ATE278711T1 - Verfahren zur selektiven acetylierung - Google Patents
Verfahren zur selektiven acetylierungInfo
- Publication number
- ATE278711T1 ATE278711T1 AT97928139T AT97928139T ATE278711T1 AT E278711 T1 ATE278711 T1 AT E278711T1 AT 97928139 T AT97928139 T AT 97928139T AT 97928139 T AT97928139 T AT 97928139T AT E278711 T1 ATE278711 T1 AT E278711T1
- Authority
- AT
- Austria
- Prior art keywords
- amino group
- epsilon
- selective acetylation
- free
- insulin
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 230000021736 acetylation Effects 0.000 title 1
- 238000006640 acetylation reaction Methods 0.000 title 1
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 3
- 102000004877 Insulin Human genes 0.000 abstract 1
- 108090001061 Insulin Proteins 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 229940125396 insulin Drugs 0.000 abstract 1
- 239000004026 insulin derivative Substances 0.000 abstract 1
- 239000002798 polar solvent Substances 0.000 abstract 1
- 239000002243 precursor Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Endocrinology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Diabetes (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Water Treatment By Electricity Or Magnetism (AREA)
- Paper (AREA)
- Compounds Of Alkaline-Earth Elements, Aluminum Or Rare-Earth Metals (AREA)
- Cephalosporin Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK77896 | 1996-07-11 | ||
| PCT/DK1997/000296 WO1998002460A1 (en) | 1996-07-11 | 1997-07-04 | Selective acylation method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE278711T1 true ATE278711T1 (de) | 2004-10-15 |
Family
ID=8097454
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97928139T ATE278711T1 (de) | 1996-07-11 | 1997-07-04 | Verfahren zur selektiven acetylierung |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP0938502B1 (de) |
| JP (1) | JP3300368B2 (de) |
| AT (1) | ATE278711T1 (de) |
| AU (1) | AU3255297A (de) |
| DE (1) | DE69731105T2 (de) |
| ES (1) | ES2230607T3 (de) |
| PT (1) | PT938502E (de) |
| WO (1) | WO1998002460A1 (de) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6451974B1 (en) | 1999-03-17 | 2002-09-17 | Novo Nordisk A/S | Method of acylating peptides and novel acylating agents |
| CA2361830A1 (en) | 1999-03-17 | 2000-09-21 | Novo Nordisk A/S | Method for acylating peptides and novel acylating agents |
| US7316999B2 (en) | 2000-06-02 | 2008-01-08 | Novo Nordisk A/S | Glucose dependent release of insulin from glucose sensing insulin derivatives |
| US7312192B2 (en) * | 2001-09-07 | 2007-12-25 | Biocon Limited | Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same |
| AU2003218110A1 (en) | 2002-03-12 | 2003-09-29 | Bristol-Myers Squibb Company | C3-cyano epothilone derivatives |
| JP4468174B2 (ja) * | 2002-09-25 | 2010-05-26 | ノボ ノルディスク アクティーゼルスカブ | ペプチドをアシル化するための方法 |
| US7273921B2 (en) | 2002-09-25 | 2007-09-25 | Novo Nordisk A/S | Method for producing acylated peptides |
| AU2004261353B2 (en) * | 2003-08-05 | 2009-12-10 | Novo Nordisk A/S | Novel insulin derivatives |
| ES2472421T3 (es) * | 2003-08-05 | 2014-07-01 | Novo Nordisk A/S | Nuevos derivados de insulina |
| EP1687428A1 (de) | 2003-11-14 | 2006-08-09 | Novo Nordisk A/S | Verfahren zur herstellung von acyliertem insulin |
| WO2006008238A1 (en) * | 2004-07-16 | 2006-01-26 | Novo Nordisk A/S | Method for selective acylation |
| TWI376234B (en) | 2005-02-01 | 2012-11-11 | Msd Oss Bv | Conjugates of a polypeptide and an oligosaccharide |
