BRPI0413276B8 - derivado de insulina, complexo de zinco do mesmo, e, composição farmacêutica - Google Patents

derivado de insulina, complexo de zinco do mesmo, e, composição farmacêutica

Info

Publication number
BRPI0413276B8
BRPI0413276B8 BRPI0413276A BRPI0413276A BRPI0413276B8 BR PI0413276 B8 BRPI0413276 B8 BR PI0413276B8 BR PI0413276 A BRPI0413276 A BR PI0413276A BR PI0413276 A BRPI0413276 A BR PI0413276A BR PI0413276 B8 BRPI0413276 B8 BR PI0413276B8
Authority
BR
Brazil
Prior art keywords
pharmaceutical composition
zinc complex
insulin derivative
insulin
amino group
Prior art date
Application number
BRPI0413276A
Other languages
English (en)
Inventor
Jonassen Ib
Madsen Peter
Havelund Svend
Hoeg-Jensen Thomas
Møller Tagmose Tina
Ribel-Madsen Ulla
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Publication of BRPI0413276A publication Critical patent/BRPI0413276A/pt
Publication of BRPI0413276B1 publication Critical patent/BRPI0413276B1/pt
Publication of BRPI0413276B8 publication Critical patent/BRPI0413276B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

derivado de insulina, complexo de zinco do mesmo, composição farmacêutica, e, método papa tratar diabete em um paciente. a presente invenção diz respeito a derivados de insulina que são insulinas que ocorrem naturalmente ou análogos destas que têm uma cadeia lateral ligada ao grupo (alfa)-amino do rcsíduo de aminoácido do terminal n da cadcia b ou ao grupo (épsilion)-amino de um resíduo lys presente na cadeia b da insulina precursora, a cadeia lateral sendo da fórmula geral: -w-x-y-z em que w, x, y e z são como definidos na divulgação.
BRPI0413276A 2003-08-05 2004-07-22 derivado de insulina, complexo de zinco do mesmo, e, composição farmacêutica BRPI0413276B8 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DKPA200301129 2003-08-05
DKPA200301129 2003-08-05
US49545103P 2003-08-14 2003-08-14
US60/495,451 2003-08-14
PCT/DK2004/000511 WO2005012347A2 (en) 2003-08-05 2004-07-22 Novel insulin derivatives

Publications (3)

Publication Number Publication Date
BRPI0413276A BRPI0413276A (pt) 2006-10-10
BRPI0413276B1 BRPI0413276B1 (pt) 2020-03-03
BRPI0413276B8 true BRPI0413276B8 (pt) 2021-05-25

Family

ID=34117520

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0413276A BRPI0413276B8 (pt) 2003-08-05 2004-07-22 derivado de insulina, complexo de zinco do mesmo, e, composição farmacêutica

Country Status (18)

Country Link
US (3) US7615532B2 (pt)
EP (3) EP2107069B1 (pt)
JP (1) JP4463814B2 (pt)
KR (1) KR101159559B1 (pt)
AU (2) AU2004261353B2 (pt)
BE (2) BE2013C035I2 (pt)
BR (1) BRPI0413276B8 (pt)
CA (1) CA2531988C (pt)
CY (5) CY1113850T1 (pt)
FR (2) FR13C0035I2 (pt)
HU (1) HUS1300033I1 (pt)
IL (1) IL172980A (pt)
LU (2) LU92213I2 (pt)
MX (1) MXPA06001283A (pt)
NO (5) NO340925B1 (pt)
PL (1) PL2107069T3 (pt)
RU (1) RU2518460C2 (pt)
WO (1) WO2005012347A2 (pt)

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IL172980A0 (en) 2006-06-11
US8828923B2 (en) 2014-09-09
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US20060183668A1 (en) 2006-08-17
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