ATE279516T1 - Menschliche neuronale nikotin-acetylcholin- rezeptor-verbindungen und methoden ihres einsatzes - Google Patents

Menschliche neuronale nikotin-acetylcholin- rezeptor-verbindungen und methoden ihres einsatzes

Info

Publication number
ATE279516T1
ATE279516T1 AT94912758T AT94912758T ATE279516T1 AT E279516 T1 ATE279516 T1 AT E279516T1 AT 94912758 T AT94912758 T AT 94912758T AT 94912758 T AT94912758 T AT 94912758T AT E279516 T1 ATE279516 T1 AT E279516T1
Authority
AT
Austria
Prior art keywords
subunits
alpha
methods
acetylcholine receptor
human neuronal
Prior art date
Application number
AT94912758T
Other languages
English (en)
Inventor
Kathryn J Elliott
Steven B Ellis
Michael M Harpold
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Application granted granted Critical
Publication of ATE279516T1 publication Critical patent/ATE279516T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70571—Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Cell Biology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
AT94912758T 1993-03-08 1994-03-08 Menschliche neuronale nikotin-acetylcholin- rezeptor-verbindungen und methoden ihres einsatzes ATE279516T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2803193A 1993-03-08 1993-03-08
PCT/US1994/002447 WO1994020617A2 (en) 1993-03-08 1994-03-08 Human neuronal nicotinic acetylcholine receptor compositions and methods employing same

Publications (1)

Publication Number Publication Date
ATE279516T1 true ATE279516T1 (de) 2004-10-15

Family

ID=21841175

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94912758T ATE279516T1 (de) 1993-03-08 1994-03-08 Menschliche neuronale nikotin-acetylcholin- rezeptor-verbindungen und methoden ihres einsatzes

Country Status (10)

Country Link
US (5) US6022704A (de)
EP (2) EP1508614A1 (de)
JP (2) JP3628691B2 (de)
AT (1) ATE279516T1 (de)
AU (1) AU694424B2 (de)
CA (1) CA2155330C (de)
DE (1) DE69434067T2 (de)
ES (1) ES2229216T3 (de)
GB (1) GB2286397B (de)
WO (1) WO1994020617A2 (de)

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US6323000B2 (en) 1996-12-20 2001-11-27 Clark A. Briggs Variant human α7 acetylcholine receptor subunit, and methods of production and uses thereof
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US6875606B1 (en) * 1997-10-23 2005-04-05 The United States Of America As Represented By The Department Of Veterans Affairs Human α-7 nicotinic receptor promoter
US6632823B1 (en) 1997-12-22 2003-10-14 Merck & Co., Inc. Substituted pyridine compounds useful as modulators of acetylcholine receptors
EP0953637A3 (de) * 1998-03-24 2001-04-25 Smithkline Beecham Plc Acetylcholine Receptor
US6252132B1 (en) * 1998-11-02 2001-06-26 Institut Pasteur Mutant mouse containing a knockout mutation in DNA encoding an endogenous alpha 4 subunit of nicotinic acetylcholine receptor
AU4980200A (en) * 1999-05-27 2000-12-18 Pharmacia & Upjohn Company Methods and compositions for measuring ion channel conductance
US6693172B1 (en) 1999-05-27 2004-02-17 Pharmacia And Upjohn Company Double mutant alpha-7 nicotinic acetylcholine receptor
GB9913248D0 (en) * 1999-06-09 1999-08-04 Babraham Inst Recombinant nematode nicotinic receptor and uses
US20030096411A1 (en) * 1999-12-07 2003-05-22 George Michalopoulos Novel long-term three-dimensional tissue culture system
US6737270B1 (en) 1999-12-07 2004-05-18 University Of Pittsburgh Of The Commonwealth System Of Higher Education Long-term three dimensional tissue culture system
DE19959582A1 (de) * 1999-12-10 2001-06-13 Bayer Ag Nukleinsäuren, die für neue Acetylcholinrezeptor-beta-Untereinheiten von Insekten kodieren
US20040038875A1 (en) * 2000-03-29 2004-02-26 Greenfield Susan Adele Alpha 7nicotinic receptor screening assays
EP1381603A2 (de) 2000-08-18 2004-01-21 PHARMACIA & UPJOHN COMPANY Mit aryl gruppen substituierte chinuklidine zur behandlung von krankheiten ( nikotin acetylcholin rezeptor liganden )
US6486172B2 (en) 2000-08-18 2002-11-26 Pharmacia & Upjohn Company Quinuclidine-substituted aryl compounds for treatment of disease
US6492385B2 (en) 2000-08-18 2002-12-10 Pharmacia & Upjohn Company Quinuclidine-substituted heteroaryl moieties for treatment of disease
AU2001284646A1 (en) 2000-08-21 2002-03-04 Pharmacia And Upjohn Company Quinuclidine-substituted heteroaryl moieties for treatment of disease
US6500840B2 (en) 2000-08-21 2002-12-31 Pharmacia & Upjohn Company Quinuclidine-substituted heteroaryl moieties for treatment of disease
AU2002215977A1 (en) * 2000-10-31 2002-05-15 Bayer Aktiengesellschaft Regulation of human serotonin receptor precursor
PE20021019A1 (es) 2001-04-19 2002-11-13 Upjohn Co Grupos azabiciclicos sustituidos
JP2005508157A (ja) * 2001-08-31 2005-03-31 アジェンシス，インコーポレイテッド 癌の処置および検出において有用な２０５ｐ１ｂ５との名称の核酸および対応するタンパク質
WO2003023014A2 (en) * 2001-09-12 2003-03-20 Pharmacia & Upjohn Company Human ion channels
US7229779B2 (en) 2001-09-18 2007-06-12 Abbott Laboratories Variant human α7 acetylcholine receptor subunit, and methods of production and use thereof
US20060126682A1 (en) * 2001-10-08 2006-06-15 Geola Technologies Ltd. Pulsed multiple colour laser system
AU2003267174A1 (en) * 2002-05-09 2003-11-11 Memory Pharmaceuticals Corporation Qm-7 and qt-6 cells transfected with mutant cell surface expressed channel receptors and assays using the transfected cells
US7176198B2 (en) * 2002-08-01 2007-02-13 Pfizer Inc. 1H-pyrazole and 1H-pyrrole-azabicyclic compounds for the treatment of disease
US20040151729A1 (en) * 2002-10-28 2004-08-05 George Michalopoulos Novel long-term three-dimensional culture system
EP1592710A2 (de) * 2003-02-14 2005-11-09 Memory Pharmaceutical Corporation Makak alpha-7 nikotin-acetylcholin-rezeptor und verfahren zu dessen anwendung
US7576878B2 (en) * 2003-04-03 2009-08-18 Hewlett-Packard Development Company, L.P. Enhanced management of raster image processing resources
WO2005030145A2 (en) * 2003-09-24 2005-04-07 Targacept, Inc. Composition and pharmacology of novel alpha-6-containing nicotinic acetylcholine receptors
US20070249011A1 (en) * 2004-03-04 2007-10-25 Riken Method for Screening Fungus-Specific Antimicrobial Agent and Kit Therefor
US7482752B2 (en) * 2005-01-20 2009-01-27 Lg Electronics Inc. Plasma display panel with electrode pairs at display and non-display regions, each pair having a different separation gap on each region
US20060269995A1 (en) * 2005-02-23 2006-11-30 Nailah Orr Novel assays utilizing nicotinic acetylcholine receptor subunits
US7879913B2 (en) * 2005-06-28 2011-02-01 Catholic Healthcare West Iptakalim hydrochloride for decreasing nicotine use
WO2018057837A1 (en) * 2016-09-23 2018-03-29 Ionis Pharmaceuticals, Inc. Gene therapy and targeted delivery of conjugated compounds
IL274702B2 (en) * 2017-11-27 2026-04-01 Coda Biotherapeutics Inc Compounds and methods for neurological diseases

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US5024939A (en) * 1987-07-09 1991-06-18 Genentech, Inc. Transient expression system for producing recombinant protein
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US5449606A (en) * 1988-03-18 1995-09-12 The Salk Institute For Biological Studies DNA encoding neuronal nicotinic acetylcholine receptor compositions containing the beta 4 subunit
US5386025A (en) * 1990-02-20 1995-01-31 The Salk Institute Biotechnology/Industrial Associates Calcium channel compositions and methods
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DE69033214T2 (de) * 1989-03-14 1999-12-09 Salk Inst For Biolog Studies L Neuronale nikotinacetylcholinrezeptorzusammensetzungen enthaltend die beta-4 subeinheit
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WO1995013299A1 (en) * 1993-11-08 1995-05-18 The Salk Institute Biotechnology/Industrial Associates, Inc. Human neuronal nicotinic acetylcholine receptor compositions and methods employing same

Also Published As

Publication number Publication date
AU694424B2 (en) 1998-07-23
EP0688361A1 (de) 1995-12-27
JPH08507441A (ja) 1996-08-13
JP3628691B2 (ja) 2005-03-16
CA2155330A1 (en) 1994-09-15
US6664375B2 (en) 2003-12-16
ES2229216T3 (es) 2005-04-16
DE69434067T2 (de) 2006-03-02
CA2155330C (en) 2002-01-29
GB2286397C (en) 1997-09-10
AU6517394A (en) 1994-09-26
EP1508614A1 (de) 2005-02-23
DE69434067D1 (de) 2004-11-18
US20020111463A1 (en) 2002-08-15
GB2286397B (en) 1997-09-10
WO1994020617A3 (en) 1994-10-27
WO1994020617A2 (en) 1994-09-15
JP2004194667A (ja) 2004-07-15
EP0688361B1 (de) 2004-10-13
GB2286397A (en) 1995-08-16
US5910582A (en) 1999-06-08
US6303753B1 (en) 2001-10-16
US6022704A (en) 2000-02-08
GB9503688D0 (en) 1995-04-12
US5837489A (en) 1998-11-17

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