ATE264292T1 - Kalzium - receptor aktive arylalkylamine - Google Patents
Kalzium - receptor aktive arylalkylamineInfo
- Publication number
- ATE264292T1 ATE264292T1 AT94931982T AT94931982T ATE264292T1 AT E264292 T1 ATE264292 T1 AT E264292T1 AT 94931982 T AT94931982 T AT 94931982T AT 94931982 T AT94931982 T AT 94931982T AT E264292 T1 ATE264292 T1 AT E264292T1
- Authority
- AT
- Austria
- Prior art keywords
- calcium
- arylalkylamins
- receptor active
- receptor
- molecules
- Prior art date
Links
- 239000011575 calcium Substances 0.000 title abstract 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 title 1
- 229910052791 calcium Inorganic materials 0.000 title 1
- 230000000694 effects Effects 0.000 abstract 4
- 102000013830 Calcium-Sensing Receptors Human genes 0.000 abstract 2
- 108010050543 Calcium-Sensing Receptors Proteins 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 229910001410 inorganic ion Inorganic materials 0.000 abstract 2
- 102000005962 receptors Human genes 0.000 abstract 2
- 108020003175 receptors Proteins 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 230000003278 mimic effect Effects 0.000 abstract 1
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Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74945191A | 1991-08-23 | 1991-08-23 | |
| US83404492A | 1992-02-11 | 1992-02-11 | |
| US93416192A | 1992-08-21 | 1992-08-21 | |
| US1712793A | 1993-02-12 | 1993-02-12 | |
| US938993A | 1993-02-23 | 1993-02-23 | |
| US14124893A | 1993-10-22 | 1993-10-22 | |
| US29282794A | 1994-08-19 | 1994-08-19 | |
| PCT/US1994/012117 WO1995011221A1 (en) | 1991-08-23 | 1994-10-21 | Calcium receptor-active arylalkyl amines |
Publications (1)
| Publication Number | Publication Date |
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| ATE264292T1 true ATE264292T1 (de) | 2004-04-15 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT94931982T ATE264292T1 (de) | 1991-08-23 | 1994-10-21 | Kalzium - receptor aktive arylalkylamine |
Country Status (11)
| Country | Link |
|---|---|
| EP (2) | EP1466888A1 (de) |
| JP (2) | JP4555401B2 (de) |
| CN (1) | CN1192011C (de) |
| AT (1) | ATE264292T1 (de) |
| AU (1) | AU702629B2 (de) |
| CA (1) | CA2173747C (de) |
| DE (1) | DE69433714T2 (de) |
| DK (1) | DK0724561T3 (de) |
| ES (1) | ES2218531T3 (de) |
| PT (1) | PT724561E (de) |
| WO (1) | WO1995011221A1 (de) |
Families Citing this family (52)
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| US6031003A (en) * | 1991-08-23 | 2000-02-29 | Nps Pharmaceuticals, Inc. | Calcium receptor-active molecules |
| US5858684A (en) * | 1991-08-23 | 1999-01-12 | The Brigham And Women's Hospital, Inc. | Method of screening calcium receptor-active molecules |
| US6313146B1 (en) | 1991-08-23 | 2001-11-06 | Nps Pharmaceuticals, Inc. | Calcium receptor-active molecules |
| US5763569A (en) * | 1991-08-23 | 1998-06-09 | The Brigham And Women's Hospital, Inc | Calcium receptor-active molecules |
| US5962314A (en) * | 1993-02-23 | 1999-10-05 | Nps Pharmaceuticals, Inc. | Calcium receptor-active molecules |
| CN1147459C (zh) | 1994-10-21 | 2004-04-28 | Nps药物有限公司 | 钙受体活性化合物 |
| US6057346A (en) * | 1994-12-12 | 2000-05-02 | The United States Of America As Represented By The Department Of Health And Human Services | Inhibition of retroviral LTR promoters by calcium response modifiers |
| US6084084A (en) * | 1996-02-21 | 2000-07-04 | Nps Pharmaceuticals, Inc. | Human metabotropic glutamate receptor |
| US6818660B2 (en) | 1996-04-09 | 2004-11-16 | Nps Pharmaceuticals, Inc. | Calcilytic compounds |
| AU726659B2 (en) | 1996-04-09 | 2000-11-16 | Nps Pharmaceuticals, Inc. | Calcilytic compounds |
