ATE270547T1 - Substituierte benzo(1,2-b:5,4-b')dipyran-4-amine als ccr5 modulatoren - Google Patents

Substituierte benzo(1,2-b:5,4-b')dipyran-4-amine als ccr5 modulatoren

Info

Publication number
ATE270547T1
ATE270547T1 AT00913848T AT00913848T ATE270547T1 AT E270547 T1 ATE270547 T1 AT E270547T1 AT 00913848 T AT00913848 T AT 00913848T AT 00913848 T AT00913848 T AT 00913848T AT E270547 T1 ATE270547 T1 AT E270547T1
Authority
AT
Austria
Prior art keywords
ccr5
dipyran
amines
receptor
substituted benzo
Prior art date
Application number
AT00913848T
Other languages
English (en)
Inventor
Frank E Blaney
William E Bondinell
James A Chan
Original Assignee
Smithkline Beecham Corp
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp, Smithkline Beecham Plc filed Critical Smithkline Beecham Corp
Application granted granted Critical
Publication of ATE270547T1 publication Critical patent/ATE270547T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
    • C07D493/14—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Dermatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Molecular Biology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)
  • Photoreceptors In Electrophotography (AREA)
AT00913848T 1999-03-10 2000-03-10 Substituierte benzo(1,2-b:5,4-b')dipyran-4-amine als ccr5 modulatoren ATE270547T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12360799P 1999-03-10 1999-03-10
PCT/US2000/006210 WO2000053175A1 (en) 1999-03-10 2000-03-10 Compounds and methods

Publications (1)

Publication Number Publication Date
ATE270547T1 true ATE270547T1 (de) 2004-07-15

Family

ID=22409688

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00913848T ATE270547T1 (de) 1999-03-10 2000-03-10 Substituierte benzo(1,2-b:5,4-b')dipyran-4-amine als ccr5 modulatoren

Country Status (8)

Country Link
US (1) US6506790B1 (de)
EP (1) EP1156801B1 (de)
JP (1) JP2002538203A (de)
AT (1) ATE270547T1 (de)
AU (1) AU3521400A (de)
DE (1) DE60011997T2 (de)
ES (1) ES2223481T3 (de)
WO (1) WO2000053175A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004080966A1 (ja) 2003-03-14 2004-09-23 Ono Pharmaceutical Co., Ltd. 含窒素複素環誘導体およびそれらを有効成分とする薬剤
JP4710606B2 (ja) 2003-04-18 2011-06-29 小野薬品工業株式会社 スピロピペリジン化合物およびその医薬用途
NZ553696A (en) 2004-09-13 2010-02-26 Ono Pharmaceutical Co Nitrogenous heterocyclic derivative and medicine containing the same as an active ingredient
US20110052612A1 (en) 2005-05-31 2011-03-03 Ono Pharmaceutical Co., Ltd. Spiropiperidine compound and medicinal use thereof
EP1942108B1 (de) 2005-10-28 2013-09-04 Ono Pharmaceutical Co., Ltd. Eine basische gruppe enthaltende verbindung und anwendung davon
EP1961744B1 (de) 2005-11-18 2013-04-17 Ono Pharmaceutical Co., Ltd. Verbindung mit basischen gruppen und deren verwendung
WO2007105637A1 (ja) 2006-03-10 2007-09-20 Ono Pharmaceutical Co., Ltd. 含窒素複素環誘導体およびそれらを有効成分とする薬剤
JP5257068B2 (ja) 2006-05-16 2013-08-07 小野薬品工業株式会社 保護されていてもよい酸性基を含有する化合物およびその用途
EP2055705A4 (de) 2006-07-31 2014-08-20 Ono Pharmaceutical Co Verbindung mit einer über eine spiro-bindung daran gebundenen cyclischen gruppe und anwendung davon
WO2008030853A2 (en) * 2006-09-06 2008-03-13 Incyte Corporation Combination therapy for human immunodeficiency virus infection
WO2010129351A1 (en) 2009-04-28 2010-11-11 Schepens Eye Research Institute Method to identify and treat age-related macular degeneration
WO2013024022A1 (en) 2011-08-12 2013-02-21 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for treatment of pulmonary hypertension
US11629196B2 (en) 2020-04-27 2023-04-18 Incelldx, Inc. Method of treating SARS-CoV-2-associated hypercytokinemia by administering a human monoclonal antibody (PRO-140) that inhibits CCR5/CCL5 binding interactions

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6281212B1 (en) * 1996-07-12 2001-08-28 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
WO1998025617A1 (en) * 1996-12-13 1998-06-18 Merck & Co., Inc. Substituted aryl piperazines as modulators of chemokine receptor activity
US5962462A (en) * 1996-12-13 1999-10-05 Merck & Co., Inc. Spiro-substituted azacycles as modulators of chemokine receptor activity
AU5812498A (en) * 1996-12-20 1998-07-17 Merck & Co., Inc. Substituted aminoquinolines as modulators of chemokine receptor activity
US6013644A (en) * 1997-12-12 2000-01-11 Merck & Co., Inc. Spiro-substituted azacycles as modulators of chemokine receptor activity

Also Published As

Publication number Publication date
US6506790B1 (en) 2003-01-14
EP1156801A4 (de) 2003-05-14
ES2223481T3 (es) 2005-03-01
WO2000053175A1 (en) 2000-09-14
AU3521400A (en) 2000-09-28
DE60011997T2 (de) 2005-07-21
EP1156801A1 (de) 2001-11-28
JP2002538203A (ja) 2002-11-12
DE60011997D1 (de) 2004-08-12
EP1156801B1 (de) 2004-07-07

Similar Documents

Publication Publication Date Title
ZA985542B (en) Substituted benzanilides as CCR5 receptor ligands antiinflammatory agents and antiviral agents
WO2004011427A3 (en) Substituted benzanilides as modulators of the ccr5 receptor
WO2004010943A3 (en) Substituted benzanilides as modulators of the ccr5 receptor
DE60011997D1 (de) SUBSTITUIERTE BENZO(1,2-b:5,4-b')DIPYRAN-4-AMINE ALS CCR5 MODULATOREN
WO2004010942A3 (en) Substituted heterocyclic compounds as modulators of the ccr5 receptor
AR013669A1 (es) Compuestos y metodos
DE69916496D1 (de) Zusammensetzung und verfahren
DK1718649T3 (da) Imidazo[1,2-c]pyrimidinyleddikesyrederivater
MY147984A (en) Pyrimidine derivatives
UY24655A1 (es) Derivados 6,6- ó 6,7-biciclicos sustituidos que contienen pirido o pirimido
TW200608995A (en) Antagonizing interleukin-21 receptor activity
PE20050306A1 (es) Compuestos imidazol condensado, 2-piridilo sustituido como inhibidores del factor de crecimiento transformante (tgf)
TW200738660A (en) Piperidinyl derivatives as modulators of chemokine receptor activity
BR0207952A (pt) Moduladores da atividade de receptores de quimiocina
BRPI0418112A (pt) inibidores de p-38 quinase bicìclico heterocìclicos
TR200402496T2 (tr) CCR5 antagonistleri olarak yararlı piperidin türevleri.
AU4455896A (en) A chemokine receptor able to bind to mcp-1, mip-1 alpha and/or rantes. its uses
BRPI0414862A (pt) derivados de tropano substituìdos com imidazopiridina com atividade antagonista do receptor ccr5, para o tratamento do hiv e da inflamação
ATE422496T1 (de) Als medikamente für die behandlung von autoimmunerkrankungen geeignete substituierte pyridoä2,3-düpyrimidinderivate
ATE449074T1 (de) 2-azabicyclo 3.3.1 nonan-derivate als antagonisten des opioid-rezeptors
WO2002034760A3 (en) Compounds and methods
NZ514696A (en) IL-8 receptor antagonists
PT1585546E (pt) Antagonistas de kim-1 e sua utilização para modular o sistema imunitário
DE602005014364D1 (de) Vla-4-antagonisten
Ahmed et al. Role of interleukin-17 and interleukin 23R gene polymorphism and serum interleukin 17A in rheumatoid arthritis

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties