ATE278960T1 - Verbessertes immundiagnostische tests durch verwendung von reduzierende agenzien - Google Patents

Verbessertes immundiagnostische tests durch verwendung von reduzierende agenzien

Info

Publication number
ATE278960T1
ATE278960T1 AT99920678T AT99920678T ATE278960T1 AT E278960 T1 ATE278960 T1 AT E278960T1 AT 99920678 T AT99920678 T AT 99920678T AT 99920678 T AT99920678 T AT 99920678T AT E278960 T1 ATE278960 T1 AT E278960T1
Authority
AT
Austria
Prior art keywords
recombinant protein
purification
recombinant
reducing agents
dtt
Prior art date
Application number
AT99920678T
Other languages
English (en)
Inventor
Geert Maertens
Joost Louwagie
Alfons Bosman
Erwin Sablon
Maan Zrein
Original Assignee
Innogenetics Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8237028&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE278960(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Innogenetics Nv filed Critical Innogenetics Nv
Application granted granted Critical
Publication of ATE278960T1 publication Critical patent/ATE278960T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C12Q1/706—Specific hybridization probes for hepatitis
    • C12Q1/707—Specific hybridization probes for hepatitis non-A, non-B Hepatitis, excluding hepatitis D
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54306—Solid-phase reaction mechanisms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54393—Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/576—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/576—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis
    • G01N33/5767—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis non-A, non-B hepatitis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
    • C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Communicable Diseases (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
AT99920678T 1998-04-17 1999-04-15 Verbessertes immundiagnostische tests durch verwendung von reduzierende agenzien ATE278960T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98870087 1998-04-17
PCT/EP1999/002547 WO1999054735A1 (en) 1998-04-17 1999-04-15 Improved immunodiagnostic assays using reducing agents

Publications (1)

Publication Number Publication Date
ATE278960T1 true ATE278960T1 (de) 2004-10-15

Family

ID=8237028

Family Applications (2)

Application Number Title Priority Date Filing Date
AT99920678T ATE278960T1 (de) 1998-04-17 1999-04-15 Verbessertes immundiagnostische tests durch verwendung von reduzierende agenzien
AT04103238T ATE401340T1 (de) 1998-04-17 1999-04-15 Verfahren zur verbesserung der proteinkonformation mit hilfe von reduktionsmitteln

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT04103238T ATE401340T1 (de) 1998-04-17 1999-04-15 Verfahren zur verbesserung der proteinkonformation mit hilfe von reduktionsmitteln

Country Status (21)

Country Link
US (1) US7935490B2 (de)
EP (2) EP1471074B1 (de)
JP (2) JP2002512370A (de)
KR (1) KR20010042807A (de)
CN (1) CN1305589A (de)
AT (2) ATE278960T1 (de)
AU (1) AU751362B2 (de)
BR (1) BRPI9909678B8 (de)
CA (2) CA2658218C (de)
CY (1) CY1108424T1 (de)
CZ (1) CZ298268B6 (de)
DE (2) DE69939132D1 (de)
DK (2) DK1071955T4 (de)
ES (2) ES2310701T3 (de)
HU (1) HUP0101719A3 (de)
IL (1) IL138791A0 (de)
PL (1) PL343469A1 (de)
PT (2) PT1071955E (de)
TR (4) TR200101647T2 (de)
WO (1) WO1999054735A1 (de)
ZA (1) ZA200005445B (de)

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JP5175417B2 (ja) * 2000-08-17 2013-04-03 トリペップ アクチ ボラゲット リバビリンを含むワクチンおよびその使用方法
US7022830B2 (en) 2000-08-17 2006-04-04 Tripep Ab Hepatitis C virus codon optimized non-structural NS3/4A fusion gene
CN1636050A (zh) * 2001-04-24 2005-07-06 基因创新有限公司 核心糖基化hcv包膜蛋白
JP2004108914A (ja) * 2002-09-18 2004-04-08 Kudo Norio コラーゲンの測定方法
AU2003283365A1 (en) * 2002-11-08 2004-06-07 Innogenetics N.V. HCV vaccine compositions comprising E1 and NS3 peptides
US20050014136A1 (en) * 2003-05-28 2005-01-20 Innogenetics N.V. Modified HCV NS5
CA2544185C (en) * 2003-10-28 2010-09-28 Advanced Life Science Institute, Inc. Method of detecting hepatitis c virus
JP2009543099A (ja) * 2006-07-07 2009-12-03 ポール・コーポレーション 親和性捕捉中の変性剤の使用
US20100304353A1 (en) * 2007-07-16 2010-12-02 Pfizer Inc Methods of improving a genomic marker index of dairy animals and products
US20110123983A1 (en) * 2007-09-12 2011-05-26 Pfizer Inc. Methods of Using Genetic Markers and Related Epistatic Interactions
BRPI0818300A2 (pt) * 2007-10-03 2017-05-09 Pfizer marcadores genéticos para gado com chifres e sem chifres e processos relacionados
WO2009085689A2 (en) * 2007-12-17 2009-07-09 Pfizer Inc. Methods of improving genetic profiles of dairy animals and products
CN102089662B (zh) * 2008-07-16 2015-05-27 雷迪奥米特医学公司 高容量固相
CN102081018A (zh) * 2009-11-30 2011-06-01 希森美康株式会社 样品的预处理方法及hcv的免疫测定方法
FR2984328B1 (fr) 2011-12-20 2016-12-30 Bio-Rad Innovations Procede de detection d'une infection par le virus de l'hepatite c
ES2828713T3 (es) 2014-10-29 2021-05-27 Abbott Lab Ensayos de detección de anticuerpos anti-VHC objeto usando péptidos de captura NS3
CN109870581B (zh) * 2017-12-04 2021-05-04 厦门万泰凯瑞生物技术有限公司 一种定量检测HBsAg的试剂盒及方法
CN109678954B (zh) * 2018-12-29 2022-01-07 山东莱博生物科技有限公司 一对能够特异性识别hcv ns3蛋白的单克隆抗体及其应用
CN110988362B (zh) * 2019-12-20 2023-11-14 迈克生物股份有限公司 抗组蛋白抗体测定试剂、试剂盒及其使用方法
CN112225783B (zh) * 2020-09-16 2021-08-31 东莞市朋志生物科技有限公司 Hcv重组抗原及其突变体
CN112285361B (zh) * 2020-09-27 2023-12-05 中国人民解放军空军军医大学 排除抗-cd38单克隆抗体药物对抗人球蛋白检测干扰的试剂
CN113219169B (zh) * 2021-05-22 2021-12-17 北京金诺百泰生物技术有限公司 生物检测用封闭剂及其制备方法、包被板及应用该包被板的试剂盒
CN115112897B (zh) * 2021-12-10 2024-11-01 中山大学附属第八医院（深圳福田） 一种用于鉴别抗体检测生物学假阳性的方法

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Also Published As

Publication number Publication date
CA2658218C (en) 2014-10-28
BRPI9909678B8 (pt) 2021-05-25
PL343469A1 (en) 2001-08-13
CA2324970C (en) 2009-06-30
PT1071955E (pt) 2005-02-28
DE69920895T2 (de) 2005-10-13
PT1471074E (pt) 2008-10-23
TR200202213T2 (tr) 2002-11-21
TR200101647T2 (tr) 2002-06-21
AU3817199A (en) 1999-11-08
AU751362B2 (en) 2002-08-15
TR200003024T2 (tr) 2000-12-21
HK1036653A1 (en) 2002-01-11
DK1071955T4 (da) 2009-06-15
EP1471074B1 (de) 2008-07-16
CY1108424T1 (el) 2014-04-09
JP2005185285A (ja) 2005-07-14
CZ20003819A3 (cs) 2001-10-17
EP1071955A1 (de) 2001-01-31
ZA200005445B (en) 2003-01-06
EP1471074A3 (de) 2004-11-10
IL138791A0 (en) 2001-10-31
DE69939132D1 (de) 2008-08-28
JP3974620B2 (ja) 2007-09-12
TR200101648T2 (tr) 2002-06-21
CN1305589A (zh) 2001-07-25
CA2658218A1 (en) 1999-10-28
US7935490B2 (en) 2011-05-03
ATE401340T1 (de) 2008-08-15
DE69920895T3 (de) 2009-09-03
DK1471074T3 (da) 2008-11-17
JP2002512370A (ja) 2002-04-23
CZ298268B6 (cs) 2007-08-08
EP1471074A2 (de) 2004-10-27
EP1071955B2 (de) 2009-02-18
HUP0101719A3 (en) 2006-05-29
BR9909678B1 (pt) 2013-11-12
ES2230851T5 (es) 2009-06-25
US20060263854A1 (en) 2006-11-23
DE69920895D1 (de) 2004-11-11
DK1071955T3 (da) 2005-02-07
ES2310701T3 (es) 2009-01-16
EP1071955B1 (de) 2004-10-06
KR20010042807A (ko) 2001-05-25
CA2324970A1 (en) 1999-10-28
HUP0101719A2 (hu) 2001-09-28
WO1999054735A1 (en) 1999-10-28
ES2230851T3 (es) 2005-05-01
BR9909678A (pt) 2000-12-19

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