DK1339703T3 - Fremgangsmåde til fremstilling af paclitaxel - Google Patents

Fremgangsmåde til fremstilling af paclitaxel

Info

Publication number
DK1339703T3
DK1339703T3 DK01985349T DK01985349T DK1339703T3 DK 1339703 T3 DK1339703 T3 DK 1339703T3 DK 01985349 T DK01985349 T DK 01985349T DK 01985349 T DK01985349 T DK 01985349T DK 1339703 T3 DK1339703 T3 DK 1339703T3
Authority
DK
Denmark
Prior art keywords
preparing paclitaxel
paclitaxel
preparing
preparation
deacetylbaccatine iii
Prior art date
Application number
DK01985349T
Other languages
Danish (da)
English (en)
Inventor
Ezio Bombardelli
Arturo Battaglia
Paolo Dambruoso
Andrea Guerrini
Alessandro Pontiroli
Original Assignee
Indena Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Indena Spa filed Critical Indena Spa
Application granted granted Critical
Publication of DK1339703T3 publication Critical patent/DK1339703T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
DK01985349T 2000-12-06 2001-12-03 Fremgangsmåde til fremstilling af paclitaxel DK1339703T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT2000MI002654A IT1319682B1 (it) 2000-12-06 2000-12-06 Procedimento di sintesi del paclitaxel.

Publications (1)

Publication Number Publication Date
DK1339703T3 true DK1339703T3 (da) 2004-09-27

Family

ID=11446197

Family Applications (1)

Application Number Title Priority Date Filing Date
DK01985349T DK1339703T3 (da) 2000-12-06 2001-12-03 Fremgangsmåde til fremstilling af paclitaxel

Country Status (22)

Country Link
US (1) US6768012B2 (de)
EP (1) EP1339703B1 (de)
JP (1) JP2004515497A (de)
KR (1) KR100846891B1 (de)
CN (1) CN1286828C (de)
AT (1) ATE267820T1 (de)
AU (2) AU3453502A (de)
CA (1) CA2430814C (de)
CZ (1) CZ300024B6 (de)
DE (1) DE60103560T2 (de)
DK (1) DK1339703T3 (de)
ES (1) ES2221656T3 (de)
HU (1) HU229373B1 (de)
IL (2) IL156331A0 (de)
IT (1) IT1319682B1 (de)
NO (1) NO328505B1 (de)
PL (1) PL195121B1 (de)
PT (1) PT1339703E (de)
RU (1) RU2276147C2 (de)
SK (1) SK286616B6 (de)
TR (1) TR200401435T4 (de)
WO (1) WO2002046177A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1319682B1 (it) * 2000-12-06 2003-10-23 Indena Spa Procedimento di sintesi del paclitaxel.
ITMI20012185A1 (it) * 2001-10-19 2003-04-19 Indena Spa Procedimento per la preparazione della 14beta-idrossi-baccatina iii-1,14-carbonato
WO2004068930A2 (en) * 2003-02-04 2004-08-19 Natural Pharmaceuticals Inc. Method and composition for preparing a compound using a benzolating agent essentially free of ring chlorination
CN1303077C (zh) 2004-01-16 2007-03-07 桂林晖昂生化药业有限责任公司 合成紫杉烷的制备工艺
ITMI20050614A1 (it) 2005-04-12 2006-10-13 Indena Spa Processo per la purificazione della 10-deacetilbaccatina iii dalla 10-deacetil-2-debenzoil-2-pentenoilbaccatina iii
ES2363524T3 (es) * 2006-05-12 2011-08-08 Indena S.P.A. Proceso de preparación de un derivado de taxano.
CN102887876B (zh) * 2012-02-15 2015-11-25 浙江大学宁波理工学院 一种改进的多西紫杉醇的半合成方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2696460B1 (fr) * 1992-10-05 1994-11-25 Rhone Poulenc Rorer Sa Procédé de préparation de dérivés du taxane.
US5380751A (en) * 1992-12-04 1995-01-10 Bristol-Myers Squibb Company 6,7-modified paclitaxels
US7288665B1 (en) * 1997-08-18 2007-10-30 Florida State University Process for selective derivatization of taxanes
US5917062A (en) * 1997-11-21 1999-06-29 Indena S.P.A Intermediates and methods useful in the semisynthesis of paclitaxel and analogs
US6020507A (en) * 1998-03-02 2000-02-01 Bristol-Myers Squibb Company Synthesis of paclitaxel from baccatin III by protection of the 7-hydroxyl of baccatin III using a strong base and an electrophile
IT1319682B1 (it) * 2000-12-06 2003-10-23 Indena Spa Procedimento di sintesi del paclitaxel.

Also Published As

Publication number Publication date
CN1286828C (zh) 2006-11-29
CN1509277A (zh) 2004-06-30
RU2276147C2 (ru) 2006-05-10
IL156331A0 (en) 2004-01-04
EP1339703B1 (de) 2004-05-26
DE60103560T2 (de) 2004-09-16
PT1339703E (pt) 2004-08-31
DE60103560D1 (de) 2004-07-01
HU229373B1 (hu) 2013-11-28
SK6972003A3 (en) 2003-11-04
CA2430814A1 (en) 2002-06-13
KR20030055332A (ko) 2003-07-02
KR100846891B1 (ko) 2008-07-17
IT1319682B1 (it) 2003-10-23
WO2002046177A1 (en) 2002-06-13
AU3453502A (en) 2002-06-18
NO20032558L (no) 2003-06-05
HK1063052A1 (en) 2004-12-10
CA2430814C (en) 2009-04-07
ITMI20002654A1 (it) 2002-06-06
PL366120A1 (en) 2005-01-24
NO328505B1 (no) 2010-03-08
EP1339703A1 (de) 2003-09-03
NO20032558D0 (no) 2003-06-05
ATE267820T1 (de) 2004-06-15
CZ20031534A3 (cs) 2003-08-13
US6768012B2 (en) 2004-07-27
TR200401435T4 (tr) 2004-08-23
IL156331A (en) 2006-10-31
US20040049060A1 (en) 2004-03-11
PL195121B1 (pl) 2007-08-31
ES2221656T3 (es) 2005-01-01
CZ300024B6 (cs) 2009-01-14
HUP0500615A2 (hu) 2005-11-28
JP2004515497A (ja) 2004-05-27
SK286616B6 (sk) 2009-02-05
AU2002234535B2 (en) 2006-02-02

Similar Documents

Publication Publication Date Title
DK1303478T3 (da) Fremgangsmåde til fremstilling af substituerede octanoylamider
DK1277722T3 (da) Fremgangsmåde til fremstilling af methanol
DK1255719T3 (da) Integreret fremgangsmåde til fremstilling af en alkenylsubstitueret aromatisk forbindelse
DK1296935T3 (da) Fremgangsmåde til fremstilling af substituerede octanoylamider
DK1633697T3 (da) Fremgangsmåde til fremstilling af substituerede 3-aryl-butyl-aminforbindelser
DK1296656T3 (da) Fremgangsmåde til fremstilling af et præparat
DK1180544T3 (da) Fremgangsmåde til fremstilling af syntesegas
DK1309581T3 (da) Fremgangsmåde til fremstilling af citalopram
DK1412459T3 (da) Fremgangsmåde til fremstilling af mellemdestillater
DK1380121T3 (da) Fremgangsmåde til fremstilling af oxazolidinoner
DK1349580T3 (da) Fremgangsmåde til forbedring af stabiliteten af en farmaceutisk sammensætning
DK1345939T3 (da) Fremgangsmåde til fremstilling af sulfonamidsubstituerede imidazotriazinoner
DK1325022T3 (da) Fremgangsmåde til fremstilling af 21-hydroxy-6,19-oxidoprogesteron (21OH-6OP)
DK1347984T3 (da) Fremgangsmåde til fremstilling af taxanderivater
DK1339703T3 (da) Fremgangsmåde til fremstilling af paclitaxel
DK1326836T3 (da) Fremgangsmåde til fremstilling af 3-amino-2-chlor-4-methylpyridin
DK1296970T3 (da) Fremgangsmåde til fremstilling af citalopram
DK1206452T3 (da) Fremgangsmåde til fremstilling af benzoperhydro-isoindolforbindelser
DK1280752T3 (da) Fremgangsmåde til fremstilling af 2-alkyl-3-chlorphenoler
DK1240173T3 (da) Fremgangsmåde til fremstilling af N-phosphonomethylglycin
DK1272486T3 (da) Fremgangsmåde til fremstilling af 7-(pyrazol-3-yl)benzoxazoler
DK1385806T3 (da) Ettrinsfremgangsmåde til fremstilling af trimethoxytoluen
DK1315702T3 (da) Fremgangsmåde til fremstilling af halogen-4-phenoxyquinoliner
DK1383737T3 (da) Fremgangsmåde til fremstillingen af alkyl-N-(3-dimethylamino)alkylcabamater
DK1436277T3 (da) Fremgangsmåde til fremstilling af 14beta-hydroxy-baccatin III-1,14-carbonat