ATE264867T1 - Reduzierung von gelation von fettsäureacylierten proteinen unter nutzung von zitratpuffer - Google Patents

Reduzierung von gelation von fettsäureacylierten proteinen unter nutzung von zitratpuffer

Info

Publication number: ATE264867T1
Authority: AT; Austria
Prior art keywords: citrate buffer; processing; acylated proteins; fatty acylated; gelation
Prior art date: 1995-06-07

Application number

AT96303973T

Other languages

German (de)

English (en)

Inventor

Jeffrey Clayton Baker

Jose M Hanquier

Warren E Shrader

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-06-07

Filing date

1996-05-31

Publication date

2004-05-15

1996-05-31 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

2004-05-15 Application granted granted Critical

2004-05-15 Publication of ATE264867T1 publication Critical patent/ATE264867T1/de

Links

239000007979 citrate buffer Substances 0.000 title abstract 2
238000001879 gelation Methods 0.000 title abstract 2
108091005632 fatty acylated proteins Proteins 0.000 title 1
238000000034 method Methods 0.000 abstract 2
108090000623 proteins and genes Proteins 0.000 abstract 2
102000004169 proteins and genes Human genes 0.000 abstract 2
KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 abstract 1
101000976075 Homo sapiens Insulin Proteins 0.000 abstract 1
239000000872 buffer Substances 0.000 abstract 1
239000006172 buffering agent Substances 0.000 abstract 1
PBGKTOXHQIOBKM-FHFVDXKLSA-N insulin (human) Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 PBGKTOXHQIOBKM-FHFVDXKLSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Zoology (AREA)
Genetics & Genomics (AREA)
Gastroenterology & Hepatology (AREA)
Endocrinology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Toxicology (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Diabetes (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Fats And Perfumes (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT96303973T 1995-06-07 1996-05-31 Reduzierung von gelation von fettsäureacylierten proteinen unter nutzung von zitratpuffer ATE264867T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US08/484,545 US5631347A (en)	1995-06-07	1995-06-07	Reducing gelation of a fatty acid-acylated protein

Publications (1)

Publication Number	Publication Date
ATE264867T1 true ATE264867T1 (de)	2004-05-15

Family

ID=23924602

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT96303973T ATE264867T1 (de)	1995-06-07	1996-05-31	Reduzierung von gelation von fettsäureacylierten proteinen unter nutzung von zitratpuffer

Country Status (10)

Country	Link
US (1)	US5631347A (2)
EP (1)	EP0747390B1 (2)
JP (1)	JP3962430B2 (2)
AT (1)	ATE264867T1 (2)
AU (1)	AU5951596A (2)
CA (1)	CA2223531A1 (2)
DE (1)	DE69632224T2 (2)
DK (1)	DK0747390T3 (2)
ES (1)	ES2218569T3 (2)
WO (1)	WO1996040188A1 (2)

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ATE541582T1 (de)	2003-06-03	2012-02-15	Novo Nordisk As	Stabilisierte pharmazeutische glp-1 peptid zusammensetzungen
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BRPI0513508B1 (pt)	2004-07-19	2021-06-01	Biocon Limited	Conjugados de insulina-oligômero, formulações e usos desses
US8710181B2 (en)	2004-08-31	2014-04-29	Novo Nordisk A/S	Use of tris(hydroxymethyl) aminomethane for the stabilization of peptides, polypeptides and proteins
RU2413530C9 (ru)	2004-11-12	2021-05-18	Ново Нордиск А/С	Стабильные препараты инсулинотропных пептидов
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1995
- 1995-06-07 US US08/484,545 patent/US5631347A/en not_active Expired - Lifetime
1996
- 1996-05-31 DE DE69632224T patent/DE69632224T2/de not_active Expired - Fee Related
- 1996-05-31 DK DK96303973T patent/DK0747390T3/da active
- 1996-05-31 ES ES96303973T patent/ES2218569T3/es not_active Expired - Lifetime
- 1996-05-31 EP EP96303973A patent/EP0747390B1/en not_active Expired - Lifetime
- 1996-05-31 AT AT96303973T patent/ATE264867T1/de not_active IP Right Cessation
- 1996-06-04 CA CA002223531A patent/CA2223531A1/en not_active Abandoned
- 1996-06-04 JP JP50083397A patent/JP3962430B2/ja not_active Expired - Fee Related
- 1996-06-04 AU AU59515/96A patent/AU5951596A/en not_active Abandoned
- 1996-06-04 WO PCT/US1996/007965 patent/WO1996040188A1/en not_active Ceased

Also Published As

Publication number	Publication date
EP0747390A3 (en)	1997-06-04
CA2223531A1 (en)	1996-12-19
JPH11506739A (ja)	1999-06-15
DE69632224D1 (de)	2004-05-27
US5631347A (en)	1997-05-20
EP0747390B1 (en)	2004-04-21
WO1996040188A1 (en)	1996-12-19
JP3962430B2 (ja)	2007-08-22
DE69632224T2 (de)	2005-04-14
EP0747390A2 (en)	1996-12-11
ES2218569T3 (es)	2004-11-16
AU5951596A (en)	1996-12-30
DK0747390T3 (da)	2004-07-26

Legal Events

Date	Code	Title	Description
2004-10-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE264867T1 (de)	2004-05-15	Reduzierung von gelation von fettsäureacylierten proteinen unter nutzung von zitratpuffer
ATE388162T1 (de)	2008-03-15	Verfahren zur beseitigung von viren
HUP9900920A2 (hu)	1999-07-28	Eljárás emlőssejt-tenyészetekben termelt proteinek szializációjának szabályozására
NZ225032A (en)	1991-02-26	Method of extracting protein from microbial cells
DE3686654D1 (de)	1992-10-08	Verfahren zur isolierung rekombinanter polypeptide in biologisch aktiver form.
HUP9900768A2 (hu)	1999-06-28	Photorhabdusból származó inszekticid protein toxinok
AU6687486A (en)	1987-06-18	Solubilization of protein aggregates
DK0378382T3 (da)	1997-06-16	Rekombinant DNA-fremgangsmåde og værtsceller
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ATE278781T1 (de)	2004-10-15	Tioredioxine h aus zwig und hart-weizen und ähnliche proteine, diese kodierende dna-fragmente und verfahren zu ihrer herstellung
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Tani et al.	1996	Academy of Dental Materials
KR930013106A (ko)	1993-07-21	연어 성장 호르몬의 정제 방법