ATE279406T1 - Piperidinderivate mit tachykinin-antagonistischer wirkung - Google Patents

Piperidinderivate mit tachykinin-antagonistischer wirkung

Info

Publication number
ATE279406T1
ATE279406T1 AT96900578T AT96900578T ATE279406T1 AT E279406 T1 ATE279406 T1 AT E279406T1 AT 96900578 T AT96900578 T AT 96900578T AT 96900578 T AT96900578 T AT 96900578T AT E279406 T1 ATE279406 T1 AT E279406T1
Authority
AT
Austria
Prior art keywords
piperidine derivatives
pct
antagonistic effect
date jul
sec
Prior art date
Application number
AT96900578T
Other languages
English (en)
Inventor
Duncan Robert Armour
Gerald Martin Paul Giblin
Andrew Michael Kenneth Pennell
Peter John Sharratt
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9500549.2A external-priority patent/GB9500549D0/en
Priority claimed from GBGB9505639.6A external-priority patent/GB9505639D0/en
Priority claimed from GBGB9505640.4A external-priority patent/GB9505640D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Application granted granted Critical
Publication of ATE279406T1 publication Critical patent/ATE279406T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Otolaryngology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT96900578T 1995-01-12 1996-01-10 Piperidinderivate mit tachykinin-antagonistischer wirkung ATE279406T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB9500549.2A GB9500549D0 (en) 1995-01-12 1995-01-12 Chemical compounds
GBGB9505639.6A GB9505639D0 (en) 1995-03-21 1995-03-21 Chemical compounds
GBGB9505640.4A GB9505640D0 (en) 1995-03-21 1995-03-21 Chemical compounds
PCT/EP1996/000082 WO1996021661A1 (en) 1995-01-12 1996-01-10 Piperidine derivatives having tachykinin antagonist activity

Publications (1)

Publication Number Publication Date
ATE279406T1 true ATE279406T1 (de) 2004-10-15

Family

ID=27267546

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96900578T ATE279406T1 (de) 1995-01-12 1996-01-10 Piperidinderivate mit tachykinin-antagonistischer wirkung

Country Status (8)

Country Link
US (1) US6020346A (de)
EP (1) EP0802912B1 (de)
JP (1) JP3925662B2 (de)
AT (1) ATE279406T1 (de)
AU (1) AU4437896A (de)
DE (1) DE69633607T2 (de)
ES (1) ES2229259T3 (de)
WO (1) WO1996021661A1 (de)

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AU1309100A (en) 1998-09-29 2000-04-17 Merck & Co., Inc. Radiolabeled neurokinin-1 receptor antagonists
US7163949B1 (en) 1999-11-03 2007-01-16 Amr Technology, Inc. 4-phenyl substituted tetrahydroisoquinolines and use thereof
WO2001032625A1 (en) 1999-11-03 2001-05-10 Du Pont Pharmaceuticals Company Aryl- and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine and serotonin
ATE367811T1 (de) * 2000-06-12 2007-08-15 Univ Rochester Methode zur behandlung von hitzewallungen, durch verwendung eines tachikinin-rezeptor antagonisten
JP5132864B2 (ja) 2000-07-11 2013-01-30 アルバニー モレキュラー リサーチ， インコーポレイテッド ４−フェニル置換テトラヒドロイソキノリンおよびその使用方法
US20040142929A1 (en) * 2001-07-06 2004-07-22 Ramon Merce-Vidal Derivatives of aryl (or heteroaryl) azolylcarbinoles for the treatment of urinary incontinence
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JP5319518B2 (ja) 2007-04-02 2013-10-16 Ｍｓｄ株式会社 インドールジオン誘導体
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AU2008269154B2 (en) 2007-06-27 2014-06-12 Merck Sharp & Dohme Llc 4-carboxybenzylamino derivatives as histone deacetylase inhibitors
JP5489997B2 (ja) 2007-07-19 2014-05-14 シマベイ セラピューティクス， インコーポレーテッド 糖尿病および代謝疾患の治療のためのＲＵＰ３またはＧＰＲｌ１９受容体のアゴニストとしてのＮ−アザ環状置換ピロール、ピラゾール、イミダゾール、トリアゾールおよびテトラゾール誘導体
CN102014631A (zh) 2008-03-03 2011-04-13 泰格尔医药科技公司 酪氨酸激酶抑制剂
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WO2010114780A1 (en) 2009-04-01 2010-10-07 Merck Sharp & Dohme Corp. Inhibitors of akt activity
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Also Published As

Publication number Publication date
JP3925662B2 (ja) 2007-06-06
AU4437896A (en) 1996-07-31
DE69633607T2 (de) 2006-02-23
WO1996021661A1 (en) 1996-07-18
DE69633607D1 (de) 2004-11-18
JPH10511973A (ja) 1998-11-17
US6020346A (en) 2000-02-01
EP0802912A1 (de) 1997-10-29
EP0802912B1 (de) 2004-10-13
ES2229259T3 (es) 2005-04-16

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