ATE277187T1 - Verfahren zur effizienten herstellung von 7-adca via 2-(carboxyethylthio)acetyl-7-adca und 3- (carboxymethylthio)propionyl-7-adca - Google Patents
Verfahren zur effizienten herstellung von 7-adca via 2-(carboxyethylthio)acetyl-7-adca und 3- (carboxymethylthio)propionyl-7-adcaInfo
- Publication number
- ATE277187T1 ATE277187T1 AT94924828T AT94924828T ATE277187T1 AT E277187 T1 ATE277187 T1 AT E277187T1 AT 94924828 T AT94924828 T AT 94924828T AT 94924828 T AT94924828 T AT 94924828T AT E277187 T1 ATE277187 T1 AT E277187T1
- Authority
- AT
- Austria
- Prior art keywords
- adca
- pct
- carboxyethylthio
- carboxymethylthio
- propionyl
- Prior art date
Links
- NVIAYEIXYQCDAN-CLZZGJSISA-N 7beta-aminodeacetoxycephalosporanic acid Chemical compound S1CC(C)=C(C(O)=O)N2C(=O)[C@@H](N)[C@@H]12 NVIAYEIXYQCDAN-CLZZGJSISA-N 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 102000057234 Acyl transferases Human genes 0.000 abstract 1
- 108700016155 Acyl transferases Proteins 0.000 abstract 1
- 101710104123 Deacetoxycephalosporin C synthase Proteins 0.000 abstract 1
- 241000228150 Penicillium chrysogenum Species 0.000 abstract 1
- 238000011084 recovery Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
- C12P35/02—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin by desacylation of the substituent in the 7 position
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Mycology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Steroid Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP93202259 | 1993-07-30 | ||
| EP93203696 | 1993-12-24 | ||
| PCT/EP1994/002543 WO1995004148A1 (en) | 1993-07-30 | 1994-07-29 | Process for the efficient production of 7-adca via 2-(carboxyethylthio)acetyl-7-adca and 3-(carboxymethylthio)propionyl-7-adca |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE277187T1 true ATE277187T1 (de) | 2004-10-15 |
Family
ID=26133940
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT94924828T ATE277187T1 (de) | 1993-07-30 | 1994-07-29 | Verfahren zur effizienten herstellung von 7-adca via 2-(carboxyethylthio)acetyl-7-adca und 3- (carboxymethylthio)propionyl-7-adca |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US5726032A (de) |
| KR (1) | KR100336174B1 (de) |
| CN (1) | CN1103814C (de) |
| AT (1) | ATE277187T1 (de) |
| BR (1) | BR9407108A (de) |
| CA (1) | CA2168431A1 (de) |
| CZ (1) | CZ285604B6 (de) |
| DE (1) | DE69434023D1 (de) |
| HU (1) | HU219259B (de) |
| PL (1) | PL180799B1 (de) |
| SK (1) | SK282624B6 (de) |
| WO (1) | WO1995004148A1 (de) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6709859B1 (en) * | 1986-01-31 | 2004-03-23 | Beecham Group P.L.C. | Chromosomal DNA Fragments Encoding Enzymes for Encoding B-Lactam Biosynthesis Enzymes, and Vector and Transformants for Their Expression |
| EP0233715B1 (de) * | 1986-01-31 | 1994-05-25 | BEECHAM GROUP plc | Isolierung und Expression von bei der Biosynthese von Beta-Laktamen beteiligten Genen |
| WO1996010084A1 (en) * | 1994-09-28 | 1996-04-04 | Novo Nordisk A/S | Process for the production of secondary metabolites |
| US5731165A (en) * | 1995-06-02 | 1998-03-24 | Gist-Brocades, B.V. | Process for the production of 7-ADCA via expandase activity on penicillin G |
| PL182509B1 (pl) * | 1995-06-02 | 2002-01-31 | Gist Brocades Bv | Sposób wytwarzania kwasu 7-aminodezacetoksycefalosporanowego (7-ADCA) |
| GB2323361A (en) * | 1995-11-27 | 1998-09-23 | Gist Brocades Bv | Improved process for the production of semi-synthetic cephalosporins via expandase activity on penicillin G |
| WO1997038107A1 (en) * | 1996-04-04 | 1997-10-16 | Gist-Brocades B.V. | An enzyme with high adipoyl-coenzyme a synthetase activity and uses thereof |
| PT970236E (pt) * | 1997-02-20 | 2006-08-31 | Dsm Ip Assets Bv | Producao fermentativa de compostos valiosos a escala industrial utilizando meios quimicamente definidos |
| PL336345A1 (en) | 1997-04-11 | 2000-06-19 | Dsm Nv | Genic conversion as a tool for constructing recombined filiform fungi |
| CN1224468A (zh) * | 1997-04-22 | 1999-07-28 | 吉斯特-布罗卡迪斯有限公司 | 去酰基化头孢菌素的发酵生产的方法 |
| RU2208643C2 (ru) * | 1997-04-22 | 2003-07-20 | Дсм Гист Б.В. | Способ получения n-деацилированного цефалоспорина |
