ATE267815T1 - Verfahren zur herstellung von piperasäure und ihre umwandlung zur n-acylierten n,n-verknüpfung enthaltenden bicyclischen ringen als zwischenprodukte für caspase hemmende verbindungen - Google Patents
Verfahren zur herstellung von piperasäure und ihre umwandlung zur n-acylierten n,n-verknüpfung enthaltenden bicyclischen ringen als zwischenprodukte für caspase hemmende verbindungenInfo
- Publication number
- ATE267815T1 ATE267815T1 AT99943814T AT99943814T ATE267815T1 AT E267815 T1 ATE267815 T1 AT E267815T1 AT 99943814 T AT99943814 T AT 99943814T AT 99943814 T AT99943814 T AT 99943814T AT E267815 T1 ATE267815 T1 AT E267815T1
- Authority
- AT
- Austria
- Prior art keywords
- acylated
- conversion
- producing
- intermediate products
- inhibiting compounds
- Prior art date
Links
- 108010076667 Caspases Proteins 0.000 title abstract 2
- 102000011727 Caspases Human genes 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- RHBGITBPARBDPH-UHFFFAOYSA-N (2E,4E)-5-(3,4-methylenedioxyphenyl)-2,4-pentadienoic acid Natural products OC(=O)C=CC=CC1=CC=C2OCOC2=C1 RHBGITBPARBDPH-UHFFFAOYSA-N 0.000 title 1
- RHBGITBPARBDPH-ZPUQHVIOSA-N (E,E)-piperic acid Chemical compound OC(=O)\C=C\C=C\C1=CC=C2OCOC2=C1 RHBGITBPARBDPH-ZPUQHVIOSA-N 0.000 title 1
- 238000006243 chemical reaction Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 230000002401 inhibitory effect Effects 0.000 title 1
- 239000013067 intermediate product Substances 0.000 title 1
- WVWHRXVVAYXKDE-UHFFFAOYSA-N piperine Natural products O=C(C=CC=Cc1ccc2OCOc2c1)C3CCCCN3 WVWHRXVVAYXKDE-UHFFFAOYSA-N 0.000 title 1
- 238000000034 method Methods 0.000 abstract 4
- 239000003112 inhibitor Substances 0.000 abstract 2
- RFIOZSIHFNEKFF-UHFFFAOYSA-N piperazine-1-carboxylic acid Chemical compound OC(=O)N1CCNCC1 RFIOZSIHFNEKFF-UHFFFAOYSA-N 0.000 abstract 2
- 230000002194 synthesizing effect Effects 0.000 abstract 2
- 108090000426 Caspase-1 Proteins 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- -1 bicyclic compound Chemical class 0.000 abstract 1
- 125000002619 bicyclic group Chemical group 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/136,339 US6201118B1 (en) | 1998-08-19 | 1998-08-19 | Process for forming an N-acylated, N,N-containing bicyclic ring from piperazic acid or an ester thereof especially useful as an intermediate in the manufacture of a caspase inhibitor |
| US09/235,894 US6177565B1 (en) | 1998-08-19 | 1999-01-22 | Process for synthesizing piperazic acid |
| PCT/US1999/019080 WO2000010979A1 (en) | 1998-08-19 | 1999-08-19 | Process for preparing piperazic acid and its conversion to n-acylated bicyclic rings containing n,n-linkages useful as intermediates for caspase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE267815T1 true ATE267815T1 (de) | 2004-06-15 |
Family
ID=26834217
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99943814T ATE267815T1 (de) | 1998-08-19 | 1999-08-19 | Verfahren zur herstellung von piperasäure und ihre umwandlung zur n-acylierten n,n-verknüpfung enthaltenden bicyclischen ringen als zwischenprodukte für caspase hemmende verbindungen |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6177565B1 (de) |
| EP (1) | EP1104409B1 (de) |
| AT (1) | ATE267815T1 (de) |
| AU (1) | AU5684099A (de) |
| DE (1) | DE69917648T2 (de) |
| DK (1) | DK1104409T3 (de) |
| ES (1) | ES2221430T3 (de) |
| PT (1) | PT1104409E (de) |
| WO (1) | WO2000010979A1 (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2777889B1 (fr) * | 1998-04-27 | 2004-07-09 | Hoechst Marion Roussel Inc | Nouveaux derives de l'acide octahydro-6,10-dioxo-6h- pyridazino[1,2-a][1,2]diazepine-1-carboxylique, leur procede de preparation et leur application a la preparation de composes therapeutiquement actifs |
| US6492170B1 (en) | 2000-09-11 | 2002-12-10 | Isis Pharmaceuticals, Inc. | Antisense modulation of caspase 9 expression |
| US6566135B1 (en) | 2000-10-04 | 2003-05-20 | Isis Pharmaceuticals, Inc. | Antisense modulation of caspase 6 expression |
| FR2853901B1 (fr) * | 2003-04-16 | 2005-06-17 | Isochem Sa | Procede de preparation de derives de l'acide hexahydropyridazine-3-carboxylique |
| DE10328888A1 (de) * | 2003-06-26 | 2005-01-20 | Honeywell Specialty Chemicals Seelze Gmbh | Verbessertes Verfahren zur Herstellung von 1,2-disubstituierten Hexahydropyridazin-3-carbonsäuren und deren Estern |
| WO2005028449A1 (en) * | 2003-06-26 | 2005-03-31 | Honeywell Specialty Chemicals Seelze Gmbh | Improved process for the manufacture of 1,2-disubstituted hexahydropyridazine-3-carboxylic acids and esters thereof |
| CN100404516C (zh) * | 2004-02-13 | 2008-07-23 | 大连绿源药业有限责任公司 | 六氢哒嗪三羧酸酯的制备方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6204261B1 (en) | 1995-12-20 | 2001-03-20 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1β Converting enzyme inhibitors |
| GB2128984B (en) * | 1982-05-12 | 1985-05-22 | Hoffmann La Roche | Diaza-bicyclic compounds |
| US4692438A (en) * | 1984-08-24 | 1987-09-08 | Hoffmann-La Roche Inc. | Pyridazo-diazepines, diazocines, and -triazepines having anti-hypertensive activity |
| DK0640086T3 (da) | 1992-05-15 | 1999-12-06 | Merrell Pharma Inc | Mercaptoacetylamido-pyridazo[1,2-a][1,2]diazepin-derivateranvendelige som enkephalinase- og ACE-inhibitorer |
| GB9223739D0 (en) | 1992-11-12 | 1992-12-23 | Univ London | Process for the preparation of (3r) and (3s) piperazic acid derivatives |
| US5716929A (en) | 1994-06-17 | 1998-02-10 | Vertex Pharmaceuticals, Inc. | Inhibitors of interleukin-1β converting enzyme |
| FR2777889B1 (fr) | 1998-04-27 | 2004-07-09 | Hoechst Marion Roussel Inc | Nouveaux derives de l'acide octahydro-6,10-dioxo-6h- pyridazino[1,2-a][1,2]diazepine-1-carboxylique, leur procede de preparation et leur application a la preparation de composes therapeutiquement actifs |
| FR2777888B1 (fr) | 1998-04-27 | 2004-07-16 | Hoechst Marion Roussel Inc | Nouveaux derives de l'acide (3,4,7,8,9,10-hexahydro-6,10- dioxo-6h-pyridazino[1,2-a][1,2]diazepine-1-carboxylique, leur procede de preparation et leur application a la preparation de medicaments |
-
1999
- 1999-01-22 US US09/235,894 patent/US6177565B1/en not_active Expired - Lifetime
- 1999-08-19 EP EP99943814A patent/EP1104409B1/de not_active Expired - Lifetime
- 1999-08-19 ES ES99943814T patent/ES2221430T3/es not_active Expired - Lifetime
- 1999-08-19 PT PT99943814T patent/PT1104409E/pt unknown
- 1999-08-19 DE DE69917648T patent/DE69917648T2/de not_active Expired - Lifetime
- 1999-08-19 AU AU56840/99A patent/AU5684099A/en not_active Abandoned
- 1999-08-19 AT AT99943814T patent/ATE267815T1/de active
- 1999-08-19 DK DK99943814T patent/DK1104409T3/da active
- 1999-08-19 WO PCT/US1999/019080 patent/WO2000010979A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| DE69917648T2 (de) | 2005-06-09 |
| US6177565B1 (en) | 2001-01-23 |
| DK1104409T3 (da) | 2004-09-13 |
| EP1104409A1 (de) | 2001-06-06 |
| EP1104409B1 (de) | 2004-05-26 |
| PT1104409E (pt) | 2004-09-30 |
| DE69917648D1 (de) | 2004-07-01 |
| WO2000010979A1 (en) | 2000-03-02 |
| AU5684099A (en) | 2000-03-14 |
| ES2221430T3 (es) | 2004-12-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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