ATE278191T1 - Messung und verwendung von molekularen wechselwirkungen - Google Patents

Messung und verwendung von molekularen wechselwirkungen

Info

Publication number
ATE278191T1
ATE278191T1 AT00925478T AT00925478T ATE278191T1 AT E278191 T1 ATE278191 T1 AT E278191T1 AT 00925478 T AT00925478 T AT 00925478T AT 00925478 T AT00925478 T AT 00925478T AT E278191 T1 ATE278191 T1 AT E278191T1
Authority
AT
Austria
Prior art keywords
measurement
molecular interactions
affinity
binding partners
dependent
Prior art date
Application number
AT00925478T
Other languages
English (en)
Inventor
David University Of Klenerman
Victor Petrovich Unive Ostanin
Fedor Nikolaievich Dultsev
Original Assignee
Akubio Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akubio Ltd filed Critical Akubio Ltd
Application granted granted Critical
Publication of ATE278191T1 publication Critical patent/ATE278191T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G01N33/5438—Electrodes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/808—Optical sensing apparatus
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/805—Optical property

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Investigating Or Analyzing Materials By The Use Of Ultrasonic Waves (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Sampling And Sample Adjustment (AREA)
AT00925478T 1999-04-22 2000-04-25 Messung und verwendung von molekularen wechselwirkungen ATE278191T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9909308.0A GB9909308D0 (en) 1999-04-22 1999-04-22 Measurement and use of molecular interactions
PCT/GB2000/001587 WO2001002857A1 (en) 1999-04-22 2000-04-25 Measurement and use of molecular interactions

Publications (1)

Publication Number Publication Date
ATE278191T1 true ATE278191T1 (de) 2004-10-15

Family

ID=10852091

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00925478T ATE278191T1 (de) 1999-04-22 2000-04-25 Messung und verwendung von molekularen wechselwirkungen

Country Status (23)

Country Link
US (2) US6589727B1 (de)
EP (1) EP1171769B1 (de)
JP (1) JP4493892B2 (de)
KR (1) KR20020022648A (de)
CN (1) CN1142435C (de)
AT (1) ATE278191T1 (de)
AU (1) AU755958B2 (de)
BR (1) BR0009865A (de)
CA (1) CA2369794A1 (de)
CZ (1) CZ20013633A3 (de)
DE (1) DE60014348T8 (de)
ES (1) ES2226825T3 (de)
GB (1) GB9909308D0 (de)
HK (1) HK1041920B (de)
HU (1) HUP0200787A2 (de)
IL (2) IL145754A0 (de)
MX (1) MXPA01010640A (de)
NO (1) NO20015096L (de)
PL (1) PL354354A1 (de)
RU (1) RU2223500C2 (de)
UA (1) UA57876C2 (de)
WO (1) WO2001002857A1 (de)
ZA (1) ZA200108562B (de)