| ZA983396B (en) * | 1997-04-22 | 1998-10-27 | Gist Brocades Bv | A method for controlling the solubility of a beta-lactam nucleus |
| ATE288962T1 (de) | 1997-04-22 | 2005-02-15 | Dsm Ip Assets Bv | Verbessertes verfahren zur fermentativen herstellung von cephalosporin |
| AU3419399A (en) | 1998-03-27 | 1999-10-18 | Dsm N.V. | Novel process for the fermentative production of cephalosporin |
| US6383773B2 (en) | 1998-04-23 | 2002-05-07 | Massachusetts Institute Of Technology | Penicillin conversion |
| PL344863A1 (en) | 1998-05-19 | 2001-11-19 | Dsm Nv | Improved in vivo |
| EP1141372A2 (de) * | 1998-12-22 | 2001-10-10 | Dsm N.V. | Verbesserte in vivo-produktion von cephalosporinen |
| ES2165276B1 (es) * | 1999-06-18 | 2003-03-01 | Antibioticos Sau | Procedimiento biotecnologico para la produccion de acido 7-aminocefal osporanico (7-adca) y compuestos de sintesis intermedios particularmente penicilina n y desacetoxicefalosporina c (daoc) |
| CA2408853C (en) | 2000-05-13 | 2012-01-10 | Smithkline Beecham P.L.C. | Process |
| EP1799817B1 (de) * | 2004-10-13 | 2012-11-21 | DSM Sinochem Pharmaceuticals Netherlands B.V. | Modifizierte expandasen |
| ES2571865T3 (es) | 2005-12-28 | 2016-05-27 | Dsm Sinochem Pharm Nl Bv | Acilasas de beta-lactama de tipo II mutantes |
| EP2123772A1 (de) | 2008-04-29 | 2009-11-25 | DSM IP Assets B.V. | Beta-Lactamantibiotikum produzierende Stämme |
| EP2392649A3 (de) | 2008-08-05 | 2012-01-11 | DSM IP Assets B.V. | Adipoyl-7-ADCA-produzierende Stämme |
| CN102131917A (zh) * | 2008-08-05 | 2011-07-20 | 帝斯曼知识产权资产管理有限公司 | 生产己二酰基-7-adca的菌株 |
| CN102369290A (zh) | 2009-04-03 | 2012-03-07 | 帝斯曼知识产权资产管理有限公司 | 发酵工艺 |
| WO2011161004A1 (en) | 2010-06-22 | 2011-12-29 | Dsm Ip Assets B.V. | Air bubble fermentation process |
| EP2614066B1 (de) | 2010-09-07 | 2017-11-29 | DSM Sinochem Pharmaceuticals Netherlands B.V. | Verfahren zur herstellung von cephalosporinen |
| CN103429596B (zh) | 2011-03-03 | 2016-03-02 | 中化帝斯曼制药有限公司荷兰公司 | 青霉素化合物的降解 |
| EP2809777B1 (de) | 2012-01-31 | 2019-05-29 | Centrient Pharmaceuticals Netherlands B.V. | Mbth-artige proteine in der herstellung von semisynthetischen antibiotika |
| WO2015091455A1 (en) | 2013-12-17 | 2015-06-25 | Dpx Holdings B.V. | Bioreactor |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5082772A (en) * | 1988-10-24 | 1992-01-21 | Eli Lilly And Company | Process for preparing deacetylcephalosporin c |
| US5318896A (en) * | 1991-09-11 | 1994-06-07 | Merck & Co., Inc. | Recombinant expandase bioprocess for preparing 7-aminodesacetoxy cephalosporanic acid (7-ADCA) |
| SK280569B6 (sk) * | 1991-10-15 | 2000-03-13 | Gist-Brocades B.V. | Biologický spôsob výroby kyseliny7-aminodeacetylce |
-
1994
- 1994-07-29 WO PCT/EP1994/002543 patent/WO1995004148A1/en not_active Ceased
- 1994-07-29 SK SK97-96A patent/SK282624B6/sk unknown
- 1994-07-29 DE DE69434023T patent/DE69434023D1/de not_active Expired - Lifetime
- 1994-07-29 US US08/592,411 patent/US5726032A/en not_active Expired - Fee Related
- 1994-07-29 CA CA002168431A patent/CA2168431A1/en not_active Abandoned
- 1994-07-29 AT AT94924828T patent/ATE277187T1/de not_active IP Right Cessation
- 1994-07-29 CN CN94192933A patent/CN1103814C/zh not_active Expired - Fee Related
- 1994-07-29 BR BR9407108A patent/BR9407108A/pt not_active Application Discontinuation
- 1994-07-29 HU HU9600194A patent/HU219259B/hu not_active IP Right Cessation
- 1994-07-29 KR KR1019960700486A patent/KR100336174B1/ko not_active Expired - Fee Related
- 1994-07-29 PL PL94312746A patent/PL180799B1/pl not_active IP Right Cessation
- 1994-07-29 CZ CZ96158A patent/CZ285604B6/cs not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CZ15896A3 (en) | 1996-06-12 |
| PL312746A1 (en) | 1996-05-13 |
| PL180799B1 (pl) | 2001-04-30 |
| CN1128045A (zh) | 1996-07-31 |
| BR9407108A (pt) | 1996-08-27 |
| KR100336174B1 (ko) | 2002-11-01 |
| US5726032A (en) | 1998-03-10 |
| SK282624B6 (sk) | 2002-10-08 |
| CN1103814C (zh) | 2003-03-26 |
| SK9796A3 (en) | 1996-09-04 |
| HU9600194D0 (en) | 1996-03-28 |
| HUT75377A (en) | 1997-05-28 |
| DE69434023D1 (de) | 2004-10-28 |
| HU219259B (en) | 2001-03-28 |
| CZ285604B6 (cs) | 1999-09-15 |
| CA2168431A1 (en) | 1995-02-09 |
| WO1995004148A1 (en) | 1995-02-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |