ATE279429T1 - Verfahren zur herstellung von 3-oxo-4- azasteroiden - Google Patents

Verfahren zur herstellung von 3-oxo-4- azasteroiden

Info

Publication number: ATE279429T1
Authority: AT; Austria
Prior art keywords: azasteroids; oxo; producing; compounds; ammonium
Prior art date: 2000-11-03

Application number

AT01988307T

Other languages

English (en)

Inventor

Roman Davis

Alan Millar

Jeffrey Thomas Sterbenz

Original Assignee

Glaxo Group Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-11-03

Filing date

2001-11-02

Publication date

2004-10-15

2001-11-02 Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd

2004-10-15 Application granted granted Critical

2004-10-15 Publication of ATE279429T1 publication Critical patent/ATE279429T1/de

Links

238000004519 manufacturing process Methods 0.000 title abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
USFZMSVCRYTOJT-UHFFFAOYSA-N Ammonium acetate Chemical compound N.CC(O)=O USFZMSVCRYTOJT-UHFFFAOYSA-N 0.000 abstract 1
239000005695 Ammonium acetate Substances 0.000 abstract 1
229940123934 Reductase inhibitor Drugs 0.000 abstract 1
229940043376 ammonium acetate Drugs 0.000 abstract 1
235000019257 ammonium acetate Nutrition 0.000 abstract 1
VZTDIZULWFCMLS-UHFFFAOYSA-N ammonium formate Chemical compound [NH4+].[O-]C=O VZTDIZULWFCMLS-UHFFFAOYSA-N 0.000 abstract 1
XJMWHXZUIGHOBA-UHFFFAOYSA-N azane;propanoic acid Chemical compound N.CCC(O)=O XJMWHXZUIGHOBA-UHFFFAOYSA-N 0.000 abstract 1
239000003054 catalyst Substances 0.000 abstract 1
238000005984 hydrogenation reaction Methods 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
-1 steroid alkene Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Steroid Compounds (AREA)
Glass Compositions (AREA)
Iron Core Of Rotating Electric Machines (AREA)
Crystals, And After-Treatments Of Crystals (AREA)
Valve Device For Special Equipments (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT01988307T 2000-11-03 2001-11-02 Verfahren zur herstellung von 3-oxo-4- azasteroiden ATE279429T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB0026876.3A GB0026876D0 (en)	2000-11-03	2000-11-03	Process
PCT/US2001/048173 WO2002046207A2 (en)	2000-11-03	2001-11-02	Process

Publications (1)

Publication Number	Publication Date
ATE279429T1 true ATE279429T1 (de)	2004-10-15

Family

ID=9902484

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT01988307T ATE279429T1 (de)	2000-11-03	2001-11-02	Verfahren zur herstellung von 3-oxo-4- azasteroiden

Country Status (23)

Country	Link
US (1)	US6794508B2 (de)
EP (1)	EP1335930B1 (de)
JP (1)	JP4257117B2 (de)
KR (1)	KR100821018B1 (de)
CN (1)	CN1313480C (de)
AT (1)	ATE279429T1 (de)
AU (2)	AU4162402A (de)
BR (1)	BR0115089A (de)
CA (1)	CA2427709A1 (de)
DE (1)	DE60106482T2 (de)
DK (1)	DK1335930T3 (de)
ES (1)	ES2230383T3 (de)
GB (1)	GB0026876D0 (de)
HU (1)	HUP0303907A3 (de)
IL (2)	IL155078A0 (de)
MX (1)	MXPA03003925A (de)
NO (1)	NO325180B1 (de)
NZ (1)	NZ525168A (de)
PL (1)	PL206539B1 (de)
PT (1)	PT1335930E (de)
SI (1)	SI1335930T1 (de)
WO (1)	WO2002046207A2 (de)
ZA (1)	ZA200302560B (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR100503193B1 (ko)	2002-08-19	2005-07-25	한미약품 주식회사	3-옥소-4-아자-5α-안드로스탄 화합물의 선택적인 제조방법
WO2005075497A1 (en) *	2004-01-07	2005-08-18	Ranbaxy Laboratories Limited	PROCESS FOR THE PREPARATION OF 17ß-SUBSTITUTED-3-OXO-4-AZA-5ALPHA-ANDROSTANE DERIVATIVES
CN100355772C (zh) *	2005-12-28	2007-12-19	天津大学	具有5α－还原酶抑制活性的甾体化合物及其制备方法
AR070313A1 (es)	2008-01-03	2010-03-31	Gador Sa	Un procedimiento para preparar una forma solida y cristalina de dutasteride, una forma polimorfica del compuesto (forma iii) y una composicion farmaceutica que incluye dicha forma
HU230730B1 (hu)	2011-06-30	2017-12-28	Richter Gedeon Nyrt	Eljárás (5alfa,17béta)-N-[2,5-bisz-(trifluormetil)-fenil]-3-oxo-4-aza-5-androszt-1-én-17-karbonsavamid előállítására
CN103059097A (zh) *	2011-10-20	2013-04-24	连云港润众制药有限公司	一种度他雄胺中间体的制备方法
CN103254268A (zh) *	2013-05-16	2013-08-21	寿光市富康化学工业有限公司	一种制备度他雄胺的工艺
CN104231033B (zh) *	2014-09-17	2016-08-24	广东众生药业股份有限公司	一种度他雄胺的制备方法
CN108051513B (zh) *	2017-11-27	2020-09-29	重庆华邦制药有限公司	Hplc法分离测定度他雄胺起始原料sm2及其相关杂质的方法
CN109438549B (zh) *	2018-12-13	2022-01-04	湖北葛店人福药业有限责任公司	一种制备N-叔丁基-3-氧代-4-氮杂-5α-雄甾-17β-甲酰胺的方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL74365A (en)	1984-02-27	1990-07-26	Merck & Co Inc	17beta-(n-t.-butylcarbamoyl)-4-aza-5alpha-androst-1-en-3-one and pharmaceutical compositions containing it
GB2264494A (en) *	1992-02-25	1993-09-01	Merck & Co Inc	17b-n-monosubstituted carbamoyl-11-oxo-4-aza-5-a-androst-1-en-3-one testosterone-5-alpha reductase inhibitors
TW408127B (en) *	1993-09-17	2000-10-11	Glaxo Inc	Androstenones

