ATE264306T1 - Synthese von 3-amino-2-chlor-4-methylpyridin aus malonsäuresäurenitril und aceton - Google Patents
Synthese von 3-amino-2-chlor-4-methylpyridin aus malonsäuresäurenitril und acetonInfo
- Publication number
- ATE264306T1 ATE264306T1 AT00902349T AT00902349T ATE264306T1 AT E264306 T1 ATE264306 T1 AT E264306T1 AT 00902349 T AT00902349 T AT 00902349T AT 00902349 T AT00902349 T AT 00902349T AT E264306 T1 ATE264306 T1 AT E264306T1
- Authority
- AT
- Austria
- Prior art keywords
- methylpyridine
- amino
- chlorine
- acetone
- synthesis
- Prior art date
Links
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 title 2
- OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 title 2
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- UOBCYTOUXLAABU-UHFFFAOYSA-N 2-chloro-4-methylpyridin-3-amine Chemical compound CC1=CC=NC(Cl)=C1N UOBCYTOUXLAABU-UHFFFAOYSA-N 0.000 abstract 1
- CUONGYYJJVDODC-UHFFFAOYSA-N malononitrile Chemical compound N#CCC#N CUONGYYJJVDODC-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/73—Unsubstituted amino or imino radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyridine Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11670499P | 1999-01-22 | 1999-01-22 | |
| PCT/US2000/000332 WO2000043365A1 (en) | 1999-01-22 | 2000-01-06 | Synthesis of 3-amino-2-chloro-4-methylpyridine from malononitrile and acetone |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE264306T1 true ATE264306T1 (de) | 2004-04-15 |
Family
ID=22368730
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00902349T ATE264306T1 (de) | 1999-01-22 | 2000-01-06 | Synthese von 3-amino-2-chlor-4-methylpyridin aus malonsäuresäurenitril und aceton |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6111112A (de) |
| EP (1) | EP1064265B8 (de) |
| JP (1) | JP2002535311A (de) |
| AT (1) | ATE264306T1 (de) |
| CA (1) | CA2318441A1 (de) |
| DE (1) | DE60009795T2 (de) |
| DK (1) | DK1064265T3 (de) |
| ES (1) | ES2218109T3 (de) |
| PT (1) | PT1064265E (de) |
| WO (1) | WO2000043365A1 (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6399781B1 (en) | 2000-10-10 | 2002-06-04 | Boehringer Ingelheim Chemicals, Inc. | Process for making 3-amino-2-chloro-4-methylpyridine |
| CN100358871C (zh) * | 2005-08-02 | 2008-01-02 | 江阴暨阳医药化工有限公司 | 氰乙酰胺和丙酮合成2-氯-3-氨基-4-甲基吡啶法 |
| WO2012095691A1 (en) * | 2011-01-15 | 2012-07-19 | Jubilant Life Sciences Ltd. | An improved process for producing aminopyridines |
| CN112899318B (zh) * | 2021-01-22 | 2022-10-11 | 沈阳药科大学 | (E)-α-氰基-β-芳基丙烯酰胺类化合物的绿色制备方法 |
| CN115504906A (zh) * | 2021-06-22 | 2022-12-23 | 山东新时代药业有限公司 | 一种吉美嘧啶中间体化合物 |
| CN113666865B (zh) * | 2021-09-07 | 2023-05-26 | 杭州科耀医药科技有限公司 | 一种2-异丙基-3-氨基-4-甲基吡啶的合成方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5366972A (en) * | 1989-04-20 | 1994-11-22 | Boehringer Ingelheim Pharmaceuticals, Inc. | 5,11-dihydro-6H-dipyrido(3,2-B:2',3'-E)(1,4)diazepines and their use in the prevention or treatment of HIV infection |
| US5200522A (en) * | 1991-06-11 | 1993-04-06 | Boehringer Ingelheim Pharmaceuticals, Inc. | Method for preparing 3-amino-2-chloro-4-alkylpyridines |
| JP3133331B2 (ja) * | 1991-06-11 | 2001-02-05 | ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド | ３―アミノ―２―クロロ―４―アルキルピリジン類の製造方法 |
| US5654429A (en) * | 1992-11-18 | 1997-08-05 | Boehringer Ingelheim Pharma | Method for the preparation of 3-amino-2-chloro-4-alkylpyridines |
| ATE192437T1 (de) * | 1993-12-02 | 2000-05-15 | Boehringer Ingelheim Pharma | Verfahren zur herstellung von 3-amino-2-chlor-4- alkyl- bzw. 4-cycloalkyl-pyridine |
-
2000
- 2000-01-06 DE DE60009795T patent/DE60009795T2/de not_active Expired - Fee Related
- 2000-01-06 WO PCT/US2000/000332 patent/WO2000043365A1/en not_active Ceased
- 2000-01-06 AT AT00902349T patent/ATE264306T1/de not_active IP Right Cessation
- 2000-01-06 CA CA002318441A patent/CA2318441A1/en not_active Abandoned
- 2000-01-06 DK DK00902349T patent/DK1064265T3/da active
- 2000-01-06 US US09/478,558 patent/US6111112A/en not_active Expired - Lifetime
- 2000-01-06 ES ES00902349T patent/ES2218109T3/es not_active Expired - Lifetime
- 2000-01-06 EP EP00902349A patent/EP1064265B8/de not_active Expired - Lifetime
- 2000-01-06 PT PT00902349T patent/PT1064265E/pt unknown
- 2000-01-06 JP JP2000594781A patent/JP2002535311A/ja not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| PT1064265E (pt) | 2004-07-30 |
| EP1064265A1 (de) | 2001-01-03 |
| WO2000043365A1 (en) | 2000-07-27 |
| ES2218109T3 (es) | 2004-11-16 |
| US6111112A (en) | 2000-08-29 |
| DE60009795D1 (en) | 2004-05-19 |
| CA2318441A1 (en) | 2000-07-27 |
| EP1064265B8 (de) | 2004-10-13 |
| JP2002535311A (ja) | 2002-10-22 |
| EP1064265A4 (de) | 2003-02-12 |
| DK1064265T3 (da) | 2004-05-10 |
| EP1064265B1 (de) | 2004-04-14 |
| DE60009795T2 (de) | 2005-03-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1064265 Country of ref document: EP |
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| REN | Ceased due to non-payment of the annual fee |