| EP1258471B1 (de) * | 1996-05-01 | 2007-01-24 | Nps Pharmaceuticals, Inc. | Verbindungen, die auf anorganische Ionen-Rezeptoren wirken |
| EP1770083B1 (de) * | 1996-05-01 | 2009-04-29 | Nps Pharmaceuticals, Inc. | Inorganische am Ionen-Rezeptor aktive Verbindungen |
| ATE430123T1 (de) * | 1996-05-01 | 2009-05-15 | Nps Pharma Inc | Inorganische am ionen-rezeptor aktive verbindungen |
| US6184254B1 (en) | 1996-05-16 | 2001-02-06 | Board Of Regents, The University Of Texas System | Methods of identifying modulators of perivascular sensory nerve Ca2+ receptors |
| ES2364179T3 (es) | 1996-07-08 | 2011-08-26 | Kyowa Hakko Kirin Co., Ltd. | Compuestos con actividad receptora de calcio. |
| TW483881B (en) | 1996-12-03 | 2002-04-21 | Nps Pharma Inc | Calcilytic compounds |
| US7202261B2 (en) | 1996-12-03 | 2007-04-10 | Nps Pharmaceuticals, Inc. | Calcilytic compounds |
| FR2812875B1 (fr) * | 2000-08-08 | 2003-12-12 | Centre Nat Rech Scient | Nouvelles diamines possedant une activite modulatrice des casr et leur mode de preparation |
| US7176322B2 (en) * | 2002-05-23 | 2007-02-13 | Amgen Inc. | Calcium receptor modulating agents |
| US6908935B2 (en) | 2002-05-23 | 2005-06-21 | Amgen Inc. | Calcium receptor modulating agents |
| US6849761B2 (en) | 2002-09-05 | 2005-02-01 | Wyeth | Substituted naphthoic acid derivatives useful in the treatment of insulin resistance and hyperglycemia |
| EP1663182B2 (de) | 2003-09-12 | 2019-11-20 | Amgen Inc. | SCHNELL AUFLÖSENDE FORMULIERUNG VON CINACALCET HCl |
| WO2005065050A2 (ja) | 2003-12-25 | 2005-07-21 | Asahi Kasei Pharma Corporation | 2環化合物 |
| ES2561111T3 (es) * | 2004-05-28 | 2016-02-24 | Mitsubishi Tanabe Pharma Corporation | Arilalquilaminas y procedimiento para la producción de las mismas |
| US7361789B1 (en) | 2004-07-28 | 2008-04-22 | Amgen Inc. | Dihydronaphthalene compounds, compositions, uses thereof, and methods for synthesis |
| FR2885129B1 (fr) | 2005-04-29 | 2007-06-15 | Proskelia Sas | Nouveaux derives de l'ureee substituee parun thiazole ou benzothiazole, leur procede de preparation, leur application a titre de medicaments, les compositions pharmaceutiques les renfermant et utilisation. |
| WO2007027548A2 (en) * | 2005-09-02 | 2007-03-08 | Amgen Inc. | Methods of modulating intestinal fluid balance |
| AU2006316705B2 (en) | 2005-11-25 | 2011-09-29 | Galapagos Sas | Urea derivatives useful as calcium receptor modulators |
| CA2645494C (en) | 2006-03-23 | 2016-01-12 | Amgen Inc. | Methods and compositions for making and using polymorphs of cinacalcet |
| EP2010150A2 (de) | 2006-04-20 | 2009-01-07 | Amgen Inc. | Stabile emulsionsformulierungen |
| US8093299B2 (en) | 2007-03-30 | 2012-01-10 | Amgen Inc. | Methods of treating bowel disorders |
| JPWO2009107660A1 (ja) | 2008-02-25 | 2011-07-07 | 味の素株式会社 | 糖尿病又は肥満病の予防又は治療剤 |
| WO2009119554A1 (ja) | 2008-03-24 | 2009-10-01 | 味の素株式会社 | 消化管の重炭酸分泌促進剤 |
| EP2286836A4 (de) | 2008-04-17 | 2011-10-12 | Ajinomoto Kk | Immunstimulierendes mittel |
| WO2010042642A1 (en) * | 2008-10-08 | 2010-04-15 | Amgen Inc. | Calcium receptor modulating agents |
| WO2010104882A1 (en) | 2009-03-10 | 2010-09-16 | Amgen Inc. | Methods of modulating sperm motility |
| CN105968022A (zh) * | 2009-04-09 | 2016-09-28 | 考格尼申治疗股份有限公司 | 认知衰退的抑制剂 |
| EP2435404A1 (de) | 2009-05-27 | 2012-04-04 | Leo Pharma A/S | Neue, calciumempfindliche rezeptoren modulierende verbindungen und deren pharmazeutische verwendung |
| EP2435400A2 (de) | 2009-05-27 | 2012-04-04 | Leo Pharma A/S | Neue, den calcium sensing receptor modulierende verbindungen und deren pharmazeutische verwendung |
