ATE264306T1 - Synthese von 3-amino-2-chlor-4-methylpyridin aus malonsäuresäurenitril und aceton - Google Patents

Synthese von 3-amino-2-chlor-4-methylpyridin aus malonsäuresäurenitril und aceton

Info

Publication number: ATE264306T1
Authority: AT; Austria
Prior art keywords: methylpyridine; amino; chlorine; acetone; synthesis
Prior art date: 1999-01-22

Application number

AT00902349T

Other languages

English (en)

Inventor

Karl Grozinger

Original Assignee

Boehringer Ingelheim Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-01-22

Filing date

2000-01-06

Publication date

2004-04-15

2000-01-06 Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma

2004-04-15 Application granted granted Critical

2004-04-15 Publication of ATE264306T1 publication Critical patent/ATE264306T1/de

Links

CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 title 2
OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 title 2
230000015572 biosynthetic process Effects 0.000 title 1
238000003786 synthesis reaction Methods 0.000 title 1
UOBCYTOUXLAABU-UHFFFAOYSA-N 2-chloro-4-methylpyridin-3-amine Chemical compound CC1=CC=NC(Cl)=C1N UOBCYTOUXLAABU-UHFFFAOYSA-N 0.000 abstract 1
CUONGYYJJVDODC-UHFFFAOYSA-N malononitrile Chemical compound N#CCC#N CUONGYYJJVDODC-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/73—Unsubstituted amino or imino radicals

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pyridine Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

AT00902349T 1999-01-22 2000-01-06 Synthese von 3-amino-2-chlor-4-methylpyridin aus malonsäuresäurenitril und aceton ATE264306T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US11670499P	1999-01-22	1999-01-22
PCT/US2000/000332 WO2000043365A1 (en)	1999-01-22	2000-01-06	Synthesis of 3-amino-2-chloro-4-methylpyridine from malononitrile and acetone

Publications (1)

Publication Number	Publication Date
ATE264306T1 true ATE264306T1 (de)	2004-04-15

Family

ID=22368730

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT00902349T ATE264306T1 (de)	1999-01-22	2000-01-06	Synthese von 3-amino-2-chlor-4-methylpyridin aus malonsäuresäurenitril und aceton

Country Status (10)

Country	Link
US (1)	US6111112A (de)
EP (1)	EP1064265B8 (de)
JP (1)	JP2002535311A (de)
AT (1)	ATE264306T1 (de)
CA (1)	CA2318441A1 (de)
DE (1)	DE60009795T2 (de)
DK (1)	DK1064265T3 (de)
ES (1)	ES2218109T3 (de)
PT (1)	PT1064265E (de)
WO (1)	WO2000043365A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6399781B1 (en)	2000-10-10	2002-06-04	Boehringer Ingelheim Chemicals, Inc.	Process for making 3-amino-2-chloro-4-methylpyridine
CN100358871C (zh) *	2005-08-02	2008-01-02	江阴暨阳医药化工有限公司	氰乙酰胺和丙酮合成2-氯-3-氨基-4-甲基吡啶法
WO2012095691A1 (en) *	2011-01-15	2012-07-19	Jubilant Life Sciences Ltd.	An improved process for producing aminopyridines
CN112899318B (zh) *	2021-01-22	2022-10-11	沈阳药科大学	(E)-α-氰基-β-芳基丙烯酰胺类化合物的绿色制备方法
CN115504906A (zh) *	2021-06-22	2022-12-23	山东新时代药业有限公司	一种吉美嘧啶中间体化合物
CN113666865B (zh) *	2021-09-07	2023-05-26	杭州科耀医药科技有限公司	一种2-异丙基-3-氨基-4-甲基吡啶的合成方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5366972A (en) *	1989-04-20	1994-11-22	Boehringer Ingelheim Pharmaceuticals, Inc.	5,11-dihydro-6H-dipyrido(3,2-B:2',3'-E)(1,4)diazepines and their use in the prevention or treatment of HIV infection
US5200522A (en) *	1991-06-11	1993-04-06	Boehringer Ingelheim Pharmaceuticals, Inc.	Method for preparing 3-amino-2-chloro-4-alkylpyridines
WO1992022531A1 (en) *	1991-06-11	1992-12-23	Boehringer Ingelheim Pharmaceuticals, Inc.	Method for the preparation of 3-amino-2-chloro-4-alkylpyridines
US5654429A (en) *	1992-11-18	1997-08-05	Boehringer Ingelheim Pharma	Method for the preparation of 3-amino-2-chloro-4-alkylpyridines
CA2155214C (en) *	1993-12-02	2005-03-29	Heinrich Schneider	Method for preparing 3-amino-2-chloro-4-alkylpyridine or -4-arylpyridine

2000
- 2000-01-06 WO PCT/US2000/000332 patent/WO2000043365A1/en not_active Ceased
- 2000-01-06 DE DE60009795T patent/DE60009795T2/de not_active Expired - Fee Related
- 2000-01-06 JP JP2000594781A patent/JP2002535311A/ja not_active Ceased
- 2000-01-06 PT PT00902349T patent/PT1064265E/pt unknown
- 2000-01-06 CA CA002318441A patent/CA2318441A1/en not_active Abandoned
- 2000-01-06 US US09/478,558 patent/US6111112A/en not_active Expired - Lifetime
- 2000-01-06 DK DK00902349T patent/DK1064265T3/da active
- 2000-01-06 EP EP00902349A patent/EP1064265B8/de not_active Expired - Lifetime
- 2000-01-06 AT AT00902349T patent/ATE264306T1/de not_active IP Right Cessation
- 2000-01-06 ES ES00902349T patent/ES2218109T3/es not_active Expired - Lifetime

Also Published As

Publication number	Publication date
DE60009795T2 (de)	2005-03-17
CA2318441A1 (en)	2000-07-27
WO2000043365A1 (en)	2000-07-27
DK1064265T3 (da)	2004-05-10
PT1064265E (pt)	2004-07-30
EP1064265A4 (de)	2003-02-12
US6111112A (en)	2000-08-29
EP1064265B1 (de)	2004-04-14
EP1064265B8 (de)	2004-10-13
DE60009795D1 (en)	2004-05-19
EP1064265A1 (de)	2001-01-03
ES2218109T3 (es)	2004-11-16
JP2002535311A (ja)	2002-10-22

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Legal Events

Date

Code

Title

Description

2005-01-15

UEP

Publication of translation of european patent specification

Ref document number: 1064265

Country of ref document: EP

2009-10-15

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Ceased due to non-payment of the annual fee