2000
- 2000-11-03 GB GBGB0026876.3A patent/GB0026876D0/en not_active Ceased
2001
- 2001-11-02 WO PCT/US2001/048173 patent/WO2002046207A2/en not_active Ceased
- 2001-11-02 KR KR1020037006176A patent/KR100821018B1/ko not_active Expired - Fee Related
- 2001-11-02 EP EP01988307A patent/EP1335930B1/de not_active Expired - Lifetime
- 2001-11-02 ES ES01988307T patent/ES2230383T3/es not_active Expired - Lifetime
- 2001-11-02 PL PL365705A patent/PL206539B1/pl not_active IP Right Cessation
- 2001-11-02 CA CA002427709A patent/CA2427709A1/en not_active Abandoned
- 2001-11-02 MX MXPA03003925A patent/MXPA03003925A/es active IP Right Grant
- 2001-11-02 CN CNB018184960A patent/CN1313480C/zh not_active Expired - Fee Related
- 2001-11-02 IL IL15507801A patent/IL155078A0/xx unknown
- 2001-11-02 DK DK01988307T patent/DK1335930T3/da active
- 2001-11-02 DE DE60106482T patent/DE60106482T2/de not_active Expired - Lifetime
- 2001-11-02 JP JP2002547944A patent/JP4257117B2/ja not_active Expired - Fee Related
- 2001-11-02 PT PT01988307T patent/PT1335930E/pt unknown
- 2001-11-02 AT AT01988307T patent/ATE279429T1/de active
- 2001-11-02 NZ NZ525168A patent/NZ525168A/en not_active IP Right Cessation
- 2001-11-02 HU HU0303907A patent/HUP0303907A3/hu unknown
- 2001-11-02 AU AU4162402A patent/AU4162402A/xx active Pending
- 2001-11-02 BR BR0115089-8A patent/BR0115089A/pt not_active Application Discontinuation
- 2001-11-02 SI SI200130241T patent/SI1335930T1/xx unknown
- 2001-11-02 AU AU2002241624A patent/AU2002241624B2/en not_active Ceased
- 2001-11-02 US US10/415,922 patent/US6794508B2/en not_active Expired - Fee Related
2003
- 2003-03-25 IL IL155078A patent/IL155078A/en not_active IP Right Cessation
- 2003-04-01 ZA ZA200302560A patent/ZA200302560B/en unknown
- 2003-05-02 NO NO20031995A patent/NO325180B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
CA2427709A1 (en)	2002-06-13
IL155078A0 (en)	2003-10-31
ES2230383T3 (es)	2005-05-01
US6794508B2 (en)	2004-09-21
NZ525168A (en)	2005-03-24
HUP0303907A3 (en)	2012-09-28
CN1473165A (zh)	2004-02-04
HK1058799A1 (en)	2004-06-04
DE60106482T2 (de)	2005-10-13
NO20031995D0 (no)	2003-05-02
PT1335930E (pt)	2005-01-31
NO325180B1 (no)	2008-02-11
GB0026876D0 (en)	2000-12-20
BR0115089A (pt)	2003-10-07
DK1335930T3 (da)	2005-02-14
WO2002046207A3 (en)	2003-03-20
EP1335930B1 (de)	2004-10-13
KR100821018B1 (ko)	2008-04-08
US20040049042A1 (en)	2004-03-11
JP2004515505A (ja)	2004-05-27
HUP0303907A2 (hu)	2004-03-01
PL206539B1 (pl)	2010-08-31
WO2002046207A2 (en)	2002-06-13
DE60106482D1 (de)	2004-11-18
MXPA03003925A (es)	2003-08-19
EP1335930A2 (de)	2003-08-20
SI1335930T1 (en)	2005-04-30
JP4257117B2 (ja)	2009-04-22
AU4162402A (en)	2002-06-18
NO20031995L (no)	2003-05-02
CN1313480C (zh)	2007-05-02
KR20030081326A (ko)	2003-10-17
AU2002241624B2 (en)	2004-10-28
PL365705A1 (en)	2005-01-10
ZA200302560B (en)	2004-04-01
IL155078A (en)	2009-06-15

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2005-10-15

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