| BR112012002246A2 (pt) | 2009-07-31 | 2019-09-24 | Cognition Therapeutics Inc | composto, composto ou sal farmaceutico aceitavel deste, composição farmaceutica, metodo para inibir, tratar e/ou reduzir o declinio cognitivol e/ou doença de akzhmer em um paciente |
| RU2599788C2 (ru) | 2010-06-30 | 2016-10-20 | Лео Фарма А/С | Новая полиморфная форма кальцимиметического соединения |
| RU2599789C2 (ru) | 2010-06-30 | 2016-10-20 | Лео Фарма А/С | Новая полиморфная форма кальцимиметического соединения |
| JP2014508104A (ja) | 2010-11-26 | 2014-04-03 | レオ ファーマ アクティーゼルスカブ | カルシウム感知受容体活性化合物 |
| WO2012069419A1 (en) | 2010-11-26 | 2012-05-31 | Leo Pharma A/S | Calcium-sensing receptor-active compounds |
| EP2643298A1 (de) | 2010-11-26 | 2013-10-02 | Leo Pharma A/S | Substituierte cyclopentylazine als casr-aktive verbindungen |
| RU2013128973A (ru) | 2010-11-26 | 2015-01-10 | Лео Фарма А/С | Соединения, активные в отношении кальций-чувствительных рецепторов |
| GB201217330D0 (en) | 2012-09-28 | 2012-11-14 | Univ Cardiff | Therapeutic for treating inflammatory lung disorders |
| DK3099296T3 (en) | 2014-01-31 | 2019-04-15 | Cognition Therapeutics Inc | ISO-INDOLINE DERIVATIVES, COMPOSITIONS AND METHODS FOR TREATING NEURODEGENERATIVE DISEASE |
| WO2015136329A1 (en) | 2014-03-14 | 2015-09-17 | Abdi Ibrahim Ilac Sanayi Ve Ticaret Anonim Sirketi | Pharmaceutical composition of cinacalcet |
| IL270251B2 (en) | 2017-05-15 | 2025-01-01 | Cognition Therapeutics Inc | 1-Phenyl-1,1-dimethyl-2-(piperidinyl/pyrrolidinyl/piperazinyl)ethane derivatives and pharmaceutical preparations containing them |
| EP4108233A1 (de) | 2021-06-24 | 2022-12-28 | Faran S.A. | Orale lösung mit cinacalcet-salz |
| CN119811491A (zh) * | 2024-12-29 | 2025-04-11 | 中国农业科学院烟草研究所(中国烟草总公司青州烟草研究所) | 一种麦芽酚作为增甜物质的筛选验证方法 |
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| US5001251A (en) * | 1988-01-15 | 1991-03-19 | E. R. Squibb & Sons, Inc. | Optical resolution of DL-3-acylthio-2-methylpropanoic acid |
| EP0508307B1 (de) * | 1991-04-08 | 1995-11-29 | Sumitomo Chemical Company Limited | Optisch aktive Sekundär-Aminverbindung, Verfahren zur Herstellung einer optisch aktiven Sekundär-Aminverbindung und Verfahren zur Herstellung optisch aktiver Carbonsäure durch die Verwendung dieser Verbindung |
| ES2256370T3 (es) * | 1991-08-23 | 2006-07-16 | Nps Pharmaceuticals, Inc. | Moleculas activas para el receptor de calcio. |
| JP3175339B2 (ja) * | 1992-10-07 | 2001-06-11 | 住友化学工業株式会社 | 光学活性アミン化合物、その製法、その中間体及びその用途 |
| DE69333527T2 (de) * | 1993-02-23 | 2005-06-16 | Brigham & Women's Hospital, Inc., Boston | Calciumrezeptoraktive moleküle |
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- 1994-10-21 JP JP51224495A patent/JP4555401B2/ja not_active Expired - Fee Related
- 1994-10-21 PT PT94931982T patent/PT724561E/pt unknown
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2007
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| Publication number | Publication date |
|---|---|
| PT724561E (pt) | 2004-07-30 |
| CA2173747C (en) | 2006-05-23 |
| DK0724561T3 (da) | 2004-06-28 |
| EP0724561B1 (de) | 2004-04-14 |
| ES2218531T3 (es) | 2004-11-16 |
| JP2007145867A (ja) | 2007-06-14 |
| AU8087294A (en) | 1995-05-08 |
| CN1139917A (zh) | 1997-01-08 |
| DE69433714D1 (de) | 2004-05-19 |
| DE69433714T2 (de) | 2005-03-31 |
| JP4555401B2 (ja) | 2010-09-29 |
| WO1995011221A1 (en) | 1995-04-27 |
| CA2173747A1 (en) | 1995-04-27 |
| EP1466888A1 (de) | 2004-10-13 |
| JPH09504032A (ja) | 1997-04-22 |
| CN1192011C (zh) | 2005-03-09 |
| EP0724561A1 (de) | 1996-08-07 |
| HK1012620A1 (en) | 1999-08-06 |
| AU702629B2 (en) | 1999-02-25 |
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