ATE273322T1 - Tfpi-verwandte peptide die das wachstums von glatten muskelzellen inhibieren - Google Patents

Tfpi-verwandte peptide die das wachstums von glatten muskelzellen inhibieren

Info

Publication number
ATE273322T1
ATE273322T1 AT96935411T AT96935411T ATE273322T1 AT E273322 T1 ATE273322 T1 AT E273322T1 AT 96935411 T AT96935411 T AT 96935411T AT 96935411 T AT96935411 T AT 96935411T AT E273322 T1 ATE273322 T1 AT E273322T1
Authority
AT
Austria
Prior art keywords
peptide
smooth muscle
amino acid
muscle cells
growth
Prior art date
Application number
AT96935411T
Other languages
English (en)
Inventor
Yo Nakahara
Saburo Hara
Yuichi Kamikubo
Sumiyo Takemoto
Seiji Miyamoto
Original Assignee
Chemo Sero Therapeut Res Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chemo Sero Therapeut Res Inst filed Critical Chemo Sero Therapeut Res Inst
Application granted granted Critical
Publication of ATE273322T1 publication Critical patent/ATE273322T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8114—Kunitz type inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT96935411T 1995-10-24 1996-10-23 Tfpi-verwandte peptide die das wachstums von glatten muskelzellen inhibieren ATE273322T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP30079295 1995-10-24
PCT/JP1996/003080 WO1997015598A1 (fr) 1995-10-24 1996-10-23 Nouveau peptide

Publications (1)

Publication Number Publication Date
ATE273322T1 true ATE273322T1 (de) 2004-08-15

Family

ID=17889159

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96935411T ATE273322T1 (de) 1995-10-24 1996-10-23 Tfpi-verwandte peptide die das wachstums von glatten muskelzellen inhibieren

Country Status (9)

Country Link
US (1) US6191113B1 (de)
EP (1) EP0867450B1 (de)
JP (1) JP3930050B2 (de)
KR (1) KR100465222B1 (de)
AT (1) ATE273322T1 (de)
AU (1) AU719366B2 (de)
CA (1) CA2232240C (de)
DE (1) DE69633133T2 (de)
WO (1) WO1997015598A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6346510B1 (en) 1995-10-23 2002-02-12 The Children's Medical Center Corporation Therapeutic antiangiogenic endostatin compositions
ATE371030T1 (de) * 1996-02-23 2007-09-15 Mochida Pharm Co Ltd Meltrine
US5981471A (en) * 1997-02-06 1999-11-09 Entremed, Inc. Compositions and methods for inhibiting cellular proliferation
TWI257307B (en) * 2000-07-12 2006-07-01 Orthologic Corp Pharmaceutical composition for cardiac tissue repair
BR0210252A (pt) 2001-07-13 2004-09-14 Pepharm R & D Ltd Peptìdeos biologicamente ativos
WO2003060131A1 (en) * 2002-01-09 2003-07-24 Suntory Limited SUGAR TRANSFERASE GnT-V HAVING ANGIOGENIC EFFECT
AU2003256343B2 (en) * 2002-07-02 2006-12-21 Orthologic Corp. Thrombin peptide derivatives
RU2263146C2 (ru) * 2003-07-10 2005-10-27 Михаил Викторович Разуменко Способ получения бактериофагов, специфично связывающихся с клетками-мишенями и предназначенных для терапевтических целей
TWI353252B (en) 2004-04-28 2011-12-01 Cms Peptides Patent Holding Company Ltd Biologically active peptide vapeehptllteaplnpk der
NZ591825A (en) 2005-07-26 2012-10-26 Cms Peptides Patent Holding Company Ltd Biologically active peptides comprising PTTKTYFPHF and their uses in the manufacture of a medicament for modulating fatigue
JP2010504336A (ja) * 2006-09-22 2010-02-12 オーソロジック コーポレイション 血管内皮機能不全を治療する方法
US20110105400A1 (en) * 2008-03-26 2011-05-05 Orthologic Corp. Methods for treating acute myocardial infarction
US9228022B2 (en) 2010-06-30 2016-01-05 Novo Nordisk A/S Antibodies that are capable of specifically binding tissue factor pathway inhibitor
JP2013533871A (ja) 2010-06-30 2013-08-29 ノヴォ ノルディスク アー／エス 組織因子経路インヒビターに特異的に結合することが可能な抗体
PL236566B1 (pl) 2012-12-17 2021-01-25 Univ Jagiellonski Peptyd chemerynowy, kompozycja farmaceutyczna zawierająca taki peptyd, oraz jego zastosowanie
JPWO2019176860A1 (ja) * 2018-03-15 2021-01-14 東レ株式会社 細胞接着性材料

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5849536A (en) * 1990-03-02 1998-12-15 Bio-Technology General Corp. Cloning and production of human von willebrand factor GPIb binding domain polypeptides and methods of using same
US5254536A (en) * 1992-01-10 1993-10-19 The Du Pont Merck Pharmaceutical Company Therapeutic utility of plasminogen activator inhibitor-1 to control bleeding
AU5715194A (en) * 1992-12-04 1994-07-04 N.V. Innogenetics S.A. New polypeptides, nucleic acid sequences encoding them, and their use to prevent the adhesion of f107-fimbriated bacteria
JP3428687B2 (ja) 1993-06-30 2003-07-22 財団法人化学及血清療法研究所 組織因子凝固系インヒビターの調製法
US5824644A (en) * 1994-07-07 1998-10-20 G. D. Searle & Co. Method of attenuating arterial stenosis
US5589359A (en) 1994-08-05 1996-12-31 Chiron Corporation Chimeric proteins
JPH0859698A (ja) * 1994-08-15 1996-03-05 Teijin Ltd 血液凝固調節能を有する新規ペプチド
US5639726A (en) * 1994-09-30 1997-06-17 The Regents Of The University Of Michigan Peptide mediated enhancement of thrombolysis methods and compositions
JPH09124506A (ja) * 1995-08-29 1997-05-13 Chemo Sero Therapeut Res Inst 組織因子凝固系インヒビター含有動脈硬化治療剤
US5772629A (en) * 1995-10-23 1998-06-30 Localmed, Inc. Localized intravascular delivery of TFPI for inhibition of restenosis in recanalized blood vessels
US5981471A (en) * 1997-02-06 1999-11-09 Entremed, Inc. Compositions and methods for inhibiting cellular proliferation

Also Published As

Publication number Publication date
EP0867450A1 (de) 1998-09-30
JP3930050B2 (ja) 2007-06-13
CA2232240A1 (en) 1997-05-01
AU7335796A (en) 1997-05-15
CA2232240C (en) 2007-01-16
DE69633133T2 (de) 2005-07-28
AU719366B2 (en) 2000-05-04
KR100465222B1 (ko) 2005-05-17
EP0867450B1 (de) 2004-08-11
EP0867450A4 (de) 2000-01-19
DE69633133D1 (de) 2004-09-16
US6191113B1 (en) 2001-02-20
WO1997015598A1 (fr) 1997-05-01
KR19990066965A (ko) 1999-08-16

Similar Documents

Publication Publication Date Title
DE69633133D1 (de) TFPI-verwandte Peptide die das Wachstums von glatten Muskelzellen inhibieren
EP0484401A4 (en) Production of vascular endothelial cell growth factor
DE69627704D1 (en) Protegrine
CA2153789A1 (en) Biologically active tgf-.beta.1 and tgf-.beta.2 peptides
DE3856265D1 (de) Varianten des pankreatischen Rinder-Trypsininhibitors, deren Herstellung und Verwendung
CA2081450A1 (en) Biologically active peptides containing d-2-alkyltrypthophan
DE68923819D1 (de) Verwendung von gamma-Hydroxy-Buttersäuresalzen zur Herstellung von pharmazeutischen Zusammensetzungen zur Verwendung bei der Behandlung von Alkoholismus und die hergestellten Zusammensetzungen.
DE68916932D1 (de) Antimikrobielle peptide, zusammensetzungen, die diese enthalten, und verwendungen daraus.
RU94036776A (ru) Домен ингибитора протеазы, днк, вектор, клетка, способ получения ингибитора протеазы, фармацевтическая композиция, применение домена ингибитора протеазы
IS2819B (is) Viðloðunarsameindir í æðum og mótun á starfsemi@þeirra
DE69126049D1 (de) Vektoren und Zusammensetzungen zur Expression von Glykosilationsmutanten des menschlichen Proteins-C
ES2081817T3 (es) Polipeptido con secuencias principales repetidas que se fijan en la celula.
HU895788D0 (en) Process for producing peptides and medical products containing them
DE68921229D1 (de) Prozess zur Behandlung von unlöslichem heterogenem Fusionsprotein.
ATE109794T1 (de) Von faktor vii abgeleitete peptide mit antihämostatischer wirkung.
UA27055C2 (uk) Лікарський препарат імуhозаміhhої дії hа осhові клітиhhої суспеhзії та спосіб лікуваhhя сиhдрому hабутого імуhодефіциту (віл-іhфекції) з використаhhям цього препарату
BG97123A (bg) Производни на човешка, стимулирана от жлъчните соли, липаза и фармацевтични състави на тяхна основа
HUT53125A (en) Process for producing peptides with anticoagulant activity
RU93041779A (ru) Средство для лечения иммунодефицитных состояний
ATE216706T1 (de) Peptide des hiv-gag proteins, ihre herstellung und verwendung
ATE154608T1 (de) Verwendung einer mischung von peptiden and aminosäuren für die prophylaxis oder behandlung von dementia
EP0241136A3 (de) Humaner, Klasse 1 Heparin bindender, Wachstumsfaktor
KR950701347A (ko) 신규한 향종양성 사이토킨(A novel anti-neoplastic cytokine)
ATE145939T1 (de) Mitogen für die glatte muskulatur und dessen kodierende dns
CA2050941A1 (en) Antibody to smooth muscle myosin heavy chains

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties