ATE270301T1 - Verfahren zur herstellung von modifizierten p- chiralen nucleotid-analoga - Google Patents

Verfahren zur herstellung von modifizierten p- chiralen nucleotid-analoga

Info

Publication number: ATE270301T1
Authority: AT; Austria
Prior art keywords: nucleotide analogs; producing modified; chiral; chiral nucleotide; modified
Prior art date: 1997-04-25

Application number

AT98915075T

Other languages

English (en)

Inventor

Wojciech J Stec

Lucyna A Wozniak

Arkadiusz Chworos

Jaroslaw Pyzowski

Original Assignee

Ct Badan Molekular I Makro

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-04-25

Filing date

1998-04-23

Publication date

2004-07-15

1998-04-23 Application filed by Ct Badan Molekular I Makro filed Critical Ct Badan Molekular I Makro

2004-07-15 Application granted granted Critical

2004-07-15 Publication of ATE270301T1 publication Critical patent/ATE270301T1/de

Links

238000004519 manufacturing process Methods 0.000 title 1
239000002773 nucleotide Substances 0.000 title 1
238000000034 method Methods 0.000 abstract 2
108091034117 Oligonucleotide Proteins 0.000 abstract 1
JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
238000009396 hybridization Methods 0.000 abstract 1
125000003729 nucleotide group Chemical group 0.000 abstract 1
125000004437 phosphorous atom Chemical group 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

AT98915075T 1997-04-25 1998-04-23 Verfahren zur herstellung von modifizierten p- chiralen nucleotid-analoga ATE270301T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
PL97319677A PL184612B1 (pl)	1997-04-25	1997-04-25	Sposób wytwarzania modyfikowanych P chiralnych analogów nukleotydów
PCT/PL1998/000014 WO1998049179A2 (en)	1997-04-25	1998-04-23	A process for the synthesis of modified p-chiral nucleotide analogues

Publications (1)

Publication Number	Publication Date
ATE270301T1 true ATE270301T1 (de)	2004-07-15

Family

ID=20069747

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT98915075T ATE270301T1 (de)	1997-04-25	1998-04-23	Verfahren zur herstellung von modifizierten p- chiralen nucleotid-analoga

Country Status (8)

Country	Link
US (1)	US6407223B1 (de)
EP (1)	EP0977769B1 (de)
AT (1)	ATE270301T1 (de)
AU (1)	AU6934398A (de)
DE (1)	DE69824843T2 (de)
ES (1)	ES2224373T3 (de)
PL (1)	PL184612B1 (de)
WO (1)	WO1998049179A2 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU2002305073A1 (en) *	2001-03-22	2002-10-08	Research Foundation Of The City University Of New York	Synthesis of selenium-derivatized nucleosides, nucleotides, phosphoramidites, triphosphates and nucleic acids
PL216525B1 (pl) *	2006-10-17	2014-04-30	Ct Badań Molekularnych I Makromolekularnych Polskiej Akademii Nauk	5'-O-[(N-acylo)amidoditiofosforano] nukleozydy oraz sposób wytwarzania 5'-O-[(N-acylo)amidofosforano]-,5'-O-[(N-acylo)amidotiofosforano]-, 5'-O-[(N-acylo)amidoditiofosforano]nukleozydów
SG171914A1 (en)	2008-12-02	2011-07-28	Chiralgen Ltd	Method for the synthesis of phosphorus atom modified nucleic acids
EP2451461A4 (de)	2009-07-06	2013-05-29	Ontorii Inc	Neuartige nukleinsäure-prodrugs und verwendungsverfahren dafür
DK2620428T3 (da)	2010-09-24	2019-07-01	Wave Life Sciences Ltd	Asymmetrisk hjælpegruppe
US9605019B2 (en)	2011-07-19	2017-03-28	Wave Life Sciences Ltd.	Methods for the synthesis of functionalized nucleic acids
CN104540843A (zh) *	2012-06-29	2015-04-22	塞纳研究股份有限公司	用作营养补剂的含硒核苷
JP6246121B2 (ja)	2012-07-13	2017-12-13	株式会社新日本科学	キラル核酸アジュバント
CN112007045B (zh)	2012-07-13	2026-01-06	波涛生命科学有限公司	手性控制
DK2872485T3 (da)	2012-07-13	2021-03-08	Wave Life Sciences Ltd	Asymmetrisk hjælpegruppe
WO2015108048A1 (ja)	2014-01-15	2015-07-23	株式会社新日本科学	抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤
EP3095461A4 (de)	2014-01-15	2017-08-23	Shin Nippon Biomedical Laboratories, Ltd.	Chirales nukleinsäure-adjuvans mit immunitätsinduktionswirkung und immunitätsinduktionsaktivator
US10322173B2 (en)	2014-01-15	2019-06-18	Shin Nippon Biomedical Laboratories, Ltd.	Chiral nucleic acid adjuvant having anti-allergic activity, and anti-allergic agent
KR102423317B1 (ko)	2014-01-16	2022-07-22	웨이브 라이프 사이언시스 리미티드	키랄 디자인

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5635488A (en) *	1991-10-15	1997-06-03	Isis Pharmaceuticals, Inc.	Compounds having phosphorodithioate linkages of high chiral purity
US5852188A (en) *	1990-01-11	1998-12-22	Isis Pharmaceuticals, Inc.	Oligonucleotides having chiral phosphorus linkages
US5359052A (en) *	1991-08-05	1994-10-25	Polish Academy Of Sciences	Chalcophospholanes useful in the synthesis of oligonucleoside phosphorothioates, phosphorodithioates and related selenates
US5599797A (en) *	1991-10-15	1997-02-04	Isis Pharmaceuticals, Inc.	Oligonucleotides having phosphorothioate linkages of high chiral purity
US5661134A (en) *	1991-10-15	1997-08-26	Isis Pharmaceuticals, Inc.	Oligonucleotides for modulating Ha-ras or Ki-ras having phosphorothioate linkages of high chiral purity
US5955597A (en) *	1993-11-16	1999-09-21	Genta, Incorporated	Chirally enriched synthetic phosphate oligomers
US5703223A (en)	1994-09-02	1997-12-30	Thomas Jefferson University	Solid phase synthesis of oligonucleotides with stereospecific substituted phosphonate linkages by pentavalent grignard coupling
JP2002500617A (ja) *	1995-05-26	2002-01-08	ジンタ・インコーポレイテッド	有機リン誘導体の合成方法および組成物
US5734041A (en) *	1995-10-20	1998-03-31	Mcgill University	Preparation of chiral phosphorothioate oligomers
CA2205218C (en)	1995-10-20	1999-05-25	Hybridon, Inc.	Improved methods for h-phosphonate synthesis of mono- and oligonucleotides
US5856465A (en) *	1996-05-24	1999-01-05	Polska Akademia Nauk Centrum Badan Molekularnych I Makromolekularnych	Compositions and methods for the synthesis of chirally pure organophosphorus nucleoside derivatives
WO1998008858A1 (en) *	1996-08-26	1998-03-05	Hybridon, Inc.	Improved reagents and process for synthesis of oligonucleotides containing phosphorodithioate internucleoside linkages

1997
- 1997-04-25 PL PL97319677A patent/PL184612B1/pl not_active IP Right Cessation
1998
- 1998-04-23 WO PCT/PL1998/000014 patent/WO1998049179A2/en not_active Ceased
- 1998-04-23 US US09/402,974 patent/US6407223B1/en not_active Expired - Fee Related
- 1998-04-23 AT AT98915075T patent/ATE270301T1/de not_active IP Right Cessation
- 1998-04-23 ES ES98915075T patent/ES2224373T3/es not_active Expired - Lifetime
- 1998-04-23 AU AU69343/98A patent/AU6934398A/en not_active Abandoned
- 1998-04-23 EP EP98915075A patent/EP0977769B1/de not_active Expired - Lifetime
- 1998-04-23 DE DE69824843T patent/DE69824843T2/de not_active Expired - Fee Related

