ATE272074T1 - An neuropeptide gebundenes rgd (arg-gly-asp) - Google Patents
An neuropeptide gebundenes rgd (arg-gly-asp)Info
- Publication number
- ATE272074T1 ATE272074T1 AT01947245T AT01947245T ATE272074T1 AT E272074 T1 ATE272074 T1 AT E272074T1 AT 01947245 T AT01947245 T AT 01947245T AT 01947245 T AT01947245 T AT 01947245T AT E272074 T1 ATE272074 T1 AT E272074T1
- Authority
- AT
- Austria
- Prior art keywords
- gly
- asp
- arg
- neuropeptides
- rgd
- Prior art date
Links
- IYMAXBFPHPZYIK-BQBZGAKWSA-N Arg-Gly-Asp Chemical group NC(N)=NCCC[C@H](N)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(O)=O IYMAXBFPHPZYIK-BQBZGAKWSA-N 0.000 title abstract 3
- 108010072041 arginyl-glycyl-aspartic acid Proteins 0.000 title abstract 2
- 108090000189 Neuropeptides Proteins 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 230000004071 biological effect Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000008177 pharmaceutical agent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1019—Tetrapeptides with the first amino acid being basic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/082—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the peptide being a RGD-containing peptide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/083—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the peptide being octreotide or a somatostatin-receptor-binding peptide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/57563—Vasoactive intestinal peptide [VIP]; Related peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/595—Gastrins; Cholecystokinins [CCK]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins
- C07K14/6555—Somatostatins at least 1 amino acid in D-form
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/75—Fibrinogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0815—Tripeptides with the first amino acid being basic
- C07K5/0817—Tripeptides with the first amino acid being basic the first amino acid being Arg
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
- C07K7/086—Bombesin; Related peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/22—Tachykinins, e.g. Eledoisins, Substance P; Related peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Endocrinology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP00201499 | 2000-04-26 | ||
| PCT/EP2001/004764 WO2001081426A2 (en) | 2000-04-26 | 2001-04-26 | Rgd (arg-gly-asp) coupled to (neuro)peptides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE272074T1 true ATE272074T1 (de) | 2004-08-15 |
Family
ID=8171409
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01947245T ATE272074T1 (de) | 2000-04-26 | 2001-04-26 | An neuropeptide gebundenes rgd (arg-gly-asp) |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US7202330B2 (de) |
| EP (2) | EP1452543A3 (de) |
| JP (1) | JP2004517034A (de) |
| AT (1) | ATE272074T1 (de) |
| AU (2) | AU6898201A (de) |
| CA (1) | CA2407514C (de) |
| CZ (1) | CZ20023539A3 (de) |
| DE (1) | DE60104552T2 (de) |
| ES (1) | ES2225570T3 (de) |
| HU (1) | HUP0301571A2 (de) |
| IL (1) | IL152466A0 (de) |
| NO (1) | NO20025064L (de) |
| NZ (1) | NZ522200A (de) |
| PL (1) | PL202279B1 (de) |
