ATE278191T1 - Messung und verwendung von molekularen wechselwirkungen - Google Patents

Messung und verwendung von molekularen wechselwirkungen

Info

Publication number
ATE278191T1
ATE278191T1 AT00925478T AT00925478T ATE278191T1 AT E278191 T1 ATE278191 T1 AT E278191T1 AT 00925478 T AT00925478 T AT 00925478T AT 00925478 T AT00925478 T AT 00925478T AT E278191 T1 ATE278191 T1 AT E278191T1
Authority
AT
Austria
Prior art keywords
measurement
molecular interactions
affinity
binding partners
dependent
Prior art date
Application number
AT00925478T
Other languages
English (en)
Inventor
David University Of Klenerman
Victor Petrovich Unive Ostanin
Fedor Nikolaievich Dultsev
Original Assignee
Akubio Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akubio Ltd filed Critical Akubio Ltd
Application granted granted Critical
Publication of ATE278191T1 publication Critical patent/ATE278191T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G01N33/5438—Electrodes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/808—Optical sensing apparatus
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/805—Optical property

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Investigating Or Analyzing Materials By The Use Of Ultrasonic Waves (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
AT00925478T 1999-04-22 2000-04-25 Messung und verwendung von molekularen wechselwirkungen ATE278191T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9909308.0A GB9909308D0 (en) 1999-04-22 1999-04-22 Measurement and use of molecular interactions
PCT/GB2000/001587 WO2001002857A1 (en) 1999-04-22 2000-04-25 Measurement and use of molecular interactions

Publications (1)

Publication Number Publication Date
ATE278191T1 true ATE278191T1 (de) 2004-10-15

Family

ID=10852091

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00925478T ATE278191T1 (de) 1999-04-22 2000-04-25 Messung und verwendung von molekularen wechselwirkungen

Country Status (23)

Country Link
US (2) US6589727B1 (de)
EP (1) EP1171769B1 (de)
JP (1) JP4493892B2 (de)
KR (1) KR20020022648A (de)
CN (1) CN1142435C (de)
AT (1) ATE278191T1 (de)
AU (1) AU755958B2 (de)
BR (1) BR0009865A (de)
CA (1) CA2369794A1 (de)
CZ (1) CZ20013633A3 (de)
DE (1) DE60014348T8 (de)
ES (1) ES2226825T3 (de)
GB (1) GB9909308D0 (de)
HK (1) HK1041920B (de)
HU (1) HUP0200787A2 (de)
IL (2) IL145754A0 (de)
MX (1) MXPA01010640A (de)
NO (1) NO20015096L (de)
PL (1) PL354354A1 (de)
RU (1) RU2223500C2 (de)
UA (1) UA57876C2 (de)
WO (1) WO2001002857A1 (de)
ZA (1) ZA200108562B (de)