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US7052854B2 (en) 2001-05-23 2006-05-30 University Of Florida Research Foundation, Inc. Application of nanotechnology and sensor technologies for ex-vivo diagnostics
WO2002095398A1 (en) 2001-05-24 2002-11-28 University Of Florida Method and apparatus for detecting environmental smoke exposure
DE10126798A1 (de) * 2001-06-01 2002-12-19 Nanotype Gmbh Verfahren zur Bestimmung einer Probe
US6865949B2 (en) 2003-01-31 2005-03-15 Hewlett-Packard Development Company, L.P. Transducer-based sensor system
US20070167853A1 (en) 2002-01-22 2007-07-19 Melker Richard J System and method for monitoring health using exhaled breath
WO2004034883A2 (en) * 2002-10-15 2004-04-29 Medtronic Inc. Synchronization and calibration of clocks for a medical device and calibrated clock
US7135806B2 (en) 2002-10-31 2006-11-14 Hewlett-Packard Development Company, L.P. Transducer-based sensor system with multiple drive signal variants
EP1588168B1 (de) * 2003-01-26 2009-07-08 Eberhard-Karls-Universität Tübingen Universitätsklinikum Verfahren zum separieren und nachweisen von zumindest einem analyten in biologischen matrizes
US20040229215A1 (en) * 2003-03-04 2004-11-18 Auburn University Methods of forming monolayers of phage-derived products and uses thereof
EP1613948B1 (de) 2003-04-17 2014-03-12 Alere Switzerland GmbH Biocapteur et procédé servant a détecter une rupture de liaison
US7117743B2 (en) 2003-07-31 2006-10-10 Hewlett-Packard Development Company, L.P. Multiple-transducer sensor system and method with selective activation and isolation of individual transducers
US6978656B2 (en) * 2003-10-31 2005-12-27 Hewlett-Packard Development Company, L.P. Transducer-based sensor system and method
NZ528338A (en) * 2004-03-19 2006-10-27 Ind Res Ltd Biosensors for detecting bond rupture
US20050226773A1 (en) * 2004-04-01 2005-10-13 Honeywell International, Inc. Multiple modes acoustic wave sensor
US7539459B2 (en) * 2004-04-02 2009-05-26 Edwards Vacuum, Inc. Active noise cancellation system, arrangement, and method
US7497133B2 (en) 2004-05-24 2009-03-03 Drexel University All electric piezoelectric finger sensor (PEFS) for soft material stiffness measurement
US20080193418A1 (en) * 2004-06-04 2008-08-14 University Of Northern Iowa Research Foundation Bacteriophages that Infect Bacillus Bacteria (Anthrax)
GB0413134D0 (en) * 2004-06-12 2004-07-14 Akubio Ltd Analytical apparatus
US7300631B2 (en) 2005-05-02 2007-11-27 Bioscale, Inc. Method and apparatus for detection of analyte using a flexural plate wave device and magnetic particles
US7749445B2 (en) 2005-05-02 2010-07-06 Bioscale, Inc. Method and apparatus for analyzing bioprocess fluids
US7611908B2 (en) 2005-05-02 2009-11-03 Bioscale, Inc. Method and apparatus for therapeutic drug monitoring using an acoustic device
US7648844B2 (en) 2005-05-02 2010-01-19 Bioscale, Inc. Method and apparatus for detection of analyte using an acoustic device
WO2007041206A2 (en) 2005-09-30 2007-04-12 Auburn University Drug delivery nanocarriers targeted by landscape phage
US8227261B2 (en) * 2005-11-23 2012-07-24 Bioscale, Inc. Methods and apparatus for assay measurements
US8171795B1 (en) 2006-01-23 2012-05-08 Drexel University Self-exciting, self-sensing piezoelectric cantilever sensor for detection of airborne analytes directly in air
CA2637930C (en) * 2006-01-23 2016-09-06 Drexel University Self-exciting, self-sensing piezoelectric cantilever sensor
WO2007133619A1 (en) * 2006-05-10 2007-11-22 Drexel University Molecular control of surface coverage
GB0609382D0 (en) * 2006-05-11 2006-06-21 Univ Cambridge Tech Acoustic wave transducer substrate and measurements using the same
DE102006034842A1 (de) * 2006-07-27 2008-02-07 Siemens Ag Fluidsensor
US7914460B2 (en) * 2006-08-15 2011-03-29 University Of Florida Research Foundation, Inc. Condensate glucose analyzer
US8481335B2 (en) * 2006-11-27 2013-07-09 Drexel University Specificity and sensitivity enhancement in cantilever sensing
US8927259B2 (en) * 2006-11-28 2015-01-06 Drexel University Piezoelectric microcantilever sensors for biosensing
US7992431B2 (en) * 2006-11-28 2011-08-09 Drexel University Piezoelectric microcantilevers and uses in atomic force microscopy
CA2677196A1 (en) * 2007-02-01 2008-09-12 Drexel University A hand-held phase-shift detector for sensor applications
US8512947B2 (en) 2007-02-16 2013-08-20 Drexel University Detection of nucleic acids using a cantilever sensor
US7892759B2 (en) 2007-02-16 2011-02-22 Drexel University Enhanced sensitivity of a cantilever sensor via specific bindings
WO2009035732A2 (en) * 2007-05-30 2009-03-19 Drexel University Detection and quantification of biomarkers via a piezoelectric cantilever sensor
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WO2009079154A2 (en) 2007-11-23 2009-06-25 Drexel University Lead-free piezoelectric ceramic films and a method for making thereof
RU2350957C1 (ru) * 2007-12-28 2009-03-27 Институт аналитического приборостроения Российской академии наук Устройство для иммунологических исследований биологических жидкостей
US8236508B2 (en) * 2008-01-29 2012-08-07 Drexel University Detecting and measuring live pathogens utilizing a mass detection device
US8741663B2 (en) 2008-03-11 2014-06-03 Drexel University Enhanced detection sensitivity with piezoelectric sensors
AU2009246115A1 (en) 2008-05-16 2009-11-19 Drexel University System and method for evaluating tissue
GB2473635A (en) * 2009-09-18 2011-03-23 Cambridge Entpr Ltd Detecting concentration of target species
US20110086368A1 (en) * 2009-10-08 2011-04-14 Drexel University Method for immune response detection
US8722427B2 (en) * 2009-10-08 2014-05-13 Drexel University Determination of dissociation constants using piezoelectric microcantilevers
CN103025859A (zh) 2010-05-25 2013-04-03 阿尔利克斯公司 用于检测生物学和化学分析中的颗粒的位置自由度的方法和装置以及在免疫诊断学中的应用
GB201020237D0 (en) * 2010-11-30 2011-01-12 Cambridge Entpr Ltd Method and apparatus for characterising molecules
NL2017705B1 (en) * 2016-11-02 2018-05-18 Lumicks Tech B V Method and system for studying biological cells
US10191036B1 (en) * 2018-03-22 2019-01-29 NUB4U, Inc. System for detecting and removing biological analytes in fluids
RU184943U1 (ru) * 2018-04-09 2018-11-15 Федеральное государственное бюджетное учреждение науки Институт физики полупроводников им. А.В. Ржанова Сибирского отделения Российской академии наук Устройство для проведения высокоспецифичной детекции биомаркеров на кварцевом резонаторе
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Also Published As

