ATE200485T1 - Verfahren zur herstellung und isolierung von atracurium besylate - Google Patents

Verfahren zur herstellung und isolierung von atracurium besylate

Info

Publication number: ATE200485T1
Authority: AT; Austria
Prior art keywords: atracurium besylate; besylate; isolation; production; reaction mixture
Prior art date: 1996-02-16

Application number

AT97905920T

Other languages

English (en)

Inventor

Steven A Chamberlin

Ashok V Bhatia

Deborah A Davis

Keith A Drengler

Original Assignee

Abbott Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-02-16

Filing date

1997-02-12

Publication date

2001-04-15

1997-02-12 Application filed by Abbott Lab filed Critical Abbott Lab

2001-04-15 Application granted granted Critical

2001-04-15 Publication of ATE200485T1 publication Critical patent/ATE200485T1/de

Links

229960002945 atracurium besylate Drugs 0.000 title abstract 3
XXZSQOVSEBAPGS-UHFFFAOYSA-L atracurium besylate Chemical compound [O-]S(=O)(=O)C1=CC=CC=C1.[O-]S(=O)(=O)C1=CC=CC=C1.C1=C(OC)C(OC)=CC=C1CC1[N+](CCC(=O)OCCCCCOC(=O)CC[N+]2(C)C(C3=CC(OC)=C(OC)C=C3CC2)CC=2C=C(OC)C(OC)=CC=2)(C)CCC2=CC(OC)=C(OC)C=C21 XXZSQOVSEBAPGS-UHFFFAOYSA-L 0.000 title abstract 3
238000000034 method Methods 0.000 title abstract 3
238000002955 isolation Methods 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
239000011541 reaction mixture Substances 0.000 abstract 2
SRSXLGNVWSONIS-UHFFFAOYSA-M benzenesulfonate Chemical compound [O-]S(=O)(=O)C1=CC=CC=C1 SRSXLGNVWSONIS-UHFFFAOYSA-M 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
230000003197 catalytic effect Effects 0.000 abstract 1
229940125904 compound 1 Drugs 0.000 abstract 1
239000012467 final product Substances 0.000 abstract 1
239000012535 impurity Substances 0.000 abstract 1
CZXGXYBOQYQXQD-UHFFFAOYSA-N methyl benzenesulfonate Chemical compound COS(=O)(=O)C1=CC=CC=C1 CZXGXYBOQYQXQD-UHFFFAOYSA-N 0.000 abstract 1
239000002904 solvent Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/18—Aralkyl radicals
- C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Photoreceptors In Electrophotography (AREA)
Paints Or Removers (AREA)
Organic Insulating Materials (AREA)
Element Separation (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Other In-Based Heterocyclic Compounds (AREA)

AT97905920T 1996-02-16 1997-02-12 Verfahren zur herstellung und isolierung von atracurium besylate ATE200485T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/602,945 US5684154A (en)	1996-02-16	1996-02-16	Process for the preparation and isolation of atracurium besylate
PCT/US1997/002196 WO1997030033A1 (en)	1996-02-16	1997-02-12	Process for the preparation and isolation of atracurium besylate

Publications (1)

Publication Number	Publication Date
ATE200485T1 true ATE200485T1 (de)	2001-04-15

Family

ID=24413409

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT97905920T ATE200485T1 (de)	1996-02-16	1997-02-12	Verfahren zur herstellung und isolierung von atracurium besylate

Country Status (10)

Country	Link
US (1)	US5684154A (de)
EP (1)	EP0882020B1 (de)
JP (1)	JP2000513328A (de)
AT (1)	ATE200485T1 (de)
DE (1)	DE69704553T2 (de)
DK (1)	DK0882020T3 (de)
ES (1)	ES2158499T3 (de)
GR (1)	GR3036083T3 (de)
PT (1)	PT882020E (de)
WO (1)	WO1997030033A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU2007328210B2 (en) *	2006-12-06	2012-11-22	Cornell Research Foundation, Inc.	Intermediate duration neuromuscular blocking agents and antagonists thereof
AU2008222298A1 (en) *	2007-03-08	2008-09-12	Chemagis Ltd.	(1R,1'R)-atracurium salts separation process
BRPI0808581A2 (pt) *	2007-03-26	2014-09-16	Chemagis Ltd	"método para separar cisatracúrio com alta pureza de uma mistura de isômeros de (1r, 1'r) - atracúrio"
WO2008132746A1 (en) *	2007-05-01	2008-11-06	Chemagis Ltd.	Novel isoquinolinium compounds useful in the preparation of cisatracurium and associated intermediates
EP2155684B1 (de) *	2007-05-01	2014-04-09	Chemagis Ltd.	Verfahren zur herstellung von cisatracuriumverbindungen und damit assoziierte zwischenprodukte
WO2009007946A1 (en) *	2007-07-09	2009-01-15	Chemagis Ltd.	Process for producing cisatracurium and associated intermediates
CA2687157A1 (en) *	2007-06-18	2008-12-24	Chemagis Ltd.	(1r,1'r)-atracurium salts separation process
AU2008320380A1 (en) *	2007-10-29	2009-05-07	Chemagis Ltd.	Novel R,R'-atracurium salts
AU2009241211A1 (en) *	2008-05-01	2009-11-05	Chemagis Ltd.	Cisatracurium derivatives, preparation and uses thereof
WO2010107488A1 (en)	2009-03-17	2010-09-23	Cornell University	Reversible nondepolarizing neuromuscular blockade agents and methods for their use
WO2011022491A1 (en)	2009-08-19	2011-02-24	Cornell University	Cysteine for physiological injection
CN114014806B (zh) *	2021-12-03	2024-11-12	江苏诚信药业有限公司	一种新晶型顺苯磺酸阿曲库铵及其结晶方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1579822A (en) *	1976-10-29	1980-11-26	Wellcome Found	Tetrahydroisoquinolinium muscle relaxants
AU506657B2 (en) *	1975-12-10	1980-01-17	Wellcome Foundation Limited, The	Isoquinoline derivatives
US5453510A (en) *	1990-07-13	1995-09-26	Burroughs Wellcome Co.	Neuromuscular blocking agents
GB9015473D0 (en) *	1990-07-13	1990-08-29	Wellcome Found	Neuromuscular blocking agents

1996
- 1996-02-16 US US08/602,945 patent/US5684154A/en not_active Expired - Lifetime
1997
- 1997-02-12 DE DE69704553T patent/DE69704553T2/de not_active Expired - Fee Related
- 1997-02-12 WO PCT/US1997/002196 patent/WO1997030033A1/en not_active Ceased
- 1997-02-12 DK DK97905920T patent/DK0882020T3/da active
- 1997-02-12 EP EP97905920A patent/EP0882020B1/de not_active Expired - Lifetime
- 1997-02-12 JP JP09529450A patent/JP2000513328A/ja not_active Ceased
- 1997-02-12 ES ES97905920T patent/ES2158499T3/es not_active Expired - Lifetime
- 1997-02-12 PT PT97905920T patent/PT882020E/pt unknown
- 1997-02-12 AT AT97905920T patent/ATE200485T1/de not_active IP Right Cessation
2001
- 2001-06-19 GR GR20010400928T patent/GR3036083T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
DE69704553D1 (de)	2001-05-17
EP0882020A1 (de)	1998-12-09
WO1997030033A1 (en)	1997-08-21
US5684154A (en)	1997-11-04
DK0882020T3 (da)	2001-08-20
DE69704553T2 (de)	2001-11-08
JP2000513328A (ja)	2000-10-10
GR3036083T3 (en)	2001-09-28
ES2158499T3 (es)	2001-09-01
EP0882020B1 (de)	2001-04-11
PT882020E (pt)	2001-09-28

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Legal Events

Date	Code	Title	Description
2010-11-15	REN	Ceased due to non-payment of the annual fee