| WO (1) | WO2001081426A2 (de) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001081426A2 (en) | 2000-04-26 | 2001-11-01 | Biosynthema Inc. | Rgd (arg-gly-asp) coupled to (neuro)peptides |
| US7122622B2 (en) | 2002-04-16 | 2006-10-17 | Biosynthema Inc. | Peptide compounds having improved binding affinity to somatostatin receptors |
| EP1358890A1 (de) | 2002-05-03 | 2003-11-05 | BioSynthema, Inc | Benzothienyl-Analoge von Somatostatine, selectiv für bestimmte Somatostatinrezeptoren |
| US7384636B2 (en) | 2003-03-31 | 2008-06-10 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Polypeptide |
| US20070025910A1 (en) | 2005-07-29 | 2007-02-01 | Norenberg Jeffrey P | Anticancer therapy |
| CN101495437A (zh) | 2006-07-24 | 2009-07-29 | 宝洁公司 | 用于差向异构环己烯基酮的方法以及其在羟醛缩合工艺中的应用 |
| KR100987592B1 (ko) * | 2008-03-10 | 2010-10-12 | 경북대학교 산학협력단 | 암진단용 ｍｒ 조영제와 그 제조방법 |
| US9517201B2 (en) * | 2008-04-04 | 2016-12-13 | Rutgers, The State University Of New Jersey | Nanocarrier and nanogel compositions |
| US8263133B2 (en) * | 2009-02-18 | 2012-09-11 | The Regents Of The University Of California | Multivalent clustering targeting strategy for drug carriers |
| CN102260352B (zh) * | 2010-05-28 | 2013-11-20 | 山东先声麦得津生物制药有限公司 | 靶向性白细胞介素融合蛋白及其制备方法与应用 |
| US9775803B2 (en) | 2011-10-19 | 2017-10-03 | Samsung Electronics Co., Ltd. | Liposome comprising elastin-like polypeptide and tumor cell targeting material and use thereof |
| EP2922578B1 (de) * | 2012-11-21 | 2018-12-12 | Serene, Llc | Tin-117m-somatostatinrezeptor-bindende verbindungen |
| SI3568205T1 (sl) | 2017-01-12 | 2023-12-29 | Radiomedix Inc. | Zdravljenje rakastih celic, ki prekomerno izražajo receptorje za somatostatin, z uporabo derivatov okreotida, kelatiranih v radioizotope |
| CN107412794B (zh) * | 2017-04-17 | 2019-01-04 | 中国医学科学院北京协和医院 | 双靶点显像分子探针及其制备方法和应用 |
| CN106967149A (zh) * | 2017-05-04 | 2017-07-21 | 苏州强耀生物科技有限公司 | 一种棕榈酰化修饰的半胱氨酸多肽的制备方法 |
| PL238941B1 (pl) * | 2018-04-04 | 2021-10-25 | Gdanski Univ Medyczny | Związki chemiczne o działaniu przeciwuszkodzeniowym i/lub neuroprotekcyjnym |
| CN116510033B (zh) * | 2023-03-09 | 2024-03-19 | 哈尔滨吉象隆生物技术有限公司 | 一种抗肿瘤的ppc药物及其制备方法与应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2878341B2 (ja) | 1989-03-03 | 1999-04-05 | 学校法人藤田学園 | 人工機能性ポリペプチド |
| US5843903A (en) * | 1995-11-27 | 1998-12-01 | The Administrators Of The Tulane Educational Fund | Targeted cytotoxic anthracycline analogs |
| WO2001081426A2 (en) | 2000-04-26 | 2001-11-01 | Biosynthema Inc. | Rgd (arg-gly-asp) coupled to (neuro)peptides |
-
2001
- 2001-04-26 WO PCT/EP2001/004764 patent/WO2001081426A2/en not_active Ceased
- 2001-04-26 CZ CZ20023539A patent/CZ20023539A3/cs unknown
- 2001-04-26 ES ES01947245T patent/ES2225570T3/es not_active Expired - Lifetime
- 2001-04-26 NZ NZ522200A patent/NZ522200A/en unknown
- 2001-04-26 HU HU0301571A patent/HUP0301571A2/hu unknown
- 2001-04-26 CA CA2407514A patent/CA2407514C/en not_active Expired - Lifetime
- 2001-04-26 IL IL15246601A patent/IL152466A0/xx unknown
- 2001-04-26 PL PL357246A patent/PL202279B1/pl not_active IP Right Cessation
- 2001-04-26 AU AU6898201A patent/AU6898201A/xx active Pending
- 2001-04-26 AT AT01947245T patent/ATE272074T1/de not_active IP Right Cessation
- 2001-04-26 AU AU2001268982A patent/AU2001268982B8/en not_active Ceased
