en) 2012-07-05 2012-08-22 Sigmoid Pharma Ltd Formulations
GB201304662D0 (en) 2013-03-14 2013-05-01 Sigmoid Pharma Ltd Compositions
GB201319791D0 (en) 2013-11-08 2013-12-25 Sigmoid Pharma Ltd Formulations
JP6716582B2 (ja) 2014-11-07 2020-07-01 サブリミティ・セラピューティクス・リミテッドＳｕｂｌｉｍｉｔｙ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｌｉｍｉｔｅｄ シクロスポリンを含む組成物
CN104940132B (zh) * 2015-06-05 2018-02-27 河南牧翔动物药业有限公司 一种硫酸小檗碱口服液及其制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2907460A1 (de) * 1978-03-07 1979-09-13 Sandoz Ag Neue resorbierbare galenische kompositionen
HU201567B (en) * 1988-07-21 1990-11-28 Gyogyszerkutato Intezet Process for production of intravenous medical compositions containing cyclosphorin
US5342625A (en) * 1988-09-16 1994-08-30 Sandoz Ltd. Pharmaceutical compositions comprising cyclosporins
HU208491B (en) * 1990-11-27 1993-11-29 Gyogyszerkutato Intezet Process for producing oral pharmaceutical composition containing cyclosporin
PT589843E (pt) * 1992-09-25 2002-04-29 Novartis Ag Composicoes farmaceuticas contendo ciclosporinas
DE4340781C3 (de) * 1993-11-30 2000-01-27 Novartis Ag Cyclosporin enthaltende flüssige Zubereitungen und Verfahren zu ihrer Herstellung
SK164796A3 (en) * 1994-11-03 1997-06-04 Dresden Arzneimittel Novel cyclosporine preparation forms for oral administration of and process for producing them

Also Published As

Publication number Publication date
BG101443A (en) 1998-03-31
KR100294935B1 (ko) 2001-07-12
DE789561T1 (de) 1999-06-10
NO971890D0 (no) 1997-04-24
IL120673A0 (en) 1997-08-14
WO1997007787A1 (en) 1997-03-06
NO971890L (no) 1997-04-24
BR9606603A (pt) 1997-09-30
AR001985A1 (es) 1998-01-07
CZ124897A3 (en) 1997-09-17
EP0789561A4 (de) 1998-12-02
HUP9801052A3 (en) 1998-12-28
EP0789561B1 (de) 2004-04-07
HK1001956A1 (en) 1998-07-24
RO119815B1 (ro) 2005-04-29
TW460287B (en) 2001-10-21
ES2129381T1 (es) 1999-06-16
MX9702809A (es) 1998-02-28
IS4460A (is) 1997-04-08
BG62875B1 (bg) 2000-10-31
HUP9801052A2 (hu) 1998-09-28
AU709548B2 (en) 1999-09-02
JP3009742B2 (ja) 2000-02-14
DE69632125D1 (de) 2004-05-13
CN1164828A (zh) 1997-11-12
GEP20012547B (en) 2001-10-25
EP0789561A1 (de) 1997-08-20
KR970706803A (ko) 1997-12-01
SI9620014A (sl) 1998-04-30
SK53697A3 (en) 1997-10-08
CA2202887A1 (en) 1997-03-06
AU6644196A (en) 1997-03-19
JPH10509462A (ja) 1998-09-14
DE69632125T2 (de) 2004-09-16
PL319898A1 (en) 1997-09-01
NZ313899A (en) 2000-03-27

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Legal Events

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