ATE279516T1 - Menschliche neuronale nikotin-acetylcholin- rezeptor-verbindungen und methoden ihres einsatzes - Google Patents

Menschliche neuronale nikotin-acetylcholin- rezeptor-verbindungen und methoden ihres einsatzes

Info

Publication number
ATE279516T1
ATE279516T1 AT94912758T AT94912758T ATE279516T1 AT E279516 T1 ATE279516 T1 AT E279516T1 AT 94912758 T AT94912758 T AT 94912758T AT 94912758 T AT94912758 T AT 94912758T AT E279516 T1 ATE279516 T1 AT E279516T1
Authority
AT
Austria
Prior art keywords
subunits
alpha
methods
acetylcholine receptor
human neuronal
Prior art date
Application number
AT94912758T
Other languages
English (en)
Inventor
Kathryn J Elliott
Steven B Ellis
Michael M Harpold
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Application granted granted Critical
Publication of ATE279516T1 publication Critical patent/ATE279516T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70571—Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Cell Biology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
AT94912758T 1993-03-08 1994-03-08 Menschliche neuronale nikotin-acetylcholin- rezeptor-verbindungen und methoden ihres einsatzes ATE279516T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2803193A 1993-03-08 1993-03-08
PCT/US1994/002447 WO1994020617A2 (en) 1993-03-08 1994-03-08 Human neuronal nicotinic acetylcholine receptor compositions and methods employing same

Publications (1)

Publication Number Publication Date
ATE279516T1 true ATE279516T1 (de) 2004-10-15

Family

ID=21841175

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94912758T ATE279516T1 (de) 1993-03-08 1994-03-08 Menschliche neuronale nikotin-acetylcholin- rezeptor-verbindungen und methoden ihres einsatzes

Country Status (10)

Country Link
US (5) US6022704A (de)
EP (2) EP1508614A1 (de)
JP (2) JP3628691B2 (de)
AT (1) ATE279516T1 (de)
AU (1) AU694424B2 (de)
CA (1) CA2155330C (de)
DE (1) DE69434067T2 (de)
ES (1) ES2229216T3 (de)
GB (1) GB2286397B (de)
WO (1) WO1994020617A2 (de)

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CA2155330C (en) 1993-03-08 2002-01-29 Kathryn J. Elliott Human neuronal nicotinic acetylcholine receptor compositions and methods employing same
US6485967B1 (en) * 1995-06-07 2002-11-26 Merck & Co., Inc. Human neuronal nicotinic acetylcholine receptor α6 and β3 nucleic acid
CA2279673A1 (en) * 1995-12-15 1997-06-16 Enzo Therapeutics, Inc. Property effecting and/or property exhibiting constructs for the expression of non-native nucleic acids for therapeutic and diagnostic uses
US6323000B2 (en) 1996-12-20 2001-11-27 Clark A. Briggs Variant human α7 acetylcholine receptor subunit, and methods of production and uses thereof
CA2293254A1 (en) * 1997-06-13 1998-12-23 Allelix Biopharmaceuticals Inc. Assay methods and compositions useful for measuring receptor ligand binding
US6875606B1 (en) * 1997-10-23 2005-04-05 The United States Of America As Represented By The Department Of Veterans Affairs Human α-7 nicotinic receptor promoter
US6632823B1 (en) 1997-12-22 2003-10-14 Merck & Co., Inc. Substituted pyridine compounds useful as modulators of acetylcholine receptors
EP0953637A3 (de) * 1998-03-24 2001-04-25 Smithkline Beecham Plc Acetylcholine Receptor
US6252132B1 (en) 1998-11-02 2001-06-26 Institut Pasteur Mutant mouse containing a knockout mutation in DNA encoding an endogenous alpha 4 subunit of nicotinic acetylcholine receptor
WO2000073431A2 (en) * 1999-05-27 2000-12-07 Pharmacia & Upjohn Company Methods and compositions for measuring ion channel conductance
US6693172B1 (en) 1999-05-27 2004-02-17 Pharmacia And Upjohn Company Double mutant alpha-7 nicotinic acetylcholine receptor
GB9913248D0 (en) * 1999-06-09 1999-08-04 Babraham Inst Recombinant nematode nicotinic receptor and uses
US20030096411A1 (en) * 1999-12-07 2003-05-22 George Michalopoulos Novel long-term three-dimensional tissue culture system
US6737270B1 (en) 1999-12-07 2004-05-18 University Of Pittsburgh Of The Commonwealth System Of Higher Education Long-term three dimensional tissue culture system
DE19959582A1 (de) * 1999-12-10 2001-06-13 Bayer Ag Nukleinsäuren, die für neue Acetylcholinrezeptor-beta-Untereinheiten von Insekten kodieren
EP1269201A1 (de) * 2000-03-29 2003-01-02 Synaptica Limited Screening nach antagonisten von alpha-7 nikotinischen rezeptoren
US6479510B2 (en) 2000-08-18 2002-11-12 Pharmacia & Upjohn Company Quinuclidine-substituted aryl compounds for treatment of disease
US6492385B2 (en) 2000-08-18 2002-12-10 Pharmacia & Upjohn Company Quinuclidine-substituted heteroaryl moieties for treatment of disease
US6486172B2 (en) 2000-08-18 2002-11-26 Pharmacia & Upjohn Company Quinuclidine-substituted aryl compounds for treatment of disease
US6599916B2 (en) 2000-08-21 2003-07-29 Pharmacia & Upjohn Company Quinuclidine-substituted heteroaryl moieties for treatment of disease
WO2002017358A2 (en) 2000-08-21 2002-02-28 Pharmacia & Upjohn Company Quinuclidine-substituted heteroaryl moieties for treatment of disease (nicotinic acetylcholine receptor antagonists)
EP1334130A2 (de) * 2000-10-31 2003-08-13 Bayer Ag Regulation des menschlichen serotoninrezeptors
PE20021019A1 (es) 2001-04-19 2002-11-13 Upjohn Co Grupos azabiciclicos sustituidos
CA2458915A1 (en) * 2001-08-31 2003-03-13 Agensys, Inc. Nucleic acid and corresponding protein entitled 205p1b5 useful in treatment and detection of cancer
US20030194720A1 (en) * 2001-09-12 2003-10-16 Roberds Steven L. Human ion channels
US7229779B2 (en) 2001-09-18 2007-06-12 Abbott Laboratories Variant human α7 acetylcholine receptor subunit, and methods of production and use thereof
US20060126682A1 (en) * 2001-10-08 2006-06-15 Geola Technologies Ltd. Pulsed multiple colour laser system
US7358057B2 (en) * 2002-05-09 2008-04-15 Memory Pharmaceuticals Corporation QM-7 and QT-6 cells transfected with mutant cell surface expressed channel receptors and assays using the transfected cells
EP1542999A1 (de) * 2002-08-01 2005-06-22 Pharmacia & Upjohn Company LLC 1h-pyrazol- und 1h-pyrrol-azabicyclische verbindungen mit alpha-7-nachr-aktivität
US20040151729A1 (en) * 2002-10-28 2004-08-05 George Michalopoulos Novel long-term three-dimensional culture system
EP1592710A2 (de) * 2003-02-14 2005-11-09 Memory Pharmaceutical Corporation Makak alpha-7 nikotin-acetylcholin-rezeptor und verfahren zu dessen anwendung
US7576878B2 (en) * 2003-04-03 2009-08-18 Hewlett-Packard Development Company, L.P. Enhanced management of raster image processing resources
WO2005030145A2 (en) * 2003-09-24 2005-04-07 Targacept, Inc. Composition and pharmacology of novel alpha-6-containing nicotinic acetylcholine receptors
JPWO2005085416A1 (ja) * 2004-03-04 2008-01-24 独立行政法人理化学研究所 糸状菌特異的抗菌剤のスクリーニング方法及びそのためのキット
DE602006019653D1 (de) * 2005-01-20 2011-03-03 Lg Electronics Inc Plasmaanzeigetafel
WO2006091672A2 (en) * 2005-02-23 2006-08-31 Dow Agrosciences Llc Novel assays utilizing nicotinic acetylcholine receptor subunits
US7879913B2 (en) * 2005-06-28 2011-02-01 Catholic Healthcare West Iptakalim hydrochloride for decreasing nicotine use
WO2018057837A1 (en) * 2016-09-23 2018-03-29 Ionis Pharmaceuticals, Inc. Gene therapy and targeted delivery of conjugated compounds
MX2020005470A (es) * 2017-11-27 2020-11-09 Coda Biotherapeutics Inc Composiciones y metodos para enfermedades neurologicas.

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US5024939A (en) * 1987-07-09 1991-06-18 Genentech, Inc. Transient expression system for producing recombinant protein
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CA1341554C (en) 1988-03-18 2007-10-09 The Salk Institute For Biological Studies Neuronal nicotinic acetylcholine receptor compositions and assay
US5449606A (en) * 1988-03-18 1995-09-12 The Salk Institute For Biological Studies DNA encoding neuronal nicotinic acetylcholine receptor compositions containing the beta 4 subunit
ATE139542T1 (de) * 1988-04-04 1996-07-15 Salk Inst Biotech Ind Calciumkanal-zusammensetzungen und verfahren
US5386025A (en) * 1990-02-20 1995-01-31 The Salk Institute Biotechnology/Industrial Associates Calcium channel compositions and methods
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WO1995013299A1 (en) * 1993-11-08 1995-05-18 The Salk Institute Biotechnology/Industrial Associates, Inc. Human neuronal nicotinic acetylcholine receptor compositions and methods employing same

Also Published As

Publication number Publication date
WO1994020617A2 (en) 1994-09-15
AU694424B2 (en) 1998-07-23
JP3628691B2 (ja) 2005-03-16
GB2286397C (en) 1997-09-10
CA2155330C (en) 2002-01-29
EP0688361B1 (de) 2004-10-13
EP0688361A1 (de) 1995-12-27
DE69434067D1 (de) 2004-11-18
WO1994020617A3 (en) 1994-10-27
EP1508614A1 (de) 2005-02-23
AU6517394A (en) 1994-09-26
US6303753B1 (en) 2001-10-16
GB2286397A (en) 1995-08-16
JP2004194667A (ja) 2004-07-15
GB9503688D0 (en) 1995-04-12
US6664375B2 (en) 2003-12-16
ES2229216T3 (es) 2005-04-16
US20020111463A1 (en) 2002-08-15
US5837489A (en) 1998-11-17
US6022704A (en) 2000-02-08
JPH08507441A (ja) 1996-08-13
DE69434067T2 (de) 2006-03-02
US5910582A (en) 1999-06-08
GB2286397B (en) 1997-09-10
CA2155330A1 (en) 1994-09-15

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