- 2001-04-26 JP JP2001578513A patent/JP2004517034A/ja active Pending
- 2001-04-26 DE DE60104552T patent/DE60104552T2/de not_active Expired - Lifetime
- 2001-04-26 EP EP04101401A patent/EP1452543A3/de not_active Withdrawn
- 2001-04-26 EP EP01947245A patent/EP1301540B1/de not_active Expired - Lifetime
- 2001-04-26 US US10/258,766 patent/US7202330B2/en not_active Expired - Lifetime
-
2002
- 2002-10-22 NO NO20025064A patent/NO20025064L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CZ20023539A3 (cs) | 2003-09-17 |
| EP1452543A3 (de) | 2005-08-03 |
| CA2407514C (en) | 2011-03-29 |
| HUP0301571A2 (hu) | 2003-09-29 |
| DE60104552T2 (de) | 2005-09-01 |
| US7202330B2 (en) | 2007-04-10 |
| IL152466A0 (en) | 2003-05-29 |
| EP1301540A2 (de) | 2003-04-16 |
| AU2001268982B8 (en) | 2006-08-03 |
| JP2004517034A (ja) | 2004-06-10 |
| AU6898201A (en) | 2001-11-07 |
| AU2001268982B2 (en) | 2006-06-15 |
| ES2225570T3 (es) | 2005-03-16 |
| US20040136907A1 (en) | 2004-07-15 |
| EP1452543A2 (de) | 2004-09-01 |
| WO2001081426A2 (en) | 2001-11-01 |
| WO2001081426A3 (en) | 2002-06-27 |
| NO20025064L (no) | 2002-12-20 |
| DE60104552D1 (de) | 2004-09-02 |
| NZ522200A (en) | 2004-07-30 |
| NO20025064D0 (no) | 2002-10-22 |
| PL202279B1 (pl) | 2009-06-30 |
| PL357246A1 (en) | 2004-07-26 |
| CA2407514A1 (en) | 2001-11-01 |
| EP1301540B1 (de) | 2004-07-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE60104552D1 (de) | An neuropeptide gebundenes rgd (arg-gly-asp) | |
| ATE297219T1 (de) | Antikörper als arzneimittel gegen lymphocytische tumore (ausschliesslich myelome) | |
| DK1105409T3 (da) | Beskyttelse af endogene terapeutiske peptider fra peptidaseaktivitet ved konjugering med blodkomponenter | |
| EP2298331A3 (de) | Verwendung von Transthyretinpeptid-/-proteinfusionen zur Erhöhung der Serumshalbwertszeit von pharmakologisch aktiven Peptiden/Proteinen | |
| CY1108007T1 (el) | Φαρμακευτικες συνθεσεις βοτουλινικης τοξινης | |
| ATE376559T1 (de) | Methoden der verhinderung und behandlung der alzheimer'schen krankheit | |
| ATE399177T1 (de) | Derivate therapeutischer peptide | |
| AT500379B8 (de) | Tau-proteine | |
| DK0771209T3 (da) | Hidtil ukendte peptider | |
| DE69942231D1 (de) | Ortspezifische duale pegylation von proteine | |
| DE60224508D1 (de) | Wti-modifiziertes peptid | |
| ATE513541T1 (de) | Pharmazeutische zusammensetzungen zur oralen verabreichung von calcitonin | |
| DK1343896T3 (da) | Lille syreoplöseligt sporeprotein og anvendelser deraf | |
| EP1023906A4 (de) | Verstärker für antikörper gegen lymphoiden tumor | |
| BR0210252A (pt) | Peptìdeos biologicamente ativos | |
| DE69836485D1 (de) | Hepatitis e-virus aus dem schwein und dessen verwendungen | |
| DK1219299T4 (da) | Allergivacciner og fremstilling deraf | |
| AU2003222944A1 (en) | Novel coupling agents, the active intermediates and the conjugates thereof and the use of said conjugates in diagnostic methods | |
| PT1150716E (pt) | Composicao farmaceutica de proteinas hedgehog hidrofobicamente modificadas e sua utilizacao | |
| WO2001090139A3 (en) | A ligand for enhancing oral and cns delivery of biological agents | |
| EP1298127A4 (de) | Aminosäure-n-carboxy-anhydride mit substituenten am stickstoff |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |