ATE275574T1 - Verfahren zur reinigung von 5'-geschützten thymidinen - Google Patents

Verfahren zur reinigung von 5'-geschützten thymidinen

Info

Publication number: ATE275574T1
Authority: AT; Austria
Prior art keywords: protected; thymidines; purifying; prior; art
Prior art date: 2001-05-15

Application number

AT02253360T

Other languages

English (en)

Inventor

Hironori Komatsu

Toshiyuki Kouno

Katsutoshi Tsuchiya

Hiroharu Tanikawa

Hiroki Ishibashi

Original Assignee

Mitsui Chemicals Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-05-15

Filing date

2002-05-14

Publication date

2004-09-15

2002-05-14 Application filed by Mitsui Chemicals Inc filed Critical Mitsui Chemicals Inc

2004-09-15 Application granted granted Critical

2004-09-15 Publication of ATE275574T1 publication Critical patent/ATE275574T1/de

Links

IQFYYKKMVGJFEH-XLPZGREQSA-N Thymidine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 IQFYYKKMVGJFEH-XLPZGREQSA-N 0.000 abstract 2
DWRXFEITVBNRMK-UHFFFAOYSA-N Beta-D-1-Arabinofuranosylthymine Natural products O=C1NC(=O)C(C)=CN1C1C(O)C(O)C(CO)O1 DWRXFEITVBNRMK-UHFFFAOYSA-N 0.000 abstract 1
IQFYYKKMVGJFEH-UHFFFAOYSA-N beta-L-thymidine Natural products O=C1NC(=O)C(C)=CN1C1OC(CO)C(O)C1 IQFYYKKMVGJFEH-UHFFFAOYSA-N 0.000 abstract 1
125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
239000013078 crystal Substances 0.000 abstract 1
239000012535 impurity Substances 0.000 abstract 1
239000002904 solvent Substances 0.000 abstract 1
229940104230 thymidine Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/067—Pyrimidine radicals with ribosyl as the saccharide radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Health & Medical Sciences (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Life Sciences & Earth Sciences (AREA)
Saccharide Compounds (AREA)
Epoxy Compounds (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Studio Circuits (AREA)

AT02253360T 2001-05-15 2002-05-14 Verfahren zur reinigung von 5'-geschützten thymidinen ATE275574T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP2001144278		2001-05-15

Publications (1)

Publication Number	Publication Date
ATE275574T1 true ATE275574T1 (de)	2004-09-15

Family

ID=18990254

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT02253360T ATE275574T1 (de)	2001-05-15	2002-05-14	Verfahren zur reinigung von 5'-geschützten thymidinen

Country Status (8)

Country	Link
US (1)	US6875860B2 (de)
EP (1)	EP1258489B1 (de)
KR (1)	KR100474629B1 (de)
CN (1)	CN1195771C (de)
AT (1)	ATE275574T1 (de)
BR (1)	BR0201842A (de)
CA (1)	CA2386285A1 (de)
DE (1)	DE60201145T2 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7160537B2 (en)	2003-12-15	2007-01-09	Siemens Medical Solutions Usa, Inc.	Method for preparing radiolabeled thymidine having low chromophoric byproducts
US20050131224A1 (en) *	2003-12-15	2005-06-16	Cti Pet Systems, Inc.	Method for preparing radiolabeled thymidine

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0090789A1 (de) *	1982-03-26	1983-10-05	Monsanto Company	Chemische DNA-Synthese
JPS60152495A (ja)	1984-01-18	1985-08-10	Nippon Zeon Co Ltd	保護化ヌクレオシドの製造法
US5672697A (en)	1991-02-08	1997-09-30	Gilead Sciences, Inc.	Nucleoside 5'-methylene phosphonates
US5719273A (en) *	1993-06-14	1998-02-17	Nexstar Pharmaceuticals, Inc.	Palladium catalyzed nucleoside modifications methods using nucleophiles and carbon monoxide
EP0644196B1 (de) *	1993-09-17	1997-11-05	Novartis AG	TTTr als Schutzgruppe in der Nukleotidsynthese
US5734041A (en)	1995-10-20	1998-03-31	Mcgill University	Preparation of chiral phosphorothioate oligomers
US6414137B1 (en) *	1998-12-23	2002-07-02	Alliedsignal Inc.	Selective solvent extraction for the purification of protected nucleosides
JP4420360B2 (ja)	1999-01-14	2010-02-24	ヤマサ醤油株式会社	５’−ｏ−トリチルヌクレオシド類の製造法
AU5460700A (en) *	1999-06-04	2000-12-28	Allied-Signal Inc.	Protected nucleosides

2002
- 2002-05-14 DE DE60201145T patent/DE60201145T2/de not_active Expired - Lifetime
- 2002-05-14 CA CA002386285A patent/CA2386285A1/en not_active Abandoned
- 2002-05-14 AT AT02253360T patent/ATE275574T1/de not_active IP Right Cessation
- 2002-05-14 EP EP02253360A patent/EP1258489B1/de not_active Expired - Lifetime
- 2002-05-15 CN CNB02119713XA patent/CN1195771C/zh not_active Expired - Fee Related
- 2002-05-15 US US10/144,802 patent/US6875860B2/en not_active Expired - Fee Related
- 2002-05-15 BR BR0201842-0A patent/BR0201842A/pt not_active Application Discontinuation
- 2002-05-15 KR KR10-2002-0026702A patent/KR100474629B1/ko not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP1258489A1 (de)	2002-11-20
KR20030022675A (ko)	2003-03-17
DE60201145T2 (de)	2005-09-22
DE60201145D1 (de)	2004-10-14
CA2386285A1 (en)	2002-11-15
BR0201842A (pt)	2003-04-29
US20030004331A1 (en)	2003-01-02
KR100474629B1 (ko)	2005-03-08
US6875860B2 (en)	2005-04-05
EP1258489B1 (de)	2004-09-08
CN1195771C (zh)	2005-04-06
CN1385437A (zh)	2002-12-18

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Legal Events

Date	Code	Title	Description
2005-03-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties