ATE265538T1 - Verfahren zur sekretion thrombopoitin polypeptide - Google Patents
Verfahren zur sekretion thrombopoitin polypeptideInfo
- Publication number
- ATE265538T1 ATE265538T1 AT95944594T AT95944594T ATE265538T1 AT E265538 T1 ATE265538 T1 AT E265538T1 AT 95944594 T AT95944594 T AT 95944594T AT 95944594 T AT95944594 T AT 95944594T AT E265538 T1 ATE265538 T1 AT E265538T1
- Authority
- AT
- Austria
- Prior art keywords
- dna constructs
- polypeptides
- dna
- thrombopoietin
- secretory peptide
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 2
- 229920001184 polypeptide Polymers 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 230000028327 secretion Effects 0.000 title 1
- 102000036693 Thrombopoietin Human genes 0.000 abstract 3
- 108010041111 Thrombopoietin Proteins 0.000 abstract 3
- 230000003248 secreting effect Effects 0.000 abstract 3
- 210000003527 eukaryotic cell Anatomy 0.000 abstract 2
- 230000004927 fusion Effects 0.000 abstract 2
- 230000006337 proteolytic cleavage Effects 0.000 abstract 1
- 238000013518 transcription Methods 0.000 abstract 1
- 230000035897 transcription Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
- C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/524—Thrombopoietin, i.e. C-MPL ligand
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
- C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21069—Protein C activated (3.4.21.69)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/036—Fusion polypeptide containing a localisation/targetting motif targeting to the medium outside of the cell, e.g. type III secretion
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/347,029 US5641655A (en) | 1994-11-30 | 1994-11-30 | Methods for producing thrombopoietin polypeptides using a mammalian tissue plasminogen activator secretory peptide |
| PCT/US1995/014932 WO1996017067A1 (en) | 1994-11-30 | 1995-11-15 | Method for secreting thrombopoietin polypeptides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE265538T1 true ATE265538T1 (de) | 2004-05-15 |
Family
ID=23362032
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT95944594T ATE265538T1 (de) | 1994-11-30 | 1995-11-15 | Verfahren zur sekretion thrombopoitin polypeptide |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US5641655A (de) |
| EP (1) | EP0799317B8 (de) |
| JP (1) | JP2002514887A (de) |
| KR (1) | KR100320106B1 (de) |
| CN (1) | CN1171819A (de) |
| AT (1) | ATE265538T1 (de) |
| AU (1) | AU689373B2 (de) |
| CA (1) | CA2206399C (de) |
| DE (1) | DE69532968T2 (de) |
| NZ (1) | NZ301858A (de) |
| WO (1) | WO1996017067A1 (de) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8357513B1 (en) | 1994-01-03 | 2013-01-22 | Genentech, Inc. | Nucleic acids encoding mpl ligand (thrombopoietin) and fragments thereof |
| US5641665A (en) * | 1994-11-28 | 1997-06-24 | Vical Incorporated | Plasmids suitable for IL-2 expression |
| US6251864B1 (en) | 1995-06-07 | 2001-06-26 | Glaxo Group Limited | Peptides and compounds that bind to a receptor |
| US5869451A (en) * | 1995-06-07 | 1999-02-09 | Glaxo Group Limited | Peptides and compounds that bind to a receptor |
| CN1966520B (zh) | 1995-06-07 | 2012-07-11 | 葛兰素集团有限公司 | 结合血小板生成素受体的肽和化合物 |