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US20050054942A1 (en) * 2002-01-22 2005-03-10 Melker Richard J. System and method for therapeutic drug monitoring
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US7052854B2 (en) 2001-05-23 2006-05-30 University Of Florida Research Foundation, Inc. Application of nanotechnology and sensor technologies for ex-vivo diagnostics
EP1393069A1 (de) 2001-05-24 2004-03-03 The University Of Florida Verfahren und vorrichtung zur rauchaussetzungfeststellung
DE10126798A1 (de) * 2001-06-01 2002-12-19 Nanotype Gmbh Verfahren zur Bestimmung einer Probe
US6865949B2 (en) 2003-01-31 2005-03-15 Hewlett-Packard Development Company, L.P. Transducer-based sensor system
US20070167853A1 (en) 2002-01-22 2007-07-19 Melker Richard J System and method for monitoring health using exhaled breath
AU2003287159A1 (en) * 2002-10-15 2004-05-04 Medtronic Inc. Synchronization and calibration of clocks for a medical device and calibrated clock
US7135806B2 (en) 2002-10-31 2006-11-14 Hewlett-Packard Development Company, L.P. Transducer-based sensor system with multiple drive signal variants
EP1588168B1 (de) * 2003-01-26 2009-07-08 Eberhard-Karls-Universität Tübingen Universitätsklinikum Verfahren zum separieren und nachweisen von zumindest einem analyten in biologischen matrizes
WO2005012909A1 (en) * 2003-03-04 2005-02-10 Auburn University Methods of forming monolayers of phage-derived products and uses thereof
JP2006523835A (ja) 2003-04-17 2006-10-19 アクビオ・リミテッド 破裂イベントセンサ装置
US7117743B2 (en) 2003-07-31 2006-10-10 Hewlett-Packard Development Company, L.P. Multiple-transducer sensor system and method with selective activation and isolation of individual transducers
US6978656B2 (en) * 2003-10-31 2005-12-27 Hewlett-Packard Development Company, L.P. Transducer-based sensor system and method
NZ528338A (en) * 2004-03-19 2006-10-27 Ind Res Ltd Biosensors for detecting bond rupture
US20050226773A1 (en) * 2004-04-01 2005-10-13 Honeywell International, Inc. Multiple modes acoustic wave sensor
US7539459B2 (en) * 2004-04-02 2009-05-26 Edwards Vacuum, Inc. Active noise cancellation system, arrangement, and method
US7497133B2 (en) 2004-05-24 2009-03-03 Drexel University All electric piezoelectric finger sensor (PEFS) for soft material stiffness measurement
CA2569554C (en) * 2004-06-04 2012-09-18 Michael H. Walter Bacteriophages that infect bacillus bacteria (anthrax)
GB0413134D0 (en) * 2004-06-12 2004-07-14 Akubio Ltd Analytical apparatus
US7749445B2 (en) 2005-05-02 2010-07-06 Bioscale, Inc. Method and apparatus for analyzing bioprocess fluids
US7611908B2 (en) 2005-05-02 2009-11-03 Bioscale, Inc. Method and apparatus for therapeutic drug monitoring using an acoustic device
US7648844B2 (en) 2005-05-02 2010-01-19 Bioscale, Inc. Method and apparatus for detection of analyte using an acoustic device
US7300631B2 (en) 2005-05-02 2007-11-27 Bioscale, Inc. Method and apparatus for detection of analyte using a flexural plate wave device and magnetic particles
EP1940355B1 (de) 2005-09-30 2012-12-19 Auburn University Nanoträger zur gezielten Freisetzung eines Wirkstoffs - enthaltend Ansammlungen von auf ein Ziel ausgerichteten Landschaftsphagenproteinen
US8227261B2 (en) * 2005-11-23 2012-07-24 Bioscale, Inc. Methods and apparatus for assay measurements
US8171795B1 (en) 2006-01-23 2012-05-08 Drexel University Self-exciting, self-sensing piezoelectric cantilever sensor for detection of airborne analytes directly in air
US7942056B2 (en) * 2006-01-23 2011-05-17 Drexel University Self-exciting, self-sensing piezoelectric cantilever sensor
WO2007133619A1 (en) * 2006-05-10 2007-11-22 Drexel University Molecular control of surface coverage
GB0609382D0 (en) * 2006-05-11 2006-06-21 Univ Cambridge Tech Acoustic wave transducer substrate and measurements using the same
DE102006034842A1 (de) * 2006-07-27 2008-02-07 Siemens Ag Fluidsensor
US7914460B2 (en) * 2006-08-15 2011-03-29 University Of Florida Research Foundation, Inc. Condensate glucose analyzer
US8481335B2 (en) * 2006-11-27 2013-07-09 Drexel University Specificity and sensitivity enhancement in cantilever sensing
WO2008067386A2 (en) 2006-11-28 2008-06-05 Drexel University Piezoelectric microcantilever sensors for biosensing
US7992431B2 (en) * 2006-11-28 2011-08-09 Drexel University Piezoelectric microcantilevers and uses in atomic force microscopy
US8456150B2 (en) * 2007-02-01 2013-06-04 Drexel University Hand-held phase-shift detector for sensor applications
US7892759B2 (en) 2007-02-16 2011-02-22 Drexel University Enhanced sensitivity of a cantilever sensor via specific bindings
US8512947B2 (en) * 2007-02-16 2013-08-20 Drexel University Detection of nucleic acids using a cantilever sensor
US7993854B2 (en) * 2007-05-30 2011-08-09 Drexel University Detection and quantification of biomarkers via a piezoelectric cantilever sensor
WO2009033056A1 (en) * 2007-09-06 2009-03-12 Bioscale, Inc. Reusable detection surfaces and methods of using same
US8241569B2 (en) * 2007-11-23 2012-08-14 Drexel University Lead-free piezoelectric ceramic films and a method for making thereof
RU2350957C1 (ru) * 2007-12-28 2009-03-27 Институт аналитического приборостроения Российской академии наук Устройство для иммунологических исследований биологических жидкостей
US8236508B2 (en) * 2008-01-29 2012-08-07 Drexel University Detecting and measuring live pathogens utilizing a mass detection device
WO2009126378A2 (en) 2008-03-11 2009-10-15 Drexel University Enhanced detection sensitivity with piezoelectric microcantilever sensors
EP2281192A4 (de) 2008-05-16 2014-02-05 Univ Drexel System und verfahren zur gewebebeurteilung
GB2473635A (en) * 2009-09-18 2011-03-23 Cambridge Entpr Ltd Detecting concentration of target species
US8722427B2 (en) * 2009-10-08 2014-05-13 Drexel University Determination of dissociation constants using piezoelectric microcantilevers
US20110086368A1 (en) * 2009-10-08 2011-04-14 Drexel University Method for immune response detection
EP2576759A4 (de) 2010-05-25 2014-01-22 Arryx Inc Verfahren und vorrichtungen zur erkennung der positionsfreiheit von partikeln in biologischen und chemischen analysen und anwendungen für immundiagnosen
GB201020237D0 (en) * 2010-11-30 2011-01-12 Cambridge Entpr Ltd Method and apparatus for characterising molecules
NL2017705B1 (en) * 2016-11-02 2018-05-18 Lumicks Tech B V Method and system for studying biological cells
US10191036B1 (en) * 2018-03-22 2019-01-29 NUB4U, Inc. System for detecting and removing biological analytes in fluids
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Also Published As

