PT1027053E - Metodo de prevencao de nefrotoxicidade provocada por ciclosporinas e tacrolimus - Google Patents

Metodo de prevencao de nefrotoxicidade provocada por ciclosporinas e tacrolimus

Info

Publication number: PT1027053E
Authority: PT; Portugal
Prior art keywords: tacrolimus; administration; patient; cyclosporin; pps
Prior art date: 1997-10-09

Application number

PT98952186T

Other languages

English (en)

Inventor

Gary E Striker

Lilliane Striker

Kenneth H Kortright

Original Assignee

Us Health

Ivax Research Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-10-09

Filing date

1998-10-09

Publication date

2004-09-30

1998-10-09 Application filed by Us Health, Ivax Research Inc filed Critical Us Health

2004-09-30 Publication of PT1027053E publication Critical patent/PT1027053E/pt

Links

QJJXYPPXXYFBGM-LFZNUXCKSA-N Tacrolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1\C=C(/C)[C@@H]1[C@H](C)[C@@H](O)CC(=O)[C@H](CC=C)/C=C(C)/C[C@H](C)C[C@H](OC)[C@H]([C@H](C[C@H]2C)OC)O[C@@]2(O)C(=O)C(=O)N2CCCC[C@H]2C(=O)O1 QJJXYPPXXYFBGM-LFZNUXCKSA-N 0.000 title abstract 4
229930182912 cyclosporin Natural products 0.000 title abstract 4
238000000034 method Methods 0.000 title abstract 4
QJJXYPPXXYFBGM-SHYZHZOCSA-N tacrolimus Natural products CO[C@H]1C[C@H](CC[C@@H]1O)C=C(C)[C@H]2OC(=O)[C@H]3CCCCN3C(=O)C(=O)[C@@]4(O)O[C@@H]([C@H](C[C@H]4C)OC)[C@@H](C[C@H](C)CC(=C[C@@H](CC=C)C(=O)C[C@H](O)[C@H]2C)C)OC QJJXYPPXXYFBGM-SHYZHZOCSA-N 0.000 title abstract 4
229960001967 tacrolimus Drugs 0.000 title abstract 4
231100000417 nephrotoxicity Toxicity 0.000 title abstract 2
108010036941 Cyclosporins Proteins 0.000 title 1
230000002265 prevention Effects 0.000 title 1
229940043138 pentosan polysulfate Drugs 0.000 abstract 4
PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 abstract 3
229930105110 Cyclosporin A Natural products 0.000 abstract 3
108010036949 Cyclosporine Proteins 0.000 abstract 3
229960001265 ciclosporin Drugs 0.000 abstract 3
239000008194 pharmaceutical composition Substances 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
206010029155 Nephropathy toxic Diseases 0.000 abstract 1
230000037396 body weight Effects 0.000 abstract 1
238000011260 co-administration Methods 0.000 abstract 1
238000002650 immunosuppressive therapy Methods 0.000 abstract 1
231100000268 induced nephrotoxicity Toxicity 0.000 abstract 1
230000007694 nephrotoxicity Effects 0.000 abstract 1
230000008085 renal dysfunction Effects 0.000 abstract 1
238000002560 therapeutic procedure Methods 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Immunology (AREA)
Organic Chemistry (AREA)
Urology & Nephrology (AREA)
Gastroenterology & Hepatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Transplantation (AREA)
Toxicology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Medicinal Preparation (AREA)
Saccharide Compounds (AREA)
Cephalosporin Compounds (AREA)

PT98952186T 1997-10-09 1998-10-09 Metodo de prevencao de nefrotoxicidade provocada por ciclosporinas e tacrolimus PT1027053E (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US6294797P	1997-10-09	1997-10-09

Publications (1)

Publication Number	Publication Date
PT1027053E true PT1027053E (pt)	2004-09-30

Family

ID=22045901

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT98952186T PT1027053E (pt)	1997-10-09	1998-10-09	Metodo de prevencao de nefrotoxicidade provocada por ciclosporinas e tacrolimus