| US7091311B2 (en) | 1996-06-07 | 2006-08-15 | Smithkline Beecham Corporation | Peptides and compounds that bind to a receptor |
| US6884419B1 (en) | 1996-12-23 | 2005-04-26 | Kyowa Hakko Kogyo, Co., Ltd. | hG-CSF fusion polypeptide having c-mpl activity, DNA coding for same and methods of treating anemia using same |
| WO1999053059A1 (en) * | 1998-04-16 | 1999-10-21 | Genentech, Inc. | Secretion of glycosylated proteins using a tissue plasminogen activator pro-sequence |
| KR19990081421A (ko) * | 1998-04-29 | 1999-11-15 | 성재갑 | 동물세포를 이용한 인간 혈소판 생성 촉진인자(tpo)의 제조방법 |
| AU761021B2 (en) * | 1998-07-10 | 2003-05-29 | U.S. Medical Research Institute Of Infectious Diseases Department Of The Army | Vaccine against staphylococcus intoxication |
| US6770479B1 (en) | 1998-07-10 | 2004-08-03 | The United States Of America As Represented By The Secretary Of The Army | Anthrax vaccine |
| ATE348163T1 (de) * | 1998-10-23 | 2007-01-15 | Amgen Inc | Thrombopoietin substitute |
| DE69939330D1 (de) | 1998-12-07 | 2008-09-25 | Zymogenetics Inc | Wachstumsfaktor-homologe zvegf-3 |
| DE60034564T2 (de) | 1999-07-07 | 2007-12-27 | Zymogenetics, Inc., Seattle | Menschlicher cytokinrezeptor |
| ES2286128T3 (es) | 2000-06-30 | 2007-12-01 | Zymogenetics, Inc. | Proteina zcyto21 tipo interferon. |
| US6673580B2 (en) * | 2000-10-27 | 2004-01-06 | Genentech, Inc. | Identification and modification of immunodominant epitopes in polypeptides |
| JP4363986B2 (ja) * | 2001-12-21 | 2009-11-11 | イミュネックス・コーポレーション | タンパク質の精製方法 |
| US20040028661A1 (en) * | 2002-08-07 | 2004-02-12 | Bartelmez Stephen H. | Expansion of cells using thrombopoietin and anti-transforming growth factor-beta |
| DK1542714T3 (da) | 2002-09-18 | 2014-05-26 | Janssen Pharmaceuticals Inc | Fremgangsmåder til forøgelse af produktion af blodplader og hæmatopoietiske stamceller |
| JP4808157B2 (ja) | 2003-08-07 | 2011-11-02 | ザイモジェネティクス リミテッド ライアビリティ カンパニー | Ｉｌ−２８およびｉｌ−２９の均一な調製物 |
| RS20060141A (sr) | 2003-08-28 | 2008-08-07 | Ortho-Mcneil Pharmaceutical Inc., | Peptidi i jedinjenja koja se vežu za receptor |
| CA2558811A1 (en) | 2004-03-08 | 2005-09-22 | Zymogenetics, Inc. | Dimeric fusion proteins and materials and methods for producing them |
| US7351689B2 (en) | 2004-07-29 | 2008-04-01 | Zymogenetics, Inc. | Use of IL-28 and IL-29 to treat cancer and autoimmune disorders |
| WO2006086396A2 (en) | 2005-02-08 | 2006-08-17 | Zymogenetics, Inc. | Anti-il-20, anti-il-22 and anti-il-22ra antibodies and binding partners and methods of using in inflammation |
| EP3683230A1 (de) | 2005-05-12 | 2020-07-22 | ZymoGenetics, Inc. | Zusammensetzungen und verfahren zur modulation von immunsystemreaktionen |
| US20120003241A1 (en) * | 2007-08-09 | 2012-01-05 | University Of Rochester | Vaccine against botulism |
| US7858759B2 (en) | 2007-10-04 | 2010-12-28 | Zymogenetics, Inc. | Anti-zB7H6 antibody-drug conjugates |
| CN101918437B (zh) | 2007-11-21 | 2013-08-14 | 罗斯基勒大学 | 具有冰结合活性的多肽 |
| KR101720760B1 (ko) * | 2008-01-25 | 2017-03-28 | 오르후스 우니베르시테트 | Ｉｇｆｂｐ-4에 대한 ｐａｐｐ-ａ 활성의 선택적 엑소사이트 억제 |
| JP5425180B2 (ja) | 2008-03-27 | 2014-02-26 | ザイモジェネティクス， インコーポレイテッド | ＰＤＧＦＲβおよびＶＥＧＦ−Ａを阻害するための組成物および方法 |
