ATE269089T1 - Verwendung von vitamin d derivaten zur verstärkung der wirkung von zytotoxischen stoffen - Google Patents
Verwendung von vitamin d derivaten zur verstärkung der wirkung von zytotoxischen stoffenInfo
- Publication number
- ATE269089T1 ATE269089T1 AT98957308T AT98957308T ATE269089T1 AT E269089 T1 ATE269089 T1 AT E269089T1 AT 98957308 T AT98957308 T AT 98957308T AT 98957308 T AT98957308 T AT 98957308T AT E269089 T1 ATE269089 T1 AT E269089T1
- Authority
- AT
- Austria
- Prior art keywords
- vitamin
- derivatives
- increase
- effect
- cytotoxic
- Prior art date
Links
- 150000003710 vitamin D derivatives Chemical class 0.000 title abstract 3
- 231100000433 cytotoxic Toxicity 0.000 title abstract 2
- 230000001472 cytotoxic effect Effects 0.000 title abstract 2
- 230000000694 effects Effects 0.000 title abstract 2
- 239000000126 substance Substances 0.000 title 1
- 229940127089 cytotoxic agent Drugs 0.000 abstract 2
- 239000002254 cytotoxic agent Substances 0.000 abstract 2
- 231100000599 cytotoxic agent Toxicity 0.000 abstract 2
- 230000001093 anti-cancer Effects 0.000 abstract 1
- 230000000118 anti-neoplastic effect Effects 0.000 abstract 1
- 230000010534 mechanism of action Effects 0.000 abstract 1
- 230000004614 tumor growth Effects 0.000 abstract 1
- 230000002476 tumorcidal effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/243—Platinum; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Inorganic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/921,170 US6087350A (en) | 1997-08-29 | 1997-08-29 | Use of pretreatment chemicals to enhance efficacy of cytotoxic agents |
| PCT/US1998/017732 WO1999016451A1 (en) | 1997-08-29 | 1998-08-27 | Use of vitamin d derivatives to enhance efficacy of cytotoxic agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE269089T1 true ATE269089T1 (de) | 2004-07-15 |
Family
ID=25445023
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98957308T ATE269089T1 (de) | 1997-08-29 | 1998-08-27 | Verwendung von vitamin d derivaten zur verstärkung der wirkung von zytotoxischen stoffen |
Country Status (10)
| Country | Link |
|---|---|
| US (5) | US6087350A (de) |
| EP (2) | EP1030670B1 (de) |
| JP (1) | JP2001517705A (de) |
| AT (1) | ATE269089T1 (de) |
| AU (1) | AU1359499A (de) |
| DE (1) | DE69824622T2 (de) |
| DK (1) | DK1030670T3 (de) |
| ES (1) | ES2222615T3 (de) |
| PT (1) | PT1030670E (de) |
| WO (1) | WO1999016451A1 (de) |
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| US6538037B2 (en) | 1991-01-08 | 2003-03-25 | Bone Care International, Inc. | Methods for preparation and use of 1α,24(S)-dihydroxyvitamin D2 |
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| US5763429A (en) * | 1993-09-10 | 1998-06-09 | Bone Care International, Inc. | Method of treating prostatic diseases using active vitamin D analogues |
| US6242434B1 (en) * | 1997-08-08 | 2001-06-05 | Bone Care International, Inc. | 24-hydroxyvitamin D, analogs and uses thereof |
| US6503893B2 (en) | 1996-12-30 | 2003-01-07 | Bone Care International, Inc. | Method of treating hyperproliferative diseases using active vitamin D analogues |
| US6566353B2 (en) * | 1996-12-30 | 2003-05-20 | Bone Care International, Inc. | Method of treating malignancy associated hypercalcemia using active vitamin D analogues |
| US20020128240A1 (en) * | 1996-12-30 | 2002-09-12 | Bone Care International, Inc. | Treatment of hyperproliferative diseases using active vitamin D analogues |
| US6573256B2 (en) | 1996-12-30 | 2003-06-03 | Bone Care International, Inc. | Method of inhibiting angiogenesis using active vitamin D analogues |
| US20030129194A1 (en) * | 1997-02-13 | 2003-07-10 | Bone Care International, Inc. | Targeted therapeutic delivery of vitamin D compounds |
| US6087350A (en) * | 1997-08-29 | 2000-07-11 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Use of pretreatment chemicals to enhance efficacy of cytotoxic agents |
| EP1064000B1 (de) * | 1998-03-27 | 2011-07-06 | Oregon Health & Science University | Vitamin d und dessen analoge zur behandlung vom tumoren und anderen hyperproliferativen erkrankungen |
| NZ512676A (en) | 1999-01-13 | 2003-01-31 | Meditech Res Ltd | A composition and method for the enhancement of the efficacy of drugs |
| EP1276482B1 (de) * | 2000-03-02 | 2008-01-16 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Kombinationschemotherapie |
| US20020137731A1 (en) | 2000-05-30 | 2002-09-26 | Gewirtz David A. | Combination of radiation and vitamin D3 analogs for the treatment of cancer |
| US9066919B2 (en) * | 2000-07-14 | 2015-06-30 | Alchemia Oncology Pty Limited | Hyaluronan as a chemo-sensitizer in the treatment of cancer |
| AUPQ879500A0 (en) * | 2000-07-14 | 2000-08-10 | Meditech Research Limited | Hyaluronan as cytotoxic agent, drug presensitizer and chemo-sensitizer in the treatment of disease |
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| US7091241B2 (en) * | 2001-06-01 | 2006-08-15 | Summa Health System | Nontoxic potentiation/sensitization of cancer therapy by supplementary treatment with combined vitamins C and K3 |
| IL144583A0 (en) * | 2001-07-26 | 2002-05-23 | Peptor Ltd | Chimeric protein kinase inhibitors |
| JP2005505540A (ja) * | 2001-08-27 | 2005-02-24 | メディテック リサーチ リミテッド | 改善された治療プロトコール |
| MXPA04005260A (es) * | 2001-12-03 | 2005-03-23 | Novacea Inc | Composiciones farmaceuticas que comprenden compuestos activos de vitamina d. |
| JP2005530858A (ja) * | 2002-06-24 | 2005-10-13 | キング・ファーマシューティカルズ・リサーチ・アンド・デベロプメント・インコーポレイティッド | アデノシンa3アンタゴニストを用いるmdrガンの治療の増強 |
| US20050101576A1 (en) * | 2003-11-06 | 2005-05-12 | Novacea, Inc. | Methods of using vitamin D compounds in the treatment of myelodysplastic syndromes |
| AU2003295773A1 (en) * | 2002-11-21 | 2004-06-18 | Novacea, Inc. | Treatment of liver disease with active vitamin d compounds |
| US20050026877A1 (en) * | 2002-12-03 | 2005-02-03 | Novacea, Inc. | Pharmaceutical compositions comprising active vitamin D compounds |
| AU2004247108A1 (en) * | 2003-06-11 | 2004-12-23 | Novacea, Inc | Treatment of immune-mediated disorders with active vitamin D compounds alone or in combination with other therapeutic agents |
| US20060189586A1 (en) * | 2003-06-11 | 2006-08-24 | Cleland Jeffrey L | Pharmaceutical compositions comprising active vitamin D compounds |
| US20050020546A1 (en) * | 2003-06-11 | 2005-01-27 | Novacea, Inc. | Pharmaceutical compositions comprising active vitamin D compounds |
| JP2007501865A (ja) * | 2003-06-11 | 2007-02-01 | ノバセア インコーポレイティッド | 放射線治療薬および放射線治療と併用した、活性ビタミンd化合物による癌の治療法 |
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| EP1734972A4 (de) * | 2004-03-29 | 2007-08-22 | Roswell Park Cancer Inst | Verfahren zur behandlung von soliden tumoren und leukämien unter verwendung einer kombinationstherapie aus vitamin d und antistoffwechsel-nukleosid-analogen |
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| US20060003950A1 (en) * | 2004-06-30 | 2006-01-05 | Bone Care International, Inc. | Method of treating prostatic diseases using a combination of vitamin D analogues and other agents |
| US7094775B2 (en) | 2004-06-30 | 2006-08-22 | Bone Care International, Llc | Method of treating breast cancer using a combination of vitamin D analogues and other agents |
| CN101287474B (zh) * | 2005-07-27 | 2014-08-20 | 阿尔卡米亚肿瘤学股份有限公司 | 使用乙酰透明质酸的治疗方案 |
| MY149606A (en) * | 2005-09-07 | 2013-09-13 | Alchemia Oncology Pty Ltd | Therapeutic compositions comprising hyaluronan and therapeutic antibodies as well as methods of treatment |
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| US20080051375A1 (en) * | 2006-08-25 | 2008-02-28 | Auerbach Alan H | Methods for treating cancer comprising the administration of a vitamin d compound and an additional therapeutic agent, and compositions containing the same |
| US20100255117A1 (en) * | 2007-04-06 | 2010-10-07 | The Johns Hopkins University | Methods and compositions for the treatment of cancer |
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| SG2014006324A (en) * | 2009-01-27 | 2014-03-28 | Berg Llc | Vitamin d3 and analogs thereof for alleviating side effects associated with chemotherapy |
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| US9061040B2 (en) | 2011-08-15 | 2015-06-23 | Mihai Ciustea | Combination therapy for breast cancer |
| WO2017136671A1 (en) * | 2016-02-04 | 2017-08-10 | Chattterjee Bandana | Combination therapy for castration-resistant prostate cancer |
| MX2019001224A (es) | 2016-07-29 | 2019-06-03 | Janssen Pharmaceutica Nv | Metodos para tratar el cancer de prostata. |
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-
1997
- 1997-08-29 US US08/921,170 patent/US6087350A/en not_active Expired - Fee Related
-
1998
- 1998-08-27 ES ES98957308T patent/ES2222615T3/es not_active Expired - Lifetime
- 1998-08-27 EP EP98957308A patent/EP1030670B1/de not_active Expired - Lifetime
- 1998-08-27 JP JP2000513585A patent/JP2001517705A/ja active Pending
- 1998-08-27 DE DE69824622T patent/DE69824622T2/de not_active Expired - Lifetime
- 1998-08-27 AT AT98957308T patent/ATE269089T1/de active
- 1998-08-27 PT PT98957308T patent/PT1030670E/pt unknown
- 1998-08-27 DK DK98957308T patent/DK1030670T3/da active
- 1998-08-27 EP EP20040014012 patent/EP1491198A1/de not_active Withdrawn
- 1998-08-27 WO PCT/US1998/017732 patent/WO1999016451A1/en not_active Ceased
- 1998-10-06 AU AU13594/99A patent/AU1359499A/en not_active Abandoned
-
2000
- 2000-04-06 US US09/544,724 patent/US6559139B1/en not_active Expired - Fee Related
-
2003
- 2003-03-17 US US10/390,234 patent/US20030176403A1/en not_active Abandoned
- 2003-05-05 US US10/429,840 patent/US20030216359A1/en not_active Abandoned
-
2007
- 2007-01-29 US US11/668,330 patent/US20080003304A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| ES2222615T3 (es) | 2005-02-01 |
| DK1030670T3 (da) | 2004-10-04 |
| US20030176403A1 (en) | 2003-09-18 |
| US20080003304A1 (en) | 2008-01-03 |
| DE69824622T2 (de) | 2009-09-24 |
| DE69824622D1 (de) | 2004-07-22 |
| EP1030670A1 (de) | 2000-08-30 |
| JP2001517705A (ja) | 2001-10-09 |
| WO1999016451A1 (en) | 1999-04-08 |
| US6559139B1 (en) | 2003-05-06 |
| US6087350A (en) | 2000-07-11 |
| EP1491198A1 (de) | 2004-12-29 |
| AU1359499A (en) | 1999-04-23 |
| US20030216359A1 (en) | 2003-11-20 |
| EP1030670B1 (de) | 2004-06-16 |
| PT1030670E (pt) | 2004-09-30 |
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