| WO2006082204A1 (en) * | 2005-02-02 | 2006-08-10 | Novo Nordisk A/S | Insulin derivatives |
| ES2435522T3 (es) * | 2005-02-02 | 2013-12-20 | Novo Nordisk A/S | Derivados de insulina |
| EP1969004B1 (de) | 2005-12-28 | 2011-08-10 | Novo Nordisk A/S | Ein acyliertes insulin und zink enthaltende zusammensetzungen und verfahren zur herstellung dieser zusammensetzungen |
| AU2007247109B2 (en) * | 2006-05-09 | 2012-03-15 | Novo Nordisk A/S | Insulin derivative |
| CN101573133B (zh) | 2006-07-31 | 2014-08-27 | 诺沃-诺迪斯克有限公司 | Peg化延长的胰岛素 |
| CN101541830A (zh) | 2006-09-22 | 2009-09-23 | 诺沃-诺迪斯克有限公司 | 蛋白酶抗性的胰岛素类似物 |
| WO2008132224A2 (en) | 2007-04-30 | 2008-11-06 | Novo Nordisk A/S | Method for drying a protein composition, a dried protein composition and a pharmaceutical composition comprising the dried protein |
| JP5552046B2 (ja) | 2007-06-13 | 2014-07-16 | ノボ・ノルデイスク・エー／エス | インスリン誘導体を含有する薬学的製剤 |
| ES2543393T3 (es) | 2007-11-08 | 2015-08-18 | Novo Nordisk A/S | Derivado de insulina |
| CN101970477B (zh) | 2008-03-14 | 2014-12-31 | 诺沃-诺迪斯克有限公司 | 蛋白酶稳定的胰岛素类似物 |
| HUE032284T2 (en) | 2008-03-18 | 2017-09-28 | Novo Nordisk As | Protease-stabilized, acylated insulin analogues |
| CN102202683A (zh) | 2008-10-30 | 2011-09-28 | 诺沃-诺迪斯克有限公司 | 用少于每日一次的注射频率注射胰岛素来治疗糖尿病 |
| DK2632478T3 (da) | 2010-10-27 | 2019-10-07 | Novo Nordisk As | Behandling af diabetes melitus under anvendelse af insulinindsprøjtninger indgivet med varierende indsprøjtningsintervaller |
| EP2836508B1 (de) | 2012-04-11 | 2016-06-29 | Novo Nordisk A/S | Insulinformulierungen |
| EP2991672A1 (de) | 2013-04-30 | 2016-03-09 | Novo Nordisk A/S | Neuartiges verabreichungsschema |
| CA2926701A1 (en) | 2013-10-07 | 2015-04-16 | Novo Nordisk A/S | Novel derivative of an insulin analogue |
| ES2886837T3 (es) | 2016-12-16 | 2021-12-21 | Novo Nordisk As | Composiciones farmacéuticas que contienen insulina |
| US10335464B1 (en) | 2018-06-26 | 2019-07-02 | Novo Nordisk A/S | Device for titrating basal insulin |
| CN114096269B (zh) | 2019-07-12 | 2024-06-11 | 诺和诺德股份有限公司 | 高浓度胰岛素制剂 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ273285A (en) * | 1993-09-17 | 1997-10-24 | Novo Nordisk As | Insulin derivatives and compositions thereof |
| US5646242A (en) * | 1994-11-17 | 1997-07-08 | Eli Lilly And Company | Selective acylation of epsilon-amino groups |
| US5693609A (en) * | 1994-11-17 | 1997-12-02 | Eli Lilly And Company | Acylated insulin analogs |
-
1997
- 1997-07-04 AT AT97928139T patent/ATE278711T1/de not_active IP Right Cessation
- 1997-07-04 ES ES97928139T patent/ES2230607T3/es not_active Expired - Lifetime
- 1997-07-04 WO PCT/DK1997/000296 patent/WO1998002460A1/en not_active Ceased
- 1997-07-04 DE DE69731105T patent/DE69731105T2/de not_active Expired - Lifetime
- 1997-07-04 PT PT97928139T patent/PT938502E/pt unknown
- 1997-07-04 AU AU32552/97A patent/AU3255297A/en not_active Abandoned
- 1997-07-04 JP JP50552498A patent/JP3300368B2/ja not_active Expired - Lifetime
- 1997-07-04 EP EP97928139A patent/EP0938502B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP0938502B1 (de) | 2004-10-06 |
| PT938502E (pt) | 2005-02-28 |
| AU3255297A (en) | 1998-02-09 |
| EP0938502A1 (de) | 1999-09-01 |
| DE69731105T2 (de) | 2005-11-17 |
| DE69731105D1 (de) | 2004-11-11 |
| WO1998002460A1 (en) | 1998-01-22 |
| ES2230607T3 (es) | 2005-05-01 |
| JP2000501419A (ja) | 2000-02-08 |
| JP3300368B2 (ja) | 2002-07-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |