NO971890L - Orale cyklosporinformuleringer - Google Patents

Orale cyklosporinformuleringer

Info

Publication number
NO971890L
NO971890L NO971890A NO971890A NO971890L NO 971890 L NO971890 L NO 971890L NO 971890 A NO971890 A NO 971890A NO 971890 A NO971890 A NO 971890A NO 971890 L NO971890 L NO 971890L
Authority
NO
Norway
Prior art keywords
formulations
solvent
oral cyclosporine
cyclosporine formulations
present formulations
Prior art date
Application number
NO971890A
Other languages
English (en)
Other versions
NO971890D0 (no
Inventor
Moo J Cho
Ralph E Levy
Philippe J Pouletty
H Robert Floc
Christian Merle
Original Assignee
Sangstat Medical Corp
Univ North Carolina
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/519,689 external-priority patent/US5834017A/en
Priority claimed from US08/620,021 external-priority patent/US5766629A/en
Priority claimed from US08/622,516 external-priority patent/US5827822A/en
Application filed by Sangstat Medical Corp, Univ North Carolina filed Critical Sangstat Medical Corp
Publication of NO971890D0 publication Critical patent/NO971890D0/no
Publication of NO971890L publication Critical patent/NO971890L/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

Det blir beskrevet forbedrede orale cyklosporinformuleringer som har høy biolilgjenge- lighet og har evnen til administrering i harde kapsler eller nanopartikler. I de aktuelle formuleringene blir cyklosporin avlevert i en oralt akseptabel bærer som omfatter minste ett alkanoloppløsningsmiddel med fra 2 til 3 karbonatomer i kombinasjon med minst et ikke-ionisk overflateaktivt middel. De aktuelle formuleringene kan videre omfatte minst et kooppløsningsmiddel, der kooppløsningsmidlene som er interessante innbefatter fettsyrer og dioler De aktuelle formuleringene finner anvendelse i immun- suppressiv terapi.
NO971890A 1995-08-25 1997-04-24 Orale cyklosporinformuleringer NO971890L (no)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US08/519,689 US5834017A (en) 1995-08-25 1995-08-25 Oral cyclopsporin formulations
US08/620,021 US5766629A (en) 1995-08-25 1996-03-21 Oral cyclosporin formulations
US08/622,516 US5827822A (en) 1996-03-25 1996-03-25 Cyclosporin a formulations as nanoparticles
PCT/US1996/012569 WO1997007787A1 (en) 1995-08-25 1996-07-31 Oral cyclosporin formulations

Publications (2)

Publication Number Publication Date
NO971890D0 NO971890D0 (no) 1997-04-24
NO971890L true NO971890L (no) 1997-04-24

Family

ID=27414735

Family Applications (1)

Application Number Title Priority Date Filing Date
NO971890A NO971890L (no) 1995-08-25 1997-04-24 Orale cyklosporinformuleringer

Country Status (26)

Country Link
EP (1) EP0789561B1 (no)
JP (1) JP3009742B2 (no)
KR (1) KR100294935B1 (no)
CN (1) CN1164828A (no)
AR (1) AR001985A1 (no)
AT (1) ATE263550T1 (no)
AU (1) AU709548B2 (no)
BG (1) BG62875B1 (no)
BR (1) BR9606603A (no)
CA (1) CA2202887A1 (no)
CZ (1) CZ124897A3 (no)
DE (2) DE789561T1 (no)
ES (1) ES2129381T1 (no)
GE (1) GEP20012547B (no)
HU (1) HUP9801052A3 (no)
IL (1) IL120673A0 (no)
IS (1) IS4460A (no)
MX (1) MX9702809A (no)
NO (1) NO971890L (no)
NZ (1) NZ313899A (no)
PL (1) PL319898A1 (no)
RO (1) RO119815B1 (no)
SI (1) SI9620014A (no)
SK (1) SK53697A3 (no)
TW (1) TW460287B (no)
WO (1) WO1997007787A1 (no)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5962019A (en) * 1995-08-25 1999-10-05 Sangstat Medical Corporation Oral cyclosporin formulations
WO1998040094A1 (en) * 1997-03-12 1998-09-17 Abbott Laboratories Hydrophilic binary systems for the administration of cyclosporine
WO1999019471A1 (en) 1997-10-16 1999-04-22 Board Of Regents, The University Of Texas System Models and treatments for cardiac hypertrophy in relation with nf-at3 function
EP1154759B1 (en) 1998-12-30 2008-08-13 Dexcel Ltd. Dispersible concentrate for the delivery of cyclosporin
US6656504B1 (en) * 1999-09-09 2003-12-02 Elan Pharma International Ltd. Nanoparticulate compositions comprising amorphous cyclosporine and methods of making and using such compositions
HRP20040354B1 (en) * 2001-10-19 2012-10-31 Isotechnika Inc. Novel cyclosporin analog microemulsion preconcentrates
EP2079456B1 (en) 2007-04-04 2012-12-05 Sigmoid Pharma Limited Pharmaceutical cyclosporin compositions
EP2586428B1 (en) 2007-04-26 2023-11-08 Sublimity Therapeutics Limited Manufacture of multiple minicapsules
US20090130198A1 (en) * 2007-11-21 2009-05-21 Innopharmax Inc. Pharmaceutical composition with enhanced bioavailability
ES2649112T3 (es) 2009-05-18 2018-01-10 Sigmoid Pharma Limited Composición que comprende gotas de aceite
CN107582526A (zh) 2009-08-12 2018-01-16 希格默伊德药业有限公司 包含聚合物基质和油相的免疫调节组合物
GB201020032D0 (en) 2010-11-25 2011-01-12 Sigmoid Pharma Ltd Composition
GB201212010D0 (en) 2012-07-05 2012-08-22 Sigmoid Pharma Ltd Formulations
GB201304662D0 (en) 2013-03-14 2013-05-01 Sigmoid Pharma Ltd Compositions
GB201319791D0 (en) 2013-11-08 2013-12-25 Sigmoid Pharma Ltd Formulations
EP3881829A1 (en) 2014-11-07 2021-09-22 Sublimity Therapeutics Limited Compositions comprising cyclosporin
CN104940132B (zh) * 2015-06-05 2018-02-27 河南牧翔动物药业有限公司 一种硫酸小檗碱口服液及其制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI65914C (fi) * 1978-03-07 1984-08-10 Sandoz Ag Foerfarande foer framstaellning av farmaceutiska kompositionerinnehaollande cyklosporin a
HU201567B (en) * 1988-07-21 1990-11-28 Gyogyszerkutato Intezet Process for production of intravenous medical compositions containing cyclosphorin
US5342625A (en) * 1988-09-16 1994-08-30 Sandoz Ltd. Pharmaceutical compositions comprising cyclosporins
HU208491B (en) * 1990-11-27 1993-11-29 Gyogyszerkutato Intezet Process for producing oral pharmaceutical composition containing cyclosporin
EP1142568A1 (en) * 1992-09-25 2001-10-10 Novartis AG Pharmaceutical compositions containing cyclosporins
DE4340781C3 (de) * 1993-11-30 2000-01-27 Novartis Ag Cyclosporin enthaltende flüssige Zubereitungen und Verfahren zu ihrer Herstellung
AU715165B2 (en) * 1994-11-03 2000-01-20 Novartis Ag Novel cyclosporine preparation forms for oral administration of simple composition and high bio-availability, and process for producing them

Also Published As

Publication number Publication date
IL120673A0 (en) 1997-08-14
BG62875B1 (bg) 2000-10-31
DE69632125D1 (de) 2004-05-13
NZ313899A (en) 2000-03-27
SK53697A3 (en) 1997-10-08
EP0789561A1 (en) 1997-08-20
DE69632125T2 (de) 2004-09-16
AU709548B2 (en) 1999-09-02
MX9702809A (es) 1998-02-28
BR9606603A (pt) 1997-09-30
JPH10509462A (ja) 1998-09-14
HUP9801052A3 (en) 1998-12-28
ES2129381T1 (es) 1999-06-16
NO971890D0 (no) 1997-04-24
EP0789561A4 (en) 1998-12-02
PL319898A1 (en) 1997-09-01
GEP20012547B (en) 2001-10-25
RO119815B1 (ro) 2005-04-29
CA2202887A1 (en) 1997-03-06
HK1001956A1 (en) 1998-07-24
JP3009742B2 (ja) 2000-02-14
SI9620014A (sl) 1998-04-30
AR001985A1 (es) 1998-01-07
HUP9801052A2 (hu) 1998-09-28
IS4460A (is) 1997-04-08
WO1997007787A1 (en) 1997-03-06
AU6644196A (en) 1997-03-19
CZ124897A3 (en) 1997-09-17
ATE263550T1 (de) 2004-04-15
DE789561T1 (de) 1999-06-10
KR100294935B1 (ko) 2001-07-12
TW460287B (en) 2001-10-21
KR970706803A (ko) 1997-12-01
BG101443A (en) 1998-03-31
CN1164828A (zh) 1997-11-12
EP0789561B1 (en) 2004-04-07

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Legal Events

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FC2A Withdrawal, rejection or dismissal of laid open patent application