Publication number Publication date
CA2369794A1 (en) 2001-01-11
HUP0200787A2 (hu) 2002-07-29
JP2003503735A (ja) 2003-01-28
IL145754A0 (en) 2002-07-25
ZA200108562B (en) 2002-09-11
GB9909308D0 (en) 1999-06-16
WO2001002857A1 (en) 2001-01-11
BR0009865A (pt) 2002-03-19
US7195909B2 (en) 2007-03-27
MXPA01010640A (es) 2003-08-20
DE60014348D1 (de) 2004-11-04
KR20020022648A (ko) 2002-03-27
PL354354A1 (en) 2004-01-12
NO20015096D0 (no) 2001-10-19
RU2223500C2 (ru) 2004-02-10
CZ20013633A3 (cs) 2002-06-12
IL145754A (en) 2006-09-05
EP1171769B1 (de) 2004-09-29
NO20015096L (no) 2001-12-14
AU755958B2 (en) 2003-01-02
HK1041920A1 (en) 2002-07-26
UA57876C2 (uk) 2003-07-15
CN1347500A (zh) 2002-05-01
AU4420300A (en) 2001-01-22
CN1142435C (zh) 2004-03-17
US6589727B1 (en) 2003-07-08
US20030194697A1 (en) 2003-10-16
DE60014348T8 (de) 2006-04-27
DE60014348T2 (de) 2006-02-16
EP1171769A1 (de) 2002-01-16
HK1041920B (en) 2005-03-18
ES2226825T3 (es) 2005-04-01
JP4493892B2 (ja) 2010-06-30

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