Country Status (23)

Country	Link
US (1)	US6187745B1 (pt)
EP (1)	EP1027053B1 (pt)
JP (1)	JP2001519392A (pt)
KR (1)	KR100515196B1 (pt)
CN (1)	CN1154492C (pt)
AT (1)	ATE269098T1 (pt)
AU (1)	AU748495B2 (pt)
BR (1)	BR9813860A (pt)
CA (1)	CA2304374A1 (pt)
CZ (1)	CZ297440B6 (pt)
DE (1)	DE69824619T2 (pt)
DK (1)	DK1027053T3 (pt)
ES (1)	ES2221714T3 (pt)
HU (1)	HUP0003904A3 (pt)
IL (1)	IL135235A0 (pt)
NO (1)	NO20001828L (pt)
NZ (1)	NZ503493A (pt)
PL (1)	PL191993B1 (pt)
PT (1)	PT1027053E (pt)
RU (1)	RU2191020C2 (pt)
SK (1)	SK285332B6 (pt)
UA (1)	UA65587C2 (pt)
WO (1)	WO1999018961A1 (pt)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
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WO2001052867A1 (en) *	2000-01-19	2001-07-26	The United States Of America, Represented By The Secretary, Department Of Health And Human Services	Use of pentosan polysulfate to treat certain conditions of the prostate
US6613083B2 (en) *	2001-05-02	2003-09-02	Eckhard Alt	Stent device and method
HRP20040354B1 (en) *	2001-10-19	2012-10-31	Isotechnika Inc.	Novel cyclosporin analog microemulsion preconcentrates
MXPA04010170A (es) *	2002-04-16	2005-02-03	Fujisawa Pharmaceutical Co	Medicamento para prevenir y/o tratar el rechazo cronico.
PL1748781T3 (pl)	2004-05-27	2013-05-31	Baxter Int	Sposoby do leczenia zaburzeń związanych z krwawieniem z zastosowaniem siarczanowanych polisacharydów
WO2010020423A2 (en)	2008-08-22	2010-02-25	Baxter Healthcare S.A.	Methods for treating bleeding disorders
AU2011205271B2 (en)	2010-01-14	2014-01-30	Baxalta GmbH	Methods and compositions for treating bleeding disorders
US8871741B2 (en) *	2010-01-15	2014-10-28	Icahn School Of Medicine At Mount Sinai	Inhibition of TNF-α induced activation of NFKB by pentosan polysulfate
CN102327282A (zh) *	2010-09-01	2012-01-25	吴洪	戊糖多聚硫酸酯用于制备治疗糖尿病肾病的药物中的用途
EP2734213B1 (en)	2011-07-19	2018-06-06	Baxalta GmbH	Resorption enhancers as additives to improve the oral formulation of non-anticoagulant sulfated polysaccharides
WO2013052380A2 (en)	2011-10-05	2013-04-11	Allergan, Inc.	Compositions for enhancing nail health
DK2885642T3 (da)	2012-08-14	2019-07-29	Baxalta GmbH	Fremgangsmåder og systemer til screening af sammensætninger omfattende ikke-antikoagulerende sulfaterede polysaccharider
KR101760510B1 (ko)	2014-12-18	2017-07-21	가톨릭대학교 산학협력단	메트포민을 포함하는 면역억제제로 인한 신장 독성 완화용 조성물 및 이를 포함하는 면역질환 예방 또는 치료용 조성물
WO2016099214A1 (ko) *	2014-12-18	2016-06-23	가톨릭대학교 산학협력단	메트포민을 포함하는 면역억제제로 인한 신장 독성 완화용 조성물 및 이를 포함하는 면역질환 예방 또는 치료용 조성물
KR20180011840A (ko) *	2015-06-12	2018-02-02	비샬 자조디아 스와티	방광 출구 폐쇄 및/또는 하부 요로 증상의 치료에서 사용하기 위한 펜토산폴리설페이트나트륨을 포함하는 조성물

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DE3843241A1 (de) *	1988-12-22	1990-06-28	Skrezek Christian	Nephroprotektive infusionsloesung
EP0466315A3 (en)	1990-05-30	1992-07-01	Larrian Gillespie	Compositions containing xylan sulphates for affecting growth factor function and for inhibiting fibroblast proliferation
US5204329A (en)	1990-06-11	1993-04-20	Du Pont Merck Pharmaceutical Company	Treatment of organ transplantation rejection
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US5605938A (en) *	1991-05-31	1997-02-25	Gliatech, Inc.	Methods and compositions for inhibition of cell invasion and fibrosis using dextran sulfate
RU2027471C1 (ru) *	1992-04-14	1995-01-27	Северо-Кавказский горно-металлургический институт	Способ очистки суспензий и вибрационный фильтр-сгуститель для его осуществления
IT1277147B1 (it) *	1995-01-20	1997-11-04	Sigma Tau Ind Farmaceuti	Uso della carnitina e i suoi derivati per ridurre gli effetti tossici della ciclosporina-a e di altri farmaci immunosoppressivi.
JPH08208489A (ja) *	1995-02-03	1996-08-13	L T T Kenkyusho:Kk	腎不全治療剤
US5643892A (en)	1995-06-07	1997-07-01	Baker Norton Pharmaceuticals, Inc.	Method of treating chronic progressive vascular diseases

1998
- 1998-09-10 UA UA2000041980A patent/UA65587C2/uk unknown
- 1998-10-01 US US09/168,974 patent/US6187745B1/en not_active Expired - Fee Related
- 1998-10-09 SK SK467-2000A patent/SK285332B6/sk unknown
- 1998-10-09 NZ NZ503493A patent/NZ503493A/en unknown
- 1998-10-09 BR BR9813860-0A patent/BR9813860A/pt not_active Application Discontinuation
- 1998-10-09 JP JP2000515596A patent/JP2001519392A/ja active Pending
- 1998-10-09 KR KR10-2000-7003305A patent/KR100515196B1/ko not_active Expired - Fee Related
- 1998-10-09 DE DE69824619T patent/DE69824619T2/de not_active Expired - Fee Related
- 1998-10-09 HU HU0003904A patent/HUP0003904A3/hu unknown
- 1998-10-09 WO PCT/US1998/021313 patent/WO1999018961A1/en not_active Ceased
- 1998-10-09 CN CNB988100363A patent/CN1154492C/zh not_active Expired - Fee Related
- 1998-10-09 ES ES98952186T patent/ES2221714T3/es not_active Expired - Lifetime
- 1998-10-09 CZ CZ20001274A patent/CZ297440B6/cs not_active IP Right Cessation
- 1998-10-09 DK DK98952186T patent/DK1027053T3/da active
- 1998-10-09 EP EP98952186A patent/EP1027053B1/en not_active Expired - Lifetime
- 1998-10-09 AU AU97943/98A patent/AU748495B2/en not_active Ceased
- 1998-10-09 RU RU2000111495/14A patent/RU2191020C2/ru not_active IP Right Cessation
- 1998-10-09 PL PL339774A patent/PL191993B1/pl not_active IP Right Cessation
- 1998-10-09 PT PT98952186T patent/PT1027053E/pt unknown
- 1998-10-09 CA CA002304374A patent/CA2304374A1/en not_active Abandoned
- 1998-10-09 IL IL13523598A patent/IL135235A0/xx not_active IP Right Cessation
- 1998-10-09 AT AT98952186T patent/ATE269098T1/de not_active IP Right Cessation
2000
- 2000-04-07 NO NO20001828A patent/NO20001828L/no unknown

Also Published As

Publication number	Publication date
DE69824619D1 (de)	2004-07-22
CA2304374A1 (en)	1999-04-22
HUP0003904A3 (en)	2006-06-28
KR20010030749A (ko)	2001-04-16
HUP0003904A1 (hu)	2001-08-28
AU9794398A (en)	1999-05-03
ES2221714T3 (es)	2005-01-01
ATE269098T1 (de)	2004-07-15
NO20001828L (no)	2000-05-15
KR100515196B1 (ko)	2005-09-16
CN1275080A (zh)	2000-11-29
BR9813860A (pt)	2001-03-20
NO20001828D0 (no)	2000-04-07
SK4672000A3 (en)	2001-09-11
PL339774A1 (en)	2001-01-02
DK1027053T3 (da)	2004-09-06
EP1027053A4 (en)	2002-05-22
HK1026845A1 (en)	2000-12-29
EP1027053A1 (en)	2000-08-16
JP2001519392A (ja)	2001-10-23
US6187745B1 (en)	2001-02-13
CZ20001274A3 (cs)	2001-12-12
PL191993B1 (pl)	2006-08-31
DE69824619T2 (de)	2005-06-23
EP1027053B1 (en)	2004-06-16
RU2191020C2 (ru)	2002-10-20
IL135235A0 (en)	2001-05-20
WO1999018961A1 (en)	1999-04-22
NZ503493A (en)	2001-11-30
SK285332B6 (sk)	2006-11-03
UA65587C2 (en)	2004-04-15
AU748495B2 (en)	2002-06-06
CN1154492C (zh)	2004-06-23
CZ297440B6 (cs)	2006-12-13

Publication	Publication Date	Title
PT1027053E (pt)	2004-09-30	Metodo de prevencao de nefrotoxicidade provocada por ciclosporinas e tacrolimus
WO2005065069A3 (en)	2005-09-22	Pharmaceutical methods, dosing regimes and dosage forms for the treatment of alzheimer's disease
CO5251419A1 (es)	2003-02-28	Composiciones nanoparticuladas de eplerenona
ES2188782T3 (es)	2003-07-01	Formulaciones farmaceuticas que contienen darifenacina.
PL350313A1 (en)	2002-12-02	Apomorphine and sildenafil composition
JP2002523370A5 (pt)	2006-08-17
MY111260A (en)	1999-10-30	Pharmaceutical composition for the treatment of nicotine dependence
US4425363A (en)	1984-01-10	Treatment of tardive dyskinesia in mammals
CA2274510A1 (en)	1998-06-18	Treatment of osteoarthritis by administering poly-n-acetyl-d-glucosamine
EP0375628A3 (en)	1991-08-14	Use of acetyl l-carnitine in the therapeutic treatment of cataract, and pharmaceutical compositions useful in such treatment
AU647463B2 (en)	1994-03-24	A method and a pharmaceutical preparation for treating pain
MY124465A (en)	2006-06-30	Reduction of infarct volume using citicoline
CA2537748A1 (en)	2005-03-17	Use of telmisartan for the prevention of vascular headache
NO974486L (no)	1997-09-29	Lavdoserte "Ridogrel"-formuleringer samt anvendelse derav ved behandling av tarmbetennelse
KR900011461A (ko)	1990-08-01	트립스타틴을 유효성분으로 하는 치료제
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RU2449796C9 (ru)	2007-10-27	Фармацевтическая комбинация этинилэстрадиола и дроспиренона для использования в качестве контрацептива
MX9800809A (es)	1998-04-30	Procedimiento para preparar formas de dosis solidas de dosis muy bajas del farmaco.
CN107519176A (zh)	2017-12-29	防治运动病、梅尼埃病的药物及莫扎伐普坦的医药用途
RU99112967A (ru)	2001-04-27	Способ лечения и профилактики дизентерии свиней
KR830008678A (ko)	1983-12-14	진통 조성물
CN108478581A (zh)	2018-09-04	防治运动病、梅尼埃病的药物及托伐普坦的医药用途
JPH07188040A (ja)	1995-07-25	鼻炎治療用組成物
JPH0296521A (ja)	1990-04-09	免疫性疾患治療剤
Di Prima et al.	1988	Clinical and bacteriological evaluation of ofloxacin in 20 cases of skin infection.