ATE270301T1 - Verfahren zur herstellung von modifizierten p- chiralen nucleotid-analoga - Google Patents

Verfahren zur herstellung von modifizierten p- chiralen nucleotid-analoga

Info

Publication number: ATE270301T1
Authority: AT; Austria
Prior art keywords: nucleotide analogs; producing modified; chiral; chiral nucleotide; modified
Prior art date: 1997-04-25

Application number

AT98915075T

Other languages

English (en)

Inventor

Wojciech J Stec

Lucyna A Wozniak

Arkadiusz Chworos

Jaroslaw Pyzowski

Original Assignee

Ct Badan Molekular I Makro

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-04-25

Filing date

1998-04-23

Publication date

2004-07-15

1998-04-23 Application filed by Ct Badan Molekular I Makro filed Critical Ct Badan Molekular I Makro

2004-07-15 Application granted granted Critical

2004-07-15 Publication of ATE270301T1 publication Critical patent/ATE270301T1/de

Links

238000004519 manufacturing process Methods 0.000 title 1
239000002773 nucleotide Substances 0.000 title 1
238000000034 method Methods 0.000 abstract 2
108091034117 Oligonucleotide Proteins 0.000 abstract 1
JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
238000009396 hybridization Methods 0.000 abstract 1
125000003729 nucleotide group Chemical group 0.000 abstract 1
125000004437 phosphorous atom Chemical group 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

AT98915075T 1997-04-25 1998-04-23 Verfahren zur herstellung von modifizierten p- chiralen nucleotid-analoga ATE270301T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
PL97319677A PL184612B1 (pl)	1997-04-25	1997-04-25	Sposób wytwarzania modyfikowanych P chiralnych analogów nukleotydów
PCT/PL1998/000014 WO1998049179A2 (en)	1997-04-25	1998-04-23	A process for the synthesis of modified p-chiral nucleotide analogues

Publications (1)

Publication Number	Publication Date
ATE270301T1 true ATE270301T1 (de)	2004-07-15

Family

ID=20069747

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT98915075T ATE270301T1 (de)	1997-04-25	1998-04-23	Verfahren zur herstellung von modifizierten p- chiralen nucleotid-analoga

Country Status (8)

Country	Link
US (1)	US6407223B1 (de)
EP (1)	EP0977769B1 (de)
AT (1)	ATE270301T1 (de)
AU (1)	AU6934398A (de)
DE (1)	DE69824843T2 (de)
ES (1)	ES2224373T3 (de)
PL (1)	PL184612B1 (de)
WO (1)	WO1998049179A2 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU2002305073A1 (en)	2001-03-22	2002-10-08	Research Foundation Of The City University Of New York	Synthesis of selenium-derivatized nucleosides, nucleotides, phosphoramidites, triphosphates and nucleic acids
PL216525B1 (pl) *	2006-10-17	2014-04-30	Ct Badań Molekularnych I Makromolekularnych Polskiej Akademii Nauk	5'-O-[(N-acylo)amidoditiofosforano] nukleozydy oraz sposób wytwarzania 5'-O-[(N-acylo)amidofosforano]-,5'-O-[(N-acylo)amidotiofosforano]-, 5'-O-[(N-acylo)amidoditiofosforano]nukleozydów
BRPI0923225A2 (pt)	2008-12-02	2016-10-04	Chiralgen Ltd	metodo para sintese de acidos nucleicos modificados no atomo de fosforo
EP2451461A4 (de)	2009-07-06	2013-05-29	Ontorii Inc	Neuartige nukleinsäure-prodrugs und verwendungsverfahren dafür
DK2620428T3 (da)	2010-09-24	2019-07-01	Wave Life Sciences Ltd	Asymmetrisk hjælpegruppe
CN107365339A (zh)	2011-07-19	2017-11-21	波涛生命科学有限公司	合成官能化核酸的方法
US20150157655A1 (en) *	2012-06-29	2015-06-11	Sena Research, Inc.	Selenium containing nucleosides as nutritional supplements
SG11201500243WA (en)	2012-07-13	2015-04-29	Shin Nippon Biomedical Lab Ltd	Chiral nucleic acid adjuvant
WO2014010250A1 (en)	2012-07-13	2014-01-16	Chiralgen, Ltd.	Asymmetric auxiliary group
DK2872147T3 (da)	2012-07-13	2023-02-20	Wave Life Sciences Ltd	Fremgangsmåde til fremstilling af kirale oligonukleotider
WO2015108046A1 (ja)	2014-01-15	2015-07-23	株式会社新日本科学	抗アレルギー作用を有するキラル核酸アジュバンド及び抗アレルギー剤
EP3095461A4 (de)	2014-01-15	2017-08-23	Shin Nippon Biomedical Laboratories, Ltd.	Chirales nukleinsäure-adjuvans mit immunitätsinduktionswirkung und immunitätsinduktionsaktivator
EP3095459A4 (de)	2014-01-15	2017-08-23	Shin Nippon Biomedical Laboratories, Ltd.	Chirales nukleinsäureadjuvans mit antitumorwirkung und antitumormittel
EP3094728B1 (de)	2014-01-16	2022-03-09	Wave Life Sciences Ltd.	Chirales design

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5852188A (en) *	1990-01-11	1998-12-22	Isis Pharmaceuticals, Inc.	Oligonucleotides having chiral phosphorus linkages
US5635488A (en) *	1991-10-15	1997-06-03	Isis Pharmaceuticals, Inc.	Compounds having phosphorodithioate linkages of high chiral purity
US5359052A (en) *	1991-08-05	1994-10-25	Polish Academy Of Sciences	Chalcophospholanes useful in the synthesis of oligonucleoside phosphorothioates, phosphorodithioates and related selenates
US5661134A (en) *	1991-10-15	1997-08-26	Isis Pharmaceuticals, Inc.	Oligonucleotides for modulating Ha-ras or Ki-ras having phosphorothioate linkages of high chiral purity
US5599797A (en) *	1991-10-15	1997-02-04	Isis Pharmaceuticals, Inc.	Oligonucleotides having phosphorothioate linkages of high chiral purity
US5955597A (en) *	1993-11-16	1999-09-21	Genta, Incorporated	Chirally enriched synthetic phosphate oligomers
US5703223A (en) *	1994-09-02	1997-12-30	Thomas Jefferson University	Solid phase synthesis of oligonucleotides with stereospecific substituted phosphonate linkages by pentavalent grignard coupling
AU707369B2 (en) *	1995-05-26	1999-07-08	Genta Incorporated	Compositions and methods for the synthesis of organophosphorus derivatives
CA2205218C (en) *	1995-10-20	1999-05-25	Hybridon, Inc.	Improved methods for h-phosphonate synthesis of mono- and oligonucleotides
US5734041A (en) *	1995-10-20	1998-03-31	Mcgill University	Preparation of chiral phosphorothioate oligomers
US5856465A (en) *	1996-05-24	1999-01-05	Polska Akademia Nauk Centrum Badan Molekularnych I Makromolekularnych	Compositions and methods for the synthesis of chirally pure organophosphorus nucleoside derivatives
US6117992A (en) *	1996-08-26	2000-09-12	Hybridon, Inc.	Reagents and process for synthesis of oligonucleotides containing phosphorodithioate internucleoside linkages

1997
- 1997-04-25 PL PL97319677A patent/PL184612B1/pl not_active IP Right Cessation
1998
- 1998-04-23 AU AU69343/98A patent/AU6934398A/en not_active Abandoned
- 1998-04-23 EP EP98915075A patent/EP0977769B1/de not_active Expired - Lifetime
- 1998-04-23 DE DE69824843T patent/DE69824843T2/de not_active Expired - Fee Related
- 1998-04-23 AT AT98915075T patent/ATE270301T1/de not_active IP Right Cessation
- 1998-04-23 ES ES98915075T patent/ES2224373T3/es not_active Expired - Lifetime
- 1998-04-23 US US09/402,974 patent/US6407223B1/en not_active Expired - Fee Related
- 1998-04-23 WO PCT/PL1998/000014 patent/WO1998049179A2/en not_active Ceased

Also Published As

Publication number	Publication date
AU6934398A (en)	1998-11-24
EP0977769B1 (de)	2004-06-30
DE69824843T2 (de)	2005-07-21
ES2224373T3 (es)	2005-03-01
US6407223B1 (en)	2002-06-18
DE69824843D1 (de)	2004-08-05
WO1998049179A2 (en)	1998-11-05
PL319677A1 (en)	1998-10-26
WO1998049179A3 (en)	1999-03-18
PL184612B1 (pl)	2002-11-29
EP0977769A2 (de)	2000-02-09

Legal Events

Date

Code

Title

Description

2005-02-15

UEP

Publication of translation of european patent specification

Ref document number: 0977769

Country of ref document: EP

2009-01-15

REN

Ceased due to non-payment of the annual fee

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ATE194142T1 (de)	2000-07-15	Verfahren zur herstellung von nukleotiden
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