Publication number Publication date
AU755958B2 (en) 2003-01-02
CN1142435C (zh) 2004-03-17
IL145754A (en) 2006-09-05
MXPA01010640A (es) 2003-08-20
NO20015096L (no) 2001-12-14
JP2003503735A (ja) 2003-01-28
DE60014348D1 (de) 2004-11-04
US7195909B2 (en) 2007-03-27
CA2369794A1 (en) 2001-01-11
KR20020022648A (ko) 2002-03-27
HUP0200787A2 (hu) 2002-07-29
PL354354A1 (en) 2004-01-12
DE60014348T2 (de) 2006-02-16
US6589727B1 (en) 2003-07-08
AU4420300A (en) 2001-01-22
WO2001002857A1 (en) 2001-01-11
GB9909308D0 (en) 1999-06-16
IL145754A0 (en) 2002-07-25
JP4493892B2 (ja) 2010-06-30
UA57876C2 (uk) 2003-07-15
US20030194697A1 (en) 2003-10-16
ZA200108562B (en) 2002-09-11
EP1171769A1 (de) 2002-01-16
BR0009865A (pt) 2002-03-19
DE60014348T8 (de) 2006-04-27
CZ20013633A3 (cs) 2002-06-12
CN1347500A (zh) 2002-05-01
RU2223500C2 (ru) 2004-02-10
HK1041920B (en) 2005-03-18
ES2226825T3 (es) 2005-04-01
HK1041920A1 (en) 2002-07-26
NO20015096D0 (no) 2001-10-19
EP1171769B1 (de) 2004-09-29

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