ATE264855T1 - 4-(aminoalkoxy)benzofurane als n- myristoyltransferasehemmer - Google Patents
4-(aminoalkoxy)benzofurane als n- myristoyltransferasehemmerInfo
- Publication number
- ATE264855T1 ATE264855T1 AT99968791T AT99968791T ATE264855T1 AT E264855 T1 ATE264855 T1 AT E264855T1 AT 99968791 T AT99968791 T AT 99968791T AT 99968791 T AT99968791 T AT 99968791T AT E264855 T1 ATE264855 T1 AT E264855T1
- Authority
- AT
- Austria
- Prior art keywords
- benzofuranes
- aminoalkoxy
- transferase inhibitors
- myristoyl transferase
- myristoyl
- Prior art date
Links
- 108010016306 Glycylpeptide N-tetradecanoyltransferase Proteins 0.000 title 1
- 239000003558 transferase inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D307/85—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C07F9/65515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring
- C07F9/65517—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring condensed with carbocyclic rings or carbocyclic ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Furan Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98124120 | 1998-12-18 | ||
| PCT/EP1999/009763 WO2000037464A2 (en) | 1998-12-18 | 1999-12-10 | 4-(aminoalkoxy)benzofurans as n-myristoyltransferase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE264855T1 true ATE264855T1 (de) | 2004-05-15 |
Family
ID=8233179
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99968791T ATE264855T1 (de) | 1998-12-18 | 1999-12-10 | 4-(aminoalkoxy)benzofurane als n- myristoyltransferasehemmer |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US6376491B1 (de) |
| EP (1) | EP1149094B1 (de) |
| JP (1) | JP3435404B2 (de) |
| KR (1) | KR20010081117A (de) |
| CN (1) | CN1333770A (de) |
| AR (1) | AR021714A1 (de) |
| AT (1) | ATE264855T1 (de) |
| AU (1) | AU754233B2 (de) |
| BR (1) | BR9916318A (de) |
| CA (1) | CA2355694A1 (de) |
| DE (1) | DE69916664T2 (de) |
| DK (1) | DK1149094T3 (de) |
| ES (1) | ES2217882T3 (de) |
| MX (1) | MXPA01006218A (de) |
| PE (1) | PE20001324A1 (de) |
| TR (1) | TR200101779T2 (de) |
| WO (1) | WO2000037464A2 (de) |
| ZA (1) | ZA200104410B (de) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2244438T3 (es) | 1999-05-24 | 2005-12-16 | Mitsubishi Pharma Corporation | Compuestos de fenoxipropilamina. |
| SE9902987D0 (sv) * | 1999-08-24 | 1999-08-24 | Astra Pharma Prod | Novel compounds |
| JP4042566B2 (ja) * | 2000-11-27 | 2008-02-06 | 田辺三菱製薬株式会社 | ピペリジン化合物およびその医薬用途 |
| US7078541B2 (en) * | 2002-02-07 | 2006-07-18 | Galileo Pharmaceuticals, Inc. | Benzofuran derivatives |
| US6653346B1 (en) * | 2002-02-07 | 2003-11-25 | Galileo Pharmaceuticals, Inc. | Cytoprotective benzofuran derivatives |
| WO2006015279A1 (en) * | 2004-07-28 | 2006-02-09 | Neurogen Corporation | Heterocyclic diamine compounds as ligands of the melanin concentrating hormone receptor useful for the treatment of obesity, diabetes, eating and sexual disorders |
| US7737166B2 (en) * | 2005-08-17 | 2010-06-15 | Daiichi Sankyo Company, Limited | Antifungal bicyclic hetero ring compounds |
| US20090270496A1 (en) * | 2007-05-03 | 2009-10-29 | Courchesne William E | Antifungal compounds |
| GB0815947D0 (en) * | 2008-09-02 | 2008-10-08 | Univ Dundee | Compounds |
| AU2009304596A1 (en) | 2008-10-17 | 2010-04-22 | Akaal Pharma Pty Ltd | S1P receptors modulators |
| WO2010043000A1 (en) | 2008-10-17 | 2010-04-22 | Akaal Pharma Pty Ltd | S1p receptors modulators and their use thereof |
| GB201120993D0 (en) | 2011-12-06 | 2012-01-18 | Imp Innovations Ltd | Novel compounds and their use in therapy |
| GB201511382D0 (en) | 2015-06-29 | 2015-08-12 | Imp Innovations Ltd | Novel compounds and their use in therapy |
| CN107540725B (zh) * | 2016-06-29 | 2020-04-07 | 孙青� | 一种水溶性丹参酮ⅱa衍生物及其制备与应用 |
| GB201820660D0 (en) | 2018-12-19 | 2019-01-30 | Imperial Innovations Ltd | Cancer treatments |
| GB201820659D0 (en) | 2018-12-19 | 2019-01-30 | Imperial Innovations Ltd | Novel compostions and their use in therapy |
| GB202014736D0 (en) | 2020-09-18 | 2020-11-04 | Imperial College Innovations Ltd | Novel compounds and their use in therapy |
| GB202017367D0 (en) | 2020-11-02 | 2020-12-16 | Imperial College Innovations Ltd | Novel use |
| WO2024052685A1 (en) | 2022-09-09 | 2024-03-14 | MyricX Pharma Limited | Cytotoxic imidazo[1,2-a]pyridine compounds and their use in therapy |
| GB202403391D0 (en) | 2024-03-08 | 2024-04-24 | Myricx Pharma Ltd | Novel compounds and their use in therapy |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1129072A (en) * | 1966-02-01 | 1968-10-02 | Ici Ltd | Benzofuran and indole derivatives |
| GB1256735A (de) * | 1969-03-06 | 1971-12-15 | ||
| CA989411A (en) * | 1971-05-13 | 1976-05-18 | Kakenyaku Kako Co. | Benzofuran derivatives and preparation thereof |
| US4056626A (en) | 1971-05-13 | 1977-11-01 | Kakenyaku Kako Co., Ltd. | Pharmaceutical composition containing benzofuran derivative |
| CA1089866A (en) * | 1975-10-20 | 1980-11-18 | Kiyoshi Ito | Benzofuran derivatives, preparation thereof and pharmaceutical compositions thereof |
| SU671256A1 (ru) * | 1977-06-08 | 1986-11-23 | Всесоюзный Научно-Исследовательский Химико-Фармацевтический Институт Им.С.Орджоникидзе | Гидрохлорид 1-(2-карбэтокси-3-метилбензофуран-4-илокси-3-изопропиламино)-2-пропанола,обладающий антиаритмическим и @ -адреноблокирующим действием |
| JPS5740479A (en) * | 1980-08-21 | 1982-03-06 | Kaken Pharmaceut Co Ltd | Preparation of benzofuran derivative and its acid addition salt |
| EP0146243A1 (de) * | 1983-10-31 | 1985-06-26 | Merck Frosst Canada Inc. | Lipoxygenase-Inhibitoren |
| US5082967A (en) * | 1988-06-16 | 1992-01-21 | Washington University | Novel fatty acid analog enzyme substrates |
| FR2672598A1 (fr) * | 1991-02-11 | 1992-08-14 | Adir | Nouveaux inhibiteurs de n-myristoyltransferase, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| JPH07215940A (ja) * | 1994-01-27 | 1995-08-15 | Torii Yakuhin Kk | 抗ウイルス活性を有する化合物 |
| JPH08198826A (ja) * | 1995-01-23 | 1996-08-06 | Torii Yakuhin Kk | 抗ウイルス活性を有する化合物 |
-
1999
- 1999-12-10 ES ES99968791T patent/ES2217882T3/es not_active Expired - Lifetime
- 1999-12-10 AT AT99968791T patent/ATE264855T1/de not_active IP Right Cessation
- 1999-12-10 BR BR9916318-7A patent/BR9916318A/pt not_active IP Right Cessation
- 1999-12-10 TR TR2001/01779T patent/TR200101779T2/xx unknown
- 1999-12-10 DE DE69916664T patent/DE69916664T2/de not_active Expired - Fee Related
- 1999-12-10 KR KR1020017007661A patent/KR20010081117A/ko not_active Abandoned
- 1999-12-10 DK DK99968791T patent/DK1149094T3/da active
- 1999-12-10 WO PCT/EP1999/009763 patent/WO2000037464A2/en not_active Ceased
- 1999-12-10 CN CN99815722A patent/CN1333770A/zh active Pending
- 1999-12-10 JP JP2000589535A patent/JP3435404B2/ja not_active Expired - Fee Related
- 1999-12-10 AU AU26606/00A patent/AU754233B2/en not_active Ceased
- 1999-12-10 CA CA002355694A patent/CA2355694A1/en not_active Abandoned
- 1999-12-10 EP EP99968791A patent/EP1149094B1/de not_active Expired - Lifetime
- 1999-12-10 MX MXPA01006218A patent/MXPA01006218A/es unknown
- 1999-12-14 PE PE1999001249A patent/PE20001324A1/es not_active Application Discontinuation
- 1999-12-15 US US09/464,240 patent/US6376491B1/en not_active Expired - Fee Related
- 1999-12-16 AR ARP990106457A patent/AR021714A1/es not_active Application Discontinuation
-
2001
- 2001-05-29 ZA ZA200104410A patent/ZA200104410B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2000037464A2 (en) | 2000-06-29 |
| EP1149094A2 (de) | 2001-10-31 |
| DE69916664T2 (de) | 2005-03-31 |
| AU754233B2 (en) | 2002-11-07 |
| CN1333770A (zh) | 2002-01-30 |
| WO2000037464A3 (en) | 2000-11-02 |
| MXPA01006218A (es) | 2002-04-17 |
| PE20001324A1 (es) | 2000-12-02 |
| JP3435404B2 (ja) | 2003-08-11 |
| DE69916664D1 (de) | 2004-05-27 |
| TR200101779T2 (tr) | 2001-12-21 |
| ES2217882T3 (es) | 2004-11-01 |
| DK1149094T3 (da) | 2004-08-16 |
| JP2002533340A (ja) | 2002-10-08 |
| BR9916318A (pt) | 2001-08-14 |
| US6376491B1 (en) | 2002-04-23 |
| ZA200104410B (en) | 2002-08-29 |
| KR20010081117A (ko) | 2001-08-27 |
| AR021714A1 (es) | 2002-07-31 |
| CA2355694A1 (en) | 2000-06-29 |
| AU2660600A (en) | 2000-07-12 |
| EP1149094B1 (de) | 2004-04-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1149094 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |