ATE269098T1 - Verfahren zur vorbeugung von durch zyklosporine oder tacrolimus verursachter nierenvergiftung - Google Patents

Verfahren zur vorbeugung von durch zyklosporine oder tacrolimus verursachter nierenvergiftung

Info

Publication number: ATE269098T1
Authority: AT; Austria
Prior art keywords: tacrolimus; administration; patient; cyclosporin; pps
Prior art date: 1997-10-09

Application number

AT98952186T

Other languages

English (en)

Inventor

Gary E Striker

Lilliane Striker

Kenneth H Kortright

Original Assignee

Ivax Research Inc

Us Health

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-10-09

Filing date

1998-10-09

Publication date

2004-07-15

1998-10-09 Application filed by Ivax Research Inc, Us Health filed Critical Ivax Research Inc

2004-07-15 Application granted granted Critical

2004-07-15 Publication of ATE269098T1 publication Critical patent/ATE269098T1/de

Links

QJJXYPPXXYFBGM-LFZNUXCKSA-N Tacrolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1\C=C(/C)[C@@H]1[C@H](C)[C@@H](O)CC(=O)[C@H](CC=C)/C=C(C)/C[C@H](C)C[C@H](OC)[C@H]([C@H](C[C@H]2C)OC)O[C@@]2(O)C(=O)C(=O)N2CCCC[C@H]2C(=O)O1 QJJXYPPXXYFBGM-LFZNUXCKSA-N 0.000 title abstract 4
229930182912 cyclosporin Natural products 0.000 title abstract 4
238000000034 method Methods 0.000 title abstract 4
QJJXYPPXXYFBGM-SHYZHZOCSA-N tacrolimus Natural products CO[C@H]1C[C@H](CC[C@@H]1O)C=C(C)[C@H]2OC(=O)[C@H]3CCCCN3C(=O)C(=O)[C@@]4(O)O[C@@H]([C@H](C[C@H]4C)OC)[C@@H](C[C@H](C)CC(=C[C@@H](CC=C)C(=O)C[C@H](O)[C@H]2C)C)OC QJJXYPPXXYFBGM-SHYZHZOCSA-N 0.000 title abstract 4
229960001967 tacrolimus Drugs 0.000 title abstract 4
108010036941 Cyclosporins Proteins 0.000 title 1
210000003734 kidney Anatomy 0.000 title 1
231100000572 poisoning Toxicity 0.000 title 1
230000000607 poisoning effect Effects 0.000 title 1
229940043138 pentosan polysulfate Drugs 0.000 abstract 4
PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 abstract 3
229930105110 Cyclosporin A Natural products 0.000 abstract 3
108010036949 Cyclosporine Proteins 0.000 abstract 3
229960001265 ciclosporin Drugs 0.000 abstract 3
239000008194 pharmaceutical composition Substances 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
206010029155 Nephropathy toxic Diseases 0.000 abstract 1
230000037396 body weight Effects 0.000 abstract 1
238000011260 co-administration Methods 0.000 abstract 1
238000002650 immunosuppressive therapy Methods 0.000 abstract 1
231100000268 induced nephrotoxicity Toxicity 0.000 abstract 1
231100000417 nephrotoxicity Toxicity 0.000 abstract 1
230000007694 nephrotoxicity Effects 0.000 abstract 1
230000008085 renal dysfunction Effects 0.000 abstract 1
238000002560 therapeutic procedure Methods 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Immunology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Urology & Nephrology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Gastroenterology & Hepatology (AREA)
Transplantation (AREA)
Toxicology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Medicinal Preparation (AREA)
Saccharide Compounds (AREA)
Cephalosporin Compounds (AREA)

AT98952186T 1997-10-09 1998-10-09 Verfahren zur vorbeugung von durch zyklosporine oder tacrolimus verursachter nierenvergiftung ATE269098T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US6294797P	1997-10-09	1997-10-09
PCT/US1998/021313 WO1999018961A1 (en)	1997-10-09	1998-10-09	Method of preventing nephrotoxicity caused by cyclosporins and tacrolimus

Publications (1)

Publication Number	Publication Date
ATE269098T1 true ATE269098T1 (de)	2004-07-15

Family

ID=22045901

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT98952186T ATE269098T1 (de)	1997-10-09	1998-10-09	Verfahren zur vorbeugung von durch zyklosporine oder tacrolimus verursachter nierenvergiftung

Country Status (23)

Country	Link
US (1)	US6187745B1 (de)
EP (1)	EP1027053B1 (de)
JP (1)	JP2001519392A (de)
KR (1)	KR100515196B1 (de)
CN (1)	CN1154492C (de)
AT (1)	ATE269098T1 (de)
AU (1)	AU748495B2 (de)
BR (1)	BR9813860A (de)
CA (1)	CA2304374A1 (de)
CZ (1)	CZ297440B6 (de)
DE (1)	DE69824619T2 (de)
DK (1)	DK1027053T3 (de)
ES (1)	ES2221714T3 (de)
HU (1)	HUP0003904A3 (de)
IL (1)	IL135235A0 (de)
NO (1)	NO20001828L (de)
NZ (1)	NZ503493A (de)
PL (1)	PL191993B1 (de)
PT (1)	PT1027053E (de)
RU (1)	RU2191020C2 (de)
SK (1)	SK285332B6 (de)
UA (1)	UA65587C2 (de)
WO (1)	WO1999018961A1 (de)

Families Citing this family (15)

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WO2001052867A1 (en)	2000-01-19	2001-07-26	The United States Of America, Represented By The Secretary, Department Of Health And Human Services	Use of pentosan polysulfate to treat certain conditions of the prostate
US6613083B2 (en) *	2001-05-02	2003-09-02	Eckhard Alt	Stent device and method
IL160761A0 (en) *	2001-10-19	2004-08-31	Isotechnika Inc	Novel cyclosporin analog microemulsion preconcentrates
IL164185A0 (en) *	2002-04-16	2005-12-18	Fujisawa Pharmaceutical Co	Pharmaceutical compositions containing trifluoromethylphenyl amide derivatives
ES2399277T3 (es)	2004-05-27	2013-03-27	Baxter International Inc.	Procedimiento de tratamiento de trastornos hemorrágicos utilizando polisacáridos sulfatados
WO2010020423A2 (en)	2008-08-22	2010-02-25	Baxter Healthcare S.A.	Methods for treating bleeding disorders
JP6393453B2 (ja)	2010-01-14	2018-09-19	バクスアルタゲーエムベーハー	出血性障害を治療するための方法及び組成物
US8871741B2 (en) *	2010-01-15	2014-10-28	Icahn School Of Medicine At Mount Sinai	Inhibition of TNF-α induced activation of NFKB by pentosan polysulfate
CN102327282A (zh) *	2010-09-01	2012-01-25	吴洪	戊糖多聚硫酸酯用于制备治疗糖尿病肾病的药物中的用途
EP2734213B1 (de)	2011-07-19	2018-06-06	Baxalta GmbH	Resorptionsförderer als additive zur verbesserung der oralen formulierung nicht-antikoagulierender sulfatierter polysaccharide
WO2013052380A2 (en)	2011-10-05	2013-04-11	Allergan, Inc.	Compositions for enhancing nail health
EP2885642B1 (de)	2012-08-14	2019-05-15	Baxalta GmbH	Verfahren und systeme zum screening von zusammensetzungen mit nicht gerinnenden sulfatierten polysacchariden
KR101760510B1 (ko)	2014-12-18	2017-07-21	가톨릭대학교 산학협력단	메트포민을 포함하는 면역억제제로 인한 신장 독성 완화용 조성물 및 이를 포함하는 면역질환 예방 또는 치료용 조성물
WO2016099214A1 (ko) *	2014-12-18	2016-06-23	가톨릭대학교 산학협력단	메트포민을 포함하는 면역억제제로 인한 신장 독성 완화용 조성물 및 이를 포함하는 면역질환 예방 또는 치료용 조성물
WO2016199161A2 (en) *	2015-06-12	2016-12-15	Swati Vishal Jajodia	A composition comprising pentosan polysulfate sodium for use in treatment of bladder outlet obstruction and/or lower urinary tract symptoms

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DE3843241A1 (de) *	1988-12-22	1990-06-28	Skrezek Christian	Nephroprotektive infusionsloesung
EP0466315A3 (en)	1990-05-30	1992-07-01	Larrian Gillespie	Compositions containing xylan sulphates for affecting growth factor function and for inhibiting fibroblast proliferation
US5204329A (en)	1990-06-11	1993-04-20	Du Pont Merck Pharmaceutical Company	Treatment of organ transplantation rejection
GB9116836D0 (en) *	1991-08-05	1991-09-18	Sandoz Ltd	Organic compounds
US5605938A (en) *	1991-05-31	1997-02-25	Gliatech, Inc.	Methods and compositions for inhibition of cell invasion and fibrosis using dextran sulfate
RU2027471C1 (ru) *	1992-04-14	1995-01-27	Северо-Кавказский горно-металлургический институт	Способ очистки суспензий и вибрационный фильтр-сгуститель для его осуществления
IT1277147B1 (it) *	1995-01-20	1997-11-04	Sigma Tau Ind Farmaceuti	Uso della carnitina e i suoi derivati per ridurre gli effetti tossici della ciclosporina-a e di altri farmaci immunosoppressivi.
JPH08208489A (ja) *	1995-02-03	1996-08-13	L T T Kenkyusho:Kk	腎不全治療剤
US5643892A (en) *	1995-06-07	1997-07-01	Baker Norton Pharmaceuticals, Inc.	Method of treating chronic progressive vascular diseases

1998
- 1998-09-10 UA UA2000041980A patent/UA65587C2/uk unknown
- 1998-10-01 US US09/168,974 patent/US6187745B1/en not_active Expired - Fee Related
- 1998-10-09 AT AT98952186T patent/ATE269098T1/de not_active IP Right Cessation
- 1998-10-09 EP EP98952186A patent/EP1027053B1/de not_active Expired - Lifetime
- 1998-10-09 AU AU97943/98A patent/AU748495B2/en not_active Ceased
- 1998-10-09 PL PL339774A patent/PL191993B1/pl not_active IP Right Cessation
- 1998-10-09 RU RU2000111495/14A patent/RU2191020C2/ru not_active IP Right Cessation
- 1998-10-09 NZ NZ503493A patent/NZ503493A/en unknown
- 1998-10-09 ES ES98952186T patent/ES2221714T3/es not_active Expired - Lifetime
- 1998-10-09 JP JP2000515596A patent/JP2001519392A/ja active Pending
- 1998-10-09 DE DE69824619T patent/DE69824619T2/de not_active Expired - Fee Related
- 1998-10-09 WO PCT/US1998/021313 patent/WO1999018961A1/en not_active Ceased
- 1998-10-09 CZ CZ20001274A patent/CZ297440B6/cs not_active IP Right Cessation
- 1998-10-09 HU HU0003904A patent/HUP0003904A3/hu unknown
- 1998-10-09 SK SK467-2000A patent/SK285332B6/sk unknown
- 1998-10-09 DK DK98952186T patent/DK1027053T3/da active
- 1998-10-09 BR BR9813860-0A patent/BR9813860A/pt not_active Application Discontinuation
- 1998-10-09 IL IL13523598A patent/IL135235A0/xx not_active IP Right Cessation
- 1998-10-09 KR KR10-2000-7003305A patent/KR100515196B1/ko not_active Expired - Fee Related
- 1998-10-09 CA CA002304374A patent/CA2304374A1/en not_active Abandoned
- 1998-10-09 PT PT98952186T patent/PT1027053E/pt unknown
- 1998-10-09 CN CNB988100363A patent/CN1154492C/zh not_active Expired - Fee Related
2000
- 2000-04-07 NO NO20001828A patent/NO20001828L/no unknown

Also Published As

Publication number	Publication date
HK1026845A1 (en)	2000-12-29
CN1154492C (zh)	2004-06-23
UA65587C2 (en)	2004-04-15
AU9794398A (en)	1999-05-03
DE69824619D1 (de)	2004-07-22
CZ297440B6 (cs)	2006-12-13
KR100515196B1 (ko)	2005-09-16
EP1027053B1 (de)	2004-06-16
NO20001828D0 (no)	2000-04-07
AU748495B2 (en)	2002-06-06
CA2304374A1 (en)	1999-04-22
PL339774A1 (en)	2001-01-02
NZ503493A (en)	2001-11-30
CZ20001274A3 (cs)	2001-12-12
WO1999018961A1 (en)	1999-04-22
SK4672000A3 (en)	2001-09-11
CN1275080A (zh)	2000-11-29
EP1027053A1 (de)	2000-08-16
PL191993B1 (pl)	2006-08-31
DK1027053T3 (da)	2004-09-06
IL135235A0 (en)	2001-05-20
ES2221714T3 (es)	2005-01-01
HUP0003904A1 (hu)	2001-08-28
HUP0003904A3 (en)	2006-06-28
SK285332B6 (sk)	2006-11-03
DE69824619T2 (de)	2005-06-23
NO20001828L (no)	2000-05-15
EP1027053A4 (de)	2002-05-22
JP2001519392A (ja)	2001-10-23
US6187745B1 (en)	2001-02-13
RU2191020C2 (ru)	2002-10-20
KR20010030749A (ko)	2001-04-16
PT1027053E (pt)	2004-09-30
BR9813860A (pt)	2001-03-20

Legal Events

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2005-03-15

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Ref document number: 1027053

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2008-07-15

REN

Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE269098T1 (de)	2004-07-15	Verfahren zur vorbeugung von durch zyklosporine oder tacrolimus verursachter nierenvergiftung
US6071918A (en)	2000-06-06	Combination of an opioid antagonist and a selective serotonin reuptake inhibitor for treatment of alcoholism and alcohol dependence
Mahattanakul et al.	1996	Treatment of chronic inflammatory demyelinating polyneuropathy with cyclosporin-A.
CO5261582A1 (es)	2003-03-31	Composiciones de valdecoxib
CA2229282A1 (en)	1997-04-03	Use of hyaluronic acid as an immunosuppressant
CA2197554A1 (en)	1996-03-28	Combination of an opioid antagonist and a selective serotonin reuptake inhibitor for treatment of alcoholism and alcohol dependence
JP2002523370A5 (de)	2006-08-17
KR910019618A (ko)	1991-12-19	발기부전증 치료용 제약 조성물
MY111260A (en)	1999-10-30	Pharmaceutical composition for the treatment of nicotine dependence
RU95101385A (ru)	1996-12-27	Продукты, содержащие g-csf и tnf связующие протеина
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KR19980701720A (ko)	1998-06-25	세스키테르펜 락톤 및 비타민 b 복합체를 함유하는 편두통 및 기타 질환 치료용 복합약
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