Also Published As

Publication number	Publication date
WO1998049179A2 (en)	1998-11-05
DE69824843T2 (de)	2005-07-21
EP0977769B1 (de)	2004-06-30
WO1998049179A3 (en)	1999-03-18
AU6934398A (en)	1998-11-24
ES2224373T3 (es)	2005-03-01
US6407223B1 (en)	2002-06-18
PL319677A1 (en)	1998-10-26
EP0977769A2 (de)	2000-02-09
PL184612B1 (pl)	2002-11-29
DE69824843D1 (de)	2004-08-05

Legal Events

Date

Code

Title

Description

2005-02-15

UEP

Publication of translation of european patent specification

Ref document number: 0977769

Country of ref document: EP

2009-01-15

REN

Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE69824843D1 (de)	2004-08-05	Verfahren zur herstellung von modifizierten p-chiralen nucleotid-analoga
ATE194142T1 (de)	2000-07-15	Verfahren zur herstellung von nukleotiden
ATE38386T1 (de)	1988-11-15	Verfahren zur herstellung von oligonucleotiden.
DE69835357D1 (de)	2006-09-07	Verfahren zur Herstellung von Synthesegas
DE69610146D1 (de)	2000-10-12	Verfahren zur Herstellung von Bilderzeugungselementen nach dem Kontrastmigrationsverfahren
DE3853060D1 (de)	1995-03-23	Verfahren zur Herstellung von Oligonucleotiden.
DE69012535D1 (de)	1994-10-20	Verfahren zur Herstellung von Hydrogensiloxanen.
DE69636852D1 (de)	2007-03-08	Verfahren zur herstellung von nukleotid-5'-phosphat ester
DE69428912D1 (de)	2001-12-06	Verfahren zur herstellung von pentafluorethan
DE69105518D1 (de)	1995-01-12	Verfahren von hohem katalysatorgehalt zur herstellung von glucamide enthaltenden reinungsmitteln.
DE69806519D1 (de)	2002-08-22	Verfahren zur Herstellung von Siliziumkarbidfasern
DE69022788D1 (de)	1995-11-09	Verfahren zur Herstellung von Polysiloxandichtungen.
ATE268749T1 (de)	2004-06-15	Verfahren zur herstellung von iopamidol
DE59501143D1 (de)	1998-02-05	Verfahren zur Herstellung von Magnesium-hydrid
DE59601683D1 (de)	1999-05-20	Sulfamat-derivate von 1,3,5(10)-estratrien-derivaten, verfahren zu ihrer herstellung und diese verbindungen enthaltende pharmazeutische zusammensetzungen
ATE207892T1 (de)	2001-11-15	Verfahren zur herstellung von dithiobis- alkanesulfonaten und phosphonaten
DE69613597D1 (de)	2001-08-09	Verfahren zur Herstellung von Cyclopentadienyl-Verbindungen und nach dem Verfahren hergestellte Verbindungen
ATE321773T1 (de)	2006-04-15	Semisynthetisches verfahren zur herstellung von didemninanalogen
ATE174601T1 (de)	1999-01-15	Verfahren zur herstellung von bisnoraldehyden aus bisnoralkohol
ATE294186T1 (de)	2005-05-15	Verfahren zur herstellung von nukleotiden oder oligonukleotiden phosphoramitiden
DE69627472D1 (de)	2003-05-22	Verfahren zur Herstellung von Platin Verbindungen
ATE39698T1 (de)	1989-01-15	Verfahren zur herstellung von oligonucleosidphosphonaten.
DE60015563D1 (de)	2004-12-09	Verfahren zur herstellung von benzoperhydroisoindolen
ATE247129T1 (de)	2003-08-15	Biologisches verfahren zur herstellung von verbindungen auf der basis der dipeptiden
DE3679672D1 (de)	1991-07-11	Verfahren zur herstellung gesinterter siliziumcarbidartikel hoher dichte.