| WO2009158696A1 (en) | 2008-06-27 | 2009-12-30 | Zymogenetics, Inc. | SOLUBLE HYBRID Fcγ RECEPTORS AND RELATED METHODS |
| EP2580238A1 (de) | 2010-06-09 | 2013-04-17 | Zymogenetics, Inc. | Dimere vstm3-fusionsproteine sowie zugehörige zusammensetzungen und verfahren |
| ES2635595T3 (es) * | 2010-11-16 | 2017-10-04 | Cadila Healthcare Limited | Un nuevo procedimiento para la purificación del activador tisular del plasminógeno |
| WO2014202089A2 (en) | 2013-06-18 | 2014-12-24 | Roskilde Universitet | Variants of anti-freeze polypeptides |
| CN107969127B (zh) | 2015-09-08 | 2022-09-06 | 赛瑞品股份有限公司 | Apoa-1融合多肽及相关组合物和方法 |
| WO2018136163A2 (en) | 2016-12-09 | 2018-07-26 | Theripion, Inc. | Tandem apoa-1 fusion polypeptides |
| EP4294916A2 (de) | 2021-02-19 | 2023-12-27 | Theripion, Inc. | Dnase-fusionspolypeptide sowie zugehörige zusammensetzungen und verfahren |
| WO2024259220A1 (en) | 2023-06-15 | 2024-12-19 | Theripion, Inc. | Pon3 and evolved pon1 fusion polypeptides |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE69026B1 (en) * | 1987-06-12 | 1996-08-07 | Immuno Ag | Novel proteins with factor VIII activity process for their preparation using genetically-engineered cells and pharmaceutical compositions containing them |
| US5037743A (en) * | 1988-08-05 | 1991-08-06 | Zymogenetics, Inc. | BAR1 secretion signal |
| US5326700A (en) * | 1990-11-06 | 1994-07-05 | Eli Lilly And Company | DNA sequences encoding t-PA derivatives with cleavable sites |
| CA2097291A1 (en) * | 1990-12-13 | 1992-06-14 | David P. Gearing | Leukemia inhibitory factor receptors |
| WO1996017062A1 (en) * | 1994-11-30 | 1996-06-06 | Zymogenetics, Inc. | Low molecular weight thrombopoietin |
-
1994
- 1994-11-30 US US08/347,029 patent/US5641655A/en not_active Expired - Lifetime
-
1995
- 1995-11-15 JP JP51885196A patent/JP2002514887A/ja not_active Ceased
- 1995-11-15 AT AT95944594T patent/ATE265538T1/de not_active IP Right Cessation
- 1995-11-15 EP EP95944594A patent/EP0799317B8/de not_active Expired - Lifetime
- 1995-11-15 CA CA002206399A patent/CA2206399C/en not_active Expired - Fee Related
- 1995-11-15 DE DE69532968T patent/DE69532968T2/de not_active Expired - Fee Related
- 1995-11-15 AU AU47376/96A patent/AU689373B2/en not_active Ceased
- 1995-11-15 KR KR1019970703625A patent/KR100320106B1/ko not_active Expired - Fee Related
- 1995-11-15 CN CN95197141A patent/CN1171819A/zh active Pending
- 1995-11-15 WO PCT/US1995/014932 patent/WO1996017067A1/en not_active Ceased
- 1995-11-15 NZ NZ301858A patent/NZ301858A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN1171819A (zh) | 1998-01-28 |
| EP0799317B8 (de) | 2006-06-07 |
| NZ301858A (en) | 1999-01-28 |
| US5641655A (en) | 1997-06-24 |
| JP2002514887A (ja) | 2002-05-21 |
| EP0799317B1 (de) | 2004-04-28 |
| DE69532968T2 (de) | 2004-10-21 |
| CA2206399A1 (en) | 1996-06-06 |
| WO1996017067A1 (en) | 1996-06-06 |
| AU4737696A (en) | 1996-06-19 |
| EP0799317A1 (de) | 1997-10-08 |
| CA2206399C (en) | 2001-02-20 |
| DE69532968D1 (de) | 2004-06-03 |
| AU689373B2 (en) | 1998-03-26 |
| KR100320106B1 (ko) | 2002-02-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |