ATE439838T1 - Radiomarkierte neurokinin-1 rezeptor antagonisten - Google Patents

Radiomarkierte neurokinin-1 rezeptor antagonisten

Info

Publication number
ATE439838T1
ATE439838T1 AT99956491T AT99956491T ATE439838T1 AT E439838 T1 ATE439838 T1 AT E439838T1 AT 99956491 T AT99956491 T AT 99956491T AT 99956491 T AT99956491 T AT 99956491T AT E439838 T1 ATE439838 T1 AT E439838T1
Authority
AT
Austria
Prior art keywords
neurokinin
receptor antagonists
radiom
labeled
mammals
Prior art date
Application number
AT99956491T
Other languages
English (en)
Inventor
H Burns
Raymond Gibson
Terence Hamill
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Application granted granted Critical
Publication of ATE439838T1 publication Critical patent/ATE439838T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/804—Radioisotope, e.g. radioimmunoassay

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Hydrogenated Pyridines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT99956491T 1998-09-29 1999-09-24 Radiomarkierte neurokinin-1 rezeptor antagonisten ATE439838T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10233498P 1998-09-29 1998-09-29
PCT/US1999/022163 WO2000018403A1 (en) 1998-09-29 1999-09-24 Radiolabeled neurokinin-1 receptor antagonists

Publications (1)

Publication Number Publication Date
ATE439838T1 true ATE439838T1 (de) 2009-09-15

Family

ID=22289321

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99956491T ATE439838T1 (de) 1998-09-29 1999-09-24 Radiomarkierte neurokinin-1 rezeptor antagonisten

Country Status (8)

Country Link
US (1) US6241964B1 (de)
EP (1) EP1119356B1 (de)
JP (1) JP2002525325A (de)
AT (1) ATE439838T1 (de)
AU (1) AU1309100A (de)
CA (1) CA2343106A1 (de)
DE (1) DE69941298D1 (de)
WO (1) WO2000018403A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7344702B2 (en) 2004-02-13 2008-03-18 Bristol-Myers Squibb Pharma Company Contrast agents for myocardial perfusion imaging
US20040171836A1 (en) * 2001-12-21 2004-09-02 Toshihiro Fujino Method for producing optical-active cis-piperidine derivatives
DE60334922D1 (de) * 2002-09-24 2010-12-23 Merck Sharp & Dohme Radioaktiv markierte neurokinin-1-rezeptor-antagonisten
EP1660433A2 (de) * 2003-07-24 2006-05-31 The Queen's Medical Center Herstellung und verwendung von alkylierungsmittel
JP4710608B2 (ja) * 2003-08-01 2011-06-29 東洋紡績株式会社 アルコキシ−テトラゾール−１−イル−ベンズアルデヒド化合物およびその製造方法
US7485283B2 (en) * 2004-04-28 2009-02-03 Lantheus Medical Imaging Contrast agents for myocardial perfusion imaging
KR100808547B1 (ko) 2005-06-22 2008-02-29 재단법인서울대학교산학협력재단 펩타이드 수용체 영상용 제제로 사용할 수 있는 ｆ－１８－플로로벤질리덴하이드라존－니코틴아마이드－펩타이드 유도체 및 펩타이드에 방사성불소를 효율적으로 표지하기 위한 방법
US7824659B2 (en) 2005-08-10 2010-11-02 Lantheus Medical Imaging, Inc. Methods of making radiolabeled tracers and precursors thereof
US7834031B2 (en) * 2005-09-29 2010-11-16 Merck Sharp & Dohme Corp. Radiolabeled glycine transporter inhibitors
US8506928B2 (en) * 2007-09-07 2013-08-13 The Regents Of The University Of California Methods and compounds for targeting tissues
WO2009108376A2 (en) 2008-02-29 2009-09-03 Lantheus Medical Imaging, Inc. Contrast agents for applications including perfusion imaging
CA2737699A1 (en) * 2008-09-16 2010-03-25 Merck Sharp & Dohme Corp. Phthalimide derivative metabotropic glutamate r4 ligands
US8592454B2 (en) 2008-09-19 2013-11-26 Takeda Pharmaceutical Company Limited Nitrogen-containing heterocyclic compound and use of same
KR20160030589A (ko) 2009-04-15 2016-03-18 랜티우스 메디컬 이메징, 인크. 아스코르브산을 사용한 방사성 약제 조성물의 안정화
DK3323810T3 (da) 2010-02-08 2022-03-28 Lantheus Medical Imaging Inc Automatiseret reaktionssystem, kassette og indretning til syntese af billeddannelsesmidler
AU2013203000B9 (en) 2012-08-10 2017-02-02 Lantheus Medical Imaging, Inc. Compositions, methods, and systems for the synthesis and use of imaging agents
EP2774930A1 (de) 2013-03-07 2014-09-10 Aptenia S.R.L. Metallocenverbindungen und markierte Moleküle damit für In-vivo-Bildgebung

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0802912B1 (de) * 1995-01-12 2004-10-13 Glaxo Group Limited Piperidinderivate mit tachykinin-antagonistischer wirkung
GB9505692D0 (en) * 1995-03-21 1995-05-10 Glaxo Group Ltd Chemical compounds
JPH08325169A (ja) * 1995-03-29 1996-12-10 Nkk Corp フッ素放射性同位元素標識有機化合物の製造方法
US5719156A (en) * 1995-05-02 1998-02-17 Schering Corporation Piperazino derivatives as neurokinin antagonists
FI104048B (fi) 1997-06-16 1999-11-15 Map Medical Technologies Oy Prosessi tuottaa radiojodattuja reseptoriaineita in vivo käyttöön

Also Published As

Publication number Publication date
EP1119356A4 (de) 2008-01-09
AU1309100A (en) 2000-04-17
JP2002525325A (ja) 2002-08-13
DE69941298D1 (de) 2009-10-01
EP1119356A1 (de) 2001-08-01
US6241964B1 (en) 2001-06-05
EP1119356B1 (de) 2009-08-19
WO2000018403A1 (en) 2000-04-06
CA2343106A1 (en) 2000-04